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Vernalis Group
Vernalis Group was a British-based pharmaceuticals business headquartered in Winnersh. The Vernalis name comes from the verb “to vernalise”, meaning nurture or develop, and is derived from the Latin word ''vernus'', meaning "of the spring". Vernalis Group was originally known as Vanguard Medica, which was founded in 1991 and based in Guildford. Its virtualised business model involved inlicensing of compounds in pre-clinical development from pharmaceuticals companies, running clinical trials through the use of contract research organisations and sharing in downstream royalties when drugs reached the market. In 1994, Vanguard Medica entered into a deal with SmithKline Beecham to develop SB 209509, its oral selective 5HT1D receptor agonist for the treatment of migraine, later known as VML251 and frovatriptan. Vanguard Medica acquired privately held Cerebrus in 1999, which specialised in discovering and developing therapeutics for disorders of the central nervous system. Vangu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Public Company
A public company is a company whose ownership is organized via shares of stock which are intended to be freely traded on a stock exchange or in over-the-counter markets. A public (publicly traded) company can be listed on a stock exchange (listed company), which facilitates the trade of shares, or not (unlisted public company). In some jurisdictions, public companies over a certain size must be listed on an exchange. In most cases, public companies are ''private'' enterprises in the ''private'' sector, and "public" emphasizes their reporting and trading on the public markets. Public companies are formed within the legal systems of particular states, and therefore have associations and formal designations which are distinct and separate in the polity in which they reside. In the United States, for example, a public company is usually a type of corporation (though a corporation need not be a public company), in the United Kingdom it is usually a public limited company (plc), i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SmithKline Beecham
GSK plc, formerly GlaxoSmithKline plc, is a British multinational pharmaceutical and biotechnology company with global headquarters in London, England. Established in 2000 by a merger of Glaxo Wellcome and SmithKline Beecham. GSK is the tenth largest pharmaceutical company and #294 on the 2022 ''Fortune'' Global 500, ranked behind other pharmaceutical companies China Resources, Sinopharm, Johnson & Johnson, Pfizer, Roche, AbbVie, Novartis, Bayer, and Merck. The company has a primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. , it had a market capitalisation of £70 billion, the eighth largest on the London Stock Exchange. It has a secondary listing on the New York Stock Exchange. The company developed the first malaria vaccine, RTS,S, which it said in 2014 it would make available for five percent above cost. Legacy products developed at GSK include several listed in the World Health Organization's List of Essential Medicines, such ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1991 Establishments In The United Kingdom
File:1991 Events Collage.png, From left, clockwise: Boris Yeltsin, elected as Russia's first president, waves the new flag of Russia after the 1991 Soviet coup d'état attempt, orchestrated by Soviet hardliners; Mount Pinatubo erupts in the Philippines, making it the second-largest volcanic eruption of the 20th century; MTS Oceanos sinks off the coast of South Africa, but the crew notoriously abandons the vessel before the passengers are rescued; Dissolution of the Soviet Union: The Soviet flag is lowered from the Kremlin for the last time and replaced with the flag of the Russian Federation; The United States and soon-to-be dissolved Soviet Union sign the START I Treaty; A tropical cyclone strikes Bangladesh, killing nearly 140,000 people; Lauda Air Flight 004 crashes after one of its thrust reversers activates during the flight; A United States-led coalition initiates Operation Desert Storm to remove Iraq and Saddam Hussein from Kuwait, 300x300px, thumb rect 0 0 200 200 1991 S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chairman
The chairperson, also chairman, chairwoman or chair, is the presiding officer of an organized group such as a board, committee, or deliberative assembly. The person holding the office, who is typically elected or appointed by members of the group, presides over meetings of the group, and conducts the group's business in an orderly fashion. In some organizations, the chairperson is also known as ''president'' (or other title). In others, where a board appoints a president (or other title), the two terms are used for distinct positions. Also, the chairman term may be used in a neutral manner not directly implying the gender of the holder. Terminology Terms for the office and its holder include ''chair'', ''chairperson'', ''chairman'', ''chairwoman'', ''convenor'', ''facilitator'', '' moderator'', ''president'', and ''presiding officer''. The chairperson of a parliamentary chamber is often called the ''speaker''. ''Chair'' has been used to refer to a seat or office of authority ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Celltech
Celltech Group plc was a leading British-based biotechnology business based in Slough. It was listed on the London Stock Exchange and was a constituent of the FTSE 100 Index. History Celltech was founded by Gerard Fairtlough in 1980 with finance from the National Enterprise Board. Amongst the work conducted at Celltech was the cloning of the glutamine synthetase (GS) gene in CHO cells leading to the creation of a biotechnology tool still widely used to express recombinant eukaryotic proteins. In 1999 Celltech led consolidation in the UK biosciences market merging with ''Chiroscience plc'', after which it was briefly referred to as ''Celltech Chiroscience,'' and then buying ''Medeva plc''. Then in 2000 it bought ''Cistron'', a US biosciences business. It expanded into Germany in 2001 buying Thiemann, a German biosciences business, and went on to buy Oxford Glycosciences in July 2003 for £102m. Celltech was acquired by UCB, a Belgian drugmaker, in 2004. Since then it has bee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chief Executive Officer
A chief executive officer (CEO), also known as a central executive officer (CEO), chief administrator officer (CAO) or just chief executive (CE), is one of a number of corporate executives charged with the management of an organization especially an independent legal entity such as a company or nonprofit institution. CEOs find roles in a range of organizations, including public and private corporations, non-profit organizations and even some government organizations (notably state-owned enterprises). The CEO of a corporation or company typically reports to the board of directors and is charged with maximizing the value of the business, which may include maximizing the share price, market share, revenues or another element. In the non-profit and government sector, CEOs typically aim at achieving outcomes related to the organization's mission, usually provided by legislation. CEOs are also frequently assigned the role of main manager of the organization and the highest-ranking offic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Biotech
British Biotech was a British-based biotechnology company founded as British Biotechnology Limited in 1986 by former G D Searle managers Keith McCullagh and Brian Richards. It was the first British biotech company to be publicly listed when it was floated on 1 July 1992. Controversy In 1996, despite having no compounds on or near the market, the company was temporarily valued at nearly $2.5 billion, largely on the basis of its two main development drugs: ''marimastat'' (a novel matrix metalloprotease inhibitor for cancer treatment) and lexipafant (''Zacutex'', for pancreatitis). ''Batimastat'' (codename BB94) progressed as far as stage 3 in its clinical trial, although not orally bioavailable, there are other methods of administration, including transdermal. In February 1998, Dr Andrew Millar was dismissed as Head of Clinical Research and went on to make allegations that "the Board were running a business plan consistent only with extreme and unfounded optimism". These e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frovatriptan
Frovatriptan, sold under the brand name Frova, is a triptan drug developed by Vernalis for the treatment of migraine headaches and for short term prevention of menstrual migraine. The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe. Medical uses Frovatriptan is used in the treatment of migraine. Available forms It is available as 2.5 mg tablets. Contraindications Frovatriptan should not be given to patients with: * Ischemic heart disease * Cerebrovascular syndrome * Peripheral vascular disease * Uncontrolled hypertension * Hemiplegic or basilar migraine Side effects Rare, but serious cardiac events have been reported in patients with risk factors predictive of CAD. These include: coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia and ventricular fibrillation. Pharmacology Pharmacodynamics Frovatriptan is a serotonin receptor agonist, with high affinity for the 5-HT1B/1D receptor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Contract Research Organization
In the life sciences, a contract research organization (CRO) is a company that provides support to the pharmaceutical, biotechnology, and medical device industries in the form of research services outsourced on a contract basis. A CRO may provide such services as biopharmaceutical development, biological assay development, commercialization, clinical development, clinical trials management, pharmacovigilance, outcomes research, and Real world evidence. CROs are designed to reduce costs for companies developing new medicines and drugs in niche markets. They aim to simplify entry into drug markets, and simplify development, as the need for large pharmaceutical companies to do everything ‘in house’ is now redundant. CROs also support foundations, research institutions, and universities, in addition to governmental organizations (such as the NIH, EMA, etc.). Many CROs specifically provide clinical-study and clinical-trial support for drugs and/or medical devices. However, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vernalis Plc
Vernalis plc was a UK-based pharmaceuticals business headquartered in Winnersh, with research in Cambridge, and with a Berwyn, PA, US-based commercial operation, Vernalis Therapeutics Inc., focusing on the sales and marketing of slow-release formulations of prescription cough and cold medicines. Tuzistra XR (codeine polistirex/ chlorpheniramine polistirex) was the first launched product which arose from this strategy, however sales did not reach expectations. As a result, the strategy was abandoned and the company was put up for sale. Vernalis plc was listed on AIM until its acquisition by Ligand Holdings (UK) Ltd, a subsidiary of Ligand Pharmaceuticals, Inc. (NASDAQ:LGND) on 10 October 2018. Vernalis plc (formerly known as British Biotech plc prior to 1 October 2003), arose from two company mergers. The first merger, with the privately held Cambridge-based RiboTargets Holdings plc, was completed in April 2003, and brought a structure-based drug discovery capability focuse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Guildford
Guildford () is a town in west Surrey, around southwest of central London. As of the 2011 census, the town has a population of about 77,000 and is the seat of the wider Borough of Guildford, which had around inhabitants in . The name "Guildford" is thought to derive from a crossing of the River Wey, a tributary of the River Thames that flows through the town centre. The earliest evidence of human activity in the area is from the Mesolithic and Guildford is mentioned in the will of Alfred the Great from . The exact location of the main Anglo-Saxon settlement is unclear and the current site of the modern town centre may not have been occupied until the early 11th century. Following the Norman Conquest, a motte-and-bailey castle was constructed, which was developed into a royal residence by Henry III. During the late Middle Ages, Guildford prospered as a result of the wool trade and the town was granted a charter of incorporation by Henry VII in 1488. The River Wey Navig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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