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Veratric Acid
Veratric acid, also known as 3,4-dimethoxybenzoic acid, is a benzoic acid. It is a plant metabolite found in species such as '' Hypericum laricifolium'', '' Artemisia sacrorum'', and '' Zeyheria montana''. Uses Medical research A 2023 study at SRM Institute of Science and Technology suggests that veratric acid has apoptotic and antiproliferative effects against triple negative breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ... cells. These effects were substantially increased when polydopamine nanoparticles were used as a sustained release drug carrier. References Benzoic acids Plant metabolism Botany Phytochemicals {{aromatic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Benzoic Acid
Benzoic acid is a white (or colorless) solid organic compound with the formula , whose structure consists of a benzene ring () with a carboxyl () substituent. It is the simplest aromatic carboxylic acid. The name is derived from gum benzoin, which was for a long time its only source. Benzoic acid occurs naturally in many plants and serves as an intermediate in the biosynthesis of many secondary metabolites. Salts of benzoic acid are used as food preservatives. Benzoic acid is an important precursor for the industrial synthesis of many other organic substances. The salts and esters of benzoic acid are known as benzoates . History Benzoic acid was discovered in the sixteenth century. The dry distillation of gum benzoin was first described by Nostradamus (1556), and then by Alexius Pedemontanus (1560) and Blaise de Vigenère (1596). Justus von Liebig and Friedrich Wöhler determined the composition of benzoic acid. These latter also investigated how hippuric acid is related ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metabolite
In biochemistry, a metabolite is an intermediate or end product of metabolism. The term is usually used for small molecules. Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and pheromones). A primary metabolite is directly involved in normal "growth", development, and reproduction. Ethylene exemplifies a primary metabolite produced large-scale by industrial microbiology. A secondary metabolite is not directly involved in those processes, but usually has an important ecological function. Examples include antibiotics and pigments such as resins and terpenes etc. Some antibiotics use primary metabolites as precursors, such as actinomycin, which is created from the primary metabolite tryptophan. Some sugars are metabolites, such as fructose or glucose, which are both p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypericum Laricifolium
''Hypericum laricifolium'' is a shrub plant in the family Hypericaceae Hypericaceae is a plant family in the order Malpighiales, comprising six to nine genera and up to 700 species, and commonly known as the St. John's wort family. Members are found throughout the world apart from extremely cold or dry habitats. '' ... which is native to Venezuela and Peru. References laricifolium Flora of Peru Flora of Ecuador {{Hypericum-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Artemisia Sacrorum
''Artemisia gmelinii'', also known as ''Artemisia sacrorum'' and Russian wormood, is a shrub in the family Asteraceae. It is native to China, Russia, Japan, and other parts of central Asia. ''A. gmelinii'' contains Veratric acid Veratric acid, also known as 3,4-dimethoxybenzoic acid, is a benzoic acid. It is a plant metabolite found in species such as '' Hypericum laricifolium'', '' Artemisia sacrorum'', and '' Zeyheria montana''. Uses Medical research A 2023 study .... It could be edible. In Korea, the leaf and stem are used to treat hepatitis, hyperlipaemia and infected cholecystitis. It contains flavonoids, sesquiterpenes and other bio-active constituents. This plant has 1% essential oil. References gmelinii {{Anthemideae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zeyheria Montana
''Zeyheria'' is a genus of plants in the family Bignoniaceae. Species include: * '' Zeyheria montana'' * ''Zeyheria tuberculosa ''Zeyheria tuberculosa'' is a species of tree in the family Bignoniaceae. It is endemic to Brazil, and is threatened by habitat loss. Description These trees reach a height of 15 to 23 meters, with a trunk diameter of 40–60 cm. The leave ...'' Burman References Bignoniaceae genera Taxonomy articles created by Polbot {{Bignoniaceae-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SRM Institute Of Science And Technology
SRM Institute of Science and Technology (SRMIST), formerly SRM University, is a private higher education institute deemed to be university, located in Kattankulathur, Chengalpattu (near Chennai), Tamil Nadu, India. Founded in 1985 as SRM Engineering College in Kattankulathur, it gained the deemed status in 2002. SRM Institute of Science and Technology includes six campuses, four in Tamil Nadu — Kattankulathur, Ramapuram and Vadapalani, and Tiruchirappalli, one in Andhra Pradesh — Amaravati, and one in NCR Delhi. History The first college of what is now SRMIST, SRM Engineering College, was established in 1985, followed by the rest of the SRM colleges in 1992 to 1997. The institute gained deemed status in 2002 as SRM Institute of Science and Technology and renamed SRM University in 2006. In 2017, it was renamed back to SRM Institute of Science and Technology following the UGC request to drop "University" from the name. Campuses Kattankulathur campus Located about away f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apoptosis
Apoptosis (from grc, ἀπόπτωσις, apóptōsis, 'falling off') is a form of programmed cell death that occurs in multicellular organisms. Biochemical events lead to characteristic cell changes (morphology) and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, DNA fragmentation, and mRNA decay. The average adult human loses between 50 and 70 billion cells each day due to apoptosis. For an average human child between eight and fourteen years old, approximately twenty to thirty billion cells die per day. In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis is a highly regulated and controlled process that confers advantages during an organism's life cycle. For example, the separation of fingers and toes in a developing human embryo occurs because cells between the digits undergo apoptosis. Unlike necrosis, apoptosis produces cell fragments called apoptotic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytostasis
Cytostasis (cyto – cell; stasis – stoppage) is the inhibition of cell growth and multiplication. Cytostatic refers to a cellular component or medicine that inhibits cell division. Cytostasis is an important prerequisite for structured multicellular organisms. Without regulation of cell growth and division only unorganized heaps of cells would be possible. Chemotherapy of cancer, treatment of skin diseases and treatment of infections are common use cases of cytostatic drugs. Active hygienic products generally contain cytostatic substances. Cytostatic mechanisms and drugs generally occur together with cytotoxic ones. Activators Nitric oxide – activated macrophages produce large amounts of nitric oxide (NO), which induces both cytostasis and cytotoxicity to tumor cells both ''in vitro'' and ''in vivo''. Nitric oxide-induced cytostasis targets ribonucleotide reductase by rapid and reversible inhibition. However, other studies show there could be other targets that are respon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triple-negative Breast Cancer
Triple-negative breast cancer (TNBC) is any breast cancer that lacks or show low levels of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) overexpression and/or gene amplification (i.e. the tumor is negative on all three tests giving the name ''triple-negative''). Triple-negative is sometimes used as a surrogate term for basal-like. Triple-negative breast cancer comprises 15–20% of all breast cancer cases and affects more young women or women with a mutation in the BRCA1 gene than other breast cancers. Triple-negative breast cancers comprise a very heterogeneous group of cancers. TNBC is the most challenging breast cancer type to treat. Hormone therapy that is used for other breast cancers does not work for TNBC. In its early stages, the cancer is typically treated through surgery, radiation and chemotherapy. In later stages where surgery is not possible or the cancer has spread from the initial localised area, treatment i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin. Risk factors for developing breast cancer include obesity, a lack of physical exercise, alcoholism, hormone replacement therapy during menopause, ionizing radiation, an early age at first menstruation, having children late in life or not at all, older age, having a prior history of breast cancer, and a family history of breast cancer. About 5–10% of cases are the result of a genetic predisposition inherited from a person's parents, including BRCA1 and BRCA2 among others. Breast cancer most commonly develops in cells from the lining of milk ducts and the lobules that supply these ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polydopamine Nanoparticles
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. Dopamine constitutes about 80% of the catecholamine content in the brain. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical, L-DOPA, which is synthesized in the brain and kidneys. Dopamine is also synthesized in plants and most animals. In the brain, dopamine functions as a neurotransmitter—a chemical released by neurons (nerve cells) to send signals to other nerve cells. Neurotransmitters are synthesized in specific regions of the brain, but affect many regions systemically. The brain includes several distinct dopamine pathways, one of which plays a major role in the motivational component of reward-motivated behavior. The anticipation of most types of rewards increases the level of dopamine in the brain, and m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
