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Thy1 (other)
Thy1 may refer to: * CD90, formal name of Thymocyte antigen 1, a cluster of differentiation 90 * Thymidylate synthase (FAD) In enzymology, a thymidylate synthase (FAD) () is an enzyme that catalyzes the chemical reaction :5,10-methylenetetrahydrofolate + dUMP + FADH2 \rightleftharpoons dTMP + tetrahydrofolate + FAD The 3 substrates of this enzyme are 5,10-methylenete ..., an enzyme * Thymidylate synthase complementing protein 1 which complements but shows no homology to thymidylate synthase {{Letter-NumberCombDisambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CD90
Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 k Da heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Structural study of Thy-1 led to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to some of the initial biochemical description and characterization of a vertebrate GPI anchor and also the first demonstration of tissue specific differential glycosylation. Discovery and nomenclature The antigen Thy-1 was the first T cell marker to be identified. Thy-1 was discovered by Reif and Allen in 1964 during a search for heterologous antisera against mouse leukemia cells, and was demonstrated by them to be present on murine thymocytes, on T lymphocytes, and on neuronal cells. It was origin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thymidylate Synthase (FAD)
In enzymology, a thymidylate synthase (FAD) () is an enzyme that catalyzes the chemical reaction :5,10-methylenetetrahydrofolate + dUMP + FADH2 \rightleftharpoons dTMP + tetrahydrofolate + FAD The 3 substrates of this enzyme are 5,10-methylenetetrahydrofolate, dUMP, and FADH2, whereas its 3 products are dTMP, tetrahydrofolate, and FAD. This enzyme belongs to the family of transferases, to be specific those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is 5,10-methylenetetrahydrofolate,FADH2:dUMP C-methyltransferase. Other names in common use include Thy1, and ThyX. This enzyme participates in pyrimidine metabolism and one carbon pool by folate. Most organisms, including humans, use the thyA- or TYMS-encoded classic thymidylate synthase whereas some bacteria use the similar flavin-dependent thymidylate synthase (FDTS) instead. Structural studies As of late 2007, 3 structures have been solved for this class of enzymes, with PDB ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |