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Tessa Holyoake
Tessa Laurie Holyoake, (17 March 1963 – 30 August 2017) was a Scottish haematology-oncology physician. She specialised in chronic myeloid leukaemia (CML), and discovered its stem cell. She was considered a world leading expert in Leukemia, leukaemia research. Early life and education Tessa Holyoake was born in Aberdeen, Scotland on 17 March 1963. She attended Albyn School. She studied medicine at the University of Glasgow, and graduated in 1985. She completed her Doctor of Philosophy, PhD at the Beatson West of Scotland Cancer Centre, Beatson Institute for Cancer Research in Glasgow. Career and research After specialising in oncology, she worked from 1992 to 1996 as a clinical research fellow at the Cancer Research Campaign, Cancer Research Campaign's laboratories in Glasgow. From 1996 to 1998, she worked at Terry Fox Laboratory in Vancouver and discovered that primitive stem cells in CML existed in a quiescent state, and therefore they did not respond to cell cycle-active a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal College Of Physicians
The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1518, the RCP is the oldest medical college in England. It set the first international standard in the classification of diseases, and its library contains medical texts of great historical interest. The college is sometimes referred to as the Royal College of Physicians of London to differentiate it from other similarly named bodies. The RCP drives improvements in health and healthcare through advocacy, education and research. Its 40,000 members work in hospitals and communities across over 30 medical specialties with around a fifth based in over 80 countries worldwide. The college hosts six training faculties: the Faculty of Forensic and Legal Medicine, the Faculty for Pharmaceutical Medicine, the Faculty of Occupational Medicine the Fac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albyn School
Albyn School is a coeducational independent day school, founded in 1867 in Aberdeen, Scotland. Albyn was originally an all-girls school before becoming co-educational in 2005. The school has a nursery, primary school and secondary school; pupils can attend from 2 years old to 18 years old. History The school was founded in 1867 by Harriet Warrack as a private school for upper-middle-class girls. Following her retirement the running of the school was passed on to Alexander Mackie. In 1886 the school moved into premises at Nos 4-6 in a terrace diagonally opposite St Margaret’s School for Girls and was officially known as the Albyn Place School for Girls, but most people knew it as "Mackie's", because of the reputation of principal Alexander Mackie. It was also known as the Union Place Ladies' School for a period. In 1967, the school celebrated its centenary. Under the direction of Headmistress Dorothy Kidd, a volume was produced outlining the school's history. For much of its ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Academy Of Medical Sciences, United Kingdom
The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its mission is to advance biomedical and health research and its translation into benefits for society. The academy consists of a group of around 1200 Fellows elected from fields across the biomedical sciences. The academy seeks ultimately to advance medical science and improve health by investing in talented researchers, engaging people on health-related issues and providing expert impartial advice. its president is Dame Anne Johnson. History The academy was established in 1998 following the recommendations of a working group chaired by Michael Atiyah, former president of the Royal Society. A single national organisation was formed to support biomedical scientists and clinical academics working together to promote advances in medical science. It is one ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lord Provost Of Glasgow
The Right Honourable Lord Provost of Glasgow is the convener of the Glasgow City Council. Elected by the city councillors, the Lord Provost serves not only as the chair of that body, but as a figurehead for the entire city. The office is equivalent in many ways to the institution of mayor In many countries, a mayor is the highest-ranking official in a municipal government such as that of a city or a town. Worldwide, there is a wide variance in local laws and customs regarding the powers and responsibilities of a mayor as well ... that exists in the cities of many other countries. The Lord Provost of the City of Glasgow, by virtue of office, is also: *Lord-Lieutenant of the County of the City of Glasgow *a Northern Lighthouse Board, Commissioner of Northern Lighthouses. Each of the 32 Scotland, Scottish Subdivisions of Scotland, local authorities elects a Provost (civil), provost, but it is only the four main cities, Glasgow, Edinburgh, Aberdeen, Scotland, Aberdeen and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society Of Edinburgh
The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established in 1783. , there are around 1,800 Fellows. The Society covers a broader selection of fields than the Royal Society of London, including literature and history. Fellowship includes people from a wide range of disciplines – science & technology, arts, humanities, medicine, social science, business, and public service. History At the start of the 18th century, Edinburgh's intellectual climate fostered many clubs and societies (see Scottish Enlightenment). Though there were several that treated the arts, sciences and medicine, the most prestigious was the Society for the Improvement of Medical Knowledge, commonly referred to as the Medical Society of Edinburgh, co-founded by the mathematician Colin Maclaurin in 1731. Maclaurin was unhapp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tyrosine Kinase Inhibitor
A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. The proteins are activated by adding a phosphate group to the protein (phosphorylation), a step that TKIs inhibit. TKIs are typically used as anticancer drugs. For example, they have substantially improved outcomes in chronic myelogenous leukemia. They have also been used to treat other diseases, such as idiopathic pulmonary fibrosis. They are also called tyrphostins, the short name for "tyrosine phosphorylation inhibitor", originally coined in a 1988 publication, which was the first description of compounds inhibiting the catalytic activity of the epidermal growth factor receptor (EGFR). The 1988 study was the first demonstration of a systematic search and discovery of small-molecular-weight inhibitors of tyrosine phosphorylation, which do not inhibit protein kinases that phosphor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Farnesyl Transferase Inhibitor
The farnesyltransferase inhibitors (FTIs) are a class of experimental cancer drugs that target protein farnesyltransferase with the downstream effect of preventing the proper functioning of the Ras (protein), which is commonly abnormally active in cancer. Background Studies have suggested that interference with certain post-translational modification processes seem to have quite a high selectivity for targeting cells displaying tumour phenotypes, although the reason for this is a matter of controversy. After translation, Ras goes through four steps of modification: isoprenylation, proteolysis, methylation and palmitoylation. Isoprenylation involves the enzyme farnesyltransferase (FTase) transferring a farnesyl group from farnesyl pyrophosphate (FPP) to the pre-Ras protein. Also, a related enzyme geranylgeranyltransferase I (GGTase I) has the ability to transfer a geranylgeranyl group to K and N-Ras (the implications of this are discussed below). Farnesyl is necessary to atta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dasatinib
Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that are Philadelphia chromosome-positive (Ph+). It is taken by mouth. Common adverse effects include low white blood cells, low blood platelets, anemia, swelling, rash, and diarrhea. Severe adverse effects may include bleeding, pulmonary edema, heart failure, and prolonged QT syndrome. Use during pregnancy may result in harm to the baby. It is a tyrosine-kinase inhibitor and works by blocking a number of tyrosine kinases such as Bcr-Abl and the Src kinase family. Dasatinib was approved for medical use in the United States and in the European Union in 2006. It is on the World Health Organization's List of Essential Medicines. Medical uses Dasatinib is used to treat people with chronic myeloid leukemia and people with acute lymphoblastic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glasgow Royal Infirmary
The Glasgow Royal Infirmary (GRI) is a large teaching hospital. With a capacity of around 1,000 beds, the hospital campus covers an area of around , and straddles the Townhead and Dennistoun districts on the north-eastern fringe of the city centre of Glasgow, Scotland. It is managed by NHS Greater Glasgow and Clyde. It was originally opened in 1794, with the present main building dating from 1914. History Founding of the infirmary A Royal Charter was obtained in 1791 granting the Crown-owned land to the hospital. The infirmary was built beside Glasgow Cathedral on land that held the ruins of the Bishop's Castle, which dated from at least the 13th century but had been allowed to fall into disrepair. George Jardine, Professor of Logic, was appointed the first manager in January 1793. Designed by Robert and James Adam, the original Royal Infirmary building was opened in December 1794. The original Adams building had five floors (one underground) holding eight wards (giving th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Imatinib
Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral chemotherapy medication used to treat cancer. Imatinib is a small molecule inhibitor targeting multiple receptor tyrosine kinases such as CSF1R, ABL, c-KIT, FLT3, and PDGFR-β. Specifically, it is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+), certain types of gastrointestinal stromal tumors (GIST), hypereosinophilic syndrome (HES), chronic eosinophilic leukemia (CEL), systemic mastocytosis, and myelodysplastic syndrome. Common side effects include vomiting, diarrhea, muscle pain, headache, and rash. Severe side effects may include fluid retention, gastrointestinal bleeding, bone marrow suppression, liver problems, and heart failure. Use during pregnancy may result in harm to the baby. Imatinib works by stopping the Bcr-Abl tyrosine-kinase. This can slow growth or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vancouver
Vancouver ( ) is a major city in western Canada, located in the Lower Mainland region of British Columbia. As the most populous city in the province, the 2021 Canadian census recorded 662,248 people in the city, up from 631,486 in 2016. The Greater Vancouver area had a population of 2.6million in 2021, making it the third-largest metropolitan area in Canada. Greater Vancouver, along with the Fraser Valley, comprises the Lower Mainland with a regional population of over 3 million. Vancouver has the highest population density in Canada, with over 5,700 people per square kilometre, and fourth highest in North America (after New York City, San Francisco, and Mexico City). Vancouver is one of the most ethnically and linguistically diverse cities in Canada: 49.3 percent of its residents are not native English speakers, 47.8 percent are native speakers of neither English nor French, and 54.5 percent of residents belong to visible minority groups. It has been consistently ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
