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Ruslan Medzhitov
Ruslan Maksutovich Medzhitov (born March 12, 1966) is a professor of immunobiology at Yale School of Medicine, a member of Yale Cancer Center, and a Howard Hughes Medical Institute investigator. His research focuses on the analysis of the innate immune system, inflammatory response, innate control of the adaptive immunity, and host-pathogen interactions. On April 27, 2010, he was elected to the US National Academy of Sciences. Biography Ruslan Medzhitov was born in 1966 in Tashkent. He earned a Bachelor of Science at Tashkent State University before going on to pursue a PhD in biochemistry at Moscow State University. In 1992 he read an article by Charles Janeway about a hypothetical flip-flop triggered innate immunity. Before coming to Yale, he was a fellow in the laboratory of Russell Doolittle at the University of California in San Diego. A graduate student with no special immunological training, he realized that it was necessary to find pattern-recognizing receptors and was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tashkent
Tashkent (, uz, Toshkent, Тошкент/, ) (from russian: Ташкент), or Toshkent (; ), also historically known as Chach is the capital and largest city of Uzbekistan. It is the most populous city in Central Asia, with a population of 2,909,500 (2022). It is in northeastern Uzbekistan, near the border with Kazakhstan. Tashkent comes from the Turkic ''tash'' and ''kent'', literally translated as "Stone City" or "City of Stones". Before Islamic influence started in the mid-8th century AD, Tashkent was influenced by the Sogdian and Turkic cultures. After Genghis Khan destroyed it in 1219, it was rebuilt and profited from the Silk Road. From the 18th to the 19th century, the city became an independent city-state, before being re-conquered by the Khanate of Kokand. In 1865, Tashkent fell to the Russian Empire; it became the capital of Russian Turkestan. In Soviet times, it witnessed major growth and demographic changes due to forced deportations from throughout the Sov ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Russell Doolittle
Russell F. Doolittle (January 10, 1931 – October 11, 2019) was an American biochemist who taught at the University of California, San Diego (UCSD). Described as a "world-renowned evolutionary biologist", Doolittle's research primarily focused on the structure and evolution of proteins. Highlights of Doolittle's decades of research include his role in co-developing the hydropathy index and determining the structure of fibrinogen. Early life and education Doolittle was born on January 10, 1931, in New Haven, Connecticut. Doolittle earned a B.A. in biology from Wesleyan University in 1952, and an M.A. in education from Trinity College in 1957. He earned his Ph.D. in biochemistry at Harvard University in 1962 with research in blood clotting. Doolittle later conducted postdoctoral research in Sweden funded by the National Institutes of Health (NIH). Career Doolittle notably co-developed the hydropathy index, and was instrumental in determining the structure of fibrinogen. Do ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dickson Prize
The Dickson Prize in Medicine and the Dickson Prize in Science were both established in 1969 by Joseph Z. Dickson and Agnes Fischer Dickson. Dickson Prize in Medicine The Dickson Prize in Medicine is awarded annually by the University of Pittsburgh and recognizes US citizens who have made "significant, progressive contributions" to medicine. The award includes $50,000, a bronze medal, and the Dickson Prize Lecture. Receiving the Dickson Prize in Medicine is strongly correlated with receiving the Lasker Award and the Nobel Prize. Recipients SourceUniversity of Pittsburgh * 1971 Earl W. Sutherland Jr. * 1972 Solomon A. Berson and Rosalyn S. Yalow * 1973 John H. Gibbon Jr. * 1974 Stephen W. Kuffler * 1975 Elizabeth F. Neufeld * 1976 Frank J. Dixon * 1977 Roger Guillemin * 1978 Paul Greengard * 1979 Bert W. O'Malley * 1980 David H. Hubel and Torsten N. Wiesel * 1981 Philip Leder * 1982 Francis H. Ruddle * 1983 Eric R. Kandel * 1984 Solomon H. Snyder * 1985 Robert C. Gallo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lewis S
Lewis may refer to: Names * Lewis (given name), including a list of people with the given name * Lewis (surname), including a list of people with the surname Music * Lewis (musician), Canadian singer * "Lewis (Mistreated)", a song by Radiohead from ''My Iron Lung'' Places * Lewis (crater), a crater on the far side of the Moon * Isle of Lewis, the northern part of Lewis and Harris, Western Isles, Scotland United States * Lewis, Colorado * Lewis, Indiana * Lewis, Iowa * Lewis, Kansas * Lewis Wharf, Boston, Massachusetts * Lewis, Missouri * Lewis, Essex County, New York * Lewis, Lewis County, New York * Lewis, North Carolina * Lewis, Vermont * Lewis, Wisconsin Ships * USS ''Lewis'' (1861), a sailing ship * USS ''Lewis'' (DE-535), a destroyer escort in commission from 1944 to 1946 Science * Lewis structure, a diagram of a molecule that shows the bonding between the atoms * Lewis acids and bases * Lewis antigen system, a human blood group system * Lewis number, a dimensionl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Munich
The Ludwig Maximilian University of Munich (simply University of Munich or LMU; german: Ludwig-Maximilians-Universität München) is a public research university in Munich, Germany. It is Germany's List of universities in Germany, sixth-oldest university in continuous operation. Originally University of Ingolstadt, established in Ingolstadt in 1472 by Louis IX, Duke of Bavaria, Duke Ludwig IX of Bavaria-Landshut, the university was moved in 1800 to Landshut by Maximilian I Joseph of Bavaria, King Maximilian I of Bavaria when the city was threatened by the French, before being relocated to its present-day location in Munich in 1826 by Ludwig I of Bavaria, King Ludwig I of Bavaria. In 1802, the university was officially named Ludwig-Maximilians-Universität by King Maximilian I of Bavaria in honor of himself and Ludwig IX. LMU is currently the second-largest university in Germany in terms of student population; in the 2018/19 winter semester, the university had a total of 51,606 m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University School Of Medicine
The Yale School of Medicine is the graduate medical school at Yale University, a private research university in New Haven, Connecticut. It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. The primary teaching hospital for the school is Yale New Haven Hospital. The school is home to the Harvey Cushing/John Hay Whitney Medical Library, one of the largest modern medical libraries which is known for its historical collections. The faculty includes 70 National Academy of Sciences members, 47 National Academy of Medicine members, and 13 Howard Hughes Medical Institute investigators. '' U.S. News & World Report'' currently ranks the Yale School of Medicine 10th in the country for research and 59th in primary care. The MD program is highly selective; for the class of 2022, the school received 4,968 applications to fill 104 seats. The median GPA for the class was 3.89, and the median MCAT was 521. Education The School of Medicine offers the Doc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sterling Professor
Sterling Professor, the highest academic rank at Yale University, is awarded to a tenured faculty member considered the best in his or her field. It is akin to the rank of university professor at other universities. The appointment, made by the President of Yale University and confirmed by the Yale Corporation, can be granted to any Yale faculty member, and up to forty professors can hold the title at the same time. The position was established through a 1918 bequest from John William Sterling, and the first Sterling Professor was appointed in 1920. History The professorships are named for and funded by a $15-million bequest left by John W. Sterling, partner in the New York law firm Shearman & Sterling and an 1864 graduate of Yale College. In addition to financing the university’s largest construction projects throughout the 1920s, including the Sterling Memorial Library and flagship facilities for many of its professional schools, Sterling stipulated the bequest would allow ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forbes
''Forbes'' () is an American business magazine owned by Integrated Whale Media Investments and the Forbes family. Published eight times a year, it features articles on finance, industry, investing, and marketing topics. ''Forbes'' also reports on related subjects such as technology, communications, science, politics, and law. It is based in Jersey City, New Jersey. Competitors in the national business magazine category include ''Fortune'' and ''Bloomberg Businessweek''. ''Forbes'' has an international edition in Asia as well as editions produced under license in 27 countries and regions worldwide. The magazine is well known for its lists and rankings, including of the richest Americans (the Forbes 400), of the America's Wealthiest Celebrities, of the world's top companies (the Forbes Global 2000), Forbes list of the World's Most Powerful People, and The World's Billionaires. The motto of ''Forbes'' magazine is "Change the World". Its chair and editor-in-chief is Steve Fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forbes Magazine
''Forbes'' () is an American business magazine owned by Integrated Whale Media Investments and the Forbes family. Published eight times a year, it features articles on finance, industry, investing, and marketing topics. ''Forbes'' also reports on related subjects such as technology, communications, science, politics, and law. It is based in Jersey City, New Jersey. Competitors in the national business magazine category include ''Fortune'' and ''Bloomberg Businessweek''. ''Forbes'' has an international edition in Asia as well as editions produced under license in 27 countries and regions worldwide. The magazine is well known for its lists and rankings, including of the richest Americans (the Forbes 400), of the America's Wealthiest Celebrities, of the world's top companies (the Forbes Global 2000), Forbes list of the World's Most Powerful People, and The World's Billionaires. The motto of ''Forbes'' magazine is "Change the World". Its chair and editor-in-chief is Steve Forbes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune Response
An immune response is a reaction which occurs within an organism for the purpose of defending against foreign invaders. These invaders include a wide variety of different microorganisms including viruses, bacteria, parasites, and fungi which could cause serious problems to the health of the host organism if not cleared from the body. There are two distinct aspects of the immune response, the innate and the adaptive, which work together to protect against pathogens. The innate branch—the body's first reaction to an invader—is known to be a non-specific and quick response to any sort of pathogen. Components of the innate immune response include physical barriers like the skin and mucous membranes, immune cells such as neutrophils, macrophages, and monocytes, and soluble factors including cytokines and complement. On the other hand, the adaptive branch is the body's immune response which is catered against specific antigens and thus, it takes longer to activate the components involv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TLR4
Toll-like receptor 4 is a protein that in humans is encoded by the ''TLR4'' gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system. TLR4 expressing cells are myeloid (erythrocytes, granulocytes, macrophages) rather than lymphoid (T-cells, B-cells, NK cells). Most myeloid cells also express high levels of CD14, which facilitates activation of TLR4 by LPS. It is most well known for recognizing lipopolysaccharide (LPS), a component present in many Gram-negative bacteria (e.g. ''Neisseria'' spp.) and selected Gram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a variety of endogenous proteins such as low-density lipoprotein, beta-defensins, and heat shock protein. Palmitic acid and lauric acid a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toll-like Receptor
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are Bitopic protein, single-pass membrane-spanning Receptor (biochemistry), receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have reached physical barriers such as the skin or intestinal tract mucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Humans lack genes for TLR11, TLR12 and TLR13 and mice lack a functional gene for TLR10. TLR1, TLR2, TLR4, TLR5, TLR6, and TLR10 are located on the cell membrane, whereas TLR3, TLR7, TLR8, and TLR9 are located in Intracellular receptor, intracellular Vesicle (biology and chemistry), vesicles (because they are sensors of nucleic acids). TLRs received their name from their similarity to th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
