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S3DB
Simple Sloppy Semantic Database (S3DB) is a distributed data management system that relies on Semantic Web concepts for management of heterogeneous data. S3DB is open source software, licensed under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 United States License. It is written in PHP. History S3DB was first proposed in 2006, following the argumentation the previous year that omics data sets would be more easily managed if stored as RDF triples. The first version, 1.0, was focused on the support of an indexing engine for triplestore management. The second version, made available in October 2007, added cross-referencing between triples in distinct S3DB deployments to support it as a distributed infrastructure. The third version was released in July 2008 and exposes its API through a specialized query language, S3QL, accessible as a REST web service. An update of that release (version 3.5) also includes a RESTful SPARQL SPARQL (pronounced " sparkle" , a re ...
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Open Source Software
Open-source software (OSS) is computer software that is released under a license in which the copyright holder grants users the rights to use, study, change, and distribute the software and its source code to anyone and for any purpose. Open-source software may be developed in a collaborative public manner. Open-source software is a prominent example of open collaboration, meaning any capable user is able to participate online in development, making the number of possible contributors indefinite. The ability to examine the code facilitates public trust in the software. Open-source software development can bring in diverse perspectives beyond those of a single company. A 2008 report by the Standish Group stated that adoption of open-source software models has resulted in savings of about $60 billion per year for consumers. Open source code can be used for studying and allows capable end users to adapt software to their personal needs in a similar way user scripts a ...
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-omics
The branches of science known informally as omics are various disciplines in biology whose names end in the suffix '' -omics'', such as genomics, proteomics, metabolomics, metagenomics, phenomics and transcriptomics. Omics aims at the collective characterization and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms . The related suffix -ome is used to address the objects of study of such fields, such as the genome, proteome or metabolome respectively. The suffix ''-ome'' as used in molecular biology refers to a ''totality'' of some sort; it is an example of a "neo-suffix" formed by abstraction from various Greek terms in , a sequence that does not form an identifiable suffix in Greek. Functional genomics aims at identifying the functions of as many genes as possible of a given organism. It combines different -omics techniques such as transcriptomics and proteomics with saturated mutant collecti ...
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Resource Description Framework
The Resource Description Framework (RDF) is a World Wide Web Consortium (W3C) standard originally designed as a data model for metadata. It has come to be used as a general method for description and exchange of graph data. RDF provides a variety of syntax notations and data serialization formats with Turtle (Terse RDF Triple Language) currently being the most widely used notation. RDF is a directed graph composed of triple statements. An RDF graph statement is represented by: 1) a node for the subject, 2) an arc that goes from a subject to an object for the predicate, and 3) a node for the object. Each of the three parts of the statement can be identified by a URI. An object can also be a literal value. This simple, flexible data model has a lot of expressive power to represent complex situations, relationships, and other things of interest, while also being appropriately abstract. RDF was adopted as a W3C recommendation in 1999. The RDF 1.0 specification was published in 2004, th ...
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Triplestore
A triplestore or RDF store is a purpose-built database for the storage and retrieval of triples through semantic queries. A triple is a data entity composed of subject–predicate–object, like "Bob is 35" or "Bob knows Fred". Much like a relational database, information in a triplestore is stored and retrieved via a query language. Unlike a relational database, a triplestore is optimized for the storage and retrieval of triples. In addition to queries, triples can usually be imported and exported using Resource Description Framework (RDF) and other formats. Implementations Some triplestores have been built as database engines from scratch, while others have been built on top of existing commercial relational database engines (such as SQL-based) or NoSQL document-oriented database engines. Like the early development of online analytical processing (OLAP) databases, this intermediate approach allowed large and powerful database engines to be constructed for little programming ef ...
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Application Programming Interface
An application programming interface (API) is a way for two or more computer programs to communicate with each other. It is a type of software interface, offering a service to other pieces of software. A document or standard that describes how to build or use such a connection or interface is called an ''API specification''. A computer system that meets this standard is said to ''implement'' or ''expose'' an API. The term API may refer either to the specification or to the implementation. In contrast to a user interface, which connects a computer to a person, an application programming interface connects computers or pieces of software to each other. It is not intended to be used directly by a person (the end user) other than a computer programmer who is incorporating it into the software. An API is often made up of different parts which act as tools or services that are available to the programmer. A program or a programmer that uses one of these parts is said to ''call'' that ...
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SPARQL
SPARQL (pronounced "sparkle" , a recursive acronym for SPARQL Protocol and RDF Query Language) is an RDF query language—that is, a semantic query language for databases—able to retrieve and manipulate data stored in Resource Description Framework (RDF) format. It was made a standard by the ''RDF Data Access Working Group'' (DAWG) of the World Wide Web Consortium, and is recognized as one of the key technologies of the semantic web. On 15 January 2008, SPARQL 1.0 was acknowledged by W3C as an official recommendation, and SPARQL 1.1 in March, 2013. SPARQL allows for a query to consist of triple patterns, conjunctions, disjunctions, and optional patterns. Implementations for multiple programming languages exist. There exist tools that allow one to connect and semi-automatically construct a SPARQL query for a SPARQL endpoint, for example ViziQuer. In addition, tools exist to translate SPARQL queries to other query languages, for example to SQL and to XQuery. Advantages ...
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University Of Texas MD Anderson Cancer Center
The University of Texas MD Anderson Cancer Center (colloquially MD Anderson Cancer Center) is a comprehensive cancer center in Houston, Texas. It is the largest cancer center in the U.S. and one of the original three comprehensive cancer centers in the country. It is both a degree-granting academic institution and a cancer treatment and research center located at the Texas Medical Center in Houston. It is affiliated with The University of Texas Health Science Center at Houston. According to Newsweek, MD Anderson Cancer Center is considered the best hospital in the world for oncology and related cancer treatment. History The cancer center is named after Monroe Dunaway Anderson, a banker and cotton trader from Jackson, Tennessee. He was a member of a business partnership with his brother-in-law Will Clayton. Their company became the largest cotton company in the world. Anderson feared that in the event of one of the partners' deaths, the company would lose a large amount of money t ...
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National Cancer Institute
The National Cancer Institute (NCI) coordinates the United States National Cancer Program and is part of the National Institutes of Health (NIH), which is one of eleven agencies that are part of the U.S. Department of Health and Human Services. The NCI conducts and supports research, training, health information dissemination, and other activities related to the causes, prevention, diagnosis, and treatment of cancer; the supportive care of cancer patients and their families; and cancer survivorship. NCI is the oldest and has the largest budget and research program of the 27 institutes and centers of the NIH ($6.9 billion in 2020). It fulfills the majority of its mission via an extramural program that provides grants for cancer research. Additionally, the National Cancer Institute has intramural research programs in Bethesda, Maryland, and at the Frederick National Laboratory for Cancer Research at Fort Detrick in Frederick, Maryland. The NCI receives more than in funding each ...
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BMC Bioinformatics
''BMC Bioinformatics'' is a peer-reviewed open access scientific journal covering bioinformatics and computational biology published by BioMed Central. It was established in 2000, and has been one of the fastest growing and most successful journals in the '' BMC Series'' of journals, publishing 1,000 articles in its first five years. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as i ... of 3.169. References External links *{{Official website, http://www.biomedcentral.com/bmcbioinformatics/ BioMed Central academic journals Bioinformatics and computational biology journals Creative Commons Attribution-licensed journals Publication ...
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