Tityus Serrulatus
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Tityus Serrulatus
''Tityus serrulatus'', the Brazilian yellow scorpion, is a species of scorpion of the family Buthidae. It is native to Brazil, and its venom is extremely toxic. It is the most dangerous scorpion in South America and is responsible for the most fatal cases. Description Adult specimens typically measure between 5–7 cm (2–3 in) in length. As suggested by its common name, coloration consists of pale-yellow legs (8 in total) and pedipalps, with a darker shade of yellowish brown on the trunk, fingers, and tip of the tail. Like other members of the family Buthidae, ''T. serrulatus'' has a bulbous tail, often carried in a characteristic forward curve over the back, which is segmented, with prominent ridges and serrations. The tail is tipped with a venom-injecting barb capable of immobilizing prey or delivering defensive strikes. Geographic range The species is endemic to Brazil and widely found throughout the country, including the states of Alagoas, Bahia, Ceará, Esp ...
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Scorpion
Scorpions are predatory arachnids of the order Scorpiones. They have eight legs, and are easily recognized by a pair of grasping pincers and a narrow, segmented tail, often carried in a characteristic forward curve over the back and always ending with a stinger. The evolutionary history of scorpions goes back 435 million years. They mainly live in deserts but have adapted to a wide range of environmental conditions, and can be found on all continents except Antarctica. There are over 2,500 described species, with 22 extant (living) families recognized to date. Their taxonomy is being revised to account for 21st-century genomic studies. Scorpions primarily prey on insects and other invertebrates, but some species hunt vertebrates. They use their pincers to restrain and kill prey, or to prevent their own predation. The venomous sting is used for offense and defense. During courtship, the male and female grasp each other's pincers and dance while he tries to move her onto his s ...
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Rio Grande Do Norte
Rio Grande do Norte (, , ) is one of the states of Brazil. It is located in the northeastern region of the country, forming the northeasternmost tip of the South American continent. The name literally translates as "Great Northern River", referring to the mouth of the Potengi River. The capital and largest city is Natal. The state has 410 km (254 mi) of sandy beaches and contains Rocas Atoll, the only atoll the Atlantic Ocean. The main economic activity is tourism, followed by the extraction of petroleum (the second largest producer in the country), agriculture, fruit growing and extraction of minerals, including considerable production of seasalt, among other economic activities. The state is home to 1.7% of the Brazilian population and produces 1% of the country's GDP. In 2000-17 the murder rate rose by 655%, making Rio Grande do Norte the state with the highest murder rate in Brazil: 63.9 per 100,000. Tourist attractions in the state include the Cashew of Pirang ...
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Sodium Channel
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily of cation channels and can be classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel; also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. These channels go through three different states called resting, active and inactive states. Even though the resting and inactive states would not allow the ions to flow through the channels the difference exists with respect to their structural conformation. Selectivity Sodium channels are highly selective for the transport of ions across cell membr ...
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TsIV
TsIV is a toxin from the venom of the Brazilian scorpion ''Tityus serrulatus'' which slows the inactivation of sodium channels. Etymology TsIV is named after the scorpion from which the toxin is isolated, namely ''Tityus serrulatus'' (Ts). Alternative names for the TsIV toxin are TsIV-5, Toxin-4, Tityustoxin IV, Ts-IV and Toxin IV. Sources TsIV is one of a variety of toxins that can be isolated from the venom of the Brazilian scorpion ''T.serrulatus''. This species of scorpion belongs to the family Buthidae and has a wide geographic distribution from northeastern to southeastern Brazil. Chemistry The composition of TsIV determined by spectrophotometry is as follows: 11 Asp, 2 Thr, 3 Ser, 2 Glu, 3 Pro, 4 Gly, 3 Ala, 8 Cys, 2 Val, 2 Ile, 3 Leu, 8/9 Tyr, 1 His, 9 Lys, 2 Trp. The amino acid composition of TsIV also shows great similarity with those of Ts III and Ts V. Ts III has one less Lys and Ts V has an additional Lys and Gly. Target and mode of action TsIV belongs to the family ...
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Parthenogenesis
Parthenogenesis (; from the Greek grc, παρθένος, translit=parthénos, lit=virgin, label=none + grc, γένεσις, translit=génesis, lit=creation, label=none) is a natural form of asexual reproduction in which growth and development of embryos occur in a gamete (egg or sperm) without combining with another gamete (e.g., egg and sperm fusing). In animals, parthenogenesis means development of an embryo from an unfertilized Gametophyte, egg cell. In plants, parthenogenesis is a component process of apomixis. In algae, parthenogenesis can mean the development of an embryo from either an individual sperm or an individual egg. Parthenogenesis occurs naturally in some plants, algae, invertebrate animal species (including nematodes, some tardigrades, water fleas, some scorpions, aphids, some mites, some bees, some Phasmatodea and parasitic wasps) and a few vertebrates (such as some fish, amphibians, reptiles and birds). This type of reproduction has been induced artificially ...
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Cockroach
Cockroaches (or roaches) are a paraphyletic group of insects belonging to Blattodea, containing all members of the group except termites. About 30 cockroach species out of 4,600 are associated with human habitats. Some species are well-known as pests. The cockroaches are an ancient group, with their ancestors, known as " roachoids", originating during the Carboniferous period, some 320 million years ago. Those early ancestors, however, lacked the internal ovipositors of modern roaches. Cockroaches are somewhat generalized insects lacking special adaptations (such as the sucking mouthparts of aphids and other true bugs); they have chewing mouthparts and are probably among the most primitive of living Neopteran insects. They are common and hardy insects capable of tolerating a wide range of climates, from Arctic cold to tropical heat. Tropical cockroaches are often much larger than temperate species. Modern cockroaches are not considered to be a monophyletic group, as it has be ...
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São Paulo
São Paulo (, ; Portuguese for 'Saint Paul') is the most populous city in Brazil, and is the capital of the state of São Paulo, the most populous and wealthiest Brazilian state, located in the country's Southeast Region. Listed by the GaWC as an alpha global city, São Paulo is the most populous city proper in the Americas, the Western Hemisphere and the Southern Hemisphere, as well as the world's 4th largest city proper by population. Additionally, São Paulo is the largest Portuguese-speaking city in the world. It exerts strong international influences in commerce, finance, arts and entertainment. The city's name honors the Apostle, Saint Paul of Tarsus. The city's metropolitan area, the Greater São Paulo, ranks as the most populous in Brazil and the 12th most populous on Earth. The process of conurbation between the metropolitan areas around the Greater São Paulo (Campinas, Santos, Jundiaí, Sorocaba and São José dos Campos) created the São Paulo Macrometr ...
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Butantan Institute
Instituto Butantan (in modern Portuguese, Instituto Butantã, ) is a Brazilian biologic research center located in Butantã, in the western part of the city of São Paulo, Brazil. Instituto Butantan is a public institution affiliated with the São Paulo State Secretariat of Health and considered one of the major scientific centers in the world. Butantan is the largest immunobiologicals and biopharmaceuticals producer in Latin America (and one of the largest in the world). It is world-renowned for its collection of venomous snakes, as well as those of venomous lizards, spiders, insects and scorpions. By extracting the reptiles' and insects' venoms, the Institute develops antivenoms and medicines against many diseases, which include tuberculosis, rabies, tetanus and diphtheria. History The Institute was founded by the Brazilian physician and biomedical scientist Vital Brazil in 1901, according to Pasteur Institute paradigm, i.e., by combining in the same institution medical rese ...
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The Guardian
''The Guardian'' is a British daily newspaper. It was founded in 1821 as ''The Manchester Guardian'', and changed its name in 1959. Along with its sister papers ''The Observer'' and ''The Guardian Weekly'', ''The Guardian'' is part of the Guardian Media Group, owned by the Scott Trust. The trust was created in 1936 to "secure the financial and editorial independence of ''The Guardian'' in perpetuity and to safeguard the journalistic freedom and liberal values of ''The Guardian'' free from commercial or political interference". The trust was converted into a limited company in 2008, with a constitution written so as to maintain for ''The Guardian'' the same protections as were built into the structure of the Scott Trust by its creators. Profits are reinvested in journalism rather than distributed to owners or shareholders. It is considered a newspaper of record in the UK. The editor-in-chief Katharine Viner succeeded Alan Rusbridger in 2015. Since 2018, the paper's main news ...
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Federal District (Brazil)
The Federal District ( pt, Distrito Federal ) is one of 27 federative units of Brazil. Located in the Center-West Region, it is the smallest Brazilian federal unit and the only one that has no municipalities, being divided into 31 administrative regions. The federal capital of Brazil, Brasília, which is also the seat of government of the Federal District, is located in its territory. History From the first republican constitution there was already a device that foresaw the move of the federal capital from Rio de Janeiro, at that time in the former Federal District (1889-1960), to the interior of the country. In 1891 the Exploration Commission of the Central Highlands of Brazil was appointed, led by astronomer Luiz Cruls and composed of doctors, geologists and botanists, who made a study on topography, climate, geology, flora, fauna and other material resources of the region of the Central Highlands The area was known as Quadrilateral Cruls and was presented in 1894 to t ...
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Sergipe
Sergipe (), officially State of Sergipe, is a state of Brazil. Located in the Northeast Region along the Atlantic coast of the country, Sergipe is the smallest state in Brazil by geographical area at , larger only than the Federal District. Sergipe borders Bahia to the south and west and Alagoas to the north. Aracaju is the capital and the largest city in the state; the state is divided into 75 municipalities. The state has 1.1% of the Brazilian population and produces only 0.6% of the Brazilian GDP. Geography As with most of the states in northeastern Brazil, inland Sergipe is almost entirely savanna (''caatinga''), and its coastline is characterized by mangroves, swamps and sandy beaches. A small strip of tropical rainforest runs down the coast. The São Francisco River forms its northern boundary, and the drainage of the northern part of the state is northward and eastward to that river. The southern half of the state slopes eastward and is drained directly into the Atlanti ...
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São Paulo (state)
São Paulo () is one of the Federative units of Brazil, 26 states of the Brazil, Federative Republic of Brazil and is named after Paul of Tarsus, Saint Paul of Tarsus. A major industrial complex, the state has 21.9% of the Brazilian population and is responsible for 33.9% of Brazil's GDP. São Paulo also has the List of Brazilian federative units by Human Development Index, second-highest Human Development Index (HDI) and GDP per capita, the List of Brazilian states by infant mortality, fourth-lowest infant mortality rate, the List of Brazilian states by life expectancy, third-highest life expectancy, and the List of Brazilian states by literacy rate, third-lowest rate of illiteracy among the federative units of Brazil. São Paulo alone is wealthier than Argentina, Uruguay, Paraguay, and Bolivia combined. São Paulo is also the world's twenty-eighth-most populous Administrative division, sub-national entity and the most populous sub-national entity in the Americas. With more than 4 ...
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