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Rs7341475
In genetics, rs7341475 is a single nucleotide polymorphism (SNP) in the '' RELN'' gene that codes the reelin protein. The gene RELN is mapped to human chromosome 7 (7q22.1). The SNP rs7341475 is located in the fourth intron of RELN. The gene RELN has many more SNPs among its 65 exons and 64 introns, — even in intron 4 there are tens of SNPs. The SNP has been investigated for a possible link to schizophrenia. A 2008 genome-wide association study pointed to that a variant of the SNP could elevate the risk for schizophrenia among women. A 2015 publication reported a meta-analysis A meta-analysis is a statistical analysis that combines the results of multiple scientific studies. Meta-analyses can be performed when there are multiple scientific studies addressing the same question, with each individual study reporting me ... across five studies concluding a slight effect of the SNP. References {{Reflist SNPs on chromosome 7 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reelin
Reelin, encoded by the ''RELN'' gene, is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates synaptic plasticity by enhancing the induction and maintenance of long-term potentiation. It also stimulates dendrite and dendritic spine development and regulates the continuing migration of neuroblasts generated in adult neurogenesis sites like the subventricular and subgranular zones. It is found not only in the brain but also in the liver, thyroid gland, adrenal gland, Fallopian tube, breast and in comparatively lower levels across a range of anatomical regions. Reelin has been suggested to be implicated in pathogenesis of several brain diseases. The expression of the protein has been found to be significantly lower in schizophrenia and psycho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genetics
Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kenneth S
Kenneth is an English given name and surname. The name is an Anglicised form of two entirely different Gaelic personal names: ''Cainnech'' and '' Cináed''. The modern Gaelic form of ''Cainnech'' is ''Coinneach''; the name was derived from a byname meaning "handsome", "comely". A short form of ''Kenneth'' is '' Ken''. Etymology The second part of the name ''Cinaed'' is derived either from the Celtic ''*aidhu'', meaning "fire", or else Brittonic ''jʉ:ð'' meaning "lord". People :''(see also Ken (name) and Kenny)'' Places In the United States: * Kenneth, Indiana * Kenneth, Minnesota * Kenneth City, Florida In Scotland: * Inch Kenneth, an island off the west coast of the Isle of Mull Other * "What's the Frequency, Kenneth?", a song by R.E.M. * Hurricane Kenneth * Cyclone Kenneth Intense Tropical Cyclone Kenneth was the strongest tropical cyclone to make landfall in Mozambique since modern records began. The cyclone also caused significant damage in the Comoro Islands and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PLOS Genetics
''PLOS Genetics'' is a peer-reviewed open access scientific journal established in 2005 and published by the Public Library of Science. The founding editor-in-chief was Wayne N. Frankel (Columbia University Medical Center). The current editors-in-chief are Gregory S. Barsh ( HudsonAlpha Institute of Biotechnology and Stanford University School of Medicine) and Gregory P. Copenhaver (The University of North Carolina at Chapel Hill). The journal covers research on all aspects of genetics and genomics. Abstracting and indexing The journal is abstracted and indexed in: According to the ''Journal Citation Reports'', the journal has a 2020 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as ... of 5.917. Research Prize Since its tenth year of publication, the journal annuall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ariel Darvasi
Ariel Darvasi ( he, אריאל דרבסי; February 17, 1962 – September 28, 2018) was a Professor of Genetics and former Head of Life Sciences Studies and Vice Dean of the Faculty of Sciences at The Hebrew University of Jerusalem. Biography Ariel Darvasi was born in Santiago de Chile. At the age of 10 his family moved to Israel and settled in Jerusalem. Darvasi obtained his BSc degree (with honors) in Biology and Computer Science in 1988, and his MSc degree (with honors) and his PhD degree (summa cum laude) in Genetics from The Hebrew University of Jerusalem, under the supervision of Moshe Soller. Subsequently, he conducted post-doctoral research at The University of Paris. As a young scientist he won the Landau Prize. in 1999, one of Israel's highest honors for sciences. Between 2006 and 2009 Darvasi was Head of Genetics Studies at the Hebrew University of Jerusalem, and then Head of the entire Life Sciences curriculum until 2012. From 2012 to 2016 Darvasi served as Vice ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jonathan Flint (scientist)
Jonathan Flint is a British behavior geneticist and Professor in Residence in the Department of Psychiatry and Biobehavioral Sciences at the David Geffen School of Medicine at UCLA. He is also a senior scientist in the Center for Neurobehavioral Genetics at UCLA's Semel Institute for Neuroscience and Human Behavior. Career and research Flint is known for his research on the genetics of complex traits in mice and major depressive disorder in humans. In 2015, he and his colleagues published a study that was the first to link two genetic variants to this disorder. In 2016, he left his post as director of the Psychiatric Genetics Group at the University of Oxford's Wellcome Trust Centre for Human Genetics to join UCLA. Upon doing so, he became one of four directors of UCLA's Depression Grand Challenge, which aims to conduct a study of 100,000 people to search for genetic risk factors for depression. This study is intended to be the largest genetic study of a disorder ever conducted ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Daniel R
Daniel is a masculine given name and a surname of Hebrew origin. It means "God is my judge"Hanks, Hardcastle and Hodges, ''Oxford Dictionary of First Names'', Oxford University Press, 2nd edition, , p. 68. (cf. Gabriel—"God is my strength"), and derives from two early biblical figures, primary among them Daniel from the Book of Daniel. It is a common given name for males, and is also used as a surname. It is also the basis for various derived given names and surnames. Background The name evolved into over 100 different spellings in countries around the world. Nicknames (Dan, Danny) are common in both English and Hebrew; "Dan" may also be a complete given name rather than a nickname. The name "Daniil" (Даниил) is common in Russia. Feminine versions (Danielle, Danièle, Daniela, Daniella, Dani, Danitza) are prevalent as well. It has been particularly well-used in Ireland. The Dutch names "Daan" and "Daniël" are also variations of Daniel. A related surname developed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael J
Michael may refer to: People * Michael (given name), a given name * Michael (surname), including a list of people with the surname Michael Given name "Michael" * Michael (archangel), ''first'' of God's archangels in the Jewish, Christian and Islamic religions * Michael (bishop elect), English 13th-century Bishop of Hereford elect * Michael (Khoroshy) (1885–1977), cleric of the Ukrainian Orthodox Church of Canada * Michael Donnellan (1915–1985), Irish-born London fashion designer, often referred to simply as "Michael" * Michael (footballer, born 1982), Brazilian footballer * Michael (footballer, born 1983), Brazilian footballer * Michael (footballer, born 1993), Brazilian footballer * Michael (footballer, born February 1996), Brazilian footballer * Michael (footballer, born March 1996), Brazilian footballer * Michael (footballer, born 1999), Brazilian footballer Rulers =Byzantine emperors= *Michael I Rangabe (d. 844), married the daughter of Emperor Nikephoros I * M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Michael C
Michael may refer to: People * Michael (given name), a given name * Michael (surname), including a list of people with the surname Michael Given name "Michael" * Michael (archangel), ''first'' of God's archangels in the Jewish, Christian and Islamic religions * Michael (bishop elect), English 13th-century Bishop of Hereford elect * Michael (Khoroshy) (1885–1977), cleric of the Ukrainian Orthodox Church of Canada * Michael Donnellan (1915–1985), Irish-born London fashion designer, often referred to simply as "Michael" * Michael (footballer, born 1982), Brazilian footballer * Michael (footballer, born 1983), Brazilian footballer * Michael (footballer, born 1993), Brazilian footballer * Michael (footballer, born February 1996), Brazilian footballer * Michael (footballer, born March 1996), Brazilian footballer * Michael (footballer, born 1999), Brazilian footballer Rulers =Byzantine emperors= *Michael I Rangabe (d. 844), married the daughter of Emperor Nikephoros I * Mi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tao Li
Tao Li (; born 10 January 1990) is a Chinese-born Singaporean competitive swimmer who specializes in the backstroke and butterfly. Tao has represented Singapore at the Southeast Asian Games (SEA Games), the Asian Games, World Championship, Commonwealth Games and Olympics. She holds several national records and is the only female Singapore swimmer who qualified for an Olympic Final. At the 2005 SEA Games in the Philippines, at just 15, she won 4 golds and a bronze. She reached the finals of the women's 50 metres, 100 metres and 200 metres butterfly events at the 2006 Commonwealth Games in Melbourne though she did not win any medal. In December 2006, Tao won gold at the 50 metres butterfly in Doha's 2006 Asian Games, beating China's multi-gold medallist Xu Yanwei and breaking her own national record in the process. She was Singapore's most medalled athlete at the 2007 SEA Games in Nakhon Ratchasima (Korat), Thailand, winning four gold medals. Earlier in the ye ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sam X
Sam, SAM or variants may refer to: Places * Sam, Benin * Sam, Boulkiemdé, Burkina Faso * Sam, Bourzanga, Burkina Faso * Sam, Kongoussi, Burkina Faso * Sam, Iran * Sam, Teton County, Idaho, United States, a populated place People and fictional characters * Sam (given name), a list of people and fictional characters with the given name or nickname * Sam (surname), a list of people with the surname ** Cen (surname) (岑), romanized "Sam" in Cantonese ** Shen (surname) (沈), often romanized "Sam" in Cantonese and other languages Religious or legendary figures * Sam (Book of Mormon), elder brother of Nephi * Sām, a Persian mythical folk hero * Sam Ziwa, an uthra (angel or celestial being) in Mandaeism Animals * Sam (army dog) (died 2000) * Sam (horse) (b 1815), British Thoroughbred * Sam (koala) (died 2009), rescued after 2009 bush fires in Victoria, Australia * Sam (orangutan), in the movie ''Dunston Checks In'' * Sam (ugly dog) (1990–2005), voted the world's ugliest dog i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
