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TsIV
TsIV is a toxin from the venom of the Brazilian scorpion ''Tityus serrulatus'' which slows the inactivation of sodium channels. Etymology TsIV is named after the scorpion from which the toxin is isolated, namely ''Tityus serrulatus'' (Ts). Alternative names for the TsIV toxin are TsIV-5, Toxin-4, Tityustoxin IV, Ts-IV and Toxin IV. Sources TsIV is one of a variety of toxins that can be isolated from the venom of the Brazilian scorpion ''T.serrulatus''. This species of scorpion belongs to the family Buthidae and has a wide geographic distribution from northeastern to southeastern Brazil. Chemistry The composition of TsIV determined by spectrophotometry is as follows: 11 Asp, 2 Thr, 3 Ser, 2 Glu, 3 Pro, 4 Gly, 3 Ala, 8 Cys, 2 Val, 2 Ile, 3 Leu, 8/9 Tyr, 1 His, 9 Lys, 2 Trp. The amino acid composition of TsIV also shows great similarity with those of Ts III and Ts V. Ts III has one less Lys and Ts V has an additional Lys and Gly. Target and mode of action TsIV belongs to the family ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tityus Serrulatus
''Tityus serrulatus'', the Brazilian yellow scorpion, is a species of scorpion of the family Buthidae. It is native to Brazil, and its venom is extremely toxic. It is the most dangerous scorpion in South America and is responsible for the most fatal cases. Description Adult specimens typically measure between 5–7 cm (2–3 in) in length. As suggested by its common name, coloration consists of pale-yellow legs (8 in total) and pedipalps, with a darker shade of yellowish brown on the trunk, fingers, and tip of the tail. Like other members of the family Buthidae, ''T. serrulatus'' has a bulbous tail, often carried in a characteristic forward curve over the back, which is segmented, with prominent ridges and serrations. The tail is tipped with a venom-injecting barb capable of immobilizing prey or delivering defensive strikes. Geographic range The species is endemic to Brazil and widely found throughout the country, including the states of Alagoas, Bahia, Ceará, Esp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tityustoxin
Tityustoxin is a toxin found in the venom of scorpions from the subfamily Tityinae. By binding to voltage-dependent sodium ion channels and potassium channels, they cause sialorrhea, lacrimation and rhinorrhea. Sources Scorpions are distributed among six families. Only those of the family Buthidae are dangerous to humans. Within this family, the subfamily Tityinae cause the most scorpion poisoning in humans. These species are found in Brazil (''Tityus serrulatus, T. bahiensis'' and '' T. stigmurus'') and in Northern and Southern Venezuela ('' T. discrepans''). The venom of ''Tityus serrulatus'' is the most potent of these. Chemistry The crude venom of ''T. serrulatus'' contains different toxins. Some of the strongest derivates are the neurotoxins tityustoxin and toxin Ts-g. Two types of toxins are considered to be responsible for the main toxic effect: toxin gamma (a β-type toxin) and tityustoxin (TsTX, an α-type toxin), both with a specific affinity to the sodi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxin
A toxin is a naturally occurring organic poison produced by metabolic activities of living cells or organisms. Toxins occur especially as a protein or conjugated protein. The term toxin was first used by organic chemist Ludwig Brieger (1849–1919) and is derived from the word toxic. Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their toxicity, ranging from usually minor (such as a bee sting) to potentially fatal even at extremely low doses (such as botulinum toxin). Toxins are largely secondary metabolites, which are organic compounds that are not directly involved in an organism's growth, development, or reproduction, instead often aiding it in matters of defense. Terminology Toxins are often distinguished from other chemical agents strictly based on their biological origin. Le ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sodium Channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's membrane. They belong to the superfamily of cation channels and can be classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change ("voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel; also called "VGSCs" or "Nav channel") or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. These channels go through three different states called resting, active and inactive states. Even though the resting and inactive states would not allow the ions to flow through the channels the difference exists with respect to their structural conformation. Selectivity Sodium channels are highly selective for the transport of ions across cell membr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Buthidae
The Buthidae are the largest family of scorpions, containing about 100 genera and 1339 species as of 2022. A few very large genera (''Ananteris'', ''Centruroides'', '' Compsobuthus'', or '' Tityus'') are known, but a high number of species-poor or monotypic ones also exist. New taxa are being described at a rate of several new species per year. They have a osmopolitandistribution throughout tropical and subtropical environments worldwide. Together with four other families, the Buthidae make up the superfamily Buthoidea. The family was established by Carl Ludwig Koch in 1837. Around 20 species of medically important (meaning potentially lethal to humans) scorpions are known, and all but one of these ('' Hemiscorpius lepturus'') are members of the Buthidae. In dead specimens, the spine beneath the stinger, characteristic for this family, can be observed. List of genera and number of species The following genera are recognised in the family Buthidae: * '' Aegaeobuthus'' Kovarik, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spectrophotometry
Spectrophotometry is a branch of electromagnetic spectroscopy concerned with the quantitative measurement of the reflection or transmission properties of a material as a function of wavelength. Spectrophotometry uses photometers, known as spectrophotometers, that can measure the intensity of a light beam at different wavelengths. Although spectrophotometry is most commonly applied to ultraviolet, visible, and infrared radiation, modern spectrophotometers can interrogate wide swaths of the electromagnetic spectrum, including x-ray, ultraviolet, visible, infrared, and/or microwave wavelengths. Overview Spectrophotometry is a tool that hinges on the quantitative analysis of molecules depending on how much light is absorbed by colored compounds. Important features of spectrophotometers are spectral bandwidth (the range of colors it can transmit through the test sample), the percentage of sample-transmission, the logarithmic range of sample-absorption, and sometimes a percentage of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sinus Tachycardia
Sinus tachycardia is an elevated sinus rhythm characterized by an increase in the rate of electrical impulses arising from the sinoatrial node. In adults, sinus tachycardia is defined as a heart rate greater than 100 beats per minute (bpm). The normal resting heart rate is 60–90 bpm in an average adult. Normal heart rates vary with age and level of fitness, from infants having faster heart rates (110-150 bpm) and the elderly having slower heart rates. Sinus tachycardia is a normal response to physical exercise, when the heart rate increases to meet the body's higher demand for energy and oxygen, but sinus tachycardia can also indicate a health problem. Thus, sinus tachycardia is a medical finding that can be either physiological or pathological. Signs and symptoms Tachycardia is often asymptomatic. It is often a resulting symptom of a primary disease state and can be an indication of the severity of a disease. If the heart rate is too high, cardiac output may fall due to the ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
LD50
In toxicology, the median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 is a toxic unit that measures the lethal dose of a toxin, radiation, or pathogen. The value of LD50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. LD50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD50 is indicative of increased toxicity. The test was created by J.W. Trevan in 1927. The term semilethal dose is occasionally used in the same sense, in particular with translations of foreign language text, but can also refer to a sublethal dose. LD50 is usually determined by tests on animals such as laboratory mice. In 2011, the U.S. Food and Drug Administration approved alternative methods to LD50 for testing the cosmetic drug Botox without animal tests. Conventions The LD50 is usually expressed as the mass of substance administered per unit ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antivenom
Antivenom, also known as antivenin, venom antiserum, and antivenom immunoglobulin, is a specific treatment for envenomation. It is composed of antibodies and used to treat certain venomous bites and stings. Antivenoms are recommended only if there is significant toxicity or a high risk of toxicity. The specific antivenom needed depends on the species involved. It is given by injection. Side effects may be severe. They include serum sickness, shortness of breath, and allergic reactions including anaphylaxis. Antivenom is traditionally made by collecting venom from the relevant animal and injecting small amounts of it into a domestic animal. The antibodies that form are then collected from the domestic animal's blood and purified. Versions are available for spider bites, snake bites, fish stings, and scorpion stings. Due to the high cost of producing antibody-based antivenoms and their short shelf lives when not refrigerated, alternative methods of production of antivenoms ar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epitope
An epitope, also known as antigenic determinant, is the part of an antigen that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The epitope is the specific piece of the antigen to which an antibody binds. The part of an antibody that binds to the epitope is called a paratope. Although epitopes are usually non-self proteins, sequences derived from the host that can be recognized (as in the case of autoimmune diseases) are also epitopes. The epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes, based on their structure and interaction with the paratope. Conformational and linear epitopes interact with the paratope based on the 3-D conformation adopted by the epitope, which is determined by the surface features of the involved epitope residues and the shape or tertiary structure of other segments of the antigen. A conformational epitope is formed by the 3-D conformation adopted by the interac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tityus Serrulatus Venom Toxins
Tityus may refer to: * A giant from Greek mythology (see Tityos) * A genus of scorpions (see ''Tityus'' (genus)) Art * ''The Punishment of Tityus'' (Michelangelo) * ''Tityus'' (Titian) * ''Tityos'' (Ribera) {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ion Channel Toxins
An ion () is an atom or molecule with a net electrical charge. The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by convention. The net charge of an ion is not zero because its total number of electrons is unequal to its total number of protons. A cation is a positively charged ion with fewer electrons than protons while an anion is a negatively charged ion with more electrons than protons. Opposite electric charges are pulled towards one another by electrostatic force, so cations and anions attract each other and readily form ionic compounds. Ions consisting of only a single atom are termed atomic or monatomic ions, while two or more atoms form molecular ions or polyatomic ions. In the case of physical ionization in a fluid (gas or liquid), "ion pairs" are created by spontaneous molecule collisions, where each generated pair consists of a free electron and a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
