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Solomon Carter Fuller
Solomon Carter Fuller (August 1, 1872 – January 16, 1953) was a pioneering Liberian neurologist, psychiatrist, pathologist, and professor. Born in Monrovia, Liberia, he completed his college education and medical degree (MD) in the United States. He studied psychiatry in Munich, Germany, then returned to the United States, where he worked for much of his career at Westborough State Hospital in Westborough, Massachusetts. In 1919, Fuller became part of the faculty at Boston University School of Medicine where he taught pathology. He made significant contributions to the study of Alzheimer's disease during his career. He also had a private practice as a physician, neurologist, and psychiatrist. Early life and education Solomon Fuller was born in Monrovia, Liberia to Americo-Liberian parents of African American descent. His father, Solomon, had become a coffee planter in Liberia and an official in its government. His mother, Anna Ursala (reported also as Ursilla or Ursula) James ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monrovia
Monrovia () is the capital city of the West African country of Liberia. Founded in 1822, it is located on Cape Mesurado on the Atlantic coast and as of the 2008 census had 1,010,970 residents, home to 29% of Liberia’s total population. As the nation's primate city, Monrovia is the country's economic, financial and cultural center; its economy is primarily centered on its harbor and its role as the seat of Liberian government. Etymology Monrovia is named in honor of U.S. President James Monroe, a prominent supporter of the colonization of Liberia and the American Colonization Society. Along with Washington, D.C., it is one of two world capitals to be named after a U.S. President. History Before 1816, the area around Cape Mesurado and the mouth of the Mesurado River was called Ducor. It had long been established as a crossroads and place of trade, and was inhabited by fishing, trading and farming communities of various ethnicities, including the Dey, Kru, Bassa, Gola, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norfolk, Virginia
Norfolk ( ) is an independent city in the Commonwealth of Virginia in the United States. Incorporated in 1705, it had a population of 238,005 at the 2020 census, making it the third-most populous city in Virginia after neighboring Virginia Beach and Chesapeake, and the 94th-largest city in the nation. Norfolk holds a strategic position as the historical, urban, financial, and cultural center of the Hampton Roads region, which has more than 1.8 million inhabitants and is the thirty-third largest Metropolitan Statistical area in the United States. Officially known as ''Virginia Beach-Norfolk-Newport News, VA-NC MSA'', the Hampton Roads region is sometimes called "Tidewater" and "Coastal Virginia"/"COVA," although these are broader terms that also include Virginia's Eastern Shore and entire coastal plain. Named for the eponymous natural harbor at the mouth of the Chesapeake Bay, Hampton Roads has ten cities, including Norfolk; seven counties in Virginia; and two counties in No ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arteriosclerosis
Arteriosclerosis is the thickening, hardening, and loss of elasticity of the walls of Artery, arteries. This process gradually restricts the blood flow to one's organs and tissues and can lead to severe health risks brought on by atherosclerosis, which is a specific form of arteriosclerosis caused by the buildup of fatty plaques, cholesterol, and some other substances in and on the artery walls. It can be brought on by smoking, a bad diet, or many genetic factors. Atherosclerosis is the primary cause of coronary artery disease (CAD) and stroke, with multiple genetic and environmental contributions. Genetic-epidemiologic studies have identified a long list of genetic and non-genetic risk factors for CAD. However, such studies indicate that family history is the most significant independent risk factor. Signs and symptoms The signs and symptoms of arteriosclerosis depend on the vessel affected by the disease. If affecting cerebral or ophthalmic vessels, as in cerebrovascular accid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurofibrillary Tangle
Neurofibrillary tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary biomarker of Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their exact relationship to the different pathologies. Formation Neurofibrillary tangles are formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate, or group, in an insoluble form. (These aggregations of hyperphosphorylated tau protein are also referred to as PHF, or " paired helical filaments"). The precise mechanism of tangle formation is not completely understood, and it is still controversial whether tangles are a primary causative factor in disease or play a more peripheral role. Cytoskeletal changes Three different maturation states of NFT have been defined using anti-tau and anti-ubiquitin immunostaining. At stage 0 there are morphologically normal pyramidal cells showing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amyloid Plaques
Amyloid plaques (also known as neuritic plaques, amyloid beta plaques or senile plaques) are extracellular deposits of the amyloid beta (Aβ) protein mainly in the grey matter of the brain. Degenerative neuronal elements and an abundance of microglia and astrocytes can be associated with amyloid plaques. Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. Abnormal neurites in amyloid plaques are tortuous, often swollen axons and dendrites. The neurites contain a variety of organelles and cellular debris, and many of them include characteristic paired helical filaments, the ultrastructural component of neurofibrillary tangles. The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve with an average plaque area of 400-450 square micrometers (µm²). The smallest plaques (less than 200 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Early-onset Alzheimer's Disease
Early-onset Alzheimer's disease, also called younger-onset Alzheimer's, is Alzheimer's disease diagnosed before the age of 65. It is an uncommon form of Alzheimer's, accounting for only 5–10% of all Alzheimer's cases. About 60% have a positive family history of Alzheimer's and 13% of them are inherited in an autosomal dominant manner. Most cases of early-onset Alzheimer's share the same traits as the "late-onset" form and are not caused by known genetic mutations. Little is understood about how it starts. Non-familial early-onset AD can develop in people who are in their 30s or 40s, but this is extremely rare, and mostly people in their 50s or early 60s are affected. Familial Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of dementia; it usually occurs in old age. Familial Alzheimer's disease is an inherited and uncommon form of AD. Familiar AD usually strikes earlier in life, defined as before the age of 65. FAD usually im ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alois Alzheimer
Alois Alzheimer ( , , ; 14 June 1864 – 19 December 1915) was a German psychiatrist and neuropathologist and a colleague of Emil Kraepelin. Alzheimer is credited with identifying the first published case of "presenile dementia", which Kraepelin would later identify as Alzheimer's disease. Early life and education Alzheimer was born in Marktbreit, Bavaria, on 14 June 1864, the son of Anna Johanna Barbara Sabina and Eduard Román Alzheimer. His father served in the office of notary public in the family's hometown. The Alzheimers moved to Aschaffenburg when Alois was still young in order to give their children an opportunity to attend the Royal Humanistic Gymnasium. After graduating with Abitur in 1883, Alzheimer studied medicine at University of Berlin, University of Tübingen, and University of Würzburg. In his final year at university, he was a member of a fencing fraternity, and even received a fine for disturbing the peace while out with his team. In 1887, Alois Alzheimer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Emil Kraepelin
Emil Wilhelm Georg Magnus Kraepelin (; ; 15 February 1856 – 7 October 1926) was a German psychiatrist. H. J. Eysenck's ''Encyclopedia of Psychology'' identifies him as the founder of modern scientific psychiatry, psychopharmacology and psychiatric genetics. Kraepelin believed the chief origin of psychiatric disease to be biological and genetic malfunction. His theories dominated psychiatry at the start of the 20th century and, despite the later psychodynamic influence of Sigmund Freud and his disciples, enjoyed a revival at century's end. While he proclaimed his own high clinical standards of gathering information "by means of expert analysis of individual cases", he also drew on reported observations of officials not trained in psychiatry. His textbooks do not contain detailed case histories of individuals but mosaic-like compilations of typical statements and behaviors from patients with a specific diagnosis. He has been described as "a scientific manager" and "a politi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated between the Baltic and North seas to the north, and the Alps to the south; it covers an area of , with a population of almost 84 million within its 16 constituent states. Germany borders Denmark to the north, Poland and the Czech Republic to the east, Austria and Switzerland to the south, and France, Luxembourg, Belgium, and the Netherlands to the west. The nation's capital and most populous city is Berlin and its financial centre is Frankfurt; the largest urban area is the Ruhr. Various Germanic tribes have inhabited the northern parts of modern Germany since classical antiquity. A region named Germania was documented before AD 100. In 962, the Kingdom of Germany formed the bulk of the Holy Roman Empire. During the 16th ce ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Munich
The Ludwig Maximilian University of Munich (simply University of Munich or LMU; german: Ludwig-Maximilians-Universität München) is a public research university in Munich, Germany. It is Germany's List of universities in Germany, sixth-oldest university in continuous operation. Originally University of Ingolstadt, established in Ingolstadt in 1472 by Louis IX, Duke of Bavaria, Duke Ludwig IX of Bavaria-Landshut, the university was moved in 1800 to Landshut by Maximilian I Joseph of Bavaria, King Maximilian I of Bavaria when the city was threatened by the French, before being relocated to its present-day location in Munich in 1826 by Ludwig I of Bavaria, King Ludwig I of Bavaria. In 1802, the university was officially named Ludwig-Maximilians-Universität by King Maximilian I of Bavaria in honor of himself and Ludwig IX. LMU is currently the second-largest university in Germany in terms of student population; in the 2018/19 winter semester, the university had a total of 51,606 m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homeopathy
Homeopathy or homoeopathy is a pseudoscientific system of alternative medicine. It was conceived in 1796 by the German physician Samuel Hahnemann. Its practitioners, called homeopaths, believe that a substance that causes symptoms of a disease in healthy people can cure similar symptoms in sick people; this doctrine is called '' similia similibus curentur'', or "like cures like". Homeopathic preparations are termed ''remedies'' and are made using homeopathic dilution. In this process, the selected substance is repeatedly diluted until the final product is chemically indistinguishable from the diluent. Often not even a single molecule of the original substance can be expected to remain in the product. Between each dilution homeopaths may hit and/or shake the product, claiming this makes the diluent remember the original substance after its removal. Practitioners claim that such preparations, upon oral intake, can treat or cure disease. All relevant scientific knowledge about ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Hospital Of Brooklyn At Long Island College Hospital
University Hospital of Brooklyn at Long Island College Hospital (or LICH) was a 506-bed teaching hospital located in the Brooklyn Heights and Cobble Hill neighborhoods of Brooklyn, New York. The hospital was founded in 1858 as Long Island College Hospital and following years-long attempts to save it through mergers and property development, it ceased operations on August 30, 2014. History Long Island College Hospital introduced the practice of bedside teaching in 1860, and it later became the first U.S. hospital to use stethoscopes and anesthesia. In 1873 it introduced the first emergency ambulance service in Brooklyn. Its collegiate division would later form the Downstate Medical Center, an academic unit of the State University of New York in 1948. The Polhemus Memorial Clinic, an eight-story 1897 tower that was part LICH until July 2008, is considered to be the first example of skyscraper hospital, anywhere in the world. Merger and closure The facility had yea ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
