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Target Malaria
Target Malaria is a not-for-profit international research consortium that aims to co-develop and share novel genetic technologies to help control malaria in Africa. The consortium brings together research institutes and universities from Africa, Europe and North America. The project is working to develop genetically modified mosquitoes that carry a trait that would result in the reduction of malaria mosquito populations. Reducing the number of mosquitoes that can transmit the malaria parasite would lead to fewer malaria infections. The project’s novel genetic approach aims to be complementary to existing malaria control interventions. The project’s research is still at an early stage, and even though results so far have been promising, there is a long way to go. The malaria burden in Africa Every year, malaria kills half a million people and infects over 200 million people; a third of the world is at risk of contracting this disease transmitted by mosquitoes. The majority of the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a mosquito-borne infectious disease that affects humans and other animals. Malaria causes symptoms that typically include fever, tiredness, vomiting, and headaches. In severe cases, it can cause jaundice, seizures, coma, or death. Symptoms usually begin ten to fifteen days after being bitten by an infected mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria. Malaria is caused by single-celled microorganisms of the ''Plasmodium'' group. It is spread exclusively through bites of infected ''Anopheles'' mosquitoes. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver where they mature and reproduce. Five species of ''Plasmodium'' can infect and be spread by h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Imperial College London
Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cultural area that included the Royal Albert Hall, Victoria & Albert Museum, Natural History Museum and royal colleges. In 1907, Imperial College was established by a royal charter, which unified the Royal College of Science, Royal School of Mines, and City and Guilds of London Institute. In 1988, the Imperial College School of Medicine was formed by merging with St Mary's Hospital Medical School. In 2004, Queen Elizabeth II opened the Imperial College Business School. Imperial focuses exclusively on science, technology, medicine, and business. The main campus is located in South Kensington, and there is an innovation campus in White City. Facilities also include teaching hospitals throughout London, and with Imperial College Healthcare ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genomics Organizations
Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dimensional structural configuration. In contrast to genetics, which refers to the study of ''individual'' genes and their roles in inheritance, genomics aims at the collective characterization and quantification of ''all'' of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genome Editing
Genome editing, or genome engineering, or gene editing, is a type of genetic engineering in which DNA is inserted, deleted, modified or replaced in the genome of a living organism. Unlike early genetic engineering techniques that randomly inserts genetic material into a host genome, genome editing targets the insertions to site-specific locations. The basic mechanism involved in genetic manipulations through programmable nucleases is the recognition of target genomic loci and binding of effector DNA-binding domain (DBD), double-strand breaks (DSBs) in target DNA by the restriction endonucleases ( FokI and Cas), and the repair of DSBs through homology-directed recombination (HDR) or non-homologous end joining (NHEJ). History Genome editing was pioneered in the 1990s, before the advent of the common current nuclease-based gene editing platforms, however, its use was limited by low efficiencies of editing. Genome editing with engineered nucleases, i.e. all three major classes of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxitec
Oxitec is a UK-based, US-owned biotechnology company that develops genetically modified insects in order to improve public health and food security through insect control. The insects act as biological insecticides. Insects are controlled without the use of chemical insecticides. Instead, the insects are genetically engineered to be unable to produce offspring. The company claims that this technology is more effective than insecticides and more environmentally friendly. History Oxitec was founded in 2002 as Oxford Insect Technologies in the United Kingdom by Luke Alphey and David Kelly, working with Oxford University's Isis Innovation technology transfer company. In August 2015, Oxitec was purchased by U.S.-based Intrexon for $160 million, and by US-based Third Security in early 2020. The company's first engineered insect was the pink bollworm (''Pectinophora gossypiella''). It was experimentally released in Arizona in 2006. It then modifed ''Aedes egyptii'', followed by a ser ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene Drive
A gene drive is a natural process and technology of genetic engineering that propagates a particular suite of genes throughout a population by altering the probability that a specific allele will be transmitted to offspring (instead of the Mendelian 50% probability). Gene drives can arise through a variety of mechanisms. They have been proposed to provide an effective means of genetically modifying specific populations and entire species. The technique can employ adding, deleting, disrupting, or modifying genes. Proposed applications include exterminating insects that carry pathogens (notably mosquitoes that transmit malaria, dengue, and zika pathogens), controlling invasive species, or eliminating herbicide or pesticide resistance. As with any potentially powerful technique, gene drives can be misused in a variety of ways or induce unintended consequences. For example, a gene drive intended to affect only a local population might spread across an entire species. Gene drives th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Oxford
, mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor = The Lord Patten of Barnes , vice_chancellor = Louise Richardson , students = 24,515 (2019) , undergrad = 11,955 , postgrad = 12,010 , other = 541 (2017) , city = Oxford , country = England , coordinates = , campus_type = University town , athletics_affiliations = Blue (university sport) , logo_size = 250px , website = , logo = University of Oxford.svg , colours = Oxford Blue , faculty = 6,995 (2020) , academic_affiliations = , The University of Oxford is a collegiate research university in Oxf ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Notre Dame
The University of Notre Dame du Lac, known simply as Notre Dame ( ) or ND, is a private Catholic research university in Notre Dame, Indiana, outside the city of South Bend. French priest Edward Sorin founded the school in 1842. The main campus covers 1,261 acres (510 ha) in a suburban setting and contains landmarks such as the Golden Dome, the ''Word of Life'' mural (commonly known as ''Touchdown Jesus''), Notre Dame Stadium, and the Basilica. Originally for men, although some women earned degrees in 1918, the university began formally accepting undergraduate female students in 1972. Notre Dame has been recognized as one of the top universities in the United States. The university is organized into seven schools and colleges. Notre Dame's graduate program includes more than 50 master, doctoral and professional degrees offered by the six schools, including the Notre Dame Law School and an MD–PhD program offered in combination with the Indiana University School of Medicine ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Ghana
The University of Ghana is a public university located in Accra, Ghana. It the oldest and largest of the thirteen Ghanaian national public universities. The university was founded in 1948 as the University College of the Gold Coast in the British colony of the Gold Coast. It was originally an affiliate college of the University of London, which supervised its academic programs and awarded degrees. After Ghana gained independence in 1957, the college was renamed the University College of Ghana. It changed its name again to the University of Ghana in 1961, when it gained full university status. The University of Ghana is situated on the West view of the Accra Legon hills and at the northeast of the centre of Accra. It has over 40,000 registered students. Introduction The original emphasis on establishing the University of Ghana was on the liberal arts, social sciences, law, basic science, agriculture and medicine. However, as part of a national educational reform program, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Uganda Virus Research Institute
The Uganda Virus Research Institute (UVRI) is a medical research institute owned by the Uganda government that carries out research on communicable diseases in man and animals, with emphasis on viral transmitted infections. UVRI is a component of Uganda National Health Research Organization (UNHRO), an umbrella organization for health research within Uganda. Location UVRI is located at 51-59 Nakiwogo Road, in Entebbe, Uganda, approximately , south of Kampala, the capital and largest city in Uganda. The coordinates of the institute are: 0°04'33.0"N, 32°27'26.0"E (Latitude:0.075833; Longitude:32.457222). Overview The organisation was established in 1936 as the Yellow Fever Research Institute by the Rockefeller Foundation. In 1947, scientists researching yellow fever placed a rhesus macaque in a cage in the Zika Forest. The monkey developed a fever, and researchers isolated from its serum a transmissible agent that was first described as Zika virus in 1952. Other noteworthy arb ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keele University
Keele University, officially known as the University of Keele, is a public research university in Keele, approximately from Newcastle-under-Lyme, Staffordshire, England. Founded in 1949 as the University College of North Staffordshire, Keele was granted university status by Royal Charter in 1962. Keele occupies a rural campus close to the village of Keele and consists of extensive woods, lakes and Keele Hall set in Staffordshire Potteries. It has a science park and a conference centre, making it the largest campus university in the UK. The university's School of Medicine operates the clinical part of its courses from a separate campus at the Royal Stoke University Hospital. The School of Nursing and Midwifery is based at the nearby Clinical Education Centre. History Establishment Cambridge and Oxford Extension Lectures had been arranged in the Potteries since the 1890s, but outside any organised educational framework or establishment. In 1904, funds were raised by local in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
