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Stetter Reaction
The Stetter reaction is a reaction used in organic chemistry to form carbon-carbon bonds through a 1,4-addition reaction utilizing a nucleophilic catalyst.Stetter, H. ''Angew. Chem. Int. Ed.'' 1976, ''15'', 639. While the related 1,2-addition reaction, the benzoin condensation, was known since the 1830s, the Stetter reaction was not reported until 1973 by Dr. Hermann Stetter.Stetter, H. and Schreckenberg, M. ''Angew. Chem. Int. Ed. Engl.'' 1973, ''12'', 81. The reaction provides synthetically useful 1,4-dicarbonyl compounds and related derivatives from aldehydes and Michael acceptors. Unlike 1,3-dicarbonyls, which are easily accessed through the Claisen condensation, or 1,5-dicarbonyls, which are commonly made using a Michael reaction, 1,4-dicarbonyls are challenging substrates to synthesize, yet are valuable starting materials for several organic transformations, including the Paal–Knorr synthesis of furans and pyrroles. Traditionally utilized catalysts for the Stetter reactio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; Greeves, N. and Warren, S. (2012) ''Organic Chemistry''. Oxford University Press. pp. 1–15. . Study of structure determines their structural formula. Study of properties includes physical and chemical properties, and evaluation of chemical reactivity to understand their behavior. The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical ( in silico) study. The range of chemicals studied in organic chemistry includes hydrocarbons (compounds containing only carbon and hydrogen) as well as compounds based on carbon, but also containing other elements, especially oxygen, nitrogen, sulfur, phosphorus (included in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbene
In organic chemistry, a carbene is a molecule containing a neutral carbon atom with a valence of two and two unshared valence electrons. The general formula is or where the R represents substituents or hydrogen atoms. The term "carbene" may also refer to the specific compound , also called methylene, the parent hydride from which all other carbene compounds are formally derived. Carbenes are classified as either singlets or triplets, depending upon their electronic structure. Most carbenes are very short lived, although persistent carbenes are known. One well-studied carbene is dichlorocarbene , which can be generated ''in situ'' from chloroform and a strong base. Structures and bonding The two classes of carbenes are singlet and triplet carbenes. Singlet carbenes are spin-paired. In the language of valence bond theory, the molecule adopts an sp2 hybrid structure. Triplet carbenes have two unpaired electrons. Most carbenes have a nonlinear triplet ground state, e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enantioselective Synthesis
Enantioselective synthesis, also called asymmetric synthesis, is a form of chemical synthesis. It is defined by IUPAC as "a chemical reaction (or reaction sequence) in which one or more new elements of chirality are formed in a substrate molecule and which produces the stereoisomeric (enantiomeric or diastereomeric) products in unequal amounts." Put more simply: it is the synthesis of a compound by a method that favors the formation of a specific enantiomer or diastereomer. Enantiomers are stereoisomers that have opposite configurations at every chiral center. Diastereomers are stereoisomers that differ at one or more chiral centers. Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of pharmaceuticals, as the different enantiomers or diastereomers of a molecule often have different biological activity. Overview Many of the building blocks of biological systems such as sugars and amino acids are produced exclusively as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brook Rearrangement
In organic chemistry the Brook rearrangement refers to any [1,''n''] carbon to oxygen silyl migration. The Rearrangement reaction, rearrangement was first observed in the late 1950s by Canadian chemist Adrian Gibbs Brook (1924–2013), after which the reaction is named. These migrations can be promoted in a number of different ways, including thermally, photolytically or under basic/acidic conditions. In the forward direction, these silyl migrations produce silyl ethers as products which is driven by the stability of the oxygen-silicon bond. The silyl substituents can be Aliphatic compound, aliphatic or Aromatic compound, aromatic, and if the silicon is a center of Chirality (chemistry), chirality, the migration occurs with retention at this center. This migration occurs through a transition state where silicon is penta-Coordination complex, coordinate and bears a partial negative charge. If a center of chirality is present at the carbon center to which the silyl group is attached ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reaction Scheme Of Cyclic Diketone Stetter Reaction
Reaction may refer to a process or to a response to an action, event, or exposure: Physics and chemistry *Chemical reaction *Nuclear reaction *Reaction (physics), as defined by Newton's third law *Chain reaction (other). Biology and medicine *Adverse drug reaction *Allergic reaction *Reflex, neural reaction *Hypersensitivity, immune reaction *Intolerance (other) *Light reaction (other). Psychology *Emotional, reaction *Reactivity (behaviour) *Proactivity, opposite of reactive behaviour *Reactive attachment disorder. Politics and culture *Reactionary, a political tendency *Reaction video *Commentary (other). Proper names and titles * ''Reaction'' (album), a 1986 album by American R&B singer Rebbie Jackson ** "Reaction" (song), the title song from the Rebbie Jackson album *"Reaction", a single by Dead Letter Circus *ReAction GUI, a GUI toolkit used on AmigaOS *Reaction.life, a political news and commentary website edited by Iain Martin *Rea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stetter Reaction With Acyclic Diketones
Stetter is a German surname. Notable people with the surname include: *Florian Stetter (born 1977), German actor *Georg Stetter (1895–1988), Austrian-German nuclear physicist * George Stetter (born 1945), American player of Canadian football * Hans Stetter (1927–2019), German actor *Karl Stetter (born 1941), German scientist *Mitch Stetter (born 1981), American baseball player * Stephan Stetter (born 1972), German politic scientist *Wilhelm Stetter (1487−1552), Alsatian painter See also *Dora Koch-Stetter (1881–1968), German artist *Stetter reaction The Stetter reaction is a reaction used in organic chemistry to form carbon-carbon bonds through a 1,4-addition reaction utilizing a nucleophilic catalyst.Stetter, H. ''Angew. Chem. Int. Ed.'' 1976, ''15'', 639. While the related 1,2-addition re ..., a reaction in organic chemistry {{surname German-language surnames ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stetter Reaction With Acylimines
Stetter is a German surname. Notable people with the surname include: *Florian Stetter (born 1977), German actor *Georg Stetter (1895–1988), Austrian-German nuclear physicist * George Stetter (born 1945), American player of Canadian football * Hans Stetter (1927–2019), German actor *Karl Stetter (born 1941), German scientist *Mitch Stetter (born 1981), American baseball player * Stephan Stetter (born 1972), German politic scientist *Wilhelm Stetter (1487−1552), Alsatian painter See also *Dora Koch-Stetter (1881–1968), German artist *Stetter reaction The Stetter reaction is a reaction used in organic chemistry to form carbon-carbon bonds through a 1,4-addition reaction utilizing a nucleophilic catalyst.Stetter, H. ''Angew. Chem. Int. Ed.'' 1976, ''15'', 639. While the related 1,2-addition re ..., a reaction in organic chemistry {{surname German-language surnames ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scope Of Stetter Reaction
Scope or scopes may refer to: People with the surname * Jamie Scope (born 1986), English footballer * John T. Scopes (1900–1970), central figure in the Scopes Trial regarding the teaching of evolution Arts, media, and entertainment * CinemaScope or Scope prints, anamorphic film prints * ''Scope'' (magazine), a South African men's magazine * ''The Scope (alternative weekly)'', a newspaper in St. John's, Newfoundland * ''Scope'' (Australian TV series) * ''Scope'' (Irish TV series) * ''Scope'' (album), a 1979 studio album by Buck Hill Quartet Computing * Scope (computer science), the range in which a variable can be referenced * scope (scopeArchiv), an archival information program * CDC SCOPE, a series of Control Data Corporation operating systems Concepts * Scope (logic), the range influenced by the quantification in logic * Scope (formal semantics), the natural language counterpart of logical scope * Scope (project management), the sum of all projects, products and their ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Asymmetric Stetter Reaction
Asymmetric may refer to: *Asymmetry in geometry, chemistry, and physics Computing *Asymmetric cryptography, in public-key cryptography *Asymmetric digital subscriber line, Internet connectivity *Asymmetric multiprocessing, in computer architecture Other *Asymmetric relation, in set theory *Asymmetric synthesis, in organic synthesis *Asymmetric warfare, in modern war *Asymmetric Publications, a video game company * ''Asymmetry'' (Mallory Knox album), 2014 * ''Asymmetry'' (Karnivool album) *Asymmetry (population ethics) *Asymmetry (novel) ''Asymmetry'' is the first novel by American author Lisa Halliday, published in February 2018 by Simon & Schuster. The novel has received critical acclaim with ''The New Yorker'' calling it "a literary phenomenon" and ''The New York Times'' inclu ..., a 2018 novel by Lisa Halliday See also * * {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stetter Reaction Mechanism
Stetter is a German surname. Notable people with the surname include: *Florian Stetter (born 1977), German actor *Georg Stetter (1895–1988), Austrian-German nuclear physicist * George Stetter (born 1945), American player of Canadian football * Hans Stetter (1927–2019), German actor *Karl Stetter (born 1941), German scientist *Mitch Stetter (born 1981), American baseball player * Stephan Stetter (born 1972), German politic scientist *Wilhelm Stetter (1487−1552), Alsatian painter See also *Dora Koch-Stetter (1881–1968), German artist *Stetter reaction The Stetter reaction is a reaction used in organic chemistry to form carbon-carbon bonds through a 1,4-addition reaction utilizing a nucleophilic catalyst.Stetter, H. ''Angew. Chem. Int. Ed.'' 1976, ''15'', 639. While the related 1,2-addition re ..., a reaction in organic chemistry {{surname German-language surnames ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthon
In retrosynthetic analysis, a synthon is a hypothetical unit within a target molecule that represents a potential starting reagent in the retroactive synthesis of that target molecule. The term was coined in 1967 by E. J. Corey. He noted in 1988 that the "word ''synthon'' has now come to be used to mean synthetic ''building block'' rather than retrosynthetic fragmentation structures". It was noted in 1998 that the phrase did not feature very prominently in Corey's 1981 book ''The Logic of Chemical Synthesis'', as it was not included in the index. Because synthons are charged, when placed into a synthesis a neutral form is found commercially instead of forming and using the potentially very unstable charged synthons. Example : In planning the synthesis of phenylacetic acid, two synthons are identified: a nucleophilic "COOH−" group, and an electrophilic "PhCH2+" group. Of course, both synthons do not exist per se; synthetic equivalents corresponding to the synthons are reacted ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
