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Translational Efficiency
In cell biology, translational efficiency or translation efficiency is the rate of mRNA translation into proteins within cells. It has been measured in protein per mRNA per hour. Several RNA elements within mRNAs have been shown to affect the rate. These include miRNA and protein binding sites. RNA structure may also affect translational efficiency through the altered protein or microRNA binding. See also * List of cis-regulatory RNA elements * Transterm * UTRdb UTRdb is a database of 5' and 3' untranslated sequences of eukaryotic mRNAs See also * Five prime untranslated region * Three prime untranslated region In molecular genetics, the three prime untranslated region (3′-UTR) is the section of ... References External links Transterm database online Cell biology {{cell-biology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Biology
Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and functioning of organisms. Cell biology is the study of structural and functional units of cells. Cell biology encompasses both prokaryotic and eukaryotic cells and has many subtopics which may include the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition. The study of cells is performed using several microscopy techniques, cell culture, and cell fractionation. These have allowed for and are currently being used for discoveries and research pertaining to how cells function, ultimately giving insight into understanding larger organisms. Knowing the components of cells and how cells work is fundamental to all biological sciences while also being essential for research in biomedical fields such as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is created during the process of Transcription (biology), transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and, utilising amino acids carried by transfer RNA (tRNA), the ribosome creates the protein. This process is known as Translation (biology), translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of genet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Translation (biology)
In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or endoplasmic reticulum synthesize proteins after the process of transcription (biology), transcription of DNA to RNA in the cell's nucleus (cell), nucleus. The entire process is called gene expression. In translation, mRNA, messenger RNA (mRNA) is decoded in a ribosome, outside the nucleus, to produce a specific amino acid chain, or polypeptide. The polypeptide later protein folding, folds into an Activation energy, active protein and performs its functions in the Cell (biology), cell. The ribosome facilitates decoding by inducing the binding of Base pair, complementary tRNA anticodon sequences to mRNA codons. The tRNAs carry specific amino acids that are chained together into a polypeptide as the mRNA passes through and is "read" by the ribosome. Translation proceeds in three phases: # Initiation: The ribosome assembles around the target mRNA. The first tRNA is attached a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell (biology)
The cell is the basic structural and functional unit of life forms. Every cell consists of a cytoplasm enclosed within a membrane, and contains many biomolecules such as proteins, DNA and RNA, as well as many small molecules of nutrients and metabolites.Cell Movements and the Shaping of the Vertebrate Body in Chapter 21 of Molecular Biology of the Cell '' fourth edition, edited by Bruce Alberts (2002) published by Garland Science. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos. It is also common to describe small molecules such as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MicroRNA
MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in mRNA molecules, then gene silence said mRNA molecules by one or more of the following processes: (1) cleavage of mRNA strand into two pieces, (2) destabilization of mRNA by shortening its poly(A) tail, or (3) translation of mRNA into proteins. This last method of gene silencing is the least efficient of the three, and requires the aid of ribosomes. miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. The human genome may encode over 1900 miRNAs, although more recent analysis suggests that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Binding Sites
In biochemistry and molecular biology, a binding site is a region on a macromolecule such as a protein that binds to another molecule with specificity. The binding partner of the macromolecule is often referred to as a ligand. Ligands may include other proteins (resulting in a protein-protein interaction), enzyme substrates, second messengers, hormones, or allosteric modulators. The binding event is often, but not always, accompanied by a conformational change that alters the protein's function. Binding to protein binding sites is most often reversible (transient and non-covalent), but can also be covalent reversible or irreversible. Function Binding of a ligand to a binding site on protein often triggers a change in conformation in the protein and results in altered cellular function. Hence binding site on protein are critical parts of signal transduction pathways. Types of ligands include neurotransmitters, toxins, neuropeptides, and steroid hormones. Binding sites incur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Cis-regulatory RNA Elements
This is a list of ''cis''-regulatory RNAs. These are RNA motifs which regulate nucleic acid regions on the same molecule, as opposed to ''trans''-acting motifs which regulate a distal molecule. Some of these RNAs are broadly distributed while others are single RNA families. {{horizontal ToC, nonum=yes # * 23S methyl RNA motif * 6C RNA A * Actino-pnp RNA motif * AdoCbl riboswitch *Alfalfa mosaic virus coat protein binding (CPB) RNA *Alfalfa mosaic virus RNA 1 5′ UTR stem-loop *Alpha operon ribosome binding site * Antizyme RNA frameshifting stimulation element * APC internal ribosome entry site (IRES) * Aphthovirus internal ribosome entry site (IRES) * Apolipoprotein B (apoB) 5′ UTR cis-regulatory element * AtoC RNA motif * ATPC RNA motif *AU-rich element B * Bag-1 internal ribosome entry site (IRES) * Bamboo mosaic potexvirus (BaMV) cis-regulatory element * Bamboo mosaic virus satellite RNA cis-regulatory element * Bovine leukaemia virus RNA packaging signal C * Citrus tri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transterm
Transterm is a database of mRNA sequences, codon usage, and associated cis-regulatory elements that regulate gene expression. Many of these elements are in the 3' UTR. Transterm is a database provided by the Biochemistry department of The University of Otago , image_name = University of Otago Registry Building2.jpg , image_size = , caption = University clock tower , motto = la, Sapere aude , mottoeng = Dare to be wise , established = 1869; 152 years ago , type = Public research collegiate u .... Transterm is used to look at the protein binding sites within mRNA. Transterm is continually updated based upon results in peer-reviewed journals. References External links Transterm database online {{bioinformatics-stub Biological databases Biology websites ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
UTRdb
UTRdb is a database of 5' and 3' untranslated sequences of eukaryotic mRNAs See also * Five prime untranslated region * Three prime untranslated region * UTRome UTRome is a database of three-prime untranslated regions in C. elegans See also * untranslated region (UTR) * UTRdb UTRdb is a database of 5' and 3' untranslated sequences of eukaryotic mRNAs See also * Five prime untranslated region * Thre ... References External links data Biological databases RNA Gene expression {{Biodatabase-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
