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Rubidium-82
Rubidium-82 (82Rb) is a radioactive isotope of rubidium. 82Rb is widely used in myocardial perfusion imaging. This isotope undergoes rapid uptake by myocardiocytes, which makes it a valuable tool for identifying myocardial ischemia in Positron Emission Tomography (PET) imaging. 82Rb is used in the pharmaceutical industry and is marketed as Rubidium-82 chloride under the trade names RUBY-FILL and CardioGen-82. History In 1953, it was discovered that rubidium carried a biological activity that was comparable to potassium. In 1959, preclinical trials showed in dogs that myocardial uptake of this radionuclide was directly proportional to myocardial blood flow. In 1979, Yano et al. compared several ion-exchange columns to be used in an automated 82Sr/82Rb generator for clinical testing. Around 1980, pre-clinical trials began using 82Rb in PET. In 1982, Selwyn et al. examined the relation between myocardial perfusion and rubidium-82 uptake during acute ischemia in six dogs after coronar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Positron Emission Tomography
Positron emission tomography (PET) is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in Metabolism, metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging purposes, depending on the target process within the body. For example, 18F-FDG, -FDG is commonly used to detect cancer, Sodium fluoride#Medical imaging, NaF is widely used for detecting bone formation, and Isotopes of oxygen#Oxygen-15, oxygen-15 is sometimes used to measure blood flow. PET is a common medical imaging, imaging technique, a Scintigraphy#Process, medical scintillography technique used in nuclear medicine. A radiopharmaceutical, radiopharmaceutical — a radioisotope attached to a drug — is injected into the body as a radioactive tracer, tracer. When the radiopharmaceutical undergoes beta plus decay, a positron is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rubidium-82 Chloride
Rubidium-82 chloride is a form of rubidium chloride containing a radioactive isotope of rubidium. It is marketed under the brand name Cardiogen-82 by Bracco Diagnostics for use in Myocardial perfusion imaging. It is rapidly taken up by heart muscle cells, and therefore can be used to identify regions of heart muscle that are receiving poor blood flow in a technique called PET perfusion imaging. The half-life of the rubidium-82 Rubidium-82 (82Rb) is a radioactive isotope of rubidium. 82Rb is widely used in myocardial perfusion imaging. This isotope undergoes rapid uptake by myocardiocytes, which makes it a valuable tool for identifying myocardial ischemia in Positron E ... is only 1.27 minutes; it is normally produced at the place of use by rubidium generators. References Further reading * (Note: only about 1/2 page on Rb-generator) * * Rubidium compounds Chlorides Metal halides Alkali metal chlorides Radiopharmaceuticals {{Pharma-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rubidium
Rubidium is the chemical element with the symbol Rb and atomic number 37. It is a very soft, whitish-grey solid in the alkali metal group, similar to potassium and caesium. Rubidium is the first alkali metal in the group to have a density higher than water. On Earth, natural rubidium comprises two isotopes: 72% is a stable isotope 85Rb, and 28% is slightly radioactive 87Rb, with a half-life of 48.8 billion years—more than three times as long as the estimated age of the universe. German chemists Robert Bunsen and Gustav Kirchhoff discovered rubidium in 1861 by the newly developed technique, flame spectroscopy. The name comes from the Latin word , meaning deep red, the color of its emission spectrum. Rubidium's compounds have various chemical and electronic applications. Rubidium metal is easily vaporized and has a convenient spectral absorption range, making it a frequent target for laser manipulation of atoms. Rubidium is not a known nutrient for any living organisms. However, r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Medicine
Nuclear medicine or nucleology is a medical specialty involving the application of radioactive substances in the diagnosis and treatment of disease. Nuclear imaging, in a sense, is "radiology done inside out" because it records radiation emitting from within the body rather than radiation that is generated by external sources like X-rays. In addition, nuclear medicine scans differ from radiology, as the emphasis is not on imaging anatomy, but on the function. For such reason, it is called a physiological imaging modality. Single photon emission computed tomography (SPECT) and positron emission tomography (PET) scans are the two most common imaging modalities in nuclear medicine. Diagnostic medical imaging Diagnostic In nuclear medicine imaging, radiopharmaceuticals are taken internally, for example, through inhalation, intravenously or orally. Then, external detectors (gamma cameras) capture and form images from the radiation emitted by the radiopharmaceuticals. This process ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myocardial Infarction
A myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to the coronary artery of the heart, causing damage to the heart muscle. The most common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck or jaw. Often it occurs in the center or left side of the chest and lasts for more than a few minutes. The discomfort may occasionally feel like heartburn. Other symptoms may include shortness of breath, nausea, feeling faint, a cold sweat or feeling tired. About 30% of people have atypical symptoms. Women more often present without chest pain and instead have neck pain, arm pain or feel tired. Among those over 75 years old, about 5% have had an MI with little or no history of symptoms. An MI may cause heart failure, an irregular heartbeat, cardiogenic shock or cardiac arrest. Most MIs occur due to coronary artery disease. Risk factors include high blood pressure, smoking, diabetes, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myocardial Perfusion Imaging
Myocardial perfusion imaging or scanning (also referred to as MPI or MPS) is a nuclear medicine procedure that illustrates the function of the heart muscle (myocardium). It evaluates many heart conditions, such as coronary artery disease (CAD), hypertrophic cardiomyopathy and heart wall motion abnormalities. It can also detect regions of myocardial infarction by showing areas of decreased resting perfusion. The function of the myocardium is also evaluated by calculating the left ventricular ejection fraction (LVEF) of the heart. This scan is done in conjunction with a cardiac stress test. The diagnostic information is generated by provoking controlled regional ischemia in the heart with variable perfusion. Planar techniques, such as conventional scintigraphy, are rarely used. Rather, single-photon emission computed tomography (SPECT) is more common in the US. With multihead SPECT systems, imaging can often be completed in less than 10 minutes. With SPECT, inferior and posterior a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Beta Plus Decay
Positron emission, beta plus decay, or β+ decay is a subtype of radioactive decay called beta decay, in which a proton inside a radionuclide nucleus is converted into a neutron while releasing a positron and an electron neutrino (). Positron emission is mediated by the weak force. The positron is a type of beta particle (β+), the other beta particle being the electron (β−) emitted from the β− decay of a nucleus. An example of positron emission (β+ decay) is shown with magnesium-23 decaying into sodium-23: : → + + Because positron emission decreases proton number relative to neutron number, positron decay happens typically in large "proton-rich" radionuclides. Positron decay results in nuclear transmutation, changing an atom of one chemical element into an atom of an element with an atomic number that is less by one unit. Positron emission occurs only very rarely naturally on earth, when induced by a cosmic ray or from one in a hundred thousand decays of potassium-4 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Strontium-82
The alkaline earth metal strontium (38Sr) has four stable, naturally occurring isotopes: 84Sr (0.56%), 86Sr (9.86%), 87Sr (7.0%) and 88Sr (82.58%). Its standard atomic weight is 87.62(1). Only 87Sr is radiogenic; it is produced by decay from the radioactive alkali metal 87rubidium, Rb, which has a half-life of 4.88 × 1010 years (i.e. more than three times longer than the current age of the universe). Thus, there are two sources of 87Sr in any material: primordial, formed during nucleosynthesis along with 84Sr, 86Sr and 88Sr; and that formed by radioactive decay of 87Rb. The ratio 87Sr/86Sr is the parameter typically reported in geology, geologic investigations; ratios in minerals and rock (geology), rocks have values ranging from about 0.7 to greater than 4.0 (see rubidium–strontium dating). Because strontium has an electron configuration similar to that of calcium, it readily substitutes for calcium in minerals. In addition to the four stable isotopes, thirty-two unstable iso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stannic Oxide
Tin(IV) oxide, also known as stannic oxide, is the inorganic compound with the formula SnO2. The mineral form of SnO2 is called cassiterite, and this is the main ore of tin. With many other names, this oxide of tin is an important material in tin chemistry. It is a colourless, diamagnetic, amphoteric solid. Structure Tin(IV) oxide crystallises with the rutile structure. As such the tin atoms are six coordinate and the oxygen atoms three coordinate. SnO2 is usually regarded as an oxygen-deficient n-type semiconductor. Hydrous forms of SnO2 have been described as stannic acid. Such materials appear to be hydrated particles of SnO2 where the composition reflects the particle size. Preparation Tin(IV) oxide occurs naturally. Synthetic tin(IV) oxide is produced by burning tin metal in air. Annual production is in the range of 10 kilotons. SnO2 is reduced industrially to the metal with carbon in a reverberatory furnace at 1200–1300 °C. Amphoterism Although SnO2 is insoluble ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bracco Diagnostics
The Bracco Group is an Italian multinational active in the healthcare sector with more than 3,300 employees worldwide, which operates in a variety of business areas. *Diagnostic imaging, with products for X-ray imaging, including computed tomography (CT), magnetic resonance imaging (MRI), ultrasound and nuclear medicine. * Contrast-agent injection systems and advanced medical devices. *Prescription and over-the-counter pharmaceuticals, supplements, medical and cosmetic devices developed and distributed in Italy. *Healthcare, prevention, diagnosis and rehabilitation services through the CDI - Centro Diagnostico Italiano. Bracco has consolidated revenues of more than 1.1 billion euro, of which 75% from international sales. The Group is present in 100 countries and invests approximately 10% of its core diagnostic imaging revenues in research and innovation. In Italy Bracco is also a brand associated with a number of historic pharmaceutical products such as Cebion, Xamamina, Euclo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Coronary Artery Disease
Coronary artery disease (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), myocardial ischemia, or simply heart disease, involves the reduction of blood flow to the heart muscle due to build-up of atherosclerotic plaque An atheroma, or atheromatous plaque, is an abnormal and reversible accumulation of material in the inner layer of an arterial wall. The material consists of mostly macrophage cells, or debris, containing lipids, calcium and a variable amount ... in the arteries of the heart. It is the most common of the cardiovascular diseases. Types include stable angina, unstable angina, myocardial infarction, and sudden cardiac death. A common symptom is chest pain or discomfort which may travel into the shoulder, arm, back, neck, or jaw. Occasionally it may feel like heartburn. Usually symptoms occur with exercise or emotional Stress (psychological), stress, last less than a few minutes, and improve with rest. Shortness of breath may also o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myocardium
Cardiac muscle (also called heart muscle, myocardium, cardiomyocytes and cardiac myocytes) is one of three types of vertebrate muscle tissues, with the other two being skeletal muscle and smooth muscle. It is an involuntary, striated muscle that constitutes the main tissue of the wall of the heart. The cardiac muscle (myocardium) forms a thick middle layer between the outer layer of the heart wall (the pericardium) and the inner layer (the endocardium), with blood supplied via the coronary circulation. It is composed of individual cardiac muscle cells joined by intercalated discs, and encased by collagen fibers and other substances that form the extracellular matrix. Cardiac muscle contracts in a similar manner to skeletal muscle, although with some important differences. Electrical stimulation in the form of a cardiac action potential triggers the release of calcium from the cell's internal calcium store, the sarcoplasmic reticulum. The rise in calcium causes the cell's m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
