The Sign of Hertoghe or Queen Anne's sign is a thinning or loss of the outer third of the eyebrows, and is a classical sign of

hypothyroidism Hypothyroidism (also called ''underactive thyroid'', ''low thyroid'' or ''hypothyreosis'') is a disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone. It can cause a number of symptoms, such as po ...

atopic dermatitis Atopic dermatitis (AD), also known as atopic eczema, is a long-term type of inflammation of the skin (dermatitis). It results in puritis, itchy, red, swollen, and cracked skin. Clear fluid may come from the affected areas, which often thickens o ...

, but it can also be detected in

lepromatous leprosy Lepromatous leprosy is a form of leprosy characterized by pale macules in the skin. It results from the failure of Th1 cell activation which is necessary to eradicate the mycobacteria (Th1 response is required to activate macrophages that engulf ...

. The sign is named after the Belgian Internist Eugene Ludovic Christian Hertoghe (April 5, 1860–January 3, 1928), who was a native of

Antwerp Antwerp (; nl, Antwerpen ; french: Anvers ; es, Amberes) is the largest city in Belgium by area at and the capital of Antwerp Province in the Flemish Region. With a population of 520,504,

, and was the first pioneer in

thyroid The thyroid, or thyroid gland, is an endocrine gland in vertebrates. In humans it is in the neck and consists of two connected lobes. The lower two thirds of the lobes are connected by a thin band of tissue called the thyroid isthmus. The thy ...

function research. __TOC__

Queen Anne's sign

The association with

Anne of Denmark Anne of Denmark (; 12 December 1574 – 2 March 1619) was the wife of King James VI and I; as such, she was Queen of Scotland The monarchy of the United Kingdom, commonly referred to as the British monarchy, is the constitutional fo ...

is based on portraiture, although history does not suggest that she suffered an underactive thyroid. The

eponym An eponym is a person, a place, or a thing after whom or which someone or something is, or is believed to be, named. The adjectives which are derived from the word eponym include ''eponymous'' and ''eponymic''. Usage of the word The term ''epon ...

is disputed by some, though it has been suggested that

Anne of France Anne of France (or Anne de Beaujeu; 3 April 146114 November 1522) was a French princess and regent, the eldest daughter of Louis XI by Charlotte of Savoy. Anne was the sister of Charles VIII, for whom she acted as regent during his minority fro ...

Anne of Brittany Anne of Brittany (; 25/26 January 1477 – 9 January 1514) was reigning Duchess of Brittany from 1488 until her death, and Queen of France from 1491 to 1498 and from 1499 to her death. She is the only woman to have been queen consort of France ...

Anne of Austria Anne of Austria (french: Anne d'Autriche, italic=no, es, Ana María Mauricia, italic=no; 22 September 1601 – 20 January 1666) was an infanta of Spain who became Queen of France as the wife of King Louis XIII from their marriage in 1615 unti ...

Anne Boleyn Anne Boleyn (; 1501 or 1507 – 19 May 1536) was Queen of England from 1533 to 1536, as the second wife of King Henry VIII. The circumstances of her marriage and of her execution by beheading for treason and other charges made her a key ...

and

Anne of Cleves Anne of Cleves (german: Anna von Kleve; 1515 – 16 July 1557) was Queen of England from 6 January to 12 July 1540 as the fourth wife of King Henry VIII. Not much is known about Anne before 1527, when she became betrothed to Francis, Duke of ...

may all be eliminated as candidates.

References

{{Thyroid disease Thyroid disease Symptoms and signs: Endocrinology, nutrition, and metabolism Anne of Denmark