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Timeline Of Tuberous Sclerosis
The history of tuberous sclerosis (TSC) research spans less than 200 years. TSC is a rare, multi-system genetic disease that can cause benign tumours to grow on the brain or other vital organs such as the kidneys, heart, eyes, lungs, and skin. A combination of symptoms may include seizures, developmental delay, behavioural problems and skin abnormalities, as well as lung and kidney disease. TSC is caused by mutations on either of two genes, TSC1 and TSC2, which encode for the proteins hamartin and tuberin respectively. These proteins act as tumour growth suppressors and regulate cell proliferation and differentiation. Originally regarded as a rare pathological curiosity, it is now an important focus of research into tumour formation and suppression. The history of TSC research is commonly divided into four periods.Rott (2005), page 2 - Introduction. In the late 19th century, notable physicians working in European teaching hospitals first described the cortical and dermatologica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Désiré-Magloire Bourneville
Désiré-Magloire Bourneville () (20 October 1840 – 28 May 1909) was a French neurologist born in Garencières. Career He studied medicine in Paris, and worked as ''interne des hôpitaux'' at the Salpêtrière, Bicêtre, Hôpital Saint-Louis and the Pitié. During the Franco-Prussian War, he served as both a surgeon and an assistant medical officer. From 1879 to 1905 he was a physician of pediatric services at Bicêtre. In Paris, he founded a day school for special instruction of children with mental disability. In 1866, during a severe cholera epidemic in Amiens, he volunteered his services, and after the siege had passed, was presented with a gold watch as an expression of the city's gratitude. During the Paris Commune (1871), when revolutionaries wanted to execute their wounded enemies, Bourneville intervened and saved the prisoners' lives. He was elected to the Paris city council in 1876 and to the French Parliament in 1883, where he served as a deputy until 1889. In ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid residue ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Vessel
The blood vessels are the components of the circulatory system that transport blood throughout the human body. These vessels transport blood cells, nutrients, and oxygen to the tissues of the body. They also take waste and carbon dioxide away from the tissues. Blood vessels are needed to sustain life, because all of the body's tissues rely on their functionality. There are five types of blood vessels: the arteries, which carry the blood away from the heart; the arterioles; the capillaries, where the exchange of water and chemicals between the blood and the tissues occurs; the venules; and the veins, which carry blood from the capillaries back towards the heart. The word ''vascular'', meaning relating to the blood vessels, is derived from the Latin ''vas'', meaning vessel. Some structures – such as cartilage, the epithelium, and the lens and cornea of the eye – do not contain blood vessels and are labeled ''avascular''. Etymology * artery: late Middle English; from Latin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pierre François Olive Rayer
Pierre François Olive Rayer (8 March 1793 – 10 September 1867) was a French physician who was a native of Saint Sylvain. He made important contributions in the fields of pathological anatomy, physiology, comparative pathology and parasitology. Biography He studied medicine at Caen, and afterwards in Paris at the Ecole Pratique des Hautes Etudes and at the Hôtel-Dieu. He became an interne of medicine in 1813, and in 1818 earned his medical doctorate. Later on, he became a physician at Hôpital Saint-Antoine (1825), and at the Hôpital de la Charité (1832), and was also a consultant-physician to King Louis-Philippe. In 1862 he attained the chair of comparative anatomy and was named dean of the Faculty of Medicine at Paris.Pierre-François-Olive Rayer @ Who Named It In 1837 Rayer discovered that the fatal equine di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroimaging
Neuroimaging is the use of quantitative (computational) techniques to study the structure and function of the central nervous system, developed as an objective way of scientifically studying the healthy human brain in a non-invasive manner. Increasingly it is also being used for quantitative studies of brain disease and psychiatric illness. Neuroimaging is a highly multidisciplinary research field and is not a medical specialty. Neuroimaging differs from neuroradiology which is a medical specialty and uses brain imaging in a clinical setting. Neuroradiology is practiced by radiologists who are medical practitioners. Neuroradiology primarily focuses on identifying brain lesions, such as vascular disease, strokes, tumors and inflammatory disease. In contrast to neuroimaging, neuroradiology is qualitative (based on subjective impressions and extensive clinical training) but sometimes uses basic quantitative methods. Functional brain imaging techniques, such as functional magnet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Who Named It
''Whonamedit?'' is an online English-language dictionary of medical eponyms and the people associated with their identification. Though it is a dictionary, many eponyms and persons are presented in extensive articles with comprehensive bibliographies. The dictionary is hosted in Norway and maintained by medical historian Ole Daniel Enersen Ole Daniel Enersen (born March 14, 1943, in Oslo, Norway) is a Norwegian climber, photographer, journalist, writer, and medical historian. In 1965 he made the first ascent of the Trollveggen mountain in Romsdalen, Norway, along with Leif Norman .... References External links * Medical websites Medical dictionaries Eponyms {{online-dict-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eponym
An eponym is a person, a place, or a thing after whom or which someone or something is, or is believed to be, named. The adjectives which are derived from the word eponym include ''eponymous'' and ''eponymic''. Usage of the word The term ''eponym'' functions in multiple related ways, all based on an explicit relationship between two named things. A person, place, or thing named after a particular person share an eponymous relationship. In this way, Elizabeth I of England is the eponym of the Elizabethan era. When Henry Ford is referred to as "the ''eponymous'' founder of the Ford Motor Company", his surname "Ford" serves as the eponym. The term also refers to the title character of a fictional work (such as Rocky Balboa of the Rocky film series, ''Rocky'' film series), as well as to ''self-titled'' works named after their creators (such as the album The Doors (album), ''The Doors'' by the band the Doors). Walt Disney created the eponymous The Walt Disney Company, Walt Disney Com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Medical Sign
Signs and symptoms are the observed or detectable signs, and experienced symptoms of an illness, injury, or condition. A sign for example may be a higher or lower temperature than normal, raised or lowered blood pressure or an abnormality showing on a medical scan. A symptom is something out of the ordinary that is experienced by an individual such as feeling feverish, a headache or other pain or pains in the body. Signs and symptoms Signs A medical sign is an objective observable indication of a disease, injury, or abnormal physiological state that may be detected during a physical examination, examining the patient history, or diagnostic procedure. These signs are visible or otherwise detectable such as a rash or bruise. Medical signs, along with symptoms, assist in formulating diagnostic hypothesis. Examples of signs include elevated blood pressure, nail clubbing of the fingernails or toenails, staggering gait, and arcus senilis and arcus juvenilis of the eyes. Indicati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dermatology
Dermatology is the branch of medicine dealing with the skin.''Random House Webster's Unabridged Dictionary.'' Random House, Inc. 2001. Page 537. . It is a speciality with both medical and surgical aspects. A dermatologist is a specialist medical doctor who manages diseases related to skin, hair, nails, and some cosmetic problems. Etymology Attested in English in 1819, the word "dermatology" derives from the Greek δέρματος (''dermatos''), genitive of δέρμα (''derma''), "skin" (itself from δέρω ''dero'', "to flay") and -λογία '' -logia''. Neo-Latin ''dermatologia'' was coined in 1630, an anatomical term with various French and German uses attested from the 1730s. History In 1708, the first great school of dermatology became a reality at the famous Hôpital Saint-Louis in Paris, and the first textbooks (Willan's, 1798–1808) and atlases ( Alibert's, 1806–1816) appeared in print around the same time.Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cerebral Cortex
The cerebral cortex, also known as the cerebral mantle, is the outer layer of neural tissue of the cerebrum of the brain in humans and other mammals. The cerebral cortex mostly consists of the six-layered neocortex, with just 10% consisting of allocortex. It is separated into two cortices, by the longitudinal fissure that divides the cerebrum into the left and right cerebral hemispheres. The two hemispheres are joined beneath the cortex by the corpus callosum. The cerebral cortex is the largest site of neural integration in the central nervous system. It plays a key role in attention, perception, awareness, thought, memory, language, and consciousness. The cerebral cortex is part of the brain responsible for cognition. In most mammals, apart from small mammals that have small brains, the cerebral cortex is folded, providing a greater surface area in the confined volume of the cranium. Apart from minimising brain and cranial volume, cortical folding is crucial for the brain ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teaching Hospital
A teaching hospital is a hospital or medical centre that provides medical education and training to future and current health professionals. Teaching hospitals are almost always affiliated with one or more universities and are often co-located with medical schools. Teaching hospitals use a residency program to educate qualified physicians, podiatrists, dentists, and pharmacists who are receiving training after attaining the degree of Doctor of Medicine, MD, Doctor of Podiatric Medicine, DPM, Doctor of Dental Surgery, DDS, DMD, Doctor of Pharmacy, PharmD, Doctor of Osteopathic Medicine, DO, Bachelor of Dental Surgery, BDS, Bachelor of Dentistry, BDent, Bachelor of Medicine, MBBS, MBChB, or BMed. Those that attend a teaching hospital or clinic would practice medicine under the direct or indirect supervision of a senior medical clinician registered in that specialty, such as an attending physician or consultant (medicine), consultant. The purpose of these residency programs is to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
