|
Stratification (clinical Trials)
Stratification of clinical trials is the partitioning of subjects and results by a factor other than the treatment given. Stratification can be used to ensure equal allocation of subgroups of participants to each experimental condition. This may be done by gender, age, or other demographic factors. Stratification can be used to control for confounding variables (variables other than those the researcher is studying), thereby making it easier for the research to detect and interpret relationships between variables. For example, if doing a study of fitness where age or gender was expected to influence the outcomes, participants could be stratified into groups by the confounding variable. A limitation of this method is that it requires knowledge of what variables need to be controlled. Types of stratification Stratified random sampling designs divide the population into homogeneous strata, and an appropriate number of participants are chosen at random from each stratum. Propor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Trial
Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietary choices, dietary supplements, and medical devices) and known interventions that warrant further study and comparison. Clinical trials generate data on dosage, safety and efficacy. They are conducted only after they have received health authority/ethics committee approval in the country where approval of the therapy is sought. These authorities are responsible for vetting the risk/benefit ratio of the trial—their approval does not mean the therapy is 'safe' or effective, only that the trial may be conducted. Depending on product type and development stage, investigators initially enroll volunteers or patients into small pilot studies, and subsequently conduct progressively larger scale comparative studies. Clinical trials can vary i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Confounding Variable
In statistics, a confounder (also confounding variable, confounding factor, extraneous determinant or lurking variable) is a variable that influences both the dependent variable and independent variable, causing a spurious association. Confounding is a causal concept, and as such, cannot be described in terms of correlations or associations.Pearl, J., (2009). Simpson's Paradox, Confounding, and Collapsibility In ''Causality: Models, Reasoning and Inference'' (2nd ed.). New York : Cambridge University Press. The existence of confounders is an important quantitative explanation why correlation does not imply causation. Confounds are threats to internal validity. Definition Confounding is defined in terms of the data generating model. Let ''X'' be some independent variable, and ''Y'' some dependent variable. To estimate the effect of ''X'' on ''Y'', the statistician must suppress the effects of extraneous variables that influence both ''X'' and ''Y''. We say that ''X'' and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Variable (research)
In science and research, an attribute is a quality of an object (person, thing, etc.).Earl R. Babbie, ''The Practice of Social Research'', 12th edition, Wadsworth Publishing, 2009, , p. 14-18 Attributes are closely related to variables. A variable is a logical set of attributes. Variables can "vary" – for example, be high or low. How high, or how low, is determined by the value of the attribute (and in fact, an attribute could be just the word "low" or "high"). ''(For example see: Binary option)'' While an attribute is often intuitive, the variable is the operationalized way in which the attribute is represented for further data processing. In data processing data are often represented by a combination of ''items'' (objects organized in rows), and multiple variables (organized in columns). Values of each variable statistically "vary" (or are distributed) across the variable's domain. A domain is a set of all possible values that a variable is allowed to have. The values are orde ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stratified Random Sample
In statistics, stratified sampling is a method of sampling (statistics), sampling from a Population (statistics), population which can be partition of a set, partitioned into subpopulations. In statistical surveys, when subpopulations within an overall population vary, it could be advantageous to sample each subpopulation (stratum) independently. Stratification is the process of dividing members of the population into homogeneous subgroups before sampling. The strata should define a partition of the population. That is, it should be ''Collectively exhaustive events, collectively exhaustive'' and ''Mutual exclusivity, mutually exclusive'': every element in the population must be assigned to one and only one stratum. Then simple random sampling is applied within each stratum. The objective is to improve the precision of the sample by reducing sampling error. It can produce a weighted mean that has less variability than the arithmetic mean of a simple random sample of the populatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homogeneous (statistics)
In statistics, homogeneity and its opposite, heterogeneity, arise in describing the properties of a dataset, or several datasets. They relate to the validity of the often convenient assumption that the statistical properties of any one part of an overall dataset are the same as any other part. In meta-analysis, which combines the data from several studies, homogeneity measures the differences or similarities between the several studies (see also Study heterogeneity). Homogeneity can be studied to several degrees of complexity. For example, considerations of homoscedasticity examine how much the variability of data-values changes throughout a dataset. However, questions of homogeneity apply to all aspects of the statistical distributions, including the location parameter. Thus, a more detailed study would examine changes to the whole of the marginal distribution. An intermediate-level study might move from looking at the variability to studying changes in the skewness. In additi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Randomized Block Design
In the statistical theory of the design of experiments, blocking is the arranging of experimental units in groups (blocks) that are similar to one another. Blocking can be used to tackle the problem of pseudoreplication. Use Blocking reduces unexplained variability. Its principle lies in the fact that variability which cannot be overcome (e.g. needing two batches of raw material to produce 1 container of a chemical) is confounded or aliased with a(n) (higher/highest order) interaction to eliminate its influence on the end product. High order interactions are usually of the least importance (think of the fact that temperature of a reactor or the batch of raw materials is more important than the combination of the two - this is especially true when more (3, 4, ...) factors are present); thus it is preferable to confound this variability with the higher interaction. Examples *Male and Female: An experiment is designed to test a new drug on patients. There are two levels of the tre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quota Sampling
Quota sampling is a method for selecting survey participants that is a non-probabilistic version of stratified sampling. Process In quota sampling, a population is first segmented into mutually exclusive sub-groups, just as in stratified sampling. Then judgment is used to select the subjects or units from each segment based on a specified proportion. For example, an interviewer may be told to sample 200 females and 300 males between the age of 45 and 60. This means that individuals can put a demand on who they want to sample (targeting). This second step makes the technique non-probability sampling. In quota sampling, there is non-random sample selection and this can be unreliable. For example, interviewers might be tempted to interview those people in the street who look most helpful, or may choose to use accidental sampling to question those closest to them, to save time. The problem is these samples may be biased in a way that is difficult to quantify or adjust for. For exampl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Non-random Sampling
In statistics, sampling bias is a bias in which a sample is collected in such a way that some members of the intended population have a lower or higher sampling probability than others. It results in a biased sample of a population (or non-human factors) in which all individuals, or instances, were not equally likely to have been selected. If this is not accounted for, results can be erroneously attributed to the phenomenon under study rather than to the method of sampling. Medical sources sometimes refer to sampling bias as ascertainment bias. Ascertainment bias has basically the same definition, but is still sometimes classified as a separate type of bias. Distinction from selection bias Sampling bias is usually classified as a subtype of selection bias, sometimes specifically termed sample selection bias, but some classify it as a separate type of bias. A distinction, albeit not universally accepted, of sampling bias is that it undermines the external validity of a test (th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Convenience Sampling
Convenience sampling (also known as grab sampling, accidental sampling, or opportunity sampling) is a type of non-probability sampling that involves the sample being drawn from that part of the population that is close to hand. This type of sampling is most useful for pilot testing. Definition A convenience sample is a type of non-probability sampling method where the sample is taken from a group of people easy to contact or to reach; for example, standing at a mall or a grocery store and asking people to answer questions. This type of sampling is also known as grab sampling or availability sampling. There are no other criteria to the sampling method except that people be available and willing to participate. In addition, this type of sampling method does not require that a simple random sample is generated since the only criterion is whether the participants agree to participate. Applications Convenience sampling is not often recommended for research due to the possibility o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stratified Sampling
In statistics, stratified sampling is a method of sampling from a population which can be partitioned into subpopulations. In statistical surveys, when subpopulations within an overall population vary, it could be advantageous to sample each subpopulation (stratum) independently. Stratification is the process of dividing members of the population into homogeneous subgroups before sampling. The strata should define a partition of the population. That is, it should be ''collectively exhaustive'' and ''mutually exclusive'': every element in the population must be assigned to one and only one stratum. Then simple random sampling is applied within each stratum. The objective is to improve the precision of the sample by reducing sampling error. It can produce a weighted mean that has less variability than the arithmetic mean of a simple random sample of the population. In computational statistics, stratified sampling is a method of variance reduction when Monte Carlo methods are us ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glossary Of Clinical Research
A glossary of terms used in clinical research. __NOTOC__ A ; Activities of daily living : The tasks of everyday life. These activities include eating, dressing, getting into or out of a bed or chair, taking a bath or shower, and using the toilet. Instrumental activities of daily living are activities related to independent living and include preparing meals, managing money, shopping, doing housework, and using a telephone. Also called ADL. (NCI) ; Adverse drug reaction : In the preapproval clinical experience with a new medicinal product or its new usages, particularly as the therapeutic dose(s) may not be established, all noxious and unintended responses to a medicinal product related to any dose should be considered adverse drug reactions. The phrase "responses to a medicinal product" means that a causal relationship between a medicinal product and an adverse event is at least a reasonable possibility, i.e., the relationship cannot be ruled out. Regarding marketed medicinal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.jpg "Click for more on -> Clinical Trial")
