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Trypanosoma Vivax
''Trypanosoma vivax'' is a parasite species in the genus ''Trypanosoma''. It causes the disease Animal trypanosomiasis, nagana, affecting cattle or wild mammals. It is mainly occurs in West Africa, although it has spread to South America. Range Historically restricted to sub-Saharan Africa especially West Africa, it has spread to 13 countries of South America. This has been made easier by its mechanical transmission route, see #Life cycle, Life cycle below. Hosts Hosts include, cattle farming, Cattle, horse husbandry, horses, sheep farming, sheep, and camel herding, camels. in South America it is an emerging agricultural pathogen, emerging pathogen of cattle, and sometimes horses and other ruminants. Life cycle Unusual for a trypanosome, ''T. vivax'' does not infect the ''Glossina'' vector midgut. Instead it infects and completes an abbreviated life cycle only in the vector's proboscis. Thus it is entirely mechanically transmitted. For this reason it has had a relatively easy t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanosoma
''Trypanosoma'' is a genus of kinetoplastids (class Trypanosomatidae), a monophyletic group of unicellular parasitic flagellate protozoa. Trypanosoma is part of the phylum Sarcomastigophora. The name is derived from the Greek ''trypano-'' (borer) and ''soma'' (body) because of their corkscrew-like motion. Most trypanosomes are heteroxenous (requiring more than one obligatory host to complete life cycle) and most are transmitted via a vector. The majority of species are transmitted by blood-feeding invertebrates, but there are different mechanisms among the varying species. Some, such as '' Trypanosoma equiperdum'', are spread by direct contact. In an invertebrate host they are generally found in the intestine, but normally occupy the bloodstream or an intracellular environment in the vertebrate host. Trypanosomes infect a variety of hosts and cause various diseases, including the fatal human diseases sleeping sickness, caused by ''Trypanosoma brucei'', and Chagas disease, caused ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ruminant
Ruminants (suborder Ruminantia) are ungulate, hoofed herbivorous grazing or browsing mammals that are able to acquire nutrients from plant-based food by Enteric fermentation, fermenting it in a specialized stomach prior to digestion, principally through microbial actions. The process, which takes place in the front part of the digestive system and therefore is called foregut fermentation, typically requires the fermented ingesta (known as cud) to be regurgitated and chewed again. The process of rechewing the cud to further break down plant matter and stimulate digestion is called rumination. The word "ruminant" comes from the Latin ''ruminare'', which means "to chew over again". The roughly 200 species of ruminants include both domestic and wild species. Ruminating mammals include cattle, all domesticated and wild bovines, goats, sheep, giraffes, deer, gazelles, and antelopes.Fowler, M.E. (2010).Medicine and Surgery of Camelids, Ames, Iowa: Wiley-Blackwell. Chapter 1 General Biolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanosomatida
Trypanosomatida is a group of kinetoplastid excavates distinguished by having only a single flagellum. The name is derived from the Greek ''trypano'' (borer) and ''soma'' (body) because of the corkscrew-like motion of some trypanosomatid species. All members are exclusively parasitic, found primarily in insects. A few genera have life-cycles involving a secondary host, which may be a vertebrate, invertebrate or plant. These include several species that cause major diseases in humans. Some trypanosomatida are intracellular parasites, with the important exception of Trypanosoma brucei. Medical importance The three major human diseases caused by trypanosomatids are; African trypanosomiasis (sleeping sickness, caused by ''Trypanosoma brucei'' and transmitted by tsetse flies), South American trypanosomiasis (Chagas disease, caused by '' T. cruzi'' and transmitted by triatomine bugs), and leishmaniasis (a set of trypanosomal diseases caused by various species of ''Leishmania'' trans ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
East Africa
East Africa, Eastern Africa, or East of Africa, is the eastern subregion of the African continent. In the United Nations Statistics Division scheme of geographic regions, 10-11-(16*) territories make up Eastern Africa: Due to the historical Omani Empire and colonial territories of the British East Africa Protectorate and German East Africa, the term ''East Africa'' is often (especially in the English language) used to specifically refer to the area now comprising the three countries of Kenya, Tanzania, and Uganda. However, this has never been the convention in many other languages, where the term generally had a wider, strictly geographic context and therefore typically included Djibouti, Eritrea, Ethiopia, and Somalia.Somaliland is not included in the United Nations geoscheme, as it is internationally recognized as a part of Somalia. *Tanzania, Kenya, Uganda, Rwanda, Burundi, Democratic Republic of Congo and South Sudan are members of the East African Community. The firs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cross-resistance
Cross-resistance is when something develops resistance to several substances that have a similar mechanism of action. For example, if a certain type of bacteria develops resistance to one antibiotic, that bacteria will also have resistance to several other antibiotics that target the same protein or use the same route to get into the bacterium. A real example of cross-resistance occurred for nalidixic acid and ciprofloxacin, which are both quinolone antibiotics. When bacteria developed resistance to ciprofloxacin, they also developed resistance to nalidixic acid because both drugs inhibit topoisomerase, a key enzyme in DNA replication. Due to cross-resistance, antimicrobial treatments like phage therapy can quickly lose their efficacy against bacteria. This makes cross-resistance an important consideration in designing evolutionary therapies. Definition Cross-resistance is the idea is that the development of resistance to one substance subsequently leads to resistance to one or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diminazene
Diminazene (INN; also known as diminazen) is an anti-infective medication for animals that is sold under a variety of brand names. It is effective against certain protozoa such as ''Babesia'', ''Trypanosoma'', and '' Cytauxzoon''. The drug may also be effective against certain bacteria including ''Brucella'' and ''Streptococcus''. Chemically it is a di-amidine and it is formulated as its aceturate salt, diminazene aceturate. The mechanism is not well understood; it probably inhibits DNA replication, but also has affinity to RNA. __TOC__ Side effects Acute side effects include vomiting, diarrhea, and hypotension (low blood pressure). Diminazen can harm the liver, kidneys and brain, which is potentially life-threatening; camels are especially susceptible to these effects. Resistance The Gibe River Valley in southwest Ethiopia showed universal resistance between July 1989 and February 1993. This likely indicates a permanent loss of function in this area against the tested target ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Isometamidium
Isometamidium chloride is a triazene trypanocidal agent used in veterinary medicine. It consists of a single Ethidium bromide like subunit linked to a fragment of the diminazene molecule. Resistance The Gibe River Valley in southwest Ethiopia showed universal resistance between July 1989 and February 1993. This likely indicates a permanent loss of function in this area against the tested target, '' T. congolense'' isolated from Boran Boran (also spelled Buran, Middle Persian: ; New Persian: پوراندخت, ''Pūrāndokht'') was Sasanian queen (or '' banbishn'') of Iran from 630 to 632, with an interruption of some months. She was the daughter of king (or ''shah'') Kho ... cattle. References Amidines Antiparasitic agents Quaternary ammonium compounds {{antiinfective-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Trypanocide Resistance
A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites. Examples include: * Aminoquinuride * benzonidazole * blasticidin S * DAPI * diminazene * diminazene aceturate * eflornithine * ethidium * isometamidium chloride * lonidamine * melaminylthioarsenate * melarsoprol * nifurtimox * pentamidine * posaconazole * puromycin * quinapyramine * salicylhydroxamic acid * suramin * tetraphenylporphine sulfonate Resistance 17 or 18 African countries had confirmed resistant parasite populations, and that was up to 21. Multiply resistant populations are an increasing problem in the Adamawa Region of Cameroon and south east Mali. The Gibe River Valley in southwest Ethiopia showed universal resistance (in '' T. congolense'' isolated from Boran cattle) between July 1989 and February 1993. This likely indicates a permanent loss of function in this area for the tested trypanocides, Diminazene aceturate, Isometamidium chloride, and Homidium chloride. See also ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pantanal
The Pantanal () is a natural region encompassing the world's largest tropical wetland area, and the world's largest flooded grasslands. It is located mostly within the Brazilian state of Mato Grosso do Sul, but it extends into Mato Grosso and portions of Bolivia and Paraguay. It sprawls over an area estimated at between . Various subregional ecosystems exist, each with distinct hydrological, geological and ecological characteristics; up to 12 of them have been defined.Susan Mcgrath, photos by Joel Sartore, ''Brazil's Wild Wet'', National Geographic Magazine, August 2005 Roughly 80% of the Pantanal floodplains are submerged during the rainy seasons, nurturing a biologically diverse collection of aquatic plants and helping to support a dense array of animal species. Etymology The name "Pantanal" comes from the Portuguese word ''pântano'' that means "big wetland", "big bog", "big swamp", "big quagmire" or "big marsh" plus the suffix ''-al'', that means "abundance, agglomeratio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Variable Surface Glycoprotein
Variant surface glycoprotein (VSG) is a ~60kDa protein which densely packs the cell surface of protozoan parasites belonging to the genus ''Trypanosoma''. This genus is notable for their cell surface proteins. They were first isolated from ''Trypanosoma brucei'' in 1975 by George Cross. VSG allows the trypanosomatid parasites to evade the mammalian host's immune system by extensive antigenic variation. They form a 12–15 nm surface coat. VSG dimers, ~90% of all cell surface protein. It also makes up ~10% of total cell protein. For this reason, these proteins are highly immunogenic and an immune response raised against a specific VSG coat will rapidly kill trypanosomes expressing this variant. However, with each cell division there is a possibility that the progeny will switch expression to change the VSG that is being expressed. VSG has no prescribed biochemical activity. The parasite has a large cellular repertoire of antigenically distinct VSGs (~1500/2000 complete and partial ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cysteine Peptidase
Cysteine proteases, also known as thiol proteases, are hydrolase enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad. Discovered by Gopal Chunder Roy in 1873, the first cysteine protease to be isolated and characterized was papain, obtained from ''Carica papaya''. Cysteine proteases are commonly encountered in fruits including the papaya, pineapple, fig and kiwifruit. The proportion of protease tends to be higher when the fruit is unripe. In fact, the latex of dozens of different plant families are known to contain cysteine proteases. Cysteine proteases are used as an ingredient in meat tenderizers. Classification The MEROPS protease classification system counts 14 superfamilies plus several currently unassigned families (as of 2013) each containing many families. Each superfamily uses the catalytic triad or dyad in a different protein fold and so represent convergent evolutio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proline Racemase
In enzymology, a proline racemase () is an enzyme that catalyzes the chemical reaction :L-proline \rightleftharpoons D-proline Hence, this enzyme has two substrates, L- and D-proline, and two products, D- and L- proline. This enzyme belongs to the family of proline racemases acting on free amino acids. The systematic name of this enzyme class is proline racemase. This enzyme participates in arginine and proline metabolism. These enzymes catalyse the interconversion of L- and D-proline in bacteria. Species distribution This first eukaryotic proline racemase was identified in ''Trypanosoma cruzi'' and fully characterized . The parasite enzyme, ''Tc''PRAC, is as a co-factor-independent proline racemase and displays B-cell mitogenic properties when released by ''T. cruzi'' upon infection, contributing to parasite escape. Novel proline racemases of medical and veterinary importance were described respectively in '' Clostridium difficile'' () and ''Trypanosoma vivax'' (). These ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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