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Valienamine
Valienamine is a C-7 aminocyclitol found as a substructure of pseudooligosaccharides such as the antidiabetic drug acarbose and the antibiotic validamycin. It can be found in ''Actinoplanes'' species. It is an intermediate formed by microbial degradation of validamycin Validamycin is an antibiotic and fungicide produced by '' Streptomyces hygroscopicus''. It is used as an inhibitor of trehalase. It is used for the control of sheath blight of rice and damping-off of cucumbers. See also *Ralstonia solanacear ...s. References External links Valienamine on chemblink.com Cyclitols Cyclohexenes Amines {{amine-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminocyclitol
The aminocyclitols are compounds related to cyclitols. They possess features of relative and absolute configuration that are characteristic of their class and have been extensively studied; but these features are not clearly displayed by general methods of stereochemical nomenclature, so that special methods of specifying their configuration are justified and have long been used. In other than stereochemical respects, their nomenclature should follow the general rules of organic chemistry. Aminocyclitol natural products The aminocyclitol family of natural products is a class of sugar-derived microbial secondary metabolites that demonstrate significant biological activities. Aminocyclitols are found as a component of aminoglycoside antibiotics which is also called as pseudosugars or pseudosaccharides. Aminocyclitols have chemical structures of a carbon ring with amine functional group(s). The class of aminocyclitol containing natural products can be divided by ring sizes or types ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acarbose
Acarbose (INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay (Bayer AG), in North America as Precose (Bayer Pharmaceuticals), and in Canada as Prandase (Bayer AG). It is cheap and popular in China, but not in the U.S. One physician explains the use in the U.S. is limited because it is not potent enough to justify the side effects of diarrhea and flatulence. However, a recent large study concludes "acarbose is effective, safe and well tolerated in a large cohort of Asian patients with type 2 diabetes." A possible explanation for the differing opinions is an observation that acarbose is significantly more effective in patients eating a relatively high carbohydrate Eastern diet. It is a starch blocker, and inhibits alpha glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates. It is composed of an acarviosin moiety with a maltose at the reducing ter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Validamycin
Validamycin is an antibiotic and fungicide produced by '' Streptomyces hygroscopicus''. It is used as an inhibitor of trehalase. It is used for the control of sheath blight of rice and damping-off of cucumbers. See also *Ralstonia solanacearum ''Ralstonia solanacearum'' is an aerobic non-spore-forming, Gram-negative, plant pathogenic bacterium. ''R. solanacearum'' is soil-borne and motile with a polar flagellar tuft. It colonises the xylem, causing bacterial wilt in a very wide rang ... References {{reflist Amino sugars Oligosaccharides Cyclitols Antibiotics Fungicides Cyclohexenes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Actinoplanes
''Actinoplanes'' is a genus in the family Micromonosporaceae. They have aerial mycelia and spherical, motile spores. ''Actinoplanes'' species produce the pharmaceutically important compounds valienamine (a precursor to the antidiabetic drug acarbose and to the antibiotic validamycin), teicoplanin, and ramoplanin Ramoplanin (INN) is a glycolipodepsipeptide antibiotic drug derived from strain ATCC 33076 of ''Actinoplanes''. It is effective against Gram-positive bacteria. Mechanism It exerts its bacteriocidal effect by inhibiting cell wall biosynthesi .... Species ''Actinoplanes'' comprises the following species: * '' A. abujensis'' Sazak et al. 2012 * "'' A. arizonaensis''" Karwowski et al. 1988 * '' A. atraurantiacus'' Zhang et al. 2012 * '' A. auranticolor'' (Couch 1963) Stackebrandt and Kroppenstedt 1988 * "'' A. aureus''" Song et al. 2021 * '' A. bogorensis'' corrig. Nurkanto et al. 2016 * '' A. brasiliensis'' Thiemann et al. 1969 (Approved Lists 1980) * '' A. camp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclitols
In organic chemistry, a cyclitol is a cycloalkane containing at least three hydroxyl, each attached to a different ring carbon atom. The general formula for an unsubstituted cyclitol is or where 3 ≤ ''x'' ≤ ''n''. The name is also used for compounds that can be viewed as result of substituting various functional groups for the hydrogen atoms in such a molecule, as well as similar molecules with one or more double bonds in the ring. Cyclitols and their derivatives are some of the compatible solutes which are formed in a plant as a response to salt or water stress. Some cyclitols (e.g. quinic or shikimic acid) are parts of hydrolysable tannins. Isomerism and nomenclature Unsubstituted cyclitols with the same ring size and number of hydroxyls may exist in several structural isomers, depending on the position of the hydroxyls along the ring. For example, cyclohexanetriol exists in three distinct isomers (1,2,3-, 1,2,4-, and 1,3,5-). Furthermore, the hydrogen and the hydroxyl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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