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Sulfathiazole
Sulfathiazole is an organosulfur compound used as a short-acting sulfa drug. Formerly, it was a common oral and topical antimicrobial, until less toxic alternatives were discovered. Sulfathiazole exists in various forms ( polymorphs). The imine tautomer is dominant, at least in the solid state. In this tautomer, the proton resides on the ring nitrogen. Cultural references * In the 1955 short story, Captive Audience by Philip K. Dick, Flannery recommends the use of sulfathiazole in lieu of the unavailable Penicillin for a ten year old boy's suppurating arm wound he received from "toxic crystalline poisoning". * 1960 Otto Preminger's movie Exodus, American nurse Kitty Fremont tells Dr. Odenheimer that sulfathiazole is the treatment for impetigo. Dr. Odenheimer tells her that sulfathiazole is not available on the ship; soaking of the lesions and exposure to sunlight "is also a cure." * 1963: Sulfathiazole is mentioned in Kurt Vonnegut's novel ''Cat's Cradle'' and New Dictionary, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organosulfur Compound
Organosulfur compounds are organic compounds that contain sulfur. They are often associated with foul odors, but many of the sweetest compounds known are organosulfur derivatives, e.g., saccharin. Nature abounds with organosulfur compounds—sulfur is vital for life. Of the 20 common amino acids, two ( cysteine and methionine) are organosulfur compounds, and the antibiotics penicillin and sulfa drugs both contain sulfur. While sulfur-containing antibiotics save many lives, sulfur mustard is a deadly chemical warfare agent. Fossil fuels, coal, petroleum, and natural gas, which are derived from ancient organisms, necessarily contain organosulfur compounds, the removal of which is a major focus of oil refineries. Sulfur shares the chalcogen group with oxygen, selenium, and tellurium, and it is expected that organosulfur compounds have similarities with carbon–oxygen, carbon–selenium, and carbon–tellurium compounds. A classical chemical test for the detection of sulfur co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kurt Vonnegut
Kurt Vonnegut Jr. (November 11, 1922 – April 11, 2007) was an American writer known for his satirical and darkly humorous novels. In a career spanning over 50 years, he published fourteen novels, three short-story collections, five plays, and five nonfiction works; further collections have been published after his death. Born and raised in Indianapolis, Vonnegut attended Cornell University but withdrew in January 1943 and enlisted in the US Army. As part of his training, he studied mechanical engineering at the Carnegie Institute of Technology (now Carnegie Mellon University) and the University of Tennessee. He was then deployed to Europe to fight in World War II and was captured by the Germans during the Battle of the Bulge. He was interned in Dresden, where he survived the Allied bombing of the city in a meat locker of the slaughterhouse where he was imprisoned. After the war, he married Jane Marie Cox, with whom he had three children. He adopted his nephews after his siste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
World War II
World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the vast majority of the world's countries—including all of the great powers—forming two opposing military alliances: the Allies and the Axis powers. World War II was a total war that directly involved more than 100 million personnel from more than 30 countries. The major participants in the war threw their entire economic, industrial, and scientific capabilities behind the war effort, blurring the distinction between civilian and military resources. Aircraft played a major role in the conflict, enabling the strategic bombing of population centres and deploying the only two nuclear weapons ever used in war. World War II was by far the deadliest conflict in human history; it resulted in 70 to 85 million fatalities, mostly among civilians. Tens of millions died due to genocides (including the Holocaust), starvation, ma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The World According To Garp
''The World According to Garp'' is John Irving's fourth novel, about a man, born out of wedlock to a feminist leader, who grows up to be a writer. Published in 1978, the book was a bestseller for several years. It was a finalist for the National Book Award for Fiction in 1979,"National Book Awards – 1979" . Retrieved 14 March 2012. and its first paperback edition won the Award the following year. [Baidu] |
John Irving
John Winslow Irving (born John Wallace Blunt Jr.; March 2, 1942) is an American-Canadian novelist, short story writer, and screenwriter. Irving achieved critical and popular acclaim after the international success of ''The World According to Garp'' in 1978. Many of Irving's novels, including ''The Hotel New Hampshire'' (1981), ''The Cider House Rules'' (1985), ''A Prayer for Owen Meany'' (1989), and ''A Widow for One Year'' (1998), have been bestsellers. He won the Academy Award for Best Adapted Screenplay in the 72nd Academy Awards (1999) for his script of ''The Cider House Rules''."John Irving 1999 Acceptance Speech on Winning the Oscar for Best Adapted Screenplay" ''oscars.org'' Five of his novels have been adapted into films (''Garp'', ''H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gonorrhea
Gonorrhea, colloquially known as the clap, is a sexually transmitted infection (STI) caused by the bacterium '' Neisseria gonorrhoeae''. Infection may involve the genitals, mouth, or rectum. Infected men may experience pain or burning with urination, discharge from the penis, or testicular pain. Infected women may experience burning with urination, vaginal discharge, vaginal bleeding between periods, or pelvic pain. Complications in women include pelvic inflammatory disease and in men include inflammation of the epididymis. Many of those infected, however, have no symptoms. If untreated, gonorrhea can spread to joints or heart valves. Gonorrhea is spread through sexual contact with an infected person. This includes oral, anal, and vaginal sex. It can also spread from a mother to a child during birth. Diagnosis is by testing the urine, urethra in males, or cervix in females. Testing all women who are sexually active and less than 25 years of age each year as well as thos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mister Roberts (novel)
''Mister Roberts'' is a 1946 novel by Thomas Heggen, based on his experiences in the South West Pacific theatre during World War II. Several characters, including the eponymous Mister Roberts, were based on real people. (See below.) Lieutenant (junior grade) Roberts defends his crew against the petty tyranny of the ship's commanding officer, while submitting transfer requests on a daily basis. Nearly all action takes place on a US Navy auxiliary cargo ship, the USS ''Reluctant,'' which sails, as written in the 1948 play adapted from the novel, "from Apathy to Tedium, with occasional side trips to Monotony and Ennui." Roberts eventually wins his freedom from the “bucket” and assignment to a destroyer, with tragic consequences. Heggen and Joshua Logan turned the novel into a Tony-award-winning hit play, which opened on Broadway in February 1948. A book dramatizing the play, co-authored by Heggen and Logan and also titled ''Mister Roberts'', was published by Random House in 19 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas Heggen
Thomas Heggen (December 23, 1918 – May 19, 1949) was an American author best known for his 1946 novel '' Mister Roberts'' and its adaptations to stage and screen. Heggen became an Oklahoman in 1935, when in the depths of the Depression his father's business failed and his family moved from Iowa to Oklahoma City for work. He was Wallace Stegner's cousin. Navy service After attending Oklahoma City University, Oklahoma State University, and graduating from the University of Minnesota, where he was classmate of Max Shulman, Thomas R. St. George and Norman Katkov, with a degree in journalism, Heggen moved to New York City and became an editor for ''Reader's Digest''. He joined the U.S. Navy immediately after the attack on Pearl Harbor and was commissioned as a lieutenant in August 1942. For the duration of the War, he served on supply vessels in the North Atlantic, the Caribbean and the Pacific, the latter as assistant communications officer on the cargo ship USS ''Virgo'' an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cat's Cradle
Cat's cradle is a game involving the creation of various string figures between the fingers, either individually or by passing a loop of string back and forth between two or more players. The true origin of the name is debated, though the first known reference is in ''The light of nature pursued'' by Abraham Tucker in 1768. The type of string, the specific figures, their order, and the names of the figures vary. Independent versions of this game have been found in indigenous cultures throughout the world, including in Africa, Eastern Asia, the Pacific Islands, Australia, the Americas, and the Arctic. Play The simplest version of the game involves a player using a long string loop to make a complex figure using their fingers and hands. Another version of the game consists of two or more players making a sequence of string figures, each altering the figure made by the previous player. The game begins with one player making the eponymous figure ''Cat's Cradle'' (above). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Impetigo
Impetigo is a bacterial infection that involves the superficial skin. The most common presentation is yellowish crusts on the face, arms, or legs. Less commonly there may be large blisters which affect the groin or armpits. The lesions may be painful or itchy. Fever is uncommon. It is typically due to either ''Staphylococcus aureus'' or ''Streptococcus pyogenes''. Risk factors include attending day care, crowding, poor nutrition, diabetes mellitus, contact sports, and breaks in the skin such as from mosquito bites, eczema, scabies, or herpes. With contact it can spread around or between people. Diagnosis is typically based on the symptoms and appearance. Prevention is by hand washing, avoiding people who are infected, and cleaning injuries. Treatment is typically with antibiotic creams such as mupirocin or fusidic acid. Antibiotics by mouth, such as cefalexin, may be used if large areas are affected. Antibiotic-resistant forms have been found. Impetigo affected about 140& ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfonamide (medicine)
Sulfonamide is a functional group (a part of a molecule) that is the basis of several groups of drugs, which are called sulphonamides, sulfa drugs or sulpha drugs. The original antibacterial sulfonamides are synthetic (nonantibiotic) antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are newer drug groups based upon the antibacterial sulfonamides. Allergies to sulfonamides are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; hence medications containing sulfonamides are prescribed carefully. Sulfonamide drugs were the first broadly effective antibacterials to be used systemically, and paved the way for the antibiotic revolution in medicine. Function In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthase (DHP ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Exodus (1960 Film)
''Exodus'' is a 1960 American epic historical drama film about the founding of the State of Israel. Produced and directed by Otto Preminger, the screenplay was adapted by Dalton Trumbo from the 1958 novel of the same name by Leon Uris. The film stars an ensemble cast including Paul Newman, Eva Marie Saint, Ralph Richardson, Peter Lawford, Lee J. Cobb, Sal Mineo, John Derek and George Maharis. The film's soundtrack music was written by Ernest Gold. Preminger openly hired screenwriter Trumbo, who had been on the Hollywood blacklist for over a decade for being a Communist and forced to work under assumed names. Together with ''Spartacus'', also written by Trumbo, ''Exodus'' is credited with ending the practice of blacklisting in the US motion picture industry. Plot After the Second World War, Katherine "Kitty" Fremont, a widowed American nurse, is sightseeing in Cyprus following a tour of duty for the U.S. Public Health Service in Greece. Her guide mentions the Karaolos int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
