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Salinispora Tropica
''Salinispora tropica'' is an obligate marine actinomycete bacterium species. It produces salinosporamide A and salinosporamide B, potential anti-cancer agents, as well as the polycyclic macrolides The Macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macr ... sporolide A and B. See also * '' Salinispora arenicola'' * '' Salinispora pacifica'' References Further reading * * * External links LPSN*WORMS entry [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salinosporamide A
Salinosporamide A (Marizomib) is a potent proteasome inhibitor being studied as a potential anticancer agent. It entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003. This marine natural product is produced by the obligate marine bacteria ''Salinispora tropica'' and ''Salinispora arenicola'', which are found in ocean sediment. Salinosporamide A belongs to a family of compounds, known collectively as salinosporamides, which possess a densely functionalized γ-lactam-β-lactone bicyclic core. History Salinosporamide A was discovered by William Fenical and Paul Jensen from Scripps Institution of Oceanography in La Jolla, CA. In preliminary screening, a high percentage of the organic extracts of cultured ''Salinispora'' strains possessed antibiotic and anticancer activities, which suggests that these bacteria are an excellent resource for drug discovery. ''Salinispora'' strain CNB-392 was isolated from a heat-tr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salinosporamide B
The salinosporamides are a group of closely related chemical compounds isolated from marine bacteria in the genus ''Salinispora''. They possess a densely functionalized γ-lactam-β-lactone bicyclic core. Salinosporamide A has attracted interest for its potential use in treating various types of cancer. In addition, a variety of synthetic analogs have been prepared. Chemical structures File:Salinosporamide A.svg, Salinosporamide A Salinosporamide A (Marizomib) is a potent proteasome inhibitor being studied as a potential anticancer agent. It entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003. This marin ... File:Salinosporamide B.svg, Salinosporamide B File:Salinosporamide C.svg, Salinosporamide C File:Salinosporamide D.svg, Salinosporamide D File:Salinosporamide E.svg, Salinosporamide E File:Salinosporamide F.svg, Salinosporamide F File:Salinosporamide G.svg, Salinosporamide G File:Salinosporamide H.svg, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Journal Of Organic Chemistry
''The Journal of Organic Chemistry'', colloquially known as ''JOC'', is a peer-reviewed scientific journal for original contributions of fundamental research in all branches of theory and practice in organic and bioorganic chemistry. It is published by the publishing arm of the American Chemical Society, with 24 issues per year. According to the ''Journal Citation Reports'', the journal had a 2017 impact factor of 4.805 and it is the journal that received the most cites (100,091 in 2017) in the field of organic chemistry. According to Web of Knowledge (and as December 2012), eleven papers from the journal have received more than 1,000 citations, with the most cited paper having received 7,967 citations. The current editor-in-chief is Scott J. Miller from Yale University. Indexing ''J. Org. Chem.'' is currently indexed in: See also *Organic Letters *Organometallics ''Organometallics'' is a biweekly journal published by the American Chemical Society. Its area of focus is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Macrolides
The Macrolides are a class of natural products that consist of a large macrocyclic lactone ring to which one or more deoxy sugars, usually cladinose and desosamine, may be attached. The lactone rings are usually 14-, 15-, or 16-membered. Macrolides belong to the polyketide class of natural products. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Rapamycin is also a macrolide and was originally developed as an antifungal, but is now used as an immunosuppressant drug and is being investigated as a potential longevity therapeutic. Macrolides are bacteriostatic in that they suppress or inhibit bacterial growth rather than killing bacteria completely. Definition In general, any macrocyclic lactone having greater than 8-membered rings are candidates for this class. The macrocycle may contain amino nitrogen, amide nitrogen (but should be differentiated from cyclopeptides), an oxazole ring, or a thiazole ring. Benzene rings are exclu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sporolides
Sporolides A and B are polycyclic macrolides extracted from the obligate marine bacterium '' Salinispora tropica'', which is found in ocean sediment. They are composed of a chlorinated cyclopenta ndene ring and a cyclohexenone moiety. They were the second group of compounds (after salinosporamide A) isolated from '' Salinispora'', and were said to indicate the potential of marine actinomycetes as a source of novel secondary metabolites. The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography. The complex aromatic structure of the sporolides was hypothesized to be derived from an unstable nine-membered ring enediyne precursor, which could undergo Bergman cyclization to generate a para-benzyne intermediate. Nucleophilic attack by chloride would account for the 1:1 mixture of sporolide A and B and for the single chlorine in these enediyne-derived natural products. This proposed mechanism was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salinispora Arenicola
''Salinispora arenicola'' is an obligate marine actinomycete bacterium species. It produces salinosporamide, a potential anti-cancer agent. See also * ''Salinispora tropica'' * ''Salinispora pacifica ''Salinispora pacifica'' is an obligate marine actinomycetes bacterium species in the genus '' Salinispora''. See also * ''Salinispora tropica ''Salinispora tropica'' is an obligate marine actinomycete bacterium species. It produces salino ...'' References Further reading * * External links LPSN [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salinispora Pacifica
''Salinispora pacifica'' is an obligate marine actinomycetes bacterium species in the genus '' Salinispora''. See also * ''Salinispora tropica ''Salinispora tropica'' is an obligate marine actinomycete bacterium species. It produces salinosporamide A and salinosporamide B, potential anti-cancer agents, as well as the polycyclic macrolides The Macrolides are a class of natural pr ...'' * '' Salinispora arenicola'' References External linksType strain of ''Salinispora pacifica'' at Bac''Dive'' - the Bacterial Diversity Metadatabase {{Taxonbar, from=Q24993759 Micromonosporaceae Marine microorganisms ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proceedings Of The National Academy Of Sciences Of The United States Of America
''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Sciences, published since 1915, and publishes original research, scientific reviews, commentaries, and letters. According to ''Journal Citation Reports'', the journal has a 2021 impact factor of 12.779. ''PNAS'' is the second most cited scientific journal, with more than 1.9 million cumulative citations from 2008 to 2018. In the mass media, ''PNAS'' has been described variously as "prestigious", "sedate", "renowned" and "high impact". ''PNAS'' is a delayed open access journal, with an embargo period of six months that can be bypassed for an author fee ( hybrid open access). Since September 2017, open access articles are published under a Creative Commons license. Since January 2019, ''PNAS'' has been online-only, although print issues are ava ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Micromonosporaceae
Micromonosporaceae is a family of bacteria of the class ''Actinomycetia''. They are gram-positive, spore-forming soil organisms that form a true mycelium. Genera Micromonosporaceae comprises the following genera: * ''Actinocatenispora'' Thawai et al. 2006 * ''Actinoplanes'' Couch 1950 (Approved Lists 1980) * ''Actinorhabdospora'' Mingma et al. 2016 * '' Allocatelliglobosispora'' Lee and Lee 2011 * ''Allorhizocola'' Sun et al. 2019 * '' Asanoa'' Lee and Hah 2002 * '' Catellatospora'' Asano and Kawamoto 1986 * ''Catelliglobosispora'' Ara et al. 2008 * '' Catenuloplanes'' Yokota et al. 1993 * '' Couchioplanes'' Tamura et al. 1994 * ''Dactylosporangium'' Thiemann et al. 1967 (Approved Lists 1980) * ''Hamadaea'' Ara et al. 2008 * ''Krasilnikovia'' Ara and Kudo 2007 * ''Longispora'' Matsumoto et al. 2003 * ''Luedemannella'' Ara and Kudo 2007 * '' Mangrovihabitans'' Liu et al. 2017 * ''Micromonospora'' Ørskov 1923 (Approved Lists 1980) * "'' Natronosporangium''" Sorokin et al. 20 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bacteria Described In 2005
Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among the first life forms to appear on Earth, and are present in most of its habitats. Bacteria inhabit soil, water, acidic hot springs, radioactive waste, and the deep biosphere of Earth's crust. Bacteria are vital in many stages of the nutrient cycle by recycling nutrients such as the fixation of nitrogen from the atmosphere. The nutrient cycle includes the decomposition of dead bodies; bacteria are responsible for the putrefaction stage in this process. In the biological communities surrounding hydrothermal vents and cold seeps, extremophile bacteria provide the nutrients needed to sustain life by converting dissolved compounds, such as hydrogen sulphide and methane, to energy. Bacteria also live in symbiotic and parasitic relationships wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
