|
Alois Alzheimer
Alois Alzheimer ( , , ; 14 June 1864 – 19 December 1915) was a German psychiatrist and neuropathologist and a colleague of Emil Kraepelin. Alzheimer is credited with identifying the first published case of "presenile dementia", which Kraepelin would later identify as Alzheimer's disease. Early life and education Alzheimer was born in Marktbreit, Bavaria, on 14 June 1864, the son of Anna Johanna Barbara Sabina and Eduard Román Alzheimer. His father served in the office of notary public in the family's hometown. The Alzheimers moved to Aschaffenburg when Alois was still young in order to give their children an opportunity to attend the Royal Humanistic Gymnasium. After graduating with Abitur in 1883, Alzheimer studied medicine at University of Berlin, University of Tübingen, and University of Würzburg. In his final year at university, he was a member of a fencing fraternity, and even received a fine for disturbing the peace while out with his team. In 1887, Alois Alzheimer ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Marktbreit
Marktbreit am Main () is a town in the district of Kitzingen in the Regierungsbezirk Unterfranken in Bavaria, Germany. It is situated at the most southern point of the Main river. Marktbreit is the birthplace of Alois Alzheimer who first identified the symptoms of what is now known as Alzheimer's disease. With its suburb , Marktbreit has around 3,700 inhabitants. Geography Location The town of Marktbreit is located in the district of Kitzingen, in the Lower Franconia region of Bavaria. Its territory lies on the left bank of the Main river, at the river's southernmost bend. The town of Kitzingen lies upriver, while downriver are Ochsenfurt and Würzburg. Marktbreit is located on the southwestern edge of the district, where it borders on the districts of Neustadt (Aisch)-Bad Windsheim and Würzburg. Subdivisions The town has two ''Stadtteile'': Marktbreit and Gnodstadt. Neighbouring communities The municipality borders on (from the north clockwise): Marktsteft, Obernbreit, Mar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuropathologist
Neuropathology is the study of disease of nervous system tissue, usually in the form of either small surgical biopsies or whole-body autopsies. Neuropathologists usually work in a department of anatomic pathology, but work closely with the clinical disciplines of neurology, and neurosurgery, which often depend on neuropathology for a diagnosis. Neuropathology also relates to forensic pathology because brain disease or brain injury can be related to cause of death. Neuropathology should not be confused with neuropathy, which refers to disorders of the nerves themselves (usually in the peripheral nervous system) rather than the tissues. In neuropathology, the branches of the specializations of nervous system as well as the tissues come together into one field of study. Methodology The work of the neuropathologist consists largely of examining autopsy or biopsy tissue from the brain and spinal cord to aid in diagnosis of disease. Tissues are also observed through the eye ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurofibrillary Tangles
Neurofibrillary tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary biomarker of Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their exact relationship to the different pathologies. Formation Neurofibrillary tangles are formed by hyperphosphorylation of a microtubule-associated protein known as tau, causing it to aggregate, or group, in an insoluble form. (These aggregations of hyperphosphorylated tau protein are also referred to as PHF, or " paired helical filaments"). The precise mechanism of tangle formation is not completely understood, and it is still controversial whether tangles are a primary causative factor in disease or play a more peripheral role. Cytoskeletal changes Three different maturation states of NFT have been defined using anti-tau and anti-ubiquitin immunostaining. At stage 0 there are morphologically normal pyramidal cells showi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amyloid
Amyloids are aggregates of proteins characterised by a Fibril, fibrillar morphology of 7–13 Nanometer, nm in diameter, a beta sheet (β-sheet) Secondary structure of proteins, secondary structure (known as cross-β) and ability to be Staining, stained by particular dyes, such as Congo red. In the human body, amyloids have been linked to the development of various diseases. Pathogenic amyloids form when previously healthy proteins lose their normal Protein structure, structure and physiology, physiological functions (Protein misfolding, misfolding) and form fibrous deposits in amyloid plaques around cells which can disrupt the healthy function of tissues and organs. Such amyloids have been associated with (but not necessarily as the cause of) more than 50 human diseases, known as amyloidosis, and may play a role in some neurodegenerative diseases. Some of these diseases are mainly sporadic and only a few cases are Genetic disorder, familial. Others are only Genetic disorder, fam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Auguste Deter
Auguste Deter (; 16 May 1850 – 8 April 1906) was a German woman notable for being the first person to be diagnosed with Alzheimer's disease. Life Auguste was born in Kassel, Hesse-Kassel on May 16, 1850. Born into a working-class family, Auguste had three siblings and was a daughter to Johannes Hohmann. Auguste's father died when she was young. Even though Auguste's family was impoverished, she was well-educated. She attended school in Cassell, and it is speculated that she may have been a student of Dr. Alois Alzheimer's grandfather, Johann. He was a schoolmaster in Cassell during the time Auguste attended school. Further education was not possible for Auguste due to social norms and her family's financial situation. Auguste started work as a full-time seamstress assistant at the age of 14. She continued this career until she married Carl August Wilhelm Deter on 1 May 1873, at the age of 23. In 1888, Carl began work as a railway clerk. After marrying Carl, Auguste mov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Habilitation
Habilitation is the highest university degree, or the procedure by which it is achieved, in many European countries. The candidate fulfills a university's set criteria of excellence in research, teaching and further education, usually including a dissertation. The degree, abbreviated "Dr. habil." (Doctor habilitatus) or "PD" (for "Privatdozent"), is a qualification for professorship in those countries. The conferral is usually accompanied by a lecture to a colloquium as well as a public inaugural lecture. History and etymology The term ''habilitation'' is derived from the Medieval Latin , meaning "to make suitable, to fit", from Classical Latin "fit, proper, skillful". The degree developed in Germany in the seventeenth century (). Initially, habilitation was synonymous with "doctoral qualification". The term became synonymous with "post-doctoral qualification" in Germany in the 19th century "when holding a doctorate seemed no longer sufficient to guarantee a proficient transfer o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Franz Nissl
Franz Alexander Nissl (9 September 1860, in Frankenthal – 11 August 1919, in Munich) was a German psychiatrist and medical researcher. He was a noted neuropathologist. Early life Nissl was born in Frankenthal to Theodor Nissl and Maria Haas. Theodor taught Latin in a Catholic school and wanted Franz to become a priest. However Franz entered the Ludwig Maximilian University of Munich to study medicine. Later, he specialized in Psychiatry. One of Nissl's university professors was Bernhard von Gudden. His assistant, Sigbert Josef Maria Ganser suggested that Nissl write an essay on the pathology of the cells of the cortex of the brain. When the medical faculty offered a competition for a prize in neurology in 1884, Nissl undertook the brain-cortex study. He used alcohol as a fixative and developed a staining technique that allowed the demonstration of several new nerve-cell constituents. Nissl won the prize, and wrote his doctoral dissertation on the same topic in 1885. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Medicine
Doctor of Medicine (abbreviated M.D., from the Latin language, Latin ''Medicinae Doctor'') is a medical degree, the meaning of which varies between different jurisdictions. In the United States, and some other countries, the M.D. denotes a professional degree. This generally arose because many in 18th-century medical professions trained in Scotland, which used the M.D. degree nomenclature. In England, however, Bachelor of Medicine, Bachelor of Surgery was used and eventually in the 19th century became the standard in Scotland too. Thus, in the United Kingdom, Republic of Ireland, Ireland and other countries, the M.D. is a research doctorate, honorary degree, honorary doctorate or applied clinical degree restricted to those who already hold a professional degree (Bachelor's/Master's/Doctoral) in medicine. In those countries, the equivalent professional degree to the North American, and some others use of M.D., is still typically titled Bachelor of Medicine, Bachelor of Surgery (M.B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Studentenverbindung
(; often referred to as Verbindung) is the umbrella term for many different kinds of fraternity-type associations in German-speaking countries, including Corps, , , , and Catholic fraternities. Worldwide, there are over 1,600 , about a thousand in Germany, with a total of over 190,000 members. In them, students spend their university years in an organized community, whose members stay connected even after graduation. A goal of this lifelong bond () is to create contacts and friendships over many generations and to facilitate networking. The is very important for the longevity of these networks. Their autonomous and grassroots democratic is also an important similarity of all student corporations. Apart from the and the , every Studentenverbindung also has a so-called (borrowed French for 'how'). The is a body of rules that organize various different aspects of fraternity life such as the , academic fencing (), and general rules of conduct. Fraternities of this particula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Würzburg
The Julius Maximilian University of Würzburg (also referred to as the University of Würzburg, in German ''Julius-Maximilians-Universität Würzburg'') is a public research university in Würzburg, Germany. The University of Würzburg is one of the oldest institutions of higher learning in Germany, having been founded in 1402. The university initially had a brief run and was closed in 1415. It was reopened in 1582 on the initiative of Julius Echter von Mespelbrunn. Today, the university is named for Julius Echter von Mespelbrunn and Maximilian Joseph. The University of Würzburg is part of the U15 group of research-intensive German universities. The university is also a member of the Coimbra Group. Name Its official name is Julius-Maximilians-Universität Würzburg (or "Julius-Maximilian University of Würzburg") but it is commonly referred to as the University of Würzburg. This name is taken from Julius Echter von Mespelbrunn, Prince-Bishop of Würzburg, who reestablishe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Humboldt University Berlin
Humboldt-Universität zu Berlin (german: Humboldt-Universität zu Berlin, abbreviated HU Berlin) is a German public research university in the central borough of Mitte in Berlin. It was established by Frederick William III on the initiative of Wilhelm von Humboldt, Johann Gottlieb Fichte and Friedrich Ernst Daniel Schleiermacher as the University of Berlin () in 1809, and opened in 1810, making it the oldest of Berlin's four universities. From 1828 until its closure in 1945, it was named Friedrich Wilhelm University (german: Friedrich-Wilhelms-Universität). During the Cold War, the university found itself in East Berlin and was ''de facto'' split in two when the Free University of Berlin opened in West Berlin. The university received its current name in honour of Alexander and Wilhelm von Humboldt in 1949. The university is divided into nine faculties including its medical school shared with the Freie Universität Berlin. The university has a student enrollment of around 32,0 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abitur
''Abitur'' (), often shortened colloquially to ''Abi'', is a qualification granted at the end of secondary education in Germany. It is conferred on students who pass their final exams at the end of ISCED 3, usually after twelve or thirteen years of schooling (see also, for Germany, ''Abitur'' after twelve years). In German, the term has roots in the archaic word , which in turn was derived from the Latin (future active participle of , thus "someone who is going to leave"). As a matriculation examination, ''Abitur'' can be compared to A levels, the ''Matura'' or the International Baccalaureate Diploma, which are all ranked as level 4 in the European Qualifications Framework. In Germany Overview The ("certificate of general qualification for university entrance"), often referred to as ("''Abitur'' certificate"), issued after candidates have passed their final exams and have had appropriate grades in both the last and second last school year, is the document which contains t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
