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Scott Strobel
Scott A. Strobel (born July 4, 1964) is the provost (education), provost, Henry Ford II professor of molecular biophysics and biochemistry, and a professor of chemistry at Yale University. He was the vice provost for Science Initiatives and vice president for West Campus Planning & Program Development. An educator and researcher, he has led a number of Yale initiatives over the past two decades. Strobel was appointed as Yale's provost in 2020. Career Strobel earned a bachelor's degree in biochemistry from Brigham Young University and a Ph.D. in biology from the California Institute of Technology, under the guidance of Peter Dervan, before doing postdoctoral research at the University of Colorado, Boulder, under the mentorship of Thomas Cech. He has been a professor with the Howard Hughes Medical Institute (HHMI) since 2006. He joined the Yale faculty in 1995 in the Department of Molecular Biophysics & Biochemistry and served as department chair from 2006 to 2009. Since 2011 he has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Provost (education)
A provost is a senior academic administrator. At many institutions of higher education, they are the chief academic officer, a role that may be combined with being deputy to the chief executive officer. They may also be the chief executive officer of a university, of a branch campus of a university, or of a college within a university. Duties, role, and selection The specific duties and areas of responsibility for a provost vary from one institution to another, but usually include supervision and oversight of curricular, instructional, and research affairs. The various deans of a university's schools, colleges, or faculties typically report to the provost, or jointly to them and the institution's chief executive officer—which office may be called president, chancellor, vice-chancellor or rector. Likewise do the heads of the various interdisciplinary units and academic support functions (such as libraries, student services, the registrar, admissions, and information technolo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Postdoctoral
A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pursue additional research, training, or teaching in order to have better skills to pursue a career in academia, research, or any other field. Postdocs often, but not always, have a temporary academic appointment, sometimes in preparation for an academic faculty position. They continue their studies or carry out research and further increase expertise in a specialist subject, including integrating a team and acquiring novel skills and research methods. Postdoctoral research is often considered essential while advancing the scholarly mission of the host institution; it is expected to produce relevant publications in peer-reviewed academic journals or conferences. In some countries, postdoctoral research may lead to further formal qualificati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ribosomal
Ribosomes ( ) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins). The ribosomes and associated molecules are also known as the ''translational apparatus''. Overview The sequence of DNA that encodes the sequence of the amino acids in a protein is transcribed into a messenger RNA chain. Ribosomes bind to messenger RNAs and use their sequences for determining the correct sequence of amino acids to generate a given protein. Amino acids are selected and carried to the ribosome by transfer RNA (tRNA) molecules, which enter the ribosome and bind to the messenger RNA chain via an anti-codon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thomas A
Thomas may refer to: People * List of people with given name Thomas * Thomas (name) * Thomas (surname) * Saint Thomas (other) * Thomas Aquinas (1225–1274) Italian Dominican friar, philosopher, and Doctor of the Church * Thomas the Apostle * Thomas (bishop of the East Angles) (fl. 640s–650s), medieval Bishop of the East Angles * Thomas (Archdeacon of Barnstaple) (fl. 1203), Archdeacon of Barnstaple * Thomas, Count of Perche (1195–1217), Count of Perche * Thomas (bishop of Finland) (1248), first known Bishop of Finland * Thomas, Earl of Mar (1330–1377), 14th-century Earl, Aberdeen, Scotland Geography Places in the United States * Thomas, Illinois * Thomas, Indiana * Thomas, Oklahoma * Thomas, Oregon * Thomas, South Dakota * Thomas, Virginia * Thomas, Washington * Thomas, West Virginia * Thomas County (other) * Thomas Township (other) Elsewhere * Thomas Glacier (Greenland) Arts, entertainment, and media * ''Thomas'' (Burton novel) 1969 nove ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyclic Di-GMP-I Riboswitch
Cyclic di-GMP-I riboswitches are a class of riboswitch that specifically bind cyclic di-GMP, which is a second messenger that is used in a variety of microbial processes including virulence, motility and biofilm formation. Cyclic di-GMP-I riboswitches were originally identified by bioinformatics as a conserved RNA-like structure called the "GEMM motif". These riboswitches are present in a wide variety of bacteria, and are most common in Clostridia and certain varieties of Pseudomonadota. The riboswitches are present in pathogens such as '' Clostridium difficile'', ''Vibrio cholerae'' (which causes cholera) and ''Bacillus anthracis'' (which causes anthrax). '' Geobacter uraniumreducens'' is predicted to have 30 instances of this riboswitch in its genome. A bacteriophage that infects ''C. difficile'' is predicted to carry a cyclic di-GMP-I riboswitch, which it might use to detect and exploit the physiological state of bacteria that it infects. The discovery of this riboswitch cl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GlmS Glucosamine-6-phosphate Activated Ribozyme
The glucosamine-6-phosphate riboswitch ribozyme ( ''glmS'' ribozyme) is an RNA structure that resides in the 5' untranslated region (UTR) of the mRNA transcript of the ''glmS'' gene. This RNA regulates the ''glmS'' gene by responding to concentrations of a specific metabolite, glucosamine-6-phosphate (GlcN6P), in addition to catalyzing a self-cleaving chemical reaction upon activation. This cleavage leads to the degradation of the mRNA that contains the ribozyme, and lowers production of GlcN6P. The ''glmS'' gene encodes for an enzyme glutamine-fructose-6-phosphate amidotransferase, which catalyzes the formation of GlcN6P, a compound essential for cell wall biosynthesis, from fructose-6-phosphate and glutamine. Thus, when GlcN6P levels are high, the ''glmS'' ribozyme is activated and the mRNA transcript is degraded but in the absence of GlcN6P the gene continues to be translated into glutamine-fructose-6-phosphate amidotransferase and GlcN6P is produced. GlcN6P is a cofact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ScienceDaily
''Science Daily'' is an American website launched in 1995 that aggregates press releases and publishes lightly edited press releases (a practice called churnalism) about science, similar to Phys.org and EurekAlert!. The site was founded by married couple Dan and Michele Hogan in 1995; Dan Hogan formerly worked in the public affairs department of Jackson Laboratory writing press releases. The site makes money from selling advertisements. As of 2010, the site said that it had grown "from a two-person operation to a full-fledged news business with worldwide contributors". At the time, it was run out of the Hogans' home, had no reporters, and only reprinted press releases. In 2012, Quantcast Quantcast is an American technology company, founded in 2006, that specializes in AI-driven real-time advertising, audience insights and measurement. It has offices in the United States, Canada, Australia, Singapore, United Kingdom, Ireland, Fran ... ranked it at 614 with 2.6 million U.S. vi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Group I Catalytic Intron
Group I introns are large self-splicing ribozymes. They catalyze their own excision from mRNA, tRNA and rRNA precursors in a wide range of organisms. The core secondary structure consists of nine paired regions (P1-P9). These fold to essentially two domains – the P4-P6 domain (formed from the stacking of P5, P4, P6 and P6a helices) and the P3-P9 domain (formed from the P8, P3, P7 and P9 helices). The secondary structure mark-up for this family represents only this conserved core. Group I introns often have long open reading frames inserted in loop regions. Catalysis Splicing of group I introns is processed by two sequential transesterification reactions. The exogenous guanosine or guanosine nucleotide (''exoG'') first docks onto the active G-binding site located in P7, and its 3'-OH is aligned to attack the phosphodiester bond at the 5' splice site located in P1, resulting in a free 3'-OH group at the upstream exon and the exoG being attached to the 5' end of the intron. Then ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Azoarcus
''Azoarcus'' is a genus of nitrogen-fixing bacteria. Species in this genus are usually found in contaminated water, as they are involved in the degradation of some contaminants, commonly inhabiting soil. These bacteria have also been found growing in the endophytic compartment (inside the plant between the living cells) of some rice species and other grasses. The genus is within the family '' Zoogloeaceae'' in the ''Rhodocyclales'' of the ''Betaproteobacteria''. Many studies reported this genus about its potential extracellular electron uptake metabolism and has been found in the cathodic part of many microbial fuel cell Microbial fuel cell (MFC) is a type of bioelectrochemical fuel cell system that generates electric current by diverting electrons produced from the microbial oxidation of reduced compounds (also known as fuel or electron donor) on the anode to oxid ...s, notably in nitrate and oxygen reducing bio-cathodes biofilms. References Further reading * *Whitman, Will ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleotide Analog Interference Mapping
Experimental approaches of determining the Biomolecular structure, structure of nucleic acids, such as RNA and DNA, can be largely classified into biophysics, biophysical and biochemistry, biochemical methods. Biophysical methods use the fundamental physical properties of molecules for structure determination, including X-ray crystallography, Nuclear magnetic resonance spectroscopy, NMR and cryo-EM. Biochemical methods exploit the chemical properties of nucleic acids using specific reagents and conditions to assay the structure of nucleic acids. Such methods may involve chemical probing with specific reagents, or rely on native or nucleoside analogue, analogue chemistry. Different experimental approaches have unique merits and are suitable for different experimental purposes. Biophysical methods X-ray crystallography X-ray crystallography is not common for nucleic acids alone, since neither DNA nor RNA readily form crystals. This is due to the greater degree of intrinsic disor ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Peptidyl Transferase
The peptidyl transferase is an aminoacyltransferase () as well as the primary enzymatic function of the ribosome, which forms peptide bonds between adjacent amino acids using tRNAs during the translation process of protein biosynthesis. The substrates for the peptidyl transferase reaction are two tRNA molecules, one bearing the growing peptide chain and the other bearing the amino acid that will be added to the chain. The peptidyl chain and the amino acids are attached to their respective tRNAs via ester bonds to the O atom at the CCA-3' ends of these tRNAs. Peptidyl transferase is an enzyme that catalyzes the addition of an amino acid residue in order to grow the polypeptide chain in protein synthesis. It is located in the large ribosomal subunit, where it catalyzes the peptide bond formation. It is composed entirely of RNA. The alignment between the CCA ends of the ribosome-bound peptidyl tRNA and aminoacyl tRNA in the peptidyl transferase center contribute to its ability to cat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Riboswitches
In molecular biology, a riboswitch is a regulatory segment of a messenger RNA molecule that binds a small molecule, resulting in a change in Translation (biology), production of the proteins encoded by the mRNA. Thus, an mRNA that contains a riboswitch is directly involved in regulating its own activity, in response to the concentrations of its Effector (biology), effector molecule. The discovery that modern organisms use RNA to bind small molecules, and discriminate against closely related analogs, expanded the known natural capabilities of RNA beyond its ability to code for proteins, ribozyme, catalyze reactions, or to bind other RNA or protein macromolecules. The original definition of the term "riboswitch" specified that they directly sense small-molecule metabolite concentrations. Although this definition remains in common use, some biologists have used a broader definition that includes other cis-regulatory element, cis-regulatory RNAs. However, this article will discuss o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
