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Sergiu P. Pașca
Sergiu P. Pașca (born January 30, 1982) is a Romanian-American scientist and physician at Stanford University in California. He is renowned for his groundbreaking work creating and developing stem cell-based models of the human brain to gain insights into neuropsychiatric disease. His lab was the first to develop and name assembloids: multi-unit self-organizing structures created in 3D cultures that allow for the study of human neural circuit and systems functions ''in vitro.'' Pașca’s lab generated and published human cortico-striatal and cortico-motor assembloids in 2020. Combining regionalized neural organoids pioneered in the lab and studies with human forebrain assembloids and transplantation, in 2024, Pașca developed a therapeutic for a severe genetic disorder called Timothy Syndrome, which was published on the cover of ''Nature''. Pașca is a pioneering neuroscientist and stem cell biologist and holds the Kenneth T. Norris Endowed Professorship in Psychiatry and Behav ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cluj-Napoca
; hu, kincses város) , official_name=Cluj-Napoca , native_name= , image_skyline= , subdivision_type1 = Counties of Romania, County , subdivision_name1 = Cluj County , subdivision_type2 = Subdivisions of Romania, Status , subdivision_name2 = County seat , settlement_type = Municipiu, City , leader_title = Mayor , leader_name = Emil Boc , leader_party = National Liberal Party (Romania), PNL , leader_title1 = Deputy Mayor , leader_name1 = Dan Tarcea (PNL) , leader_title2 = Deputy Mayor , leader_name2 = Emese Oláh (Democratic Alliance of Hungarians in Romania, UDMR) , leader_title3 = City Manager , leader_name3 = Gheorghe Șurubaru (PNL) , established_title= Founded , established_date = 1213 (first official record as ''Clus'') , area_total_km2 = 179.5 , area_total_sq_mi = 69.3 , area_metro_km2 = 1537.5 , elevation_m = 340 , population_as_of = 2011 Romanian census, 2011 , population_total = 324,576 , population_foot ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TED (conference)
TED Conferences, LLC (Technology, Entertainment, Design) is an American-Canadian non-profit media organization that posts international talks online for free distribution under the slogan "ideas worth spreading". TED was founded by Richard Saul Wurman and Harry Marks in February 1984 as a tech conference, in which gave a demo of the compact disc that was invented in October 1982. It has been held annually since 1990. TED covers almost all topics – from science to business to global issues – in more than 100 languages. To date, more than 13,000 TEDx events have been held in at least 150 countries. TED's early emphasis was on technology and design, consistent with its Silicon Valley origins. It has since broadened its perspective to include talks on many scientific, cultural, political, humanitarian, and academic topics. It has been curated by Chris Anderson, a British-American businessman, through the non-profit TED Foundation since July 2019 (originally by the non ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phenotype
In genetics, the phenotype () is the set of observable characteristics or traits of an organism. The term covers the organism's morphology or physical form and structure, its developmental processes, its biochemical and physiological properties, its behavior, and the products of behavior. An organism's phenotype results from two basic factors: the expression of an organism's genetic code, or its genotype, and the influence of environmental factors. Both factors may interact, further affecting phenotype. When two or more clearly different phenotypes exist in the same population of a species, the species is called polymorphic. A well-documented example of polymorphism is Labrador Retriever coloring; while the coat color depends on many genes, it is clearly seen in the environment as yellow, black, and brown. Richard Dawkins in 1978 and then again in his 1982 book ''The Extended Phenotype'' suggested that one can regard bird nests and other built structures such as cad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Induced Pluripotent Stem Cells
Induced pluripotent stem cells (also known as iPS cells or iPSCs) are a type of pluripotent stem cell that can be generated directly from a somatic cell. The iPSC technology was pioneered by Shinya Yamanaka's lab in Kyoto, Japan, who showed in 2006 that the introduction of four specific genes (named Myc, Oct3/4, Sox2 and Klf4), collectively known as Yamanaka factors, encoding transcription factors could convert somatic cells into pluripotent stem cells. He was awarded the 2012 Nobel Prize along with Sir John Gurdon "for the discovery that mature cells can be reprogrammed to become pluripotent." Pluripotent stem cells hold promise in the field of regenerative medicine. Because they can propagate indefinitely, as well as give rise to every other cell type in the body (such as neurons, heart, pancreatic, and liver cells), they represent a single source of cells that could be used to replace those lost to damage or disease. The most well-known type of pluripotent stem cell is the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurons
A neuron, neurone, or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. Non-animals like plants and fungi do not have nerve cells. Neurons are typically classified into three types based on their function. Sensory neurons respond to stimuli such as touch, sound, or light that affect the cells of the sensory organs, and they send signals to the spinal cord or brain. Motor neurons receive signals from the brain and spinal cord to control everything from muscle contractions to glandular output. Interneurons connect neurons to other neurons within the same region of the brain or spinal cord. When multiple neurons are connected together, they form what is called a neural circuit. A typical neuron consists of a cell body (soma), dendrites, and a single axon. The soma is a compact structure, and the axon and dend ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Postdoctoral Fellow
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pursue additional research, training, or teaching in order to have better skills to pursue a career in academia, research, or any other field. Postdocs often, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further formal qualificati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frankfurt
Frankfurt, officially Frankfurt am Main (; Hessian: , "Frank ford on the Main"), is the most populous city in the German state of Hesse. Its 791,000 inhabitants as of 2022 make it the fifth-most populous city in Germany. Located on its namesake Main River, it forms a continuous conurbation with the neighboring city of Offenbach am Main and its urban area has a population of over 2.3 million. The city is the heart of the larger Rhine-Main metropolitan region, which has a population of more than 5.6 million and is Germany's second-largest metropolitan region after the Rhine-Ruhr region. Frankfurt's central business district, the Bankenviertel, lies about northwest of the geographic center of the EU at Gadheim, Lower Franconia. Like France and Franconia, the city is named after the Franks. Frankfurt is the largest city in the Rhine Franconian dialect area. Frankfurt was a city state, the Free City of Frankfurt, for nearly five centuries, and was one of the most import ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Max Planck Institute For Brain Research
The Max Planck Institute for Brain Research is located in Frankfurt, Germany. It was founded as Kaiser Wilhelm Institute for Brain Research in Berlin 1914, moved to Frankfurt-Niederrad in 1962 and more recently in a new building in Frankfurt-Riedberg. It is one of 83 institutes in the Max Planck Society (Max Planck Gesellschaft). Research Research at the Max Planck Institute for Brain Research focuses on the operation of networks of neurons in the brain. The institute hosts three scientific departments (with directors Moritz Helmstaedter of the Helmstaedter Department, Gilles Laurent of the Laurent Department, and Erin Schuman of the Schuman Department), the Singer Emeritus Group, two Max Planck Research Groups, namely Johannes Letzkus' Neocortical Circuits Group and Tatjana Tchumatchenko's Theory of Neural Dynamics Group, as well as several additional research units. The common research goal of the Institute is a mechanistic understanding of neurons and synapses, of the s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrophysiology
Electrophysiology (from Greek , ''ēlektron'', "amber" etymology of "electron"">Electron#Etymology">etymology of "electron" , ''physis'', "nature, origin"; and , '' -logia'') is the branch of physiology that studies the electrical properties of biological cells and tissues. It involves measurements of voltage changes or electric current or manipulations on a wide variety of scales from single ion channel proteins to whole organs like the heart. In neuroscience, it includes measurements of the electrical activity of neurons, and, in particular, action potential activity. Recordings of large-scale electric signals from the nervous system, such as electroencephalography, may also be referred to as electrophysiological recordings. They are useful for electrodiagnosis and monitoring. Definition and scope Classical electrophysiological techniques Principle and mechanisms Electrophysiology is the branch of physiology that pertains broadly to the flow of ions (ion current) in biologi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autism Spectrum Disorder
The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental disorder, neurodevelopmental condition (or conditions) characterized by difficulties in Social relation, social interaction, verbal and nonverbal communication, and the presence of repetitive behavior and restricted interests. Other common signs include unusual responses to Multisensory integration, sensory stimuli. Autism is generally understood as a ''spectrum disorder'', which means that it can manifest differently in each person: any given autistic individual is likely to show some, but not all, of the characteristics associated with it, and the person may exhibit them to varying degrees. Some autistic people remain nonverbal autism, nonspeaking over the course of their lifespan, while others have relatively unimpaired spoken language. There is large variation in the level of support peop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry Olympiad
The International Chemistry Olympiad (IChO) is an annual academic competition for high school students. It is one of the International Science Olympiads. The first IChO was held in Prague, Czechoslovakia, in 1968. The event has been held every year since then, with the exception of 1971. The delegations that attended the first events were mostly countries of the former Eastern bloc and it was not until 1980, the 12th annual International Chemistry Olympiad, that the event was held outside of the bloc in Austria. Up to 4 students for each national team compete around July in both a theoretical and an experimental sections, with about half of the participants being awarded medals. About The International Chemistry Olympiad (IChO) is an annual competition for the world’s most talented chemistry students at the secondary school level. Nations around the world send a team of four students who are tested on their chemistry knowledge and skills in a five-hour laboratory practical exam an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the science, scientific study of the properties and behavior of matter. It is a natural science that covers the Chemical element, elements that make up matter to the chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during a Chemical reaction, reaction with other Chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the properties ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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