The salinosporamides are a group of closely related chemical compounds isolated from
marine bacteria
Marine prokaryotes are marine bacteria and marine archaea. They are defined by their habitat as prokaryotes that live in marine environments, that is, in the saltwater of seas or oceans or the brackish water of coastal estuaries. All cellular ...
in the genus ''
Salinispora
''Salinispora'' is a genus of obligately aerobic, gram-positive, non-acid-fast bacteria belonging to the family of Micromonosporaceae. They are heterotrophic, non-motile, and obligately grow under high osmotic/ ionic-strength conditions. They ...
''. They possess a densely functionalized γ-lactam-β-lactone
bicyclic core.
Salinosporamide A
Salinosporamide A (Marizomib) is a potent proteasome inhibitor being studied as a potential anticancer agent. It entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003. This marin ...
has attracted interest for its potential use in treating various types of cancer.
In addition, a variety of synthetic
analogs have been prepared.
Chemical structures
File:Salinosporamide A.svg, Salinosporamide A
Salinosporamide A (Marizomib) is a potent proteasome inhibitor being studied as a potential anticancer agent. It entered phase I human clinical trials for the treatment of multiple myeloma, only three years after its discovery in 2003. This marin ...
File:Salinosporamide B.svg, Salinosporamide B
File:Salinosporamide C.svg, Salinosporamide C
File:Salinosporamide D.svg, Salinosporamide D
File:Salinosporamide E.svg, Salinosporamide E
File:Salinosporamide F.svg, Salinosporamide F
File:Salinosporamide G.svg, Salinosporamide G
File:Salinosporamide H.svg, Salinosporamide H
File:Salinosporamide I.svg, Salinosporamide I
File:Salinosporamide J.svg, Salinosporamide J
File:Salinosporamide K.svg, Salinosporamide K
References
External links
* {{Commons category-inline, Salinosporamides
Natural products
Lactams
Lactones