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Steven M. Weinreb
Steven M. Weinreb (born May 10, 1941) is an American chemist and is a professor of chemistry at Pennsylvania State University in United States. Together with Steven Nahm, he developed the Weinreb ketone synthesis, which allows for mono-addition of an organometallic reagent such as a Grignard reagent or organolithium reagent to an amide. Weinreb received his PhD for work with Marshall Gates at the University of Rochester in 1967. After post-docs with Gilbert Stork and George H. Buchi, he worked at Fordham University Fordham University () is a Private university, private Jesuit universities, Jesuit research university in New York City. Established in 1841 and named after the Fordham, Bronx, Fordham neighborhood of the The Bronx, Bronx in which its origina .... He joined the Pennsylvania State University in 1978, where he holds the Russell and Mildred Marker Professor of Natural Products Chemistry chair. References * 1941 births University of Rochester alumni Pen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States
The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territories, nine Minor Outlying Islands, and 326 Indian reservations. The United States is also in free association with three Pacific Island sovereign states: the Federated States of Micronesia, the Marshall Islands, and the Republic of Palau. It is the world's third-largest country by both land and total area. It shares land borders with Canada to its north and with Mexico to its south and has maritime borders with the Bahamas, Cuba, Russia, and other nations. With a population of over 333 million, it is the most populous country in the Americas and the third most populous in the world. The national capital of the United States is Washington, D.C. and its most populous city and principal financial center is New York City. Paleo-Americ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organometallic
Organometallic chemistry is the study of organometallic compounds, chemical compounds containing at least one chemical bond between a carbon atom of an organic molecule and a metal, including alkali, alkaline earth, and transition metals, and sometimes broadened to include metalloids like boron, silicon, and selenium, as well. Aside from bonds to organyl fragments or molecules, bonds to 'inorganic' carbon, like carbon monoxide (metal carbonyls), cyanide, or carbide, are generally considered to be organometallic as well. Some related compounds such as transition metal hydrides and metal phosphine complexes are often included in discussions of organometallic compounds, though strictly speaking, they are not necessarily organometallic. The related but distinct term " metalorganic compound" refers to metal-containing compounds lacking direct metal-carbon bonds but which contain organic ligands. Metal β-diketonates, alkoxides, dialkylamides, and metal phosphine complexes are repres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pennsylvania State University Faculty
Pennsylvania (; (Pennsylvania Dutch language, Pennsylvania Dutch: )), officially the Commonwealth of Pennsylvania, is a U.S. state, state spanning the Mid-Atlantic (United States), Mid-Atlantic, Northeastern United States, Northeastern, Appalachian, and Great Lakes region, Great Lakes regions of the United States. It borders Delaware to its southeast, Maryland to its south, West Virginia to its southwest, Ohio to its west, Lake Erie and the List of Canadian provinces and territories, Canadian province of Ontario to its northwest, New York (state), New York to its north, and the Delaware River and New Jersey to its east. Pennsylvania is the List of U.S. states and territories by population, fifth-most populous state in the nation with over 13 million residents 2020 United States census, as of 2020. It is the List of U.S. states and territories by area, 33rd-largest state by area and ranks List of states and territories of the United States by population density, ninth among al ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Rochester Alumni
A university () is an institution of higher (or tertiary) education and research which awards academic degrees in several academic disciplines. Universities typically offer both undergraduate and postgraduate programs. In the United States, the designation is reserved for colleges that have a graduate school. The word ''university'' is derived from the Latin ''universitas magistrorum et scholarium'', which roughly means "community of teachers and scholars". The first universities were created in Europe by Catholic Church monks. The University of Bologna (''Università di Bologna''), founded in 1088, is the first university in the sense of: *Being a high degree-awarding institute. *Having independence from the ecclesiastic schools, although conducted by both clergy and non-clergy. *Using the word ''universitas'' (which was coined at its foundation). *Issuing secular and non-secular degrees: grammar, rhetoric, logic, theology, canon law, notarial law.Hunt Janin: "The university ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1941 Births
Events Below, the events of World War II have the "WWII" prefix. January * January–August – 10,072 men, women and children with mental and physical disabilities are asphyxiated with carbon monoxide in a gas chamber, at Hadamar Euthanasia Centre in Germany, in the first phase of mass killings under the Action T4 program here. * January 1 – Thailand's Prime Minister Plaek Phibunsongkhram decrees January 1 as the official start of the Thai solar calendar new year (thus the previous year that began April 1 had only 9 months). * January 3 – A decree (''Normalschrifterlass'') promulgated in Germany by Martin Bormann, on behalf of Adolf Hitler, requires replacement of blackletter typefaces by Antiqua. * January 4 – The short subject ''Elmer's Pet Rabbit'' is released, marking the second appearance of Bugs Bunny, and also the first to have his name on a title card. * January 5 – WWII: Battle of Bardia in Libya: Australian and British troops def ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fordham University
Fordham University () is a Private university, private Jesuit universities, Jesuit research university in New York City. Established in 1841 and named after the Fordham, Bronx, Fordham neighborhood of the The Bronx, Bronx in which its original campus is located, Fordham is the oldest Catholic Church, Catholic and Society of Jesus, Jesuit university in the northeastern United States and the third-oldest university in New York (state), New York State. Founded as St. John's College by John Hughes (archbishop), John Hughes, then a coadjutor bishop of New York, the college was placed in the care of the Society of Jesus shortly thereafter, and has since become a Association of Jesuit Colleges and Universities, Jesuit-affiliated independent school under a laity, lay board of trustees. The college's first president, John McCloskey, was later the first Catholic Cardinal (Catholic Church), cardinal in the United States. While governed independently of the church since 1969, every List o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gilbert Stork
Gilbert Stork (December 31, 1921 – October 21, 2017) was an organic chemist. For a quarter of a century he was the Eugene Higgins Professor of Chemistry Emeritus at Columbia University. He is known for making significant contributions to the total synthesis of natural products, including a lifelong fascination with the synthesis of quinine. In so doing he also made a number of contributions to mechanistic understanding of reactions, and performed pioneering work on enamine chemistry, leading to development of the Stork enamine alkylation. It is believed he was responsible for the first planned stereocontrolled synthesis as well as the first natural product to be synthesised with high stereoselectivity. Stork was also an accomplished mentor of young chemists and many of his students have gone on to make significant contributions in their own right. Early years Gilbert Stork was born in the Ixelles municipality of Brussels, Belgium on December 31, 1921. The oldest of 3 childre ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organolithium Reagent
In organometallic chemistry, organolithium reagents are chemical compounds that contain carbon–lithium (C–Li) bonds. These reagents are important in organic synthesis, and are frequently used to transfer the organic group or the lithium atom to the substrates in synthetic steps, through nucleophilic addition or simple deprotonation. Organolithium reagents are used in industry as an initiator for anionic polymerization, which leads to the production of various elastomers. They have also been applied in asymmetric synthesis in the pharmaceutical industry. Due to the large difference in electronegativity between the carbon atom and the lithium atom, the C−Li bond is highly ionic. Owing to the polar nature of the C−Li bond, organolithium reagents are good nucleophiles and strong bases. For laboratory organic synthesis, many organolithium reagents are commercially available in solution form. These reagents are highly reactive, and are sometimes pyrophoric. History and dev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Grignard Reaction
The Grignard reaction () is an organometallic chemical reaction in which alkyl, allyl, vinyl, or aryl-magnesium halides ( Grignard reagent) is added to a carbonyl group in an aldehyde or ketone. This reaction is important for the formation of carbon–carbon bonds. The reaction of an organic halide with magnesium is ''not'' a Grignard reaction, but provides a Grignard reagent. : Grignard reactions and reagents were discovered by and are named after the French chemist François Auguste Victor Grignard (University of Nancy, France), who published it in 1900 and was awarded the 1912 Nobel Prize in Chemistry for this work. Reaction mechanism Because carbon is more electronegative than magnesium, the carbon attached to magnesium functions as a nucleophile and attacks the electrophilic carbon atom that is present within the polar bond of a carbonyl group. The addition of the Grignard reagent to the carbonyl typically proceeds through a six-membered ring transition state. Based on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetrahedron Letters
''Tetrahedron Letters'' is a weekly international journal for rapid publication of full original research papers in the field of organic chemistry. According to the ''Journal Citation Reports'', the journal has a 2020 impact factor of 2.415. Indexing ''Tetrahedron Letters'' is indexed in: References See also *''Tetrahedron In geometry, a tetrahedron (plural: tetrahedra or tetrahedrons), also known as a triangular pyramid, is a polyhedron composed of four triangular faces, six straight edges, and four vertex corners. The tetrahedron is the simplest of all the o ...'' *'' Tetrahedron: Asymmetry'' Chemistry journals Weekly journals Publications established in 1959 Elsevier academic journals {{chem-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; Greeves, N. and Warren, S. (2012) ''Organic Chemistry''. Oxford University Press. pp. 1–15. . Study of structure determines their structural formula. Study of properties includes physical and chemical properties, and evaluation of chemical reactivity to understand their behavior. The study of organic reactions includes the chemical synthesis of natural products, drugs, and polymers, and study of individual organic molecules in the laboratory and via theoretical ( in silico) study. The range of chemicals studied in organic chemistry includes hydrocarbons (compounds containing only carbon and hydrogen) as well as compounds based on carbon, but also containing other elements, especially oxygen, nitrogen, sulfur, phosphorus (included in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pennsylvania State University
The Pennsylvania State University (Penn State or PSU) is a Public university, public Commonwealth System of Higher Education, state-related Land-grant university, land-grant research university with campuses and facilities throughout Pennsylvania. Founded in 1855 as the Farmers' High School of Pennsylvania, Penn State became the state's only Land-grant university, land-grant university in 1863. Today, Penn State is a major research university which conducts teaching, research, and public service. Its instructional mission includes undergraduate, graduate, professional and continuing education offered through resident instruction and online delivery. The University Park campus has been labeled one of the "Public Ivy, Public Ivies", a publicly funded university considered as providing a quality of education comparable to those of the Ivy League. In addition to its land-grant designation, it also participates in the sea-grant, space-grant, and sun-grant research consortia; it is on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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