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Sign Of Hertoghe
The Sign of Hertoghe or Queen Anne's sign is a thinning or loss of the outer third of the eyebrows, and is a classical sign of hypothyroidism or atopic dermatitis, but it can also be detected in lepromatous leprosy. The sign is named after the Belgian Internist Eugene Ludovic Christian Hertoghe (April 5, 1860–January 3, 1928), who was a native of Antwerp, and was the first pioneer in thyroid function research. __TOC__ Queen Anne's sign The association with Anne of Denmark is based on portraiture, although history does not suggest that she suffered an underactive thyroid. The eponym is disputed by some, though it has been suggested that Anne of France, Anne of Brittany, Anne of Austria, Anne Boleyn and Anne of Cleves Anne of Cleves (german: Anna von Kleve; 1515 – 16 July 1557) was Queen of England from 6 January to 12 July 1540 as the fourth wife of King Henry VIII. Not much is known about Anne before 1527, when she became betrothed to Francis, Duke of ... may all be e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypothyroidism
Hypothyroidism (also called ''underactive thyroid'', ''low thyroid'' or ''hypothyreosis'') is a disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone. It can cause a number of symptoms, such as poor ability to tolerate cold, a feeling of tiredness, constipation, slow heart rate, depression, and weight gain. Occasionally there may be swelling of the front part of the neck due to goiter. Untreated cases of hypothyroidism during pregnancy can lead to delays in growth and intellectual development in the baby or congenital iodine deficiency syndrome. Worldwide, too little iodine in the diet is the most common cause of hypothyroidism. Hashimoto's thyroiditis is the most common cause of hypothyroidism in countries with sufficient dietary iodine. Less common causes include previous treatment with radioactive iodine, injury to the hypothalamus or the anterior pituitary gland, certain medications, a lack of a functioning thyroid at bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atopic Dermatitis
Atopic dermatitis (AD), also known as atopic eczema, is a long-term type of inflammation of the skin (dermatitis). It results in puritis, itchy, red, swollen, and cracked skin. Clear fluid may come from the affected areas, which often thickens over time. While the condition may occur at any age, it typically starts in childhood, with changing severity over the years. In children under one year of age, much of the body may be affected. As children get older, the areas on the insides of the knees and elbows are most commonly affected. In adults, the hands and feet are most commonly affected. Scratching the affected areas worsens the symptoms, and those affected have an increased risk of skin infections. Many people with atopic dermatitis develop hay fever or asthma. The cause is unknown but believed to involve genetics, immune system dysfunction, environmental exposures, and difficulties with the Semipermeable membrane, permeability of the skin. If one identical twin is affected, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lepromatous Leprosy
Lepromatous leprosy is a form of leprosy characterized by pale macules in the skin. It results from the failure of Th1 cell activation which is necessary to eradicate the mycobacteria (Th1 response is required to activate macrophages that engulf and contain the disease). In lepromatous leprosy, TH2 response is turned on, and because of reciprocal inhibition (IL-4; IL-10), the cell-mediated response (TH1) is depressed. Lepromatous leprosy, in contrast to the tuberculoid form of leprosy, is characterized by the absence of epithelioid cells in the lesions. In this form of leprosy ''Mycobacterium leprae'' are found in lesion in large numbers. This is the most unfavorable clinical variant of leprosy. This debilitating form of leprosy begins to spread causing the eyebrows to disappear and spongy tumor like swellings appear on the face and body. The disease attacks the internal organs, bones, joints and marrow of the body resulting in physical degeneration. The result is deformity w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antwerp
Antwerp (; nl, Antwerpen ; french: Anvers ; es, Amberes) is the largest city in Belgium by area at and the capital of Antwerp Province in the Flemish Region. With a population of 520,504,Statistics Belgium; ''Loop van de bevolking per gemeente'' (Excel file) Population of all municipalities in Belgium, . Retrieved 1 November 2017. it is the most populous municipality in Belgium, and with a metropolitan population of around 1,200,000 people, it is the second-largest metrop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thyroid
The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans it is in the neck and consists of two connected lobes. The lower two thirds of the lobes are connected by a thin band of tissue called the thyroid isthmus. The thyroid is located at the front of the neck, below the Adam's apple. Microscopically, the functional unit of the thyroid gland is the spherical thyroid follicle, lined with follicular cells (thyrocytes), and occasional parafollicular cells that surround a lumen containing colloid. The thyroid gland secretes three hormones: the two thyroid hormones triiodothyronine (T3) and thyroxine (T4)and a peptide hormone, calcitonin. The thyroid hormones influence the metabolic rate and protein synthesis, and in children, growth and development. Calcitonin plays a role in calcium homeostasis. Secretion of the two thyroid hormones is regulated by thyroid-stimulating hormone (TSH), which is secreted from the anterior pituitary gland. TSH is regula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anne Of Denmark
Anne of Denmark (; 12 December 1574 – 2 March 1619) was the wife of King James VI and I; as such, she was Queen of Scotland The monarchy of the United Kingdom, commonly referred to as the British monarchy, is the constitutional form of government by which a hereditary sovereign reigns as the head of state of the United Kingdom, the Crown Dependencies (the Bailiw ... from their marriage on 20 August 1589 and Queen of England and Ireland from the union of the Scottish and English crowns on 24 March 1603 until her death in 1619. The second daughter of King Frederick II of Denmark and Sophie of Mecklenburg-Güstrow, Anne married James at age 14. They had three children who survived infancy: Henry Frederick, Prince of Wales, who predeceased his parents; Elizabeth Stuart, Queen of Bohemia, Princess Elizabeth, who became Queen of Bohemia; and James's future successor, Charles I of England, Charles I. Anne demonstrated an independent streak and a willingness to use fa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eponym
An eponym is a person, a place, or a thing after whom or which someone or something is, or is believed to be, named. The adjectives which are derived from the word eponym include ''eponymous'' and ''eponymic''. Usage of the word The term ''eponym'' functions in multiple related ways, all based on an explicit relationship between two named things. A person, place, or thing named after a particular person share an eponymous relationship. In this way, Elizabeth I of England is the eponym of the Elizabethan era. When Henry Ford is referred to as "the ''eponymous'' founder of the Ford Motor Company", his surname "Ford" serves as the eponym. The term also refers to the title character of a fictional work (such as Rocky Balboa of the Rocky film series, ''Rocky'' film series), as well as to ''self-titled'' works named after their creators (such as the album The Doors (album), ''The Doors'' by the band the Doors). Walt Disney created the eponymous The Walt Disney Company, Walt Disney Com ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anne Of France
Anne of France (or Anne de Beaujeu; 3 April 146114 November 1522) was a French princess and regent, the eldest daughter of Louis XI by Charlotte of Savoy. Anne was the sister of Charles VIII, for whom she acted as regent during his minority from 1483 until 1491. During the regency she was one of the most powerful women of late fifteenth-century Europe, and was referred to as "Madame la Grande". Between 1503 and 1521, she also acted as de facto regent of the Duchy of Bourbon during the reign of her daughter Suzanne, Duchess of Bourbon. Early life Anne was born at the Chateau of Genappe in Brabant on 3 April 1461, the eldest surviving daughter of King Louis XI of France and Charlotte of Savoy. Her brother, Charles would later succeed their father as Charles VIII of France. Her younger sister Joan became for a brief period, a queen consort of France as the first wife of Louis XII. Marriage Anne was originally betrothed to Nicholas, Duke of Lorraine, and was created Viscounte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anne Of Brittany
Anne of Brittany (; 25/26 January 1477 – 9 January 1514) was reigning Duchess of Brittany from 1488 until her death, and Queen of France from 1491 to 1498 and from 1499 to her death. She is the only woman to have been queen consort of France twice. During the Italian Wars, Anne also became Queen of Naples, from 1501 to 1504, and Duchess of Milan, in 1499–1500 and from 1500 to 1512. Anne was raised in Nantes during a series of conflicts in which the King of France sought to assert his suzerainty over Brittany. Her father, Francis II, Duke of Brittany, was the last male of the House of Montfort. Upon his death in 1488, Anne became duchess regnant of Brittany, countess of Nantes, Montfort, and Richmond, and viscountess of Limoges. She was only 11 at that time, but she was already a coveted heiress because of Brittany's strategic position. The next year, she married Maximilian I of Austria by proxy, but Charles VIII of France saw this as a threat since his realm was located be ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anne Of Austria
Anne of Austria (french: Anne d'Autriche, italic=no, es, Ana María Mauricia, italic=no; 22 September 1601 – 20 January 1666) was an infanta of Spain who became Queen of France as the wife of King Louis XIII from their marriage in 1615 until Louis XIII died in 1643. She was also Queen of Navarre until that kingdom was annexed into the French crown in 1620. After her husband's death, Anne was regent to her son Louis XIV, during his minority, until 1651. During her regency, Cardinal Mazarin served as France's chief minister. Accounts of French court life of Anne's era emphasize her difficult marital relations with her husband, her closeness to her son, and her disapproval of her son's marital infidelity to her niece and daughter-in-law Maria Theresa. Early life Born at the in Valladolid, Spain, and baptised Ana María Mauricia, she was the eldest daughter of King Philip III of Spain and his wife Margaret of Austria. She held the titles of Infanta of Spain and of Portugal ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anne Boleyn
Anne Boleyn (; 1501 or 1507 – 19 May 1536) was Queen of England from 1533 to 1536, as the second wife of King Henry VIII. The circumstances of her marriage and of her execution by beheading for treason and other charges made her a key figure in the political and religious upheaval that marked the start of the English Reformation. Anne was the daughter of Thomas Boleyn, 1st Earl of Wiltshire, and his wife, Lady Elizabeth Howard, and was educated in the Netherlands and France, largely as a maid of honour to Queen Claude of France. Anne returned to England in early 1522, to marry her Irish cousin James Butler, 9th Earl of Ormond; the marriage plans were broken off, and instead, she secured a post at court as maid of honour to Henry VIII's wife, Catherine of Aragon. Early in 1523, Anne was secretly betrothed to Henry Percy, son of Henry Percy, 5th Earl of Northumberland, but the betrothal was broken off when the Earl refused to support their engagement. Cardinal Thoma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anne Of Cleves
Anne of Cleves (german: Anna von Kleve; 1515 – 16 July 1557) was Queen of England from 6 January to 12 July 1540 as the fourth wife of King Henry VIII. Not much is known about Anne before 1527, when she became betrothed to Francis, Duke of Bar, son and heir of Antoine, Duke of Lorraine, although their marriage did not proceed. In March 1539, negotiations for Anne's marriage to Henry began, as Henry believed that he needed to form a political alliance with her brother, William, who was a leader of the Protestants of western Germany, to strengthen his position against potential attacks from Catholic France and the Holy Roman Empire. Anne arrived in England on 27 December 1539 and married Henry on 6 January 1540, but after six months, the marriage was declared unconsummated and, as a result, she was not crowned queen consort. Following the annulment, Henry gave her a generous settlement, and she was thereafter known as ''the King's Beloved Sister''. Remaining in England, she ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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