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UCbase
UCbase is a database of ultraconserved sequences (UCRs or UCEs) that were first described by Bejerano, G. et al. in 2004. They are highly conserved genome regions that share 100% identity among human, mouse and rat. UCRs are 481 sequences longer than 200 bases. They are frequently located at genomic regions involved in cancer, differentially expressed in human leukemias and carcinomas and in some instances regulated by microRNAs. The first release of UCbase was published by Taccioli, C. et al. in 2009. Recent updates include new annotation based on hg19 Human genome, information about disorders related to the chromosome coordinates using the SNOMED CT classification, a query tool to search for SNPs, and a new text box to directly interrogate the database using a MySQL interface. Moreover, a sequence comparison tool allows the researchers to match selected sequences against ultraconserved elements located in genomic regions involved in specific disorders. To facilitate the interactiv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ultra-conserved Element
An ultra-conserved element (UCE) was originally defined as a genome segment longer than 200 base pairs (bp) that is absolutely conserved, with no insertions or deletions and 100% identity, between orthologous regions of the human, rat, and mouse genomes. 481 ultra-conserved elements have been identified in the human genome. If ribosomal DNA (rDNA regions) are excluded, these range in size from 200 bp to 781 bp. UCRs are found on all chromosomes except for 21 and Y. A database collecting genomic information about ultra-conserved elements ( UCbase) is available at http://ucbase.unimore.it. Since its creation, this term's usage has broadened to include more evolutionary distant species or shorter segments, for example 100 bp instead of 200 bp. By some definitions, segments need not be syntetic between species. Human UCEs also show high conservation with more evolutionarily distant species, such as chicken and fugu. Out of 481 identified human UCEs, approximately 97% align with high id ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sequence Conservation
In evolutionary biology, conserved sequences are identical or similar sequences in nucleic acids ( DNA and RNA) or proteins across species ( orthologous sequences), or within a genome ( paralogous sequences), or between donor and receptor taxa ( xenologous sequences). Conservation indicates that a sequence has been maintained by natural selection. A highly conserved sequence is one that has remained relatively unchanged far back up the phylogenetic tree, and hence far back in geological time. Examples of highly conserved sequences include the RNA components of ribosomes present in all domains of life, the homeobox sequences widespread amongst Eukaryotes, and the tmRNA in Bacteria. The study of sequence conservation overlaps with the fields of genomics, proteomics, evolutionary biology, phylogenetics, bioinformatics and mathematics. History The discovery of the role of DNA in heredity, and observations by Frederick Sanger of variation between animal insulins in 1949, promp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Database
In computing, a database is an organized collection of data stored and accessed electronically. Small databases can be stored on a file system, while large databases are hosted on computer clusters or cloud storage. The design of databases spans formal techniques and practical considerations, including data modeling, efficient data representation and storage, query languages, security and privacy of sensitive data, and distributed computing issues, including supporting concurrent access and fault tolerance. A database management system (DBMS) is the software that interacts with end users, applications, and the database itself to capture and analyze the data. The DBMS software additionally encompasses the core facilities provided to administer the database. The sum total of the database, the DBMS and the associated applications can be referred to as a database system. Often the term "database" is also used loosely to refer to any of the DBMS, the database system or an appli ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homo Sapiens
Humans (''Homo sapiens'') are the most abundant and widespread species of primate, characterized by bipedalism and exceptional cognitive skills due to a large and complex brain. This has enabled the development of advanced tools, culture, and language. Humans are highly social and tend to live in complex social structures composed of many cooperating and competing groups, from families and kinship networks to political states. Social interactions between humans have established a wide variety of values, social norms, and rituals, which bolster human society. Its intelligence and its desire to understand and influence the environment and to explain and manipulate phenomena have motivated humanity's development of science, philosophy, mythology, religion, and other fields of study. Although some scientists equate the term ''humans'' with all members of the genus ''Homo'', in common usage, it generally refers to ''Homo sapiens'', the only extant member. Anatomically mod ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mus Musculus
Mus or MUS may refer to: Abbreviations * MUS, the NATO country code for Mauritius * MUS, the IATA airport code for Minami Torishima Airport * MUS, abbreviation for the Centre for Modern Urban Studies on Campus The Hague, Leiden University, Netherlands * MUS, abbreviation for Medically unexplained physical symptoms * MUS, abbreviation for the Memphis University School * MUS, abbreviation for the Movimiento Unión Soberanista * MUS, abbreviation for Multiple-use water supply system, a low-cost, equitable water supply systems * Mus, abbreviation for Musca, a southern constellation * mus, ISO-639 code for the Muscogee language * Mus., abbreviation used in music degrees such as B.Mus. and M.Mus. * MUs, or million units of energy, used in India for a gigawatt hour People * Anders Mus (fl. 1501–1535), Danish civil servant in Norway * Conny Mus (1950–2010), Dutch journalist, best known as a correspondent for ''RTL Nieuws'' in Israel and the Middle East * Gus Mus (born 1944), I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rattus Norvegicus
''Rattus'' is a genus of muroid rodents, all typically called rats. However, the term rat can also be applied to rodent species outside of this genus. Species and description The best-known ''Rattus'' species are the black rat (''R. rattus'') and the brown rat (''R. norvegicus''). The group is generally known as the Old World rats or true rats and originated in Asia. Rats are bigger than most Old World mice, which are their relatives, but seldom weigh over in the wild. Taxonomy of ''Rattus'' The genus ''Rattus'' is a member of the giant subfamily Murinae. Several other murine genera are sometimes considered part of ''Rattus'': ''Lenothrix'', ''Anonymomys'', ''Sundamys'', ''Kadarsanomys'', ''Diplothrix'', ''Margaretamys'', ''Lenomys'', ''Komodomys'', ''Palawanomys'', ''Bunomys'', ''Nesoromys'', ''Stenomys'', ''Taeromys'', ''Paruromys'', ''Abditomys'', ''Tryphomys'', ''Limnomys'', ''Tarsomys'', '' Bullimus'', ''Apomys'', ''Millardia'', '' Srilankamys'', ''Niviventer'', ''Maxomy ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carlo M
Carlo is a given name. It is an Italian form of Charles. It can refer to: *Carlo (name) *Monte Carlo *Carlingford, New South Wales, a suburb in north-west Sydney, New South Wales, Australia *A satirical song written by Dafydd Iwan about Prince Charles. *A former member of Dion and the Belmonts best known for his 1964 song, Ring A Ling. *Carlo (submachine gun), an improvised West Bank gun. * Carlo, a fictional character from Animal Crossing: Pocket Camp * It can be confused with Carlos * Carlo means “man” (from Germanic “karal”), “free man” (from Middle Low German “kerle”) and “warrior”, “army” (from Germanic “hari”). See also *Carl (name) *Carle (other) *Carlos (given name) Carlos is a masculine given name, and is the Portuguese and Spanish variant of the English name ''Charles'', from the Germanic ''Carl''. Notable people with the name include: Royalty *Carlos I of Portugal (1863–1908), second to last King of P ... {{disambig Italian ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SNOMED CT
SNOMED CT or SNOMED Clinical Terms is a systematically organized computer-processable collection of medical terms providing codes, terms, synonyms and definitions used in clinical documentation and reporting. SNOMED CT is considered to be the most comprehensive, multilingual clinical healthcare terminology in the world. The primary purpose of SNOMED CT is to encode the meanings that are used in health information and to support the effective clinical recording of data with the aim of improving patient care. SNOMED CT provides the core general terminology for electronic health records. SNOMED CT comprehensive coverage includes: clinical findings, symptoms, diagnoses, procedures, body structures, organisms and other etiologies, substances, pharmaceuticals, devices and specimens. SNOMED CT is maintained and distributed by SNOMED International, an international non-profit standards development organization, located in London, UK. SNOMED International is the trading name of the Intern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UCSC Genome Browser
The UCSC Genome Browser is an online and downloadable genome browser hosted by the University of California, Santa Cruz (UCSC). It is an interactive website offering access to genome sequence data from a variety of vertebrate and invertebrate species and major Model organism, model organisms, integrated with a large collection of aligned annotations. The Browser is a graphical viewer optimized to support fast interactive performance and is an open-source, web-based tool suite built on top of a MySQL database for rapid visualization, examination, and querying of the data at many levels. The Genome Browser Database, browsing tools, downloadable data files, and documentation can all be found on the UCSC Genome Bioinformatics website. History Initially built and still managed by Jim Kent, then a graduate student, and David Haussler, professor of Computer Science (now Biomolecular Engineering) at the University of California, Santa Cruz in 2000, the UCSC Genome Browser began as a resou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Database (journal)
''Database: The Journal of Biological Databases and Curation'' is an online peer-reviewed open access scientific journal that covers research on databases and biocuration. The journal was established in 2009 with David Landsman as the editor-in-chief. DATABASE is the official journal of the International Society for Biocuration. The journal has published the proceedings of the International Biocuration Conferences since 2009. Abstracting and indexing The journal is abstracted and indexed in MEDLINE/PubMed, Asian Science Citation Index, and Chemical Abstracts. According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 3.451. References External links * {{Authority control Biology journal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Conservation Biology
Conservation biology is the study of the conservation of nature and of Earth's biodiversity with the aim of protecting species, their habitats, and ecosystems from excessive rates of extinction and the erosion of biotic interactions. It is an interdisciplinary subject drawing on natural and social sciences, and the practice of natural resource management. The conservation ethic is based on the findings of conservation biology. Origins The term conservation biology and its conception as a new field originated with the convening of "The First International Conference on Research in Conservation Biology" held at the University of California, San Diego in La Jolla, California, in 1978 led by American biologists Bruce A. Wilcox and Michael E. Soulé with a group of leading university and zoo researchers and conservationists including Kurt Benirschke, Sir Otto Frankel, Thomas Lovejoy, and Jared Diamond. The meeting was prompted due to concern over tropical deforestation, disappearin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
