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Seoul Virus
''Seoul orthohantavirus'' (SEOV) is a member of the ''Orthohantavirus'' family of rodent-borne viruses and is one of the 4 hantaviruses that are known to be able to cause Hantavirus hemorrhagic fever with renal syndrome (HFRS).US Centers for Disease Control''Virology, Hantaviruses''Page last reviewed: August 29, 2012. It is an Old World hantavirus; a negative sense, single-stranded, tri-segmented RNA virus. Seoul virus is found in ''Rattus'' species rats, most commonly ''Rattus norvegicus,'' but occasionally ''Rattus rattus''. The two distinct hantaviruses have been identified in Korea in 1976, from '' Apodemus agrarius'', and in 1980, from ''Rattus norvegicus''. In 1994, a genetically different hantavirus was identified from '' Apodemus peninsulae''. Rats do not show physiological symptoms when carrying the virus, but humans can be infected through exposure to infected rodent body fluids (blood, saliva, urine), exposure to aerosolized rat excrement, or bites from infected rats. W ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gou Virus
Gou virus (GOUV) is a single-stranded, negative-sense, enveloped novel RNA orthohantavirus. It is one of the known hantaviruses responsible for hantavirus hemorrhagic fever with renal syndrome in humans. Natural reservoir Gou virus was first isolated from black rats (R. rattus) captured in Zhejiang Province in 2000. Genetically variant strains of GOUV have been found in black rats in Longquan, China. In addition, hantavirus strains isolated from R. flavipectus and R. norvegicus in Longquan are most closely related to GOUV. Transmission Like all hantaviruses, transmission to humans is primarily through aerosolized rodent excreta and hand-to-mouth contamination from fomites. No human-to-human transmission has been documented. Longquan City, Zhejiang province, China, has a persistently high rate of human infection with GOUV. There is speculation that a variant strain of GOUV is transmissible from human-to-human. However, this has not yet been confirmed with epidemiological tra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Consensus Sequence
In molecular biology and bioinformatics, the consensus sequence (or canonical sequence) is the calculated order of most frequent residues, either nucleotide or amino acid, found at each position in a sequence alignment. It serves as a simplified representation of the population. It represents the results of multiple sequence alignments in which related sequences are compared to each other and similar sequence motifs are calculated. Such information is important when considering sequence-dependent enzymes such as RNA polymerase.Pierce, Benjamin A. 2002. Genetics : A Conceptual Approach. 1st ed. New York: W.H. Freeman and Co. Biological significance A protein binding site, represented by a consensus sequence, may be a short sequence of nucleotides which is found several times in the genome and is thought to play the same role in its different locations. For example, many transcription factors recognize particular patterns in the promoters of the genes they regulate. In the same way, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thailand Virus
Thailand virus (THAIV) is a single-stranded, enveloped, negative-sense RNA orthohantavirus. Natural reservoir THAIV was first isolated from rodents in two Thai provinces, Nakhon Pathom Province and Nakhon Ratchasima Province, in 1994. The greater bandicoot rat (''Bandicota indica'') was found to be the primary reservoir for THAIV. Serological studies have revealed, but not confirmed, other rodents in Thailand as possible reservoirs, including the black rat (''Rattus rattus''), Polynesian rat (''R. exulans''), brown rat (''R. norvegicus'') and lesser rice-field rat (''R. losea''). Virology Thailand virus (THAIV) is genetically diverse from other hantaviruses. The L, M, and S nucleotide segments reveal its most recent ancestor in common to be the Seoul virus(SEOV). However, four recently isolated THAIV strains from R.Rattus show genetic diversity between themselves and are distinct from SEOV in that they show geographical clustering. This is a distinct featur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serology
Serology is the scientific study of Serum (blood), serum and other body fluids. In practice, the term usually refers to the medical diagnosis, diagnostic identification of Antibody, antibodies in the serum. Such antibodies are typically formed in response to an infection (against a given microorganism), against other foreign proteins (in response, for example, to a Acute hemolytic transfusion reaction, mismatched blood transfusion), or to one's own proteins (in instances of autoimmune disease). In either case, the procedure is simple. Serological tests Serological tests are diagnostic methods that are used to identify antibodies and antigens in a patient's sample. Serological tests may be performed to diagnose infections and autoimmune illnesses, to check if a person has immunity (medical), immunity to certain diseases, and in many other situations, such as determining an individual's blood type. Serological tests may also be used in forensic serology to investigate crime scene evid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hantavirus Pulmonary Syndrome
Hantavirus pulmonary syndrome (HPS) is one of two potentially fatal syndromes of zoonotic origin caused by species of hantavirus. These include Black Creek Canal virus (BCCV), New York orthohantavirus (NYV), Monongahela virus (MGLV), ''Sin Nombre orthohantavirus'' (SNV), and certain other members of hantavirus genera that are native to the United States and Canada. Specific rodents are the principal hosts of the hantaviruses including the hispid cotton rat (''Sigmodon hispidus'') in southern Florida, which is the principal host of Black Creek Canal virus. The deer mouse (''Peromyscus maniculatus'') in Canada and the Western United States is the principal host of Sin Nombre virus. The white-footed mouse (''Peromyscus leucopus'') in the eastern United States is the principal host of New York virus. In South America, the long-tailed mouse (''Oligoryzomys longicaudatus'') and other species of the genus ''Oligoryzomys'' have been documented as the reservoir for Andes virus. Signs a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CBC News
CBC News is a division of the Canadian Broadcasting Corporation responsible for the news gathering and production of news programs on the corporation's English-language operations, namely CBC Television, CBC Radio, CBC News Network, and CBC.ca. Founded in 1941, CBC News is the largest news broadcaster in Canada and has local, regional, and national broadcasts and stations. It frequently collaborates with its organizationally separate French-language counterpart, Radio-Canada Info. History The first CBC newscast was a bilingual radio report on November 2, 1936. The CBC News Service was inaugurated during World War II on January 1, 1941, when Dan McArthur, chief news editor, had Wells Ritchie prepare for the announcer Charles Jennings a national report at 8:00 pm. Readers who followed Jennings were Lorne Greene, Frank Herbert and Earl Cameron. ''CBC News Roundup'' (French counterpart: ''La revue de l'actualité'') started on August 16, 1943, at 7:45 pm, being replaced by ''T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Centers For Disease Control And Prevention
The Centers for Disease Control and Prevention (CDC) is the national public health agency of the United States. It is a United States federal agency, under the Department of Health and Human Services, and is headquartered in Atlanta, Georgia. The agency's main goal is the protection of public health and safety through the control and prevention of disease, injury, and disability in the US and worldwide. The CDC focuses national attention on developing and applying disease control and prevention. It especially focuses its attention on infectious disease, food borne pathogens, environmental health, occupational safety and health, health promotion, injury prevention and educational activities designed to improve the health of United States citizens. The CDC also conducts research and provides information on non-infectious diseases, such as obesity and diabetes, and is a founding member of the International Association of National Public Health Institutes. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Integrin Beta 3
Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ''ITGB3'' gene. CD61 is a cluster of differentiation found on thrombocytes. Structure and function The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling. Role in endometriosis Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition. Interactions CD61 has been shown to interact with PTK2, ITGB3BP, TLN1 and CIB1. See also * Glycoprotein IIb/IIIa In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelet ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Golgi Apparatus
The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination. It resides at the intersection of the secretory, lysosomal, and endocytic pathways. It is of particular importance in processing proteins for secretion, containing a set of glycosylation enzymes that attach various sugar monomers to proteins as the proteins move through the apparatus. It was identified in 1897 by the Italian scientist Camillo Golgi and was named after him in 1898. Discovery Owing to its large size and distinctive structure, the Golgi apparatus was one of the first organelles to be discovered and observed in detail. It was discovered in 1898 by Italian physician Camillo Golgi during an investigation of the nervous system. After first observing it under his ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viral Replication
Viral replication is the formation of biological viruses during the infection process in the target host cells. Viruses must first get into the cell before viral replication can occur. Through the generation of abundant copies of its genome and packaging these copies, the virus continues infecting new hosts. Replication between viruses is greatly varied and depends on the type of genes involved in them. Most DNA viruses assemble in the nucleus while most RNA viruses develop solely in cytoplasm. Viral production / replication Viruses multiply only in living cells. The host cell must provide the energy and synthetic machinery and the low- molecular-weight precursors for the synthesis of viral proteins and nucleic acids. The virus replication occurs in seven stages, namely; # Attachment # Entry, # Uncoating, # Transcription / mRNA production, # Synthesis of virus components, # Virion assembly and # Release (Liberation Stage). Attachment It is the first step of viral replication ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Dimer
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound. Many macromolecules, such as proteins or nucleic acids, form dimers. The word ''dimer'' has roots meaning "two parts", '' di-'' + '' -mer''. A protein dimer is a type of protein quaternary structure. A protein homodimer is formed by two identical proteins. A protein heterodimer is formed by two different proteins. Most protein dimers in biochemistry are not connected by covalent bonds. An example of a non-covalent heterodimer is the enzyme reverse transcriptase, which is composed of two different amino acid chains. An exception is dimers that are linked by disulfide bridges such as the homodimeric protein NEMO. Some proteins contain specialized domains to ensure dimerization (dimerization domains) and specificity. The G protein-coupled cannabinoid receptors have the ability to form both homo- and heterodimers with several ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleic Acid Secondary Structure
Nucleic acid secondary structure is the basepairing interactions within a single nucleic acid polymer or between two polymers. It can be represented as a list of bases which are paired in a nucleic acid molecule. The secondary structures of biological DNAs and RNAs tend to be different: biological DNA mostly exists as fully base paired double helices, while biological RNA is single stranded and often forms complex and intricate base-pairing interactions due to its increased ability to form hydrogen bonds stemming from the extra hydroxyl group in the ribose sugar. In a non-biological context, secondary structure is a vital consideration in the nucleic acid design of nucleic acid structures for DNA nanotechnology and DNA computing, since the pattern of basepairing ultimately determines the overall structure of the molecules. Fundamental concepts Base pairing In molecular biology, two nucleotides on opposite complementary DNA or RNA strands that are connected via hydrogen b ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
