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Sarah Martins Da Silva
Sarah Martins da Silva is a British gynaecologist and researcher specialising in male infertility. Martins da Silva is a Clinical Reader in reproductive medicine at the University of Dundee. She also works as an honorary consultant gynaecologist at Ninewells Hospital in Dundee, specialising in fertility problems and assisted conception. She was named one of the BBC's "100 Women of 2019" for her contribution to fertility science. Early life and education Martins da Silva was born and raised near Cambridge, England. Her father was an engineer and her mother was engaged in charity work. From a young age, she aspired to become a doctor and scientist. Martins da Silva attended the Perse School for Girls in Cambridge from 1978 to 1990. In 1995, she received a Bachelor of Medicine, Bachelor of Surgery (MBChB) from the University of Edinburgh Medical School. In 2001, Martins da Silva qualified with a Diploma of the Faculty of Family Planning (DFFP) from the Royal College of Obste ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fertility
Fertility is the capability to produce offspring through reproduction following the onset of sexual maturity. The fertility rate is the average number of children born by a female during her lifetime and is quantified demographically. Fertility is addressed when there is a difficulty or an inability to reproduce naturally, which is referred to as infertility. Infertility is widespread, with fertility specialists available all over the world to assist mothers and couples who experience difficulties having a baby. Human fertility depends on factors of nutrition, sexual behaviour, consanguinity, culture, instinct, endocrinology, timing, economics, personality, way of life, and emotions. Fertility differs from fecundity, which is defined as the ''potential'' for reproduction (influenced by gamete production, fertilization and carrying a pregnancy to term). Where a woman or the lack of fertility is infertility while a lack of fecundity would be called sterility. Demography I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ovaries
The ovary is an organ in the female reproductive system that produces an ovum. When released, this travels down the fallopian tube into the uterus, where it may become fertilized by a sperm. There is an ovary () found on each side of the body. The ovaries also secrete hormones that play a role in the menstrual cycle and fertility. The ovary progresses through many stages beginning in the prenatal period through menopause. It is also an endocrine gland because of the various hormones that it secretes. Structure The ovaries are considered the female gonads. Each ovary is whitish in color and located alongside the lateral wall of the uterus in a region called the ovarian fossa. The ovarian fossa is the region that is bounded by the external iliac artery and in front of the ureter and the internal iliac artery. This area is about 4 cm x 3 cm x 2 cm in size.Daftary, Shirish; Chakravarti, Sudip (2011). Manual of Obstetrics, 3rd Edition. Elsevier. pp. 1-16. . The ovarie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bill & Melinda Gates Foundation
The Bill & Melinda Gates Foundation (BMGF), a merging of the William H. Gates Foundation and the Gates Learning Foundation, is an American private foundation founded by Bill Gates and Melinda French Gates. Based in Seattle, Washington, it was launched in 2000 and is reported as of 2020 to be the second largest charitable foundation in the world, holding $49.8 billion in assets. On his 43rd birthday, Bill Gates gave the foundation $1 billion. The primary stated goals of the foundation are to enhance healthcare and reduce extreme poverty across the world, and to expand educational opportunities and access to information technology in the U.S. Key individuals of the foundation include Bill Gates, Melinda French Gates, Warren Buffett, chief executive officer Mark Suzman, and Michael Larson. The BMGF had an endowment of approximately $50 billion . The scale of the foundation and the way it seeks to apply business techniques to giving makes it one of the leaders in venture philanthr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cation Channels Of Sperm
The cation channels of sperm also known as Catsper channels or CatSper, are ion channels that are related to the two-pore channels and distantly related to TRP channels. The four members of this family form voltage-gated Ca2+ channels that seem to be specific to sperm. As sperm encounter the more alkaline environment of the female reproductive tract, CatSper channels become activated by the altered ion concentration. These channels are required for proper fertilization. The study of these channels has been slow because they do not traffic to the cell membrane in many heterologous systems. There are several factors that can activate the CatSper calcium channel, depending on species. In the human, the channel is activated by progesterone released by the oocyte. Progesterone binds to the protein ABHD2 which is present in the sperm plasma membrane, which causes ABHD2 to cleave an inhibitor of CatSper (2-arachidonoylglycerol) into arachidonic acid and glycerol. The human CatSp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calcium Channel
A calcium channel is an ion channel which shows selective permeability to calcium ions. It is sometimes synonymous with voltage-gated calcium channel, although there are also ligand-gated calcium channels. Comparison tables The following tables explain gating, gene, location and function of different types of calcium channels, both voltage and ligand-gated. Voltage-gated Ligand-gated *the ''receptor-operated calcium channels'' (in vasoconstriction) **P2X receptors Page 479 Pharmacology L-type calcium channel blockers are used to treat hypertension. In most areas of the body, depolarization is mediated by sodium influx into a cell; changing the calcium permeability has little effect on action potentials. However, in many smooth muscle tissues, depolarization is mediated primarily by calcium influx into the cell. L-type calcium channel blockers selectively inhibit these action potentials in smooth muscle which leads to dilation of blood vessels; this in turn corrects hypert ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sperm
Sperm is the male reproductive cell, or gamete, in anisogamous forms of sexual reproduction (forms in which there is a larger, female reproductive cell and a smaller, male one). Animals produce motile sperm with a tail known as a flagellum, which are known as spermatozoa, while some red algae and fungi produce non-motile sperm cells, known as spermatia. Flowering plants contain non-motile sperm inside pollen, while some more basal plants like ferns and some gymnosperms have motile sperm. Sperm cells form during the process known as spermatogenesis, which in amniotes ( reptiles and mammals) takes place in the seminiferous tubules of the testes. This process involves the production of several successive sperm cell precursors, starting with spermatogonia, which differentiate into spermatocytes. The spermatocytes then undergo meiosis, reducing their chromosome number by half, which produces spermatids. The spermatids then mature and, in animals, construct a tail, or flagellum, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Intracytoplasmic Sperm Injection
Intracytoplasmic sperm injection (ICSI ) is an in vitro fertilization (IVF) procedure in which a single sperm cell is injected directly into the cytoplasm of an egg. This technique is used in order to prepare the gametes for the obtention of embryos that may be transferred to a maternal uterus. With this method, the acrosome reaction is skipped. There are several differences between classic IVF and ICSI. However, the steps to be followed before and after insemination are the same. In terms of insemination, ICSI needs only one sperm cell per oocyte, while IVF needs 50,000–100,000. This is because the acrosome reaction has to take place and thousands of sperm cells have to be involved in IVF. Once fertilized, the egg is transformed into a pre-embryo and it has to be transferred to the uterus to continue its development. The first human pregnancy generated by ICSI was carried out in 1991 by Gianpiero Palermo and his team. Round spermatid injection (ROSI) Round spermatid inject ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Male Infertility Crisis
The male infertility crisis is an increase in male infertility since the mid-1970s. The issue attracted media attention after a 2017 meta-analysis found that sperm counts had declined by 52.4 percent between 1973 and 2011. The decline is particularly prevalent in Western countries such as New Zealand and Australia, Europe and North America. A 2022 meta-analysis reported that this decline extends to non-Western countries, namely those in Asia, Africa, Central America, and South America. This meta-analysis also suggests that the decline in sperm counts may be accelerating. This decline in male fertility is the subject of research and debate. Proposed explanations include lifestyle factors, such as changes in diet and physical activity levels, and increased exposure to endocrine disrupting chemicals, such as those found in plastics. Some scientists have questioned the extent of the crisis, saying that sperm-count studies are geographically sparse, often fail to account for a subje ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
In Vitro Fertilisation
In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm in vitro ("in glass"). The process involves monitoring and stimulating an individual's ovulatory process, removing an ovum or ova (egg or eggs) from their ovaries and letting sperm fertilise them in a culture medium in a laboratory. After the fertilised egg (zygote) undergoes embryo culture for 2–6 days, it is transferred by catheter into the uterus, with the intention of establishing a successful pregnancy. IVF is a type of assisted reproductive technology used for infertility treatment, gestational surrogacy, and, in combination with pre-implantation genetic testing, avoiding transmission of genetic conditions. A fertilised egg from a donor may implant into a surrogate's uterus, and the resulting child is genetically unrelated to the surrogate. Some countries have banned or otherwise regulate the availability of IVF treatment, giving rise to fertility tourism. Restrictions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NHS Tayside
NHS Tayside is an NHS board which forms one of the fourteen regions of NHS Scotland. It provides healthcare services in Angus, the City of Dundee and Perth and Kinross. NHS Tayside is headquartered at Ninewells Hospital in Dundee; one of the largest hospitals in the world. It has three Health and Social Care Partnerships (HSCPs): Angus, Dundee and Perth and Kinross. Performance In July 2020 the board announced that it had achieved the Scottish Government’s 2024 target of a 90% reduction in prevalence of hepatitis C, after 1970 people were diagnosed and treated, making it the first region in the world to effectively eliminate the virus. It signed a five-year agreement with Alcidion to deploy Miya Observations, an electronic monitoring system which alerts clinical staff when patients show signs of deterioration, in 2022. History NHS Tayside was originally formed as Tayside Health Board in April 1974. It replaced the Eastern Regional Hospital Board, that had been created in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Dundee School Of Medicine
The University of Dundee School of Medicine is the school concerned with medical education and clinical research at the University of Dundee in Scotland. In 1967, Dundee's medical school became independent in its own right having started in 1889 as a joint venture between the University of St Andrews and University College Dundee. In 1974 the medical school moved to a large teaching facility based at Ninewells Hospital in the west of Dundee. The School of Medicine now encompasses undergraduate, postgraduate, specialist teaching centres and four research divisions. History The Conjoint Medical School (1887-1967) In 1881, when University College Dundee was founded, the city of Dundee contained the Royal Infirmary and the Royal Lunatic Asylum which would provide medical teaching space for the new institution. The college however, had no power to award degrees and thus in 1887 proposed a merger with the nearby University of St Andrews. The Universities (Scotland) Act 1889 paved th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NHS Lothian
NHS Lothian is one of the 14 regions of NHS Scotland. It provides healthcare services in the City of Edinburgh, East Lothian, Midlothian and West Lothian areas. Its headquarters are at Waverley Gate, Edinburgh Services It is responsible for the care provided by around 29,000 staff at a number of locations: * 21 hospitals, including four major teaching hospitals * 126 General practitioner, GP practices * 180 Community pharmacy, community pharmacies * 173 Dentist, dental practices * 112 Optometry, ophthalmic practices Community Health Partnerships The Edinburgh Community Health Partnership (CHP) has responsibilities around delivering community health services and also addressing inequalities in Edinburgh for NHS Lothian. When the CHPs were established in 2005 they provided a single management structure, taking over control of community services which were transferred under their control. On 1 April 2007, Edinburgh Community Health Partnership was formed by the merging of 2 CHPs: ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
