Tessa Laurie Holyoake, (17 March 1963 – 30 August 2017) was a Scottish

haematology Hematology ( always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the produc ...

oncology Oncology is a branch of medicine that deals with the study, treatment, diagnosis and prevention of cancer. A medical professional who practices oncology is an ''oncologist''. The name's etymological origin is the Greek word ὄγκος (''ó ...

physician. She specialised in chronic myeloid leukaemia (CML), and discovered its

stem cell In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type o ...

. She was considered a world leading expert in

leukaemia Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...

research.

Early life and education

Tessa Holyoake was born in

Aberdeen Aberdeen (; sco, Aiberdeen ; gd, Obar Dheathain ; la, Aberdonia) is a city in North East Scotland, and is the third most populous city in the country. Aberdeen is one of Scotland's 32 local government council areas (as Aberdeen City), and ...

Scotland Scotland (, ) is a country that is part of the United Kingdom. Covering the northern third of the island of Great Britain, mainland Scotland has a border with England to the southeast and is otherwise surrounded by the Atlantic Ocean to the ...

on 17 March 1963. She attended

Albyn School Albyn School is a coeducational independent day school, founded in 1867 in Aberdeen, Scotland. Albyn was originally an all-girls school before becoming co-educational in 2005. The school has a nursery, primary school and secondary school; pupi ...

. She studied medicine at the

University of Glasgow , image = UofG Coat of Arms.png , image_size = 150px , caption = Coat of arms Flag , latin_name = Universitas Glasguensis , motto = la, Via, Veritas, Vita , ...

, and graduated in 1985. She completed her PhD at the Beatson Institute for Cancer Research in Glasgow.

Career and research

After specialising in oncology, she worked from 1992 to 1996 as a clinical research fellow at the Cancer Research Campaign's laboratories in Glasgow. From 1996 to 1998, she worked at Terry Fox Laboratory in

Vancouver Vancouver ( ) is a major city in western Canada, located in the Lower Mainland region of British Columbia. As the List of cities in British Columbia, most populous city in the province, the 2021 Canadian census recorded 662,248 people in the ...

and discovered that primitive

s in CML existed in a quiescent state, and therefore they did not respond to cell cycle-active agents like

imatinib Imatinib, sold under the brand names Gleevec and Glivec (both marketed worldwide by Novartis) among others, is an oral chemotherapy medication used to treat cancer. Imatinib is a small molecule inhibitor targeting multiple receptor tyrosine kin ...

. In 1999, she returned to

Glasgow Royal Infirmary The Glasgow Royal Infirmary (GRI) is a large teaching hospital. With a capacity of around 1,000 beds, the hospital campus covers an area of around , and straddles the Townhead and Dennistoun districts on the north-eastern fringe of the city cen ...

and in 2004, became Professor of Experimental Haematology, and Director of the Paul O'Gorman Leukaemia Research Centre. In 2005, she first presented work showing that a combination of

dasatinib Dasatinib, sold under the brand name Sprycel among others, is a targeted therapy medication used to treat certain cases of chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Specifically it is used to treat cases that ar ...

with a farnesyl transferase inhibitor was better at eradicating CML stem cells, which was published in 2007. She developed a drug treatment to target the abnormal CML

, to go beyond the current lifelong

tyrosine kinase inhibitor A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. The proteins are activated by adding a phosph ...

treatment.

Awards and honours

* Scottish Health Awards Cancer Care Award, 2009 * Fellow of the

Royal Society of Edinburgh The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established i ...

, 2007 and recipient of the

Royal Medal The Royal Medal, also known as The Queen's Medal and The King's Medal (depending on the gender of the monarch at the time of the award), is a silver-gilt medal, of which three are awarded each year by the Royal Society, two for "the most important ...

in 2017 *

Lord Provost of Glasgow The Right Honourable Lord Provost of Glasgow is the convener of the Glasgow City Council. Elected by the city councillors, the Lord Provost serves not only as the chair of that body, but as a figurehead for the entire city. The office is equiv ...

Health Award, 2011 * Fellow of the

Academy of Medical Sciences, United Kingdom The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its mission is to ad ...

, 2013 * Scottish Alba Saltire Society Fletcher of Saltoun Award, 2015 *Scottish Cancer Foundation Inaugural Prize, 2015 * Evans/Forrest Medal, 2015 * Rowley Prize (International Chronic Myeloid Leukemia Foundation), 2017 * Fellow of the

Royal College of Pathologists The Royal College of Pathologists (RCPath) is a professional membership organisation. Its main function is the overseeing of postgraduate training, and its Fellowship Examination (FRCPath) is recognised as the standard assessment of fitness to pr ...

* Fellow of the

Royal College of Physicians The Royal College of Physicians (RCP) is a British professional membership body dedicated to improving the practice of medicine, chiefly through the accreditation of physicians by examination. Founded by royal charter from King Henry VIII in 1 ...

Personal life

Tessa Holyoake was married to Andy, a general practitioner; they had no children. She enjoyed

mountain biking Mountain biking is a sport of riding bicycles off-road, often over rough terrain, usually using specially designed mountain bikes. Mountain bikes share similarities with other bikes but incorporate features designed to enhance durability and pe ...

hill walking Walking is one of the most popular outdoor recreational activities in the United Kingdom, and within England and Wales there is a comprehensive network of rights of way that permits access to the countryside. Furthermore, access to much uncultiv ...

, and

kayaking Kayaking is the use of a kayak for moving over water. It is distinguished from canoeing by the sitting position of the paddler and the number of blades on the paddle. A kayak is a low-to-the-water, canoe-like boat in which the paddler sits fac ...

, and fundraised for the Leukaemia Research Centre by cycling and climbing

Munro A Munro () is defined as a mountain in Scotland with a height over , and which is on the Scottish Mountaineering Club (SMC) official list of Munros; there is no explicit topographical prominence requirement. The best known Munro is Ben Nevis ...

s. In addition to her research work, she continued a clinical practice as a consultant at the Beatson West of Scotland Cancer Centre in Glasgow. On 31 August 2017 she died of

metastatic breast cancer Metastatic breast cancer, also referred to as metastases, advanced breast cancer, secondary tumors, secondaries or stage IV breast cancer, is a stage of breast cancer where the breast cancer cells have spread to distant sites beyond the axillary l ...

near

Loch Tummel Loch Tummel (Scottish Gaelic: Loch Teimheil) is a long, narrow loch, northwest of Pitlochry in the council area of Perth and Kinross, Scotland. It is fed and drained by the River Tummel, which flows into the River Tay about south-east of the C ...

, Perthshire. The disease had been diagnosed in 2016.

References

External links

Interview on stem cell research, 2014
YouTube, 2:48min {{DEFAULTSORT:Holyoake, Tessa 1963 births 2017 deaths Scottish medical researchers Scottish women medical doctors Scottish women scientists Alumni of the University of Glasgow Academics of the University of Glasgow Fellows of the Royal Society of Edinburgh Fellows of the Academy of Medical Sciences (United Kingdom) Cancer researchers British oncologists Women oncologists Fellows of the Royal College of Physicians Fellows of the Royal College of Pathologists Scottish women academics