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RUB A535
RUB A535 (also known as Antiphlogistine) is a rubefacient introduced in 1919 and manufactured by Church & Dwight in Montreal, Quebec, Canada. While little known outside of Canada, it is used there for the treatment of tough muscle pain, arthritic pains, rheumatic pains, bursitis, lumbago, etc. Church and Dwight say on their website that nearly all the research, development and production of RUB A535 is carried out in Canada. Patients who are allergic to salicylates (ASA based drugs, such as aspirin), or who are taking anticoagulant medications should avoid the use of the product. It is also recommended to not use it more than 3–4 times a day. Ingredients The active ingredients in RUB A535 are camphor, eucalyptus oil, menthol, and methyl salicylate. Some formulations also contain capsaicin and triethanolamine. Varieties Currently, RUB A535 has been released in a variety of products: * Originally, it was produced in a particular white cream, carrying a rather offensiv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rubefacient
A rubefacient is a substance for topical application that produces redness of the skin, e.g. by causing dilation of the capillaries and an increase in blood circulation. They have sometimes been used to relieve acute or chronic pain, but there is limited evidence as to their efficacy,Mason et al. 200''Systematic review of efficacy of topical rubefacients containing salicylates for the treatment of acute and chronic pain''BMJ 328:995 and as of 2014 the best evidence does not support using gels and creams containing rubefacients for this purpose. Examples Common medicinal rubefacients include: *Salicylates, such as methyl salicylate (oil of wintergreen) *Nicotinate esters *Capsaicin, derived from chili pepper, ''Capsicum minimum'', "incites irritation without rubefaction" *Isopropanol (rubbing alcohol) *Menthol *Minoxidil * Thurfyl nicotinate (Trafuril) Common herbal rubefacients include:{{citation needed, date=October 2016 *Cloves (''Syzygium aromaticum'') *Garlic (''Allium sativum'' ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Camphor
Camphor () is a waxy, colorless solid with a strong aroma. It is classified as a terpenoid and a cyclic ketone. It is found in the wood of the camphor laurel ('' Cinnamomum camphora''), a large evergreen tree found in East Asia; and in the kapur tree ( ''Dryobalanops'' sp.), a tall timber tree from South East Asia. It also occurs in some other related trees in the laurel family, notably '' Ocotea usambarensis''. Rosemary leaves (''Rosmarinus officinalis'') contain 0.05 to 0.5% camphor, while camphorweed (''Heterotheca'') contains some 5%. A major source of camphor in Asia is camphor basil (the parent of African blue basil). Camphor can also be synthetically produced from oil of turpentine. The compound is chiral, existing in two possible enantiomers as shown in the structural diagrams. The structure on the left is the naturally occurring (+)-camphor ((1''R'',4''R'')-bornan-2-one), while its mirror image shown on the right is the (−)-camphor ((1''S'',4''S'')-bornan-2-one). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ointments
A topical medication is a medication that is applied to a particular place on or in the body. Most often topical medication means application to body surfaces such as the skin or mucous membranes to treat ailments via a large range of classes including creams, foams, gels, lotions, and ointments. Many topical medications are epicutaneous, meaning that they are applied directly to the skin. Topical medications may also be inhalational, such as asthma medications, or applied to the surface of tissues other than the skin, such as eye drops applied to the conjunctiva, or ear drops placed in the ear, or medications applied to the surface of a tooth. The word ''topical'' derives from Greek τοπικός ''topikos'', "of a place". Justification Topical drug delivery is a route of administering drugs via the skin to provide topical therapeutic effects. As skin is one of the largest and most superficial organs in the human body, pharmacists utilise it to deliver various drugs. This ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analgesics
An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It is typically used to induce cooperation with a medical procedure. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and anesthetic effects. Analgesic choice is also determined by the type of pain: For neuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants. Various analgesics, such as many NSAIDs, are available over the counter in most countries, whereas various others are prescription drugs owing to t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liniment
Liniment (from la, linere, meaning "to anoint"), also called embrocation and heat rub, is a medicated topical preparation for application to the skin. Some liniments have viscosity similar to that of water; others are lotion or balm; still others are in transdermal patches, soft solid sticks, and sprays. Liniment usually is rubbed in to the skin, which the active ingredients penetrate. Liniments are typically sold to relieve pain and stiffness, such as from muscular aches and strains, and arthritis. These are typically formulated from alcohol, acetone, or similar quickly evaporating solvents and contain counterirritant aromatic chemical compounds, such as methyl salicilate, benzoin resin, menthol, and capsaicin. They produce a feeling of warmth within the muscle of the area they are applied to, typically acting as rubefacients via a counterirritant effect. Methyl salicylate, which is the analgesic ingredient in some heat rubs, can be toxic if used to excess. Heating pads are als ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Triethanolamine
Triethanolamine, or TEA is a viscous organic compound that is both a tertiary amine and a triol. A triol is a molecule with three alcohol groups. Approximately 150,000 tonnes were produced in 1999. It is a colourless compound although samples may appear yellow because of impurities. Production Triethanolamine is produced from the reaction of ethylene oxide with aqueous ammonia, also produced are ethanolamine and diethanolamine. The ratio of the products can be controlled by changing the stoichiometry of the reactants. : Applications Triethanolamine is used primarily in making surfactants, such as for emulsifier. It is a common ingredient in formulations used for both industrial and consumer products. The triethanolamine neutralizes fatty acids, adjusts and pH buffer, buffers the pH, and solubilizes oils and other ingredients that are not completely Solubility, soluble in water. Triethanolammonium salts in some cases are more soluble than salts of alkali metals that might be us ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Capsaicin
Capsaicin (8-methyl-''N''-vanillyl-6-nonenamide) ( or ) is an active component of chili peppers, which are plants belonging to the genus ''Capsicum''. It is a chemical irritant for mammals, including humans, and produces a sensation of burning in any tissue with which it comes into contact. Capsaicin and several related alkaloids are called capsaicinoids and are produced as secondary metabolites by chili peppers, probably as deterrents against certain mammals and fungi.What Made Chili Peppers So Spicy? Talk of the Nation, 15 August 2008. Pure capsaicin is a , colorless, highly |
Methyl Salicylate
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula C8H8O3. It is the methyl ester of salicylic acid. It is a colorless, viscous liquid with a sweet, fruity odor reminiscent of root beer, but often associatively called "minty", as it is an ingredient in mint candies. It is produced by many species of plants, particularly wintergreens. It is also produced synthetically, used as a fragrance and as a flavoring agent. Biosynthesis and occurrence Methyl salicylate was first isolated (from the plant ''Gaultheria procumbens'') in 1843 by the French chemist Auguste André Thomas Cahours (1813–1891), who identified it as an ester of salicylic acid and methanol. The biosynthesis of methyl salicylate arises via the hydroxylation of benzoic acid by a cytochrome P450 followed by methylation by a methylase enzyme. Methyl salicylate as a plant metabolite Many plants produce methyl salicylate in small quantities. Methyl salicylate levels are o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Menthol
Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints. It is a waxy, clear or white crystalline substance, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1''R'',2''S'',5''R'') configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. Menthol also acts as a weak κ-opioid receptor agonist. Structure Natural menthol exists as one pure stereoisomer, nearly always the (1''R'',2''S'',5''R'') form (bottom left corner of the diagram below). The eight possible stereoisomers are: : In the natural compound, the isopropyl group is in the ''trans'' orientation to both the methyl and hydroxyl groups. Thus, it can be drawn in any of the ways shown: : The (+)- and (−)-enantiomers of menthol are the most stable among ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Eucalyptus Oil
Eucalyptus oil is the generic name for distilled oil from the leaf of ''Eucalyptus'', a genus of the plant family Myrtaceae native to Australia and cultivated worldwide. Eucalyptus oil has a history of wide application, as a pharmaceutical, antiseptic, repellent, flavouring, fragrance and industrial uses. The leaves of selected ''Eucalyptus'' species are steam distilled to extract eucalyptus oil. Types and production Eucalyptus oils in the trade are categorized into three broad types according to their composition and main end-use: medicinal, perfumery and industrial. The most prevalent is the standard cineole-based "oil of eucalyptus", a colourless mobile liquid (yellow with age) with a penetrating, camphoraceous, woody-sweet scent. China produces about 75% of the world trade, but most of this is derived from the cineole fractions of camphor laurel rather than being true eucalyptus oil. Significant producers of true eucalyptus include South Africa, Portugal, Spain, Brazil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anticoagulant
Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals. Some anticoagulants are used in medical equipment, such as sample tubes, blood transfusion bags, heart–lung machines, and dialysis equipment. One of the first anticoagulants, warfarin, was initially approved as a rodenticide. Anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood coagulation. Specifically, antiplatelet drugs inhibit platelet agg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Church & Dwight
Church & Dwight is an American consumer goods company focusing on personal care, household products, and specialty products. The company was founded in 1846 and is headquartered in Ewing, New Jersey. It is the parent company of well-known brands such as Arm & Hammer, Trojan, OxiClean, and First Response. In 2021, Church & Dwight reported annual revenue of $3.6 billion. The company's products and services include a wide range of consumer goods, including laundry detergent, air fresheners, baking soda, condoms, pregnancy tests, and oral hygiene products. History The company was founded in 1847 to unify two companies created by John Dwight of Massachusetts and his brother-in-law, Austin Church of Connecticut. Their partnership had begun in 1846 with the two founders selling sodium bicarbonate (also known as baking soda) that they refined in Dwight's kitchen. The Arm & Hammer name and logo, which dates back to the 1860s, is often incorrectly claimed to have originated with tycoon ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
