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Thebaine Skeletal
Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid, its name coming from the Greek Θῆβαι, '' Thēbai'' (Thebes), an ancient city in Upper Egypt. A minor constituent of opium, thebaine is chemically similar to both morphine and codeine, but has stimulatory rather than depressant effects. At high doses, it causes convulsions similar to strychnine poisoning. The synthetic enantiomer (+)-thebaine does show analgesic effects apparently mediated through opioid receptors, unlike the inactive natural enantiomer (−)-thebaine. While thebaine is not used therapeutically, it is the main alkaloid extracted from ''Papaver bracteatum'' (Iranian opium / Persian poppy) and can be converted industrially into a variety of compounds, including hydrocodone, hydromorphone, oxycodone, oxymorphone, nalbuphine, naloxone, naltrexone, buprenorphine, butorphanol and etorphine. Thebaine is controlled under international law, is listed as a Class A drug under th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Opiate
An opiate, in classical pharmacology, is a substance derived from opium. In more modern usage, the term ''opioid'' is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain (including antagonists). Opiates are alkaloid compounds naturally found in the opium poppy plant ''Papaver somniferum''. The psychoactive compounds found in the opium plant include morphine, codeine, and thebaine. Opiates have long been used for a variety of medical conditions with evidence of opiate trade and use for pain relief as early as the eighth century AD. Opiates are considered drugs with moderate to high abuse potential and are listed on various "Substance-Control Schedules" under the Uniform Controlled Substances Act of the United States of America. In 2014, between 13 and 20 million people used opiates recreationally (0.3% to 0.4% of the global population between the ages of 15 and 65). According to the CDC, from this population, there were 47,00 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naltrexone
Naltrexone, sold under the brand name Revia among others, is a medication primarily used to manage alcohol or opioid use disorder by reducing cravings and feelings of euphoria associated with substance use disorder. It has also been found to be effective in the treatment of other addictions and may be used for them off-label. An opioid-dependent person should not receive naltrexone before detoxification. It is taken by mouth or by injection into a muscle. Effects begin within 30 minutes. A decreased desire for opioids may take a few weeks to occur. Side effects may include trouble sleeping, anxiety, nausea, and headaches. In those still on opioids, opioid withdrawal may occur. Use is not recommended in people with liver failure. It is unclear if use is safe during pregnancy. Naltrexone is an opioid antagonist and works by blocking the effects of opioids, including both opioid drugs as well as opioids naturally produced in the brain. Naltrexone was first made in 1965 and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New South Wales
) , nickname = , image_map = New South Wales in Australia.svg , map_caption = Location of New South Wales in AustraliaCoordinates: , subdivision_type = Country , subdivision_name = Australia , established_title = Before federation , established_date = Colony of New South Wales , established_title2 = Establishment , established_date2 = 26 January 1788 , established_title3 = Responsible government , established_date3 = 6 June 1856 , established_title4 = Federation , established_date4 = 1 January 1901 , named_for = Wales , demonym = , capital = Sydney , largest_city = capital , coordinates = , admin_center = 128 local government areas , admin_center_type = Administration , leader_title1 = Monarch , leader_name1 = Charles III , leader_title2 = Governor , leader_name2 = Margaret Beazley , leader_title3 = Premier , leader_name3 = Dominic Perrottet (Liberal) , national_representation = Parliament of Australia , national_representation_type1 = Senat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canberra Times
''The Canberra Times'' is a daily newspaper in Canberra, Australia, which is published by Australian Community Media. It was founded in 1926, and has changed ownership and format several times. History ''The Canberra Times'' was launched in 1926 by Thomas Shakespeare along with his oldest son Arthur Shakespeare and two younger sons Christopher and James. The newspaper's headquarters were originally located in the Civic retail precinct, in Cooyong Street and Mort Street, in blocks bought by Thomas Shakespeare in the first sale of Canberra leases in 1924. The newspaper's first issue was published on 3 September 1926. It was the second paper to be printed in the city, the first being ''The Federal Capital Pioneer''. Between September 1926 and February 1928, the newspaper was a weekly issue. The first daily issue was 28 February 1928. In June 1956, ''The Canberra Times'' converted from broadsheet to tabloid format. Arthur Shakespeare sold the paper to John Fairfax Lt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Poppy Straw
Poppy straw (also known as opium straw, mowed opium straw, crushed poppy capsule, poppy chaff, or poppy husk) is derived from opium poppies (''Papaver somniferum'') that are harvested when fully mature and dried by mechanical means, minus the ripe poppy seeds. Opium poppy straw today can be one of several different things. It is what remains after the poppy seed harvest, that is, the dried stalks, stem and leaves of poppies grown for their seeds. The dried leaves and stalks are harvested after the seed pods have been used for traditional opium extraction. The field dried leaves, stalk and seed pod are used in commercial manufacture of morphine or other poppy alkaloid derived drugs, by first processing the material to make poppy straw separating the seeds then making concentrate of poppy straw, where no extraction using traditional methods of latex extraction has been made. The straw was originally considered an agricultural by-product of the mechanised poppy seed harvest, which was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reticuline
Reticuline is a chemical compound found in a variety of plants including ''Lindera aggregata'', ''Annona squamosa'', and '' Ocotea fasciculata'' (also known as ''Ocotea duckei''). It is based on the benzylisoquinoline structure. Reticuline is one of the alkaloids found in opium, and experiments in rodents suggest it possesses potent central nervous system depressing effects. It is the precursor of morphine and many other alkaloids. It is also toxic to dopaminergic neurons causing a form of atypical parkinsonism known as Guadeloupean Parkinsonism. Metabolism 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase uses ''S''-adenosyl methionine and 3'-hydroxy-''N''-methyl-(''S'')- coclaurine to produce ''S''-adenosylhomocysteine and (''S'')-reticuline. Reticuline oxidase uses (''S'')-reticuline and O2 to produce (''S'')-scoulerine and H2O2. Salutaridine synthase uses (''R'')-reticuline, NADPH, H+, and O2 to produce salutaridine, NADP+, and H2O. Salutaridine can then be t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oripavine
Oripavine is an opioid and the major metabolite of thebaine. It is the parent compound from which a series of semi-synthetic opioids are derived, which includes the compounds etorphine and buprenorphine. Although its analgesic potency is comparable to morphine, it is not used clinically due to its severe toxicity and low therapeutic index. Due to its use in manufacture of strong opioids, oripavine is a controlled substance in some jurisdictions. Pharmacological properties Oripavine possesses an analgesic potency comparable to morphine; however, it is not clinically useful due to severe toxicity and low therapeutic index. In both mice and rats, toxic doses caused tonic-clonic seizures followed by death, similar to thebaine. Oripavine has a potential for dependence which is significantly greater than that of thebaine but slightly less than that of morphine. Bridged derivatives Of much greater relevance are the properties of the orvinols, a large family of semi-synthetic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salutaridine
Salutaridine, also known as floripavine, is an alkaloid that is present in the morphinian alkaloid pathway of opium poppy. Its biosynthetic precursor is the alkaloid reticuline, (''R'')-reticuline. (''R'')-Reticuline is converted to salutaridine by the enzyme salutaridine synthase. Salutaridine is converted to salutaridinol by the enzyme salutaridine reductase (SalR), with the reduction of NADPH to NADP+. References Morphinans Phenols Enones Phenol ethers {{alkaloid-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Enforcement Administration
The Drug Enforcement Administration (DEA; ) is a Federal law enforcement in the United States, United States federal law enforcement agency under the U.S. Department of Justice tasked with combating drug trafficking and distribution within the U.S. It is the lead agency for domestic enforcement of the Controlled Substances Act, sharing concurrent jurisdiction with the Federal Bureau of Investigation, the U.S. Immigration and Customs Enforcement, and U.S. Customs and Border Protection although the DEA has sole responsibility for coordinating and pursuing U.S. drug investigations both domestically and abroad. The DEA has an DEA Office of National Security Intelligence, intelligence unit that is also a member of the United States Intelligence Community, U.S. Intelligence Community. While the unit is part of the DEA chain-of-command, it also reports to the Director of National Intelligence. History and mandate The Drug Enforcement Administration was established on July 1, 1973, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Controlled Drugs And Substances Act
The ''Controlled Drugs and Substances Act'' (french: Loi réglementant certaines drogues et autres substances) (the ''Act'') is Canada's federal drug control statute. Passed in 1996 under Prime Minister Jean Chrétien's government, it repeals the ''Narcotic Control Act'' and Parts III and IV of the ''Food and Drugs Act'', and establishes eight Schedules of controlled substances and two Classes of precursors. It provides that "The Governor in Council may, by order, amend any of Schedules I to VIII by adding to them or deleting from them any item or portion of an item, where the Governor in Council deems the amendment to be necessary in the public interest." The ''Act'' serves as the implementing legislation for the Single Convention on Narcotic Drugs, the Convention on Psychotropic Substances, and the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances. Amendments to the act In November 2007, the Justice Minister Rob Nicholson intr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analog Act
The Federal Analogue Act, , is a section of the United States Controlled Substances Act passed in 1986 which allows any chemical "substantially similar" to a controlled substance listed in Schedule I or II to be treated as if it were listed in Schedule I, but only if intended for human consumption. These similar substances are often called designer drugs. The law's constitutionality has been questioned by now Supreme Court Justice Neil Gorsuch; its broad reach has been used to successfully prosecute possession of chemicals openly sold as dietary supplements and naturally contained in foods such as chocolate. Definition (32) *(A) Except as provided in subparagraph (C), the term ''controlled substance analogue'' means a substance - **(i) the chemical structure of which is substantially similar to the chemical structure of a controlled substance in schedule I or II; **(ii) which has a stimulant, depressant, or hallucinogenic effect on the central nervous system that is substant ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Misuse Of Drugs Act 1971
The Misuse of Drugs Act 1971 is an Act of the Parliament of the United Kingdom. It represents action in line with treaty commitments under the Single Convention on Narcotic Drugs, the Convention on Psychotropic Substances, and the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances. Offences under the Act include: * Possession of a controlled drug unlawfully * Possession of a controlled drug with intent to supply it * Supplying or offering to supply a controlled drug (even where no charge is made for the drug) * Allowing premises you occupy or manage to be used unlawfully for the purpose of producing or supplying controlled drugs It is often presented as little more than a list of prohibited drugs and of penalties linked to their possession and supply. In practice, however, the act establishes the Home Secretary as a key player in a drug licensing system. Therefore, for example, various opiates are available legally as prescription-o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
