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Temefos
Temefos or temephos (trade name Abate) is an organophosphate larvicide used to treat water infested with disease-carrying insects including mosquitoes, midges, and black fly larvae. As with other organophosphates, temephos affects the central nervous system through inhibition of cholinesterase. In larvae, this results in death before reaching the adult stage. In the developing world where the vector-borne disease dengue fever is endemic, temephos is widely used and applied by both private and public pest control in areas of standing water where the ''Aedes aegypti'' mosquito breeds in order to reduce the population of this disease-carrying insect. Temephos is also used in the Guinea worm eradication program to kill water fleas that carry guinea worm larvae. Resistance to temephos by ''A. aegypti'' has been seen in Brazil. The Brazilian Aedes aegypti resistance monitoring program detected temephos resistance in ''A. aegypti'' populations from several localities in the country i ...
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Organophosphate
In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered as esters of phosphoric acid. Like most functional groups, organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and ATP, as well as many insecticides, herbicides, nerve agents and flame retardants. OPEs have been widely used in various products as flame retardants, plasticizers, and performance additives to engine oil. The popularity of OPEs as flame retardants came as a substitution for the highly regulated brominated flame retardants. The low cost of production and compatibility to diverse polymers made OPEs to be widely used in industry including textile, furniture, electronics as plasticizers and flame retardants. These compounds are added to the final product physica ...
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Endemic (epidemiology)
In epidemiology, an infection is said to be endemic in a specific population or populated place when that infection is constantly maintained at a baseline level without extra infections being brought into the group as a result of travel or similar means. An endemic disease always has a steady, predictable number of people getting sick, but that number can be high (''hyperendemic'') or low (''hypoendemic''), and the disease can be severe or mild. Also, a disease that is usually endemic can become epidemic. For example, chickenpox is endemic (steady state) in the United Kingdom, but malaria is not. Every year, there are a few cases of malaria reported in the UK, but these do not lead to sustained transmission in the population due to the lack of a suitable vector (mosquitoes of the genus ''Anopheles''). Consequently, the number of people infected by malaria is too variable to be called endemic. However, the number of people who get chickenpox in the UK varies little from year ...
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Organophosphate Insecticides
In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered as esters of phosphoric acid. Like most functional groups, organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and ATP, as well as many insecticides, herbicides, nerve agents and flame retardants. OPEs have been widely used in various products as flame retardants, plasticizers, and performance additives to engine oil. The popularity of OPEs as flame retardants came as a substitution for the highly regulated brominated flame retardants. The low cost of production and compatibility to diverse polymers made OPEs to be widely used in industry including textile, furniture, electronics as plasticizers and flame retardants. These compounds are added to the final product physica ...
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Acetylcholinesterase Inhibitors
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and neuromuscular junctions, which are rich in acetylcholine receptors. Acetylcholinesterase inhibitors are one of two types of cholinesterase inhibitors; the other being butyryl-cholinesterase inhibitors. Acetylcholinesterase is the primary member of the cholinesterase enzyme family. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible). Mechanism of action Organophosphates Organophosphates like TEPP and sarin inhibit cholinesterases, enzymes that hydrolyze the neurotransmitter acetylcholine. The active centre of cholinesterases feature two important sites, namely th ...
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Rio De Janeiro
Rio de Janeiro ( , , ; literally 'River of January'), or simply Rio, is the capital of the state of the same name, Brazil's third-most populous state, and the second-most populous city in Brazil, after São Paulo. Listed by the GaWC as a beta global city, Rio de Janeiro is the sixth-most populous city in the Americas. Part of the city has been designated as a World Heritage Site, named "Rio de Janeiro: Carioca Landscapes between the Mountain and the Sea", on 1 July 2012 as a Cultural Landscape. Founded in 1565 by the Portuguese, the city was initially the seat of the Captaincy of Rio de Janeiro, a domain of the Portuguese Empire. In 1763, it became the capital of the State of Brazil, a state of the Portuguese Empire. In 1808, when the Portuguese Royal Court moved to Brazil, Rio de Janeiro became the seat of the court of Queen Maria I of Portugal. She subsequently, under the leadership of her son the prince regent João VI of Portugal, raised Brazil to the dignity of a k ...
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Brazil
Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area and the seventh most populous. Its capital is Brasília, and its most populous city is São Paulo. The federation is composed of the union of the 26 States of Brazil, states and the Federal District (Brazil), Federal District. It is the largest country to have Portuguese language, Portuguese as an List of territorial entities where Portuguese is an official language, official language and the only one in the Americas; one of the most Multiculturalism, multicultural and ethnically diverse nations, due to over a century of mass Immigration to Brazil, immigration from around the world; and the most populous Catholic Church by country, Roman Catholic-majority country. Bounded by the Atlantic Ocean on the east, Brazil has a Coastline of Brazi ...
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Cladocera
The Diplostraca or Cladocera, commonly known as water fleas, are a superorder of small crustaceans that feed on microscopic chunks of organic matter (excluding some predatory forms). Over 1000 species have been recognised so far, with many more undescribed. The oldest fossils of diplostracans date to the Jurassic, though their modern morphology suggests that they originated substantially earlier, during the Paleozoic. Some have also adapted to a life in the ocean, the only members of Branchiopoda to do so, even if several anostracans live in hypersaline lakes. Most are long, with a down-turned head with a single median compound eye, and a carapace covering the apparently unsegmented thorax and abdomen. Most species show cyclical parthenogenesis, where asexual reproduction is occasionally supplemented by sexual reproduction, which produces resting eggs that allow the species to survive harsh conditions and disperse to distant habitats. Description They are mostly long, with t ...
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Guinea Worm Eradication
Dracunculiasis, or Guinea worm disease, is an infection by the Guinea worm. In 1986, there were an estimated 3.5 million cases of Guinea worm in 20 endemic nations in Asia and Africa. Ghana alone reported 180,000 cases in 1989. The number of cases has since been reduced by more than 99.999% to 22 in 2015 in the five remaining endemic nations of Africa: South Sudan, Chad, Mali, Ethiopia, and Angola. The World Health Organization (WHO) is the international body that certifies whether a disease has been eliminated from a country or eradicated from the world. The Carter Center, a nongovernmental, not-for-profit organization founded by former U.S. President Jimmy Carter, also reports the status of the Guinea worm eradication program by country. As of 2019, the WHO goal for eradication in humans and animals is 2030 (previously targets have been set at 1991, 2009, 2015, and 2020). Eradication program Since humans are the principal host for Guinea worm, and there is no evidence th ...
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Aedes Aegypti
''Aedes aegypti'', the yellow fever mosquito, is a mosquito that can spread dengue fever, chikungunya, Zika fever, Mayaro and yellow fever viruses, and other disease agents. The mosquito can be recognized by black and white markings on its legs and a marking in the form of a lyre on the upper surface of its thorax. This mosquito originated in Africa, but is now found in tropical, subtropical and temperate regions throughout the world. Biology ''Aedes aegypti'' is a long, dark mosquito which can be recognized by white markings on its legs and a marking in the form of a lyre on the upper surface of its thorax. Females are larger than males. Microscopically females possess small palps tipped with silver or white scales, and their antennae have sparse short hairs, whereas those of males are feathery. ''Aedes aegypti'' can be mixed up with Aedes albopictus without a magnifying glass: The latter have a white stripe on the top of the mid thorax. Males live off fruit and only the f ...
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Standing Water
Water stagnation occurs when water stops flowing. Stagnant water can be a major environmental hazard. Dangers Malaria and dengue are among the main dangers of stagnant water, which can become a breeding ground for the mosquitoes that transmit these diseases. Stagnant water can be dangerous for drinking because it provides a better incubator than running water for many kinds of bacteria and parasites. Stagnant water can be contaminated with human and animal feces, particularly in deserts or other areas of low rainfall. Water stagnation for as little as six days can completely change bacterial community composition and increase cell count. Stagnant water may be classified into the following basic, although overlapping, types: * Water body stagnation (stagnation in swamp, lake, lagoon, river, etc.) * Surface and ground waters stagnation * Trapped water stagnation. The water may be trapped in human artifacts (discarded cans, plant pots, tires, dug-outs, roofs, etc.), as well as ...
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Dengue Fever
Dengue fever is a mosquito-borne tropical disease caused by the dengue virus. Symptoms typically begin three to fourteen days after infection. These may include a high fever, headache, vomiting, muscle and joint pains, and a characteristic skin itching and skin rash. Recovery generally takes two to seven days. In a small proportion of cases, the disease develops into a more severe dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage, or into dengue shock syndrome, where dangerously low blood pressure occurs. Dengue is spread by several species of female mosquitoes of the ''Aedes'' genus, principally ''Aedes aegypti''. The virus has five serotypes; infection with one type usually gives lifelong immunity to that type, but only short-term immunity to the others. Subsequent infection with a different type increases the risk of severe complications. A number of tests are available to confirm the diagnosis including detecti ...
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Larvicide
A larvicide (alternatively larvacide) is an insecticide that is specifically targeted against the larval life stage of an insect. Their most common use is against mosquitoes. Larvicides may be contact poisons, stomach poisons, growth regulators, or (increasingly) biological control agents. Biological agents The biological control agent '' Bacillus thuringiensis'', also known as ''Bt'', is a bacterial disease specific to Lepidopteran caterpillars. '' Bacillus thuringiensis israelensis'', also known as ''Bti'', and ''Bacillus sphaericus'', which affect larval mosquitoes and some midges, have come into increasing use in recent times. ''Bti'' and ''B. sphaericus'' are both naturally occurring soil bacterium registered as larvicides under the names Bactivec, Bacticide, Aquabac, Teknar, Vectobac, LarvX, and VectoLex CG. Typically in granular form, pellets are distributed on the surface of stagnant water locations. When the mosquito larvae ingest the bacteria, crystallized toxins are p ...
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