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Thomas Maniatis
Tom Maniatis (born May 8, 1943), is an American professor of molecular and cellular biology. He is a professor at Columbia University, and serves as the Scientific Director and CEO of the New York Genome Center. Education Maniatis received B.A. and M.S. degrees from the University of Colorado in Boulder, and a PhD in Molecular Biology from Vanderbilt University. He carried out postdoctoral studies at Harvard University and at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, England. Research and career Maniatis developed and disseminated gene cloning technologies and their applications in the study of gene regulatory mechanisms. cDNA Cloning While an assistant professor of Biochemistry and Molecular Biology at Harvard, and a member of the Cold Spring Harbor Laboratory (CSHL) faculty, Maniatis collaborated with Drs. Fotis Kafatos and Argiris Efstratiadis to develop a method for synthesizing and cloning full length double stranded DNA copies ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Denver
Denver () is a consolidated city and county, the capital, and most populous city of the U.S. state of Colorado. Its population was 715,522 at the 2020 census, a 19.22% increase since 2010. It is the 19th-most populous city in the United States and the fifth most populous state capital. It is the principal city of the Denver–Aurora–Lakewood, CO Metropolitan Statistical Area and the first city of the Front Range Urban Corridor. Denver is located in the Western United States, in the South Platte River Valley on the western edge of the High Plains just east of the Front Range of the Rocky Mountains. Its downtown district is immediately east of the confluence of Cherry Creek and the South Platte River, approximately east of the foothills of the Rocky Mountains. It is named after James W. Denver, a governor of the Kansas Territory. It is nicknamed the ''Mile High City'' because its official elevation is exactly one mile () above sea level. The 105th meridian we ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New York Genome Center
The New York Genome Center (NYGC) is an independent 501(c)(3) nonprofit academic research institution in New York, New York. It serves as a multi-institutional collaborative hub focused on the advancement of genomic science and its application to drive novel biomedical discoveries. NYGC's areas of focus include the development of computational and experimental genomic methods and disease-focused research to better understand the genetic basis of cancer, neurodegenerative disease, and neuropsychiatric disease. In 2020, the NYGC also has directed its expertise to COVID-19 genomics research. Purpose and organization The Center leverages strengths in whole genome sequencing, genomic analysis, and development of genomic tools to advance genomic discovery. Its faculty hold joint tenure-track appointments at its member institutions and lead independent research labs at the center. NYGC's scientists bring a multidisciplinary and in-depth approach to the field of genomics, conducting ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics Institute
:''This article is primarily about Genetics Institute prior to its 1996 acquisition by Wyeth. For that successor company, see Wyeth.'' Genetics Institute, Inc. was a biotechnology research and development company founded by Thomas Maniatis and Mark Ptashne, two Harvard molecular biologists, in 1980 in Massachusetts. Originally operating out of Ptashne's house in Boston, the company found more spacious quarters first in Boston and then Cambridge before expanding further. Gabriel Schmergel joined soon afterwards as CEO. Many leading scientists joined G.I. from academia and it proved to be a fertile source of patents for some time. Historical background One of the two largest national clusters of biotechnology in the U.S. (the other being the San Francisco Bay area), the greater Boston area has been the birthplace of many innovative corporations and non-profit research centers. Beginning in the late 1970s and 1980s, this biotech trend saw three early large for-profit corporations: ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ed Fritsch
Ed, ed or ED may refer to: Arts and entertainment * ''Ed'' (film), a 1996 film starring Matt LeBlanc * Ed (''Fullmetal Alchemist'') or Edward Elric, a character in ''Fullmetal Alchemist'' media * ''Ed'' (TV series), a TV series that ran from 2000 to 2004 Businesses and organizations * Ed (supermarket), a French brand of discount stores founded in 1978 * Consolidated Edison, from their NYSE stock symbol * United States Department of Education, a department of the United States government * Enforcement Directorate, a law enforcement and economic intelligence agency in India * European Democrats, a loose association of conservative political parties in Europe * Airblue (IATA code ED), a private Pakistani airline * Eagle Dynamics, a Swiss software company Places * Ed, Kentucky, an unincorporated community in the United States * Ed, Sweden, a town in Dals-Ed, Sweden * Erode Junction railway station, station code ED Health and medicine * Eating disorder, mental disorders defin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, protein or non-coding RNA, and ultimately affect a phenotype, as the final effect. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA. Gene expression is summarized in the central dogma of molecular biology first formulated by Francis Crick in 1958, further developed in his 1970 article, and expanded by the subsequent discoveries of reverse transcription and RNA replication. The process of gene expression is used by all known life—eukaryotes (including multicellular organisms), prokaryotes (bacteria and archaea), and utilized by viruses—to generate the macromolecular machinery for life. In genetics, gene expression is the most fundamental level at which the genotype gives rise to the phenotype, '' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Transcription (biology)
Transcription is the process of copying a segment of DNA into RNA. The segments of DNA transcribed into RNA molecules that can encode proteins are said to produce messenger RNA (mRNA). Other segments of DNA are copied into RNA molecules called non-coding RNAs (ncRNAs). mRNA comprises only 1–3% of total RNA samples. Less than 2% of the human genome can be transcribed into mRNA ( Human genome#Coding vs. noncoding DNA), while at least 80% of mammalian genomic DNA can be actively transcribed (in one or more types of cells), with the majority of this 80% considered to be ncRNA. Both DNA and RNA are nucleic acids, which use base pairs of nucleotides as a complementary language. During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, antiparallel RNA strand called a primary transcript. Transcription proceeds in the following general steps: # RNA polymerase, together with one or more general transcription factors, binds to promoter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Library (biology)
In molecular biology, a library is a collection of DNA fragments that is stored and propagated in a population of micro-organisms through the process of molecular cloning. There are different types of DNA libraries, including cDNA libraries (formed from reverse-transcribed RNA), genomic libraries (formed from genomic DNA) and randomized mutant libraries (formed by de novo gene synthesis where alternative nucleotides or codons are incorporated). DNA library technology is a mainstay of current molecular biology, genetic engineering, and protein engineering, and the applications of these libraries depend on the source of the original DNA fragments. There are differences in the cloning vectors and techniques used in library preparation, but in general each DNA fragment is uniquely inserted into a cloning vector and the pool of recombinant DNA molecules is then transferred into a population of bacteria (a Bacterial Artificial Chromosome or BAC library) or yeast such that each or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Genome
The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the nuclear genome and the mitochondrial genome. Human genomes include both protein-coding DNA sequences and various types of DNA that does not encode proteins. The latter is a diverse category that includes DNA coding for non-translated RNA, such as that for ribosomal RNA, transfer RNA, ribozymes, small nuclear RNAs, and several types of regulatory RNAs. It also includes promoters and their associated gene-regulatory elements, DNA playing structural and replicatory roles, such as scaffolding regions, telomeres, centromeres, and origins of replication, plus large numbers of transposable elements, inserted viral DNA, non-functional pseudogenes and simple, highly-repetitive sequences. Introns make up a large percentage of non-coding DNA. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pasadena, California
Pasadena ( ) is a city in Los Angeles County, California, northeast of downtown Los Angeles. It is the most populous city and the primary cultural center of the San Gabriel Valley. Old Pasadena is the city's original commercial district. Its population was 138,699 at the 2020 census, making it the 44th largest city in California and the ninth-largest city in Los Angeles County. Pasadena was incorporated on June 19, 1886, becoming one of the first cities to be incorporated in what is now Los Angeles County, following the city of Los Angeles (April 4, 1850). Pasadena is known for hosting the annual Rose Bowl football game and Tournament of Roses Parade. It is also home to many scientific, educational, and cultural institutions, including Caltech, Pasadena City College, Kaiser Permanente Bernard J. Tyson School of Medicine, Fuller Theological Seminary, ArtCenter College of Design, the Pasadena Playhouse, the Ambassador Auditorium, the Norton Simon Museum, and the USC Pacif ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Complementary DNA
In genetics, complementary DNA (cDNA) is DNA synthesized from a single-stranded RNA (e.g., messenger RNA (mRNA) or microRNA (miRNA)) template in a reaction catalyzed by the enzyme reverse transcriptase. cDNA is often used to express a specific protein in a cell that does not normally express that protein (i.e., heterologous expression), or to sequence or quantify mRNA molecules using DNA based methods (qPCR, RNA-seq). cDNA that codes for a specific protein can be transferred to a recipient cell for expression, often bacterial or yeast expression systems. cDNA is also generated to analyze transcriptomic profiles in bulk tissue, single cells, or single nuclei in assays such as microarrays, qPCR, and RNA-seq. cDNA is also produced naturally by retroviruses (such as HIV-1, HIV-2, simian immunodeficiency virus, etc.) and then integrated into the host's genome, where it creates a provirus. The term ''cDNA'' is also used, typically in a bioinformatics context, to refer to a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fotis Kafatos
Fotis Constantine Kafatos ( el, Φώτης Κ. Καφάτος; 16 April 1940 – 18 November 2017) was a Greek biologist. Between 2007-2010 he was the founding president of the European Research Council (ERC). He chaired the ERC Scientific Council from 2006-2010. Thereafter, he was appointed Honorary President of the ERC. Education Fotis Kafatos graduated from the Lyceum Korais in Heraklion in 1958 and from Cornell University in 1961, where he was mentored by Thomas Eisner and assisted by the Fulbright Program and a scholarship from Anne Gruner Schlumberger. He earned his PhD at Harvard in 1965 for research on entomology, supervised by Carroll Williams. Research and career Fotis Kafatos was an influential Greek biologist, having had a pivotal role in triggering the interest of the Greek government for Science, with the establishment of the Faculty of Biology in the University of Athens, the Faculty of Biology in the University of Crete and the IMBB in Heraklion. At the begin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by Ro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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