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Sylvain Lesné
Sylvain E. Lesné (born 1974) is a French neuroscientist and associate professor at the Department of Neuroscience at the University of Minnesota (UMN) Medical School, known for his research into Alzheimer's disease. He is the primary author of a 2006 ''Nature'' paper that is foundational in the hypothesis that one specific toxic oligomer of the amyloid beta protein, known as Aβ*56, is a cause of memory impairment in Alzheimer's, aligned with the prevailing amyloid hypothesis. As of July 2022, Lesné's work in the 2006 publication and others is being investigated on charges that he manipulated images to inflate the role of Aβ*56 in Alzheimer's. Responses from other researchers indicate that, while the allegations are of significant concern, the overall impact on amyloid research is small and most Alzheimer's research is not compromised. Personal life and education Sylvain E. Lesné was born in 1974 and raised in Luc-sur-Mer, a small town in the Normandy region in northwestern ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroscience
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and Mathematical Modeling, mathematical modeling to understand the fundamental and emergent properties of neurons, glia and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the Biology, biological sciences. The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular biology, molecular and cell biology, cellular studies of individual neurons to neuroimaging, imaging ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'', also widely referred to as ''Science Magazine'', is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Matthew Schrag
{{disambiguation ...
Matthew may refer to: * Matthew (given name) * Matthew (surname) * ''Matthew'' (ship), the replica of the ship sailed by John Cabot in 1497 * ''Matthew'' (album), a 2000 album by rapper Kool Keith * Matthew (elm cultivar), a cultivar of the Chinese Elm ''Ulmus parvifolia'' Christianity * Matthew the Apostle, one of the apostles of Jesus * Gospel of Matthew, a book of the Bible See also * Matt (given name), the diminutive form of Matthew * Mathew, alternative spelling of Matthew * Matthews (other) * Matthew effect * Tropical Storm Matthew (other) The name Matthew was used for three tropical cyclones in the Atlantic Ocean, replacing Mitch after 1998. * Tropical Storm Matthew (2004) - Brought heavy rain to the Gulf Coast of Louisiana, causing light damage but no deaths. * Tropical Storm Matt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Western Blot
The western blot (sometimes called the protein immunoblot), or western blotting, is a widely used analytical technique in molecular biology and immunogenetics to detect specific proteins in a sample of tissue homogenate or extract. Besides detecting the proteins, this technique is also utilized to visualize, distinguish, and quantify the different proteins in a complicated protein combination. Western blot technique uses three elements to achieve its task of separating a specific protein from a complex: separation by size, transfer of protein to a solid support, and marking target protein using a primary and secondary antibody to visualize. A synthetic or animal-derived antibody (known as the primary antibody) is created that recognizes and binds to a specific target protein. The electrophoresis membrane is washed in a solution containing the primary antibody, before excess antibody is washed off. A secondary antibody is added which recognizes and binds to the primary antibody ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles Piller
Charles Piller is an American investigative journalist and author who writes for ''Science'' magazine . His focus is on health and biological warfare. Journalism Prior to writing at ''Science'', Piller was an associate editor at ''Macworld'' magazine and wrote for the ''Los Angeles Times'', the STAT website, and ''The Sacramento Bee''. At the ''Times'', he investigated the impact of the Bill & Melinda Gates Foundation on Africa. In July 2022, he authored an investigation published in ''Science'' that questioned the authenticity of images used in Sylvain Lesné's research on Alzheimer's disease at the University of Minnesota Medical School. Center for Public Integrity Along with Charles Lewis and Alejandro Benes, Piller was a founding member of the Center for Public Integrity, where he served as board chair. Books * ''Gene Wars: Military Control over the New Genetic Technologies'' (with Keith R. Yamamoto), Beech Tree Books * ''The Fail-Safe Society: Community Defian ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sophia Antipolis
(wisdom), gr, (Ἀντίπολις, antipolis) ("opposite city" from its position on the opposite side of the Var estuary from Nice, also former name of Antibes, part of the technology park) , postal_code = 06220 (Vallauris), 06250 (Mougins), 06410 (Biot), 06560 (Valbonne), 06600 (Antibes) , coordinates = , pushpin_map = France#France Provence-Alpes-Côte d'Azur , website sophia-antipolis.fr Sophia Antipolis is a 2,400 hectare technology park in southeast France, and as of 2021 home to 2,500 companies, valued today at more than 5.6 billion euros and employing more than 38,000 people counting more than 80 nationalities. The park is known to be Europe's first science and technology hub. The technology park is also a platform, cluster and creation-hub for start-ups. The "technopole" houses primarily companies in the fields of computing, electronics, telecommunication, pharmacology and biotechnology. Several institutions of higher learning ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alzheimer Research Forum
Alzheimer Research Forum (ARF), or Alzforum is a website which uses web technology to accelerate research into Alzheimer's disease. History The website was founded in 1996 by June Kinoshita, funded by an anonymous philanthropic foundation, and launched at the International Conference on Alzheimer's Disease and Related Disorders in Osaka, Japan, The forum brings together a team of specialists in science writing and editing, data curation, information architecture, project management and technology. Alzforum was established as an independent neutral Non-profit organization, without affiliation to any specific university or research institute. Its relations with the scientific community include an advisory board with leaders in the scientific community representing diverse points of view. At first the site took the form of ‘Papers of the Week’ listings, including abstracts of all relevant publications (initially manually produced in order to avoid copyright infringemen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Daily Telegraph
''The Daily Telegraph'', known online and elsewhere as ''The Telegraph'', is a national British daily broadsheet newspaper published in London by Telegraph Media Group and distributed across the United Kingdom and internationally. It was founded by Arthur B. Sleigh in 1855 as ''The Daily Telegraph & Courier''. Considered a newspaper of record over ''The Times'' in the UK in the years up to 1997, ''The Telegraph'' generally has a reputation for high-quality journalism, and has been described as being "one of the world's great titles". The paper's motto, "Was, is, and will be", appears in the editorial pages and has featured in every edition of the newspaper since 19 April 1858. The paper had a circulation of 363,183 in December 2018, descending further until it withdrew from newspaper circulation audits in 2019, having declined almost 80%, from 1.4 million in 1980.United Newspapers PLC and Fleet Holdings PLC', Monopolies and Mergers Commission (1985), pp. 5–16. Its si ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Atlantic
''The Atlantic'' is an American magazine and multi-platform publisher. It features articles in the fields of politics, foreign affairs, business and the economy, culture and the arts, technology, and science. It was founded in 1857 in Boston, as ''The Atlantic Monthly'', a literary and cultural magazine that published leading writers' commentary on education, the abolition of slavery, and other major political issues of that time. Its founders included Francis H. Underwood and prominent writers Ralph Waldo Emerson, Oliver Wendell Holmes Sr., Henry Wadsworth Longfellow, Harriet Beecher Stowe, and John Greenleaf Whittier. James Russell Lowell was its first editor. In addition, ''The Atlantic Monthly Almanac'' was an annual almanac published for ''Atlantic Monthly'' readers during the 19th and 20th centuries. A change of name was not officially announced when the format first changed from a strict monthly (appearing 12 times a year) to a slightly lower frequency. It was a mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Guardian
''The Guardian'' is a British daily newspaper. It was founded in 1821 as ''The Manchester Guardian'', and changed its name in 1959. Along with its sister papers ''The Observer'' and ''The Guardian Weekly'', ''The Guardian'' is part of the Guardian Media Group, owned by the Scott Trust. The trust was created in 1936 to "secure the financial and editorial independence of ''The Guardian'' in perpetuity and to safeguard the journalistic freedom and liberal values of ''The Guardian'' free from commercial or political interference". The trust was converted into a limited company in 2008, with a constitution written so as to maintain for ''The Guardian'' the same protections as were built into the structure of the Scott Trust by its creators. Profits are reinvested in journalism rather than distributed to owners or shareholders. It is considered a newspaper of record in the UK. The editor-in-chief Katharine Viner succeeded Alan Rusbridger in 2015. Since 2018, the paper's main news ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dementia
Dementia is a disorder which manifests as a set of related symptoms, which usually surfaces when the brain is damaged by injury or disease. The symptoms involve progressive impairments in memory, thinking, and behavior, which negatively affects a person's ability to function and carry out everyday activities. Aside from memory impairment and a disruption in thought patterns, the most common symptoms include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum over several stages. Consciousness is not affected. Dementia ultimately has a significant effect on the individual, caregivers, and on social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning, and a greater cognitive decline than what is caused by normal aging. Several diseases and injuries to the brain, such as a stroke, can give rise to dementia. However, th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Minnesota Daily
The ''Minnesota Daily'' is the campus newspaper of the University of Minnesota, published Monday and Thursday while school is in session, and published weekly on Wednesdays during summer sessions. Published since 1900, the paper is currently the largest student-run and student-written newspaper in the United States and the largest paper in the state of Minnesota behind the ''Minneapolis Star Tribune'' and the ''St. Paul Pioneer Press''. The ''Daily'' was named best daily college newspaper in the United States in 2009 and 2010 by the Society of Professional Journalists. The paper is independent from the University, but receives $500,000 worth of student service fees funding. The ''Daily'' has a distribution of 12,150 copies per day (Monday and Thursday during the school year) and 10,000 copies per day (Wednesdays during summer) – available at over 200 locations on and near campus free of charge, as it is largely funded by advertising. A typical edition has about a dozen pages. The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
