Transcriptor
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Transcriptor
A transcriptor is a transistor-like device composed of DNA and RNA rather than a semiconducting material such as silicon. Prior to its invention in 2013, the transcriptor was considered an important component to build biological computers. Background To function, a modern computer needs three different capabilities: It must be able to store information, transmit information between components, and possess a basic system of logic. Prior to March 2013, scientists had successfully demonstrated the ability to store and transmit data using biological components made of proteins and DNA. Simple two-terminal logic gates had been demonstrated, but required multiple layers of inputs and thus were impractical due to scaling difficulties. Invention and description On March 28, 2013, a team of bioengineers from Stanford University led by Drew Endy announced that they had created the biological equivalent of a transistor, which they named a "transcriptor". That is, they created a thr ...
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Transistor
upright=1.4, gate (G), body (B), source (S) and drain (D) terminals. The gate is separated from the body by an insulating layer (pink). A transistor is a semiconductor device used to Electronic amplifier, amplify or electronic switch, switch electrical signals and electrical power, power. The transistor is one of the basic building blocks of modern electronics. It is composed of semiconductor material, usually with at least three terminals for connection to an electronic circuit. A voltage or current applied to one pair of the transistor's terminals controls the current through another pair of terminals. Because the controlled (output) power can be higher than the controlling (input) power, a transistor can amplify a signal. Some transistors are packaged individually, but many more are found embedded in integrated circuits. Austro-Hungarian physicist Julius Edgar Lilienfeld proposed the concept of a field-effect transistor in 1926, but it was not possible to actually constru ...
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NOR Gate
The NOR gate is a digital logic gate that implements logical NOR - it behaves according to the truth table to the right. A HIGH output (1) results if both the inputs to the gate are LOW (0); if one or both input is HIGH (1), a LOW output (0) results. NOR is the result of the negation of the OR operator. It can also in some senses be seen as the inverse of an AND gate. NOR is a functionally complete operation—NOR gates can be combined to generate any other logical function. It shares this property with the NAND gate. By contrast, the OR operator is ''monotonic'' as it can only change LOW to HIGH but not vice versa. In most, but not all, circuit implementations, the negation comes for free—including CMOS and TTL. In such logic families, OR is the more complicated operation; it may use a NOR followed by a NOT. A significant exception is some forms of the domino logic family. The original Apollo Guidance Computer used 4,100 integrated circuits (IC), each one containing o ...
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DNA Nanotechnology
DNA nanotechnology is the design and manufacture of artificial nucleic acid structures for technological uses. In this field, nucleic acids are used as non-biological engineering materials for nanotechnology rather than as the carriers of genetic information in living cells. Researchers in the field have created static structures such as two- and three-dimensional crystal lattices, nanotubes, polyhedra, and arbitrary shapes, and functional devices such as molecular machines and DNA computers. The field is beginning to be used as a tool to solve basic science problems in structural biology and biophysics, including applications in X-ray crystallography and nuclear magnetic resonance spectroscopy of proteins to determine structures. Potential applications in molecular scale electronics and nanomedicine are also being investigated. The conceptual foundation for DNA nanotechnology was first laid out by Nadrian Seeman in the early 1980s, and the field began to attract widespread int ...
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American Inventions
The following articles cover the timeline of United States inventions: *Timeline of United States inventions (before 1890), before the turn of the century * Timeline of United States inventions (1890–1945), before World War II *Timeline of United States inventions (1946–1991), for the post-war era *Timeline of United States inventions (after 1991), after the Fall of the Soviet Union {{DEFAULTSORT:Timeline of United States Inventions United States inventions United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territorie ...
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Science (journal)
''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' c ...
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Jay Keasling
Jay D. Keasling is a professor of chemical engineering and bioengineering at the University of California, Berkeley. He is also associate laboratory director for biosciences at the Lawrence Berkeley National Laboratory and chief executive officer of the Joint BioEnergy Institute. He is considered one of the foremost authorities in synthetic biology, especially in the field of metabolic engineering. Keasling was elected a member of the National Academy of Engineering in 2010 for developing synthetic biology tools to engineer the antimalarial drug artemisinin. Education Keasling received his bachelor's degree at the University of Nebraska-Lincoln where he was a member of Delta Tau Delta International Fraternity. He went on to complete his Doctor of Philosophy degree at the University of Michigan in 1991 under the supervision of Bernhard Palsson. Keasling performed post-doctoral research with Arthur Kornberg at Stanford University in 1991-1992. Research Keasling's current research i ...
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University Of California, Berkeley
The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant university and the founding campus of the University of California system. Its fourteen colleges and schools offer over 350 degree programs and enroll some 31,800 undergraduate and 13,200 graduate students. Berkeley ranks among the world's top universities. A founding member of the Association of American Universities, Berkeley hosts many leading research institutes dedicated to science, engineering, and mathematics. The university founded and maintains close relationships with three national laboratories at Berkeley, Livermore and Los Alamos, and has played a prominent role in many scientific advances, from the Manhattan Project and the discovery of 16 chemical elements to breakthroughs in computer science and genomics. Berkeley is ...
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ExtremeTech
ExtremeTech is a technology weblog, launched in June 2001, which focuses on hardware, computer software, science and other technologies. Between 2003 and 2005, ExtremeTech was also a print magazine and the publisher of a popular series of how-to and do-it-yourself books. ExtremeTech.com ExtremeTech was launched as a website in June 2001, with co-founder Bill Machrone as Editor-in-Chief, and fellow co-founder Nick Stam as Senior Technical Director. Loyd Case, Dave Salvator, Mark Hachman, and Jim Lynch were other original core ET staff. In 2002 Jim Louderback became the Editor-in-Chief. When initially launched, ExtremeTech covered a broad range of technical topics with very indepth technical stories. Topic areas included core PC techniques (CPUs/GPUs), networking, operating systems, software development, display technology, printers, scanners etc. By 2003, Ziff Davis management wanted to reduce expenses and cut back content to core PC tech areas, focusing on how to build and opti ...
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Metabolism
Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run cellular processes; the conversion of food to building blocks for proteins, lipids, nucleic acids, and some carbohydrates; and the elimination of metabolic wastes. These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transportation of substances into and between different cells, in which case the above described set of reactions within the cells is called intermediary (or intermediate) metabolism. Metabolic reactions may be categorized as ''catabolic'' – the ''breaking down'' of compounds (for example, of glucose to pyruvate by ce ...
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Public Domain
The public domain (PD) consists of all the creative work A creative work is a manifestation of creative effort including fine artwork (sculpture, paintings, drawing, sketching, performance art), dance, writing (literature), filmmaking, and composition. Legal definitions Creative works require a cre ... to which no exclusive intellectual property rights apply. Those rights may have expired, been forfeited, expressly waived, or may be inapplicable. Because those rights have expired, anyone can legally use or reference those works without permission. As examples, the works of William Shakespeare, Ludwig van Beethoven, Leonardo da Vinci and Georges Méliès are in the public domain either by virtue of their having been created before copyright existed, or by their copyright term having expired. Some works are not covered by a country's copyright laws, and are therefore in the public domain; for example, in the United States, items excluded from copyright include the for ...
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XNOR Gate
The XNOR gate (sometimes XORN'T, ENOR, EXNOR or NXOR and pronounced as Exclusive NOR. Alternatively XAND, pronounced Exclusive AND) is a digital logic gate whose function is the logical complement of the Exclusive OR (XOR gate, XOR) gate. It is equivalent to the logical connective (\leftrightarrow) from mathematical logic, also known as the material biconditional. The two-input version implements logical equality, behaving according to the truth table to the right, and hence the gate is sometimes called an "equivalence gate". A high output (1) results if both of the inputs to the gate are the same. If one but not both inputs are high (1), a low output (0) results. The Boolean algebra, algebraic notation used to represent the XNOR operation is S = A \odot B. The algebraic expressions (A + \overline) \cdot (\overline + B) and A \cdot B + \overline A \cdot \overline B both represent the XNOR gate with inputs ''A'' and ''B''. Symbols There are logic gate#Symbols, two symbols for XN ...
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XOR Gate
XOR gate (sometimes EOR, or EXOR and pronounced as Exclusive OR) is a digital logic gate that gives a true (1 or HIGH) output when the number of true inputs is odd. An XOR gate implements an exclusive or (\nleftrightarrow) from mathematical logic; that is, a true output results if one, and only one, of the inputs to the gate is true. If both inputs are false (0/LOW) or both are true, a false output results. XOR represents the inequality function, i.e., the output is true if the inputs are not alike otherwise the output is false. A way to remember XOR is "must have one or the other but not both". An XOR gate may serve as a "programmable inverter" in which one input determines whether to invert the other input, or to simply pass it along with no change. Hence it functions as a inverter A power inverter, inverter or invertor is a power electronic device or circuitry that changes direct current (DC) to alternating current (AC). The resulting AC frequency obtained depends on ...
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