|
Utako Okamoto
was a Japanese medical doctor working as a medical scientist who discovered tranexamic acid in the 1950s in her quest to find a drug that would treat bleeding after childbirth ( post-partum haemorrhage). After publishing results in 1962 she became a chair at Kobe Gakuin University, where she worked from 1966 until her retirement in 1990. Okamoto's career was hampered by a very male dominated environment. During her lifetime she was unable to persuade obstetricians at Kobe to trial the antifibrinolytic agent, which had become a drug on the WHO list of essential medicines in 2009. She lived to see the 2010 beginning of the study of tranexamic acid in 20 000 women with post-partum haemorrhage, but died before its completion in 2016 and the publication of tranexamic acids fatality preventing results in 2017, that she had predicted. Education Okamoto began studying dentistry in 1936. She very soon switched to medicine enrolling at the Tokyo Women's Medical University and graduated in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tranexamic Acid
Tranexamic acid (TXA) is a medication used to treat or prevent excessive blood loss from major trauma, postpartum bleeding, surgery, tooth removal, nosebleeds, and heavy menstruation. It is also used for hereditary angioedema. It is taken either orally or by injection into a vein. Mechanism of action Tranexamic acid is a synthetic analog of the amino acid lysine. It serves as an antifibrinolytic by reversibly binding four to five lysine receptor sites on plasminogen. This decreases the conversion of plasminogen to plasmin, preventing fibrin degradation and preserving the framework of fibrin's matrix structure. Tranexamic acid has roughly eight times the antifibrinolytic activity of an older analogue, ε-aminocaproic acid. Tranexamic acid also directly inhibits the activity of plasmin with weak potency ( IC50 = 87 mM), and it can block the active-site of urokinase plasminogen activator (uPA) with high specificity ( Ki = 2 mM), one of the highest among all the serine proteases. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Randomised Controlled Trial
A randomized controlled trial (or randomized control trial; RCT) is a form of scientific experiment used to control factors not under direct experimental control. Examples of RCTs are clinical trials that compare the effects of drugs, surgical techniques, medical devices, diagnostic procedures or other medical treatments. Participants who enroll in RCTs differ from one another in known and unknown ways that can influence study outcomes, and yet cannot be directly controlled. By randomly allocating participants among compared treatments, an RCT enables ''statistical control'' over these influences. Provided it is designed well, conducted properly, and enrolls enough participants, an RCT may achieve sufficient control over these confounding factors to deliver a useful comparison of the treatments studied. Definition and examples An RCT in clinical research typically compares a proposed new treatment against an existing standard of care; these are then termed the 'experimental' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People From Tokyo
A person ( : people) is a being that has certain capacities or attributes such as reason, morality, consciousness or self-consciousness, and being a part of a culturally established form of social relations such as kinship, ownership of property, or legal responsibility. The defining features of personhood and, consequently, what makes a person count as a person, differ widely among cultures and contexts. In addition to the question of personhood, of what makes a being count as a person to begin with, there are further questions about personal identity and self: both about what makes any particular person that particular person instead of another, and about what makes a person at one time the same person as they were or will be at another time despite any intervening changes. The plural form "people" is often used to refer to an entire nation or ethnic group (as in "a people"), and this was the original meaning of the word; it subsequently acquired its use as a plural form of per ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japanese Women Physicians
Japanese may refer to: * Something from or related to Japan, an island country in East Asia * Japanese language, spoken mainly in Japan * Japanese people, the ethnic group that identifies with Japan through ancestry or culture ** Japanese diaspora, Japanese emigrants and their descendants around the world * Japanese citizens, nationals of Japan under Japanese nationality law ** Foreign-born Japanese, naturalized citizens of Japan * Japanese writing system, consisting of kanji and kana * Japanese cuisine, the food and food culture of Japan See also * List of Japanese people * * Japonica (other) * Japonicum * Japonicus * Japanese studies {{disambiguation Language and nationality disambiguation pages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japanese Women Academics
Japanese may refer to: * Something from or related to Japan, an island country in East Asia * Japanese language, spoken mainly in Japan * Japanese people, the ethnic group that identifies with Japan through ancestry or culture ** Japanese diaspora, Japanese emigrants and their descendants around the world * Japanese citizens, nationals of Japan under Japanese nationality law ** Foreign-born Japanese, naturalized citizens of Japan * Japanese writing system, consisting of kanji and kana * Japanese cuisine, the food and food culture of Japan See also * List of Japanese people * * Japonica (other) * Japonicum * Japonicus * Japanese studies Japanese studies (Japanese: ) or Japan studies (sometimes Japanology in Europe), is a sub-field of area studies or East Asian studies involved in social sciences and humanities research on Japan. It incorporates fields such as the study of Japanese ... {{disambiguation Language and nationality disambiguation pages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1918 Births
This year is noted for the end of the World War I, First World War, on the eleventh hour of the eleventh day of the eleventh month, as well as for the Spanish flu pandemic that killed 50–100 million people worldwide. Events Below, the events of World War I have the "WWI" prefix. January * January – 1918 flu pandemic: The "Spanish flu" (influenza) is first observed in Haskell County, Kansas. * January 4 – The Finnish Declaration of Independence is recognized by Russian Soviet Federative Socialist Republic, Soviet Russia, Sweden, German Empire, Germany and France. * January 9 – Battle of Bear Valley: U.S. troops engage Yaqui people, Yaqui Native American warriors in a minor skirmish in Arizona, and one of the last battles of the American Indian Wars between the United States and Native Americans. * January 15 ** The keel of is laid in Britain, the first purpose-designed aircraft carrier to be laid down. ** The Red Army (The Workers and Peasants Red Army) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Japanese Medical Researchers
Japanese may refer to: * Something from or related to Japan, an island country in East Asia * Japanese language, spoken mainly in Japan * Japanese people, the ethnic group that identifies with Japan through ancestry or culture ** Japanese diaspora, Japanese emigrants and their descendants around the world * Japanese citizens, nationals of Japan under Japanese nationality law ** Foreign-born Japanese, naturalized citizens of Japan * Japanese writing system, consisting of kanji and kana * Japanese cuisine, the food and food culture of Japan See also * List of Japanese people * * Japonica (other) * Japonicum * Japonicus * Japanese studies Japanese studies (Japanese: ) or Japan studies (sometimes Japanology in Europe), is a sub-field of area studies or East Asian studies involved in social sciences and humanities research on Japan. It incorporates fields such as the study of Japanese ... {{disambiguation Language and nationality disambiguation pages ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2016 Deaths
This is a list of deaths of notable people, organised by year. New deaths articles are added to their respective month (e.g., Deaths in ) and then linked here. 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 See also * Lists of deaths by day The following pages, corresponding to the Gregorian calendar, list the historical events, births, deaths, and holidays and observances of the specified day of the year: Footnotes See also * Leap year * List of calendars * List of non-standard ... * Deaths by year {{DEFAULTSORT:deaths by year ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sexism In Academia
Sexism in academia refers to the discrimination and subordination of a particular sex or gender academic institutions, particularly universities, due to the ideologies, practices, and reinforcements that privilege one sex or gender over another. Sexism in academia is not limited to but primarily affects women who are denied the professional achievements awarded to men in their respective fields such as positions, tenure and awards. Sexism in academia encompasses institutionalized and cultural sexist ideologies; it is not limited to the admission process and the under-representation of women in the sciences but also includes the lack of women represented in college course materials and the denial of tenure, positions and awards that are generally accorded to men. Positions Controversy exists over whether women's under-representation in specific academic fields is the result of gender discrimination or of other factors such as personal inclination. Some individuals have argued th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Women In Japan
Although women in Japan were recognized as having equal legal rights to men after World War II, economic conditions for women remain unbalanced. Modern policy initiatives to encourage motherhood and workplace participation have had mixed results. Women in Japan obtained the right to vote in 1945. While Japanese women's status has steadily improved in the decades since then, traditional expectations for married women and mothers are cited as a barrier to full economic equality. The monarchy is strictly males-only and a princess has to give up her royal status when she marries a commoner. Cultural history The extent to which women could participate in Japanese society has varied over time and social classes. In the 8th century, Japan had an empress, and in the 12th century during the Heian period, women in Japan could inherit property in their own names and manage it by themselves: "Women could own property, be educated, and were allowed, if discrete (sic), to take lovers." ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Obstetrical Bleeding
Obstetrical bleeding is bleeding in pregnancy that occurs before, during, or after childbirth. Bleeding before childbirth is that which occurs after 24 weeks of pregnancy. Bleeding may be vaginal or less commonly into the abdominal cavity. Bleeding which occurs before 24 weeks is known as early pregnancy bleeding. Causes of bleeding before and during childbirth include cervicitis, placenta previa, placental abruption and uterine rupture. Causes of bleeding after childbirth include poor contraction of the uterus, retained products of conception, and bleeding disorders. About 8.7 million cases of severe maternal bleeding occurred in 2015 resulting in 83,000 deaths. Between 2003 and 2009, bleeding accounted for 27% of maternal deaths globally. Later pregnancy Antepartum bleeding (APH), also prepartum hemorrhage, is bleeding during pregnancy from the 24th week [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
London School Of Hygiene & Tropical Medicine
The London School of Hygiene and Tropical Medicine (LSHTM) is a public research university in Bloomsbury, central London, and a member institution of the University of London that specialises in public health and tropical medicine. The institution was founded in 1899 by Sir Patrick Manson, after a donation from the Indian Parsi philanthropist B. D. Petit. Since its foundation it has become one of the most highly placed institutions in global rankings in the fields of public health and infectious diseases. The annual income of the institution for 2020–21 was £244.2 million, of which £167.6 million was from research grants and contracts, with expenditures totalling £235.2 million during the same period. History Origins (1899–1913) The school was founded on October 2, 1899, by Sir Patrick Manson as the London School of Tropical Medicine after the Parsi philanthropist Bomanjee Dinshaw Petit made a donation of £6,666. It was initially located at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
_1938.jpg "Click for more on -> People From Tokyo")
.jpg "Click for more on -> Sexism In Academia")
