WD repeat domain 18 is a
protein that in humans is encoded by the WDR18
gene.
[
]
Function
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
WDR18 forms a nucleolar complex with
LAS1L
LAS1-like protein is a protein that in humans is encoded by the ''LAS1L'' gene.
References
Further reading
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{{gene-X-stub ...
,
PELP1,
TEX10
Testis-expressed sequence 10 protein is a protein that in humans is encoded by the ''TEX10'' gene.
TEX10 forms part of a complex with WDR18
WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene.
Function
This gen ...
called the rixosome which is involved in RNA degradation.
[ ][ ] The rixosome is a nucleolar complex that cofractionates with the 60S preribosomal subunit. Recruitment of the rixosome by the
Polycomb Repressive Complex 1 has been proposed to lead to its functioning in establishing repressive chromatin structures by assisting in degrading nascent RNA.
[ ]
References
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