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Timeline Of The Opioid Epidemic
The timeline of the opioid epidemic includes selected events related to the origins of Stamford, Connecticut-based Purdue Pharma, the Sackler family, the development and marketing of oxycodone, selected FDA activities related to the abuse and misuse of opioids, the recognition of the opioid epidemic, the social impact of the crisis, lawsuits against Purdue and the Sackler family. * 1911 - 1990s According to the FDA'Timeline of Selected FDA Activities and Significant Events Addressing Opioid Misuse and Abuse before the 1990s, most opioid pain medications were used to manage pain that was either acute or related to cancer. The FDA said that there was an increase in the use of opioids because physicians were not treating "chronic non-cancer pain" adequately. * 1952 Mortimer David Sackler (1916–2010) and Raymond became the co-chairmen of a small Greenwich Village-based pharmaceutical company financed by their brother Arthur. The Purdue Frederick Company, became the Stamford, Con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Purdue Pharma
Purdue Pharma L.P., formerly the Purdue Frederick Company, is an American privately held pharmaceutical company founded by John Purdue Gray. It was owned principally by members of the Sackler family as descendants of Mortimer and Raymond Sackler. In 2007, it paid out one of the largest fines ever levied against a pharmaceutical firm for misleading the public about how addictive the drug OxyContin was compared to other pain medications. In September 2021 Purdue Pharma announced that it rebrand itself as Knoa Pharma. Although the company shifted its focus to abuse-deterrent formulations, Purdue continued to market and sell opioids as late as 2019 and continued to be involved in lawsuits around the opioid epidemic in the United States. Purdue filed for Chapter 11 bankruptcy protection on September 15, 2019, in New York City. On October 21, 2020, it was reported that Purdue had reached a settlement potentially worth US$8.3 billion, admitting that it "knowingly and intentionally consp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fentanyl
Fentanyl, also spelled fentanil, is a very potent synthetic opioid used as a pain medication. Together with other drugs, fentanyl is used for anesthesia. It is also used illicitly as a recreational drug, sometimes mixed with heroin, cocaine, benzodiazepines or methamphetamine, among others. Its potentially deadly overdose effects can be neutralized by naloxone. Fentanyl is commonly used to create counterfeit pills disguised as OxyContin, Xanax, Adderall, among others. It has a rapid onset and its effects generally last under two hours. Medically, it is used by injection, nasal spray, or skin patch, or absorbed through the cheek as a lozenge or tablet. Common adverse effects of fentanyl include nausea, vomiting, constipation, itching, sedation, confusion, and injuries related to poor coordination. Serious adverse effects may include respiratory depression, hallucinations, serotonin syndrome, low blood pressure, or development of an opioid use disorder. Fentanyl works b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
James P
James is a common English language surname and given name: *James (name), the typically masculine first name James * James (surname), various people with the last name James James or James City may also refer to: People * King James (other), various kings named James * Saint James (other) * James (musician) * James, brother of Jesus Places Canada * James Bay, a large body of water * James, Ontario United Kingdom * James College, York, James College, a college of the University of York United States * James, Georgia, an unincorporated community * James, Iowa, an unincorporated community * James City, North Carolina * James City County, Virginia ** James City (Virginia Company) ** James City Shire * James City, Pennsylvania * St. James City, Florida Arts, entertainment, and media * James (2005 film), ''James'' (2005 film), a Bollywood film * James (2008 film), ''James'' (2008 film), an Irish short film * James (2022 film), ''James'' (2022 film), an Indian Kannada ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmaceutical Fraud
Pharmaceutical fraud involves activities that result in false claims to insurers or programs such as Medicare in the United States or equivalent state programs for financial gain to a pharmaceutical company. There are several different schemes used to defraud the health care system which are particular to the pharmaceutical industry. These include: Good Manufacturing Practice (GMP) Violations, Off Label Marketing, Best Price Fraud, CME Fraud, Medicaid Price Reporting, and Manufactured Compound Drugs. Examples of fraud cases include the GlaxoSmithKline $3 billion settlement, Pfizer $2.3 billion settlement, and Merck $650 million settlement. Damages from fraud can be recovered by use of the False Claims Act, most commonly under the ''qui tam'' provisions which rewards an individual for being a "whistleblower", or relator (law). Types of fraud There are several different schemes used to defraud the health care system which are particular to the pharmaceutical industry. *Good Manufa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
President (corporate Title)
A president is a leader of an organization, company, community, club, trade union, university or other group. The relationship between a president and a chief executive officer varies, depending on the structure of the specific organization. In a similar vein to a chief operating officer, the title of corporate president as a separate position (as opposed to being combined with a "C-suite" designation, such as "president and chief executive officer" or "president and chief operating officer") is also loosely defined; the president is usually the legally recognized highest rank of corporate officer, ranking above the various vice presidents (including senior vice president and executive vice president), but on its own generally considered subordinate, in practice, to the CEO. The powers of a president vary widely across organizations and such powers come from specific authorization in the bylaws like ''Robert's Rules of Order'' (e.g. the president can make an "executive decision" on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roanoke, Virginia
Roanoke ( ) is an independent city in the U.S. state of Virginia. At the 2020 census, the population was 100,011, making it the 8th most populous city in the Commonwealth of Virginia and the largest city in Virginia west of Richmond. It is located in the Roanoke Valley of the Roanoke Region of Virginia. Roanoke is the largest municipality in Southwest Virginia, and is the principal municipality of the Roanoke Metropolitan Statistical Area (MSA), which had a 2020 population of 315,251. It is composed of the independent cities of Roanoke and Salem, and Botetourt, Craig, Franklin, and Roanoke counties. Bisected by the Roanoke River, Roanoke is the commercial and cultural hub of much of Southwest Virginia and portions of Southern West Virginia. History Timeline * 1835 - Town of Gainesborough incorporated. * 1838 - Roanoke County created. * 1852 - Big Lick Depot built near Gainesborough; Virginia & Tennessee Railroad begins operating. * 1865 - April: Big Lick settlement sa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Assistant Attorney General
Many of the divisions and offices of the United States Department of Justice are headed by an assistant attorney general. The president of the United States appoints individuals to the position of assistant attorney general with the advice and consent of the Senate. United States Department of Justice components that are led by an assistant attorney general are: * Antitrust Division * Civil Division *Civil Rights Division * Criminal Division *National Security Division * Environment and Natural Resources Division (ENRD) *Justice Management Division (JMD) * Tax Division *Office of Justice Programs (OJP) *Office of Legal Counsel (OLC) *Office of Legal Policy (OLP) * Office of Legislative Affairs (OLA) Assistant attorneys general report either to the deputy attorney general (in the case of the Criminal Division, the Justice Management Division and the Offices of Legal Counsel, Legislative Affairs, and Legal Policy) or to the associate attorney general (in the case of the Antitru ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alice S
Alice may refer to: * Alice (name), most often a feminine given name, but also used as a surname Literature * Alice (''Alice's Adventures in Wonderland''), a character in books by Lewis Carroll * ''Alice'' series, children's and teen books by Phyllis Reynolds Naylor * ''Alice'' (Hermann book), a 2009 short story collection by Judith Hermann Computers * Alice (computer chip), a graphics engine chip in the Amiga computer in 1992 * Alice (programming language), a functional programming language designed by the Programming Systems Lab at Saarland University * Alice (software), an object-oriented programming language and IDE developed at Carnegie Mellon * Alice mobile robot * Artificial Linguistic Internet Computer Entity, an open-source chatterbot * Matra Alice, a home micro-computer marketed in France * Alice, a brand name used by Telecom Italia for internet and telephone services Video games * '' Alice: An Interactive Museum'', a 1991 adventure game * ''American McGee's Alice ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CNBC
CNBC (formerly Consumer News and Business Channel) is an American basic cable business news channel. It provides business news programming on weekdays from 5:00 a.m. to 7:00 p.m., Eastern Time, while broadcasting talk shows, investigative reports, documentaries, infomercials, reality shows, and other programs at all other times. Along with Fox Business and Bloomberg Television, it is one of the three major business news channels. It also operates a website and mobile apps, whereby users can watch the channel via streaming media, and which provide some content that is only accessible to paid subscribers. CNBC content is available on demand on smart speakers including Amazon Echo devices with Amazon Alexa, Google Home and app devices with Google Assistant, and on Apple Siri voice interfaces including iPhones. Many CNBC TV shows are available as podcasts for on-demand listening. Graphics are designed by Sweden-based Magoo 3D studios. CNBC is a divisi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bracewell & Giuliani
Bracewell LLP is an international law firm based in Houston, Texas, that began in 1945. The firm has approximately 350 lawyers, and has United States offices in New York City, Washington, D.C., Hartford, San Antonio, Seattle, Dallas and Austin, as well as offices in Dubai, and London. The firm works primarily in the energy, infrastructure, finance and technology sectors, with practices in transactional, litigation, regulatory and government relations matters. History The firm was founded on November 1, 1945, when J. S. Bracewell and his two sons, J. Searcy Bracewell Jr. and Fentress Bracewell, joined with Bert H. Tunks to practice together in Houston under the name of Bracewell & Tunks. Searcy Bracewell was elected to the Texas Senate in 1946, representing Harris County, and ultimately becoming the Majority Leader of the Senate. Fentress Bracewell led the development of the firm, serving as the firm’s first managing partner. Fentress was appointed Houston Port Commissioner in 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rudy Giuliani
Rudolph William Louis Giuliani (, ; born May 28, 1944) is an American politician and lawyer who served as the 107th Mayor of New York City from 1994 to 2001. He previously served as the United States Associate Attorney General from 1981 to 1983 and the United States Attorney for the Southern District of New York from 1983 to 1989. Giuliani led the Mafia Commission Trial, 1980s federal prosecution of Five Families, New York City mafia bosses as U.S. Attorney for the Southern District of New York. After a failed campaign for Mayor of New York City in the 1989 New York City mayoral election, 1989 election, he succeeded in 1993, and was reelected in 1997, campaigning on a "tough on crime" platform. He led New York's controversial "civic cleanup" as its Mayor of New York City, mayor from 1994 to 2001.Whether lionized or criticized, "Giuliani's cleanup", especially of Manhattan, most famously Times Square, is widely recognized: B. McKee, "Rules and regulations alone can't revive Amer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Time Release Technology
Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release R, XR, XLdosage) or to a specific target in the body (targeted-release dosage).Pharmaceutics: Drug Delivery and Targeting p. 7-13 Sustained-release dosage forms are s designed to release (liberate) a drug at a predetermined rate in order to maintain a constant drug concentrati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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