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Ariel Darvasi ( he, אריאל דרבסי; February 17, 1962 – September 28, 2018) was a Professor of Genetics and former Head of Life Sciences Studies and Vice Dean of the Faculty of Sciences at
The Hebrew University of Jerusalem The Hebrew University of Jerusalem (HUJI; he, הַאוּנִיבֶרְסִיטָה הַעִבְרִית בִּירוּשָׁלַיִם) is a public research university based in Jerusalem, Israel. Co-founded by Albert Einstein and Dr. Chaim Weiz ...
.


Biography

Ariel Darvasi was born in
Santiago de Chile Santiago (, ; ), also known as Santiago de Chile, is the capital and largest city of Chile as well as one of the largest cities in the Americas. It is the center of Chile's most densely populated region, the Santiago Metropolitan Region, whose ...
. At the age of 10 his family moved to
Israel Israel (; he, יִשְׂרָאֵל, ; ar, إِسْرَائِيل, ), officially the State of Israel ( he, מְדִינַת יִשְׂרָאֵל, label=none, translit=Medīnat Yīsrāʾēl; ), is a country in Western Asia. It is situated ...
and settled in
Jerusalem Jerusalem (; he, יְרוּשָׁלַיִם ; ar, القُدس ) (combining the Biblical and common usage Arabic names); grc, Ἱερουσαλήμ/Ἰεροσόλυμα, Hierousalḗm/Hierosóluma; hy, Երուսաղեմ, Erusałēm. i ...
. Darvasi obtained his
BSc A Bachelor of Science (BS, BSc, SB, or ScB; from the Latin ') is a bachelor's degree awarded for programs that generally last three to five years. The first university to admit a student to the degree of Bachelor of Science was the University of ...
degree (with honors) in
Biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary i ...
and
Computer Science Computer science is the study of computation, automation, and information. Computer science spans theoretical disciplines (such as algorithms, theory of computation, information theory, and automation) to Applied science, practical discipli ...
in 1988, and his MSc degree (with honors) and his PhD degree (summa cum laude) in
Genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar wor ...
from The Hebrew University of Jerusalem, under the supervision of Moshe Soller. Subsequently, he conducted post-doctoral research at The University of Paris. As a young scientist he won the Landau Prize. in 1999, one of Israel's highest honors for sciences. Between 2006 and 2009 Darvasi was Head of Genetics Studies at the Hebrew University of Jerusalem, and then Head of the entire Life Sciences curriculum until 2012. From 2012 to 2016 Darvasi served as Vice Dean of the Faculty of Sciences of The Hebrew University.


Academic career

Darvasi published over 100 scientific articles. His research can be divided into 5 major themes: * The theoretical basis of
gene mapping Gene mapping describes the methods used to identify the locus of a gene and the distances between genes. Gene mapping can also describe the distances between different sites within a gene. The essence of all genome mapping is to place a co ...
. The early studies of Darvasi were aimed to develop experimental and computational strategies for the identification of genes affecting
complex traits Complex traits, also known as quantitative traits, are traits that do not behave according to simple Mendelian inheritance laws. More specifically, their inheritance cannot be explained by the genetic segregation of a single gene. Such traits show ...
. Several of the strategies developed by Darvasi are widely used by many geneticists all over the world till this day. * The genetic basis of
chronic pain Chronic pain is classified as pain that lasts longer than three to six months. In medicine, the distinction between Acute (medicine), acute and Chronic condition, chronic pain is sometimes determined by the amount of time since onset. Two commonly ...
. Darvasi, in collaboration with Marshall Devor, studied the genetic basis of chronic pain. Using a mouse model they identified a novel gene affecting predisposition to chronic pain. Their findings were shown to affect chronic pain in humans as well. * The Genetic basis of
schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...
. Adopting experimental strategies he developed, Darvasi discovered one of the strongest genetic associations at the time (published in the
American Journal of Human Genetics The ''American Journal of Human Genetics'' is a monthly peer-reviewed scientific journal in the field of human genetics. It was established in 1948 by the American Society of Human Genetics and covers all aspects of heredity in humans, including t ...
, 2002) between a gene and predisposition to schizophrenia. More recently, he was part of a large international consortium that discovered over 100 genes affecting schizophrenia (published in
Nature Nature, in the broadest sense, is the physics, physical world or universe. "Nature" can refer to the phenomenon, phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. ...
2014). * DNA
Forensics Forensic science, also known as criminalistics, is the application of science to criminal and civil laws, mainly—on the criminal side—during criminal investigation, as governed by the legal standards of admissible evidence and crimina ...
. Darvasi developed experimental and computational strategies in DNA forensics. He holds a US patent for the identification of a suspect's DNA in a scene of crime where a mixture of DNA from several individuals is present. * The evolutionary basis of
human behavior Human behavior is the potential and expressed capacity ( mentally, physically, and socially) of human individuals or groups to respond to internal and external stimuli throughout their life. Kagan, Jerome, Marc H. Bornstein, and Richard M. L ...
. Darvasi's current field of research is the evolutionary basis of human behavior – he teaches a unique course in this topic at The Hebrew University. His interest is in mind mechanisms that drive evolutionary beneficial behaviors. In this context he developed the "Boss Theory", an evolutionary driven theory that aims to describe a conceptual framework for
conscious Consciousness, at its simplest, is sentience and awareness of internal and external existence. However, the lack of definitions has led to millennia of analyses, explanations and debates by philosophers, theologians, linguisticians, and scien ...
and
unconscious mind The unconscious mind (or the unconscious) consists of the processes in the mind which occur automatically and are not available to introspection and include thought processes, memories, interests, and motivations. Even though these processes exis ...
processes.


Business career

Along with teaching and research, Darvasi founded IDgene, a biotechnology company that studied the genetic basis of common diseases (such as diabetes, asthma, cancer, schizophrenia and many others) as a mean to discover novel therapies. In 1999 the company raised over US$15 million from various venture capital firms, including world leaders such as
Apax Partners Apax Partners LLP is a British private equity firm, headquartered in London, England. The company also operates out of six other offices in New York, Hong Kong, Mumbai, Tel Aviv, Munich and Shanghai. As of December 2017, the firm, including its ...
. At its peak, IDgene employed 50 employees in its Jerusalem central facilities. In 2004 the company ceased formal operations and all intellectual property was transferred to the Hebrew University of Jerusalem. Over the years, Darvasi also co-founded several other biotechnology companies in Israel and the US. In March 2017, Darvasi was under investigation by the SEC (Security Exchange Commission) for suspicion of alleged insider trading of
Mobileye Mobileye Global Inc. is a company developing autonomous driving technologies and advanced driver-assistance systems (ADAS) including cameras, computer chips and software. Mobileye was acquired by Intel in 2017 and went public again in 2022. Mobi ...
shares. The case was settled with a fine and no conviction of any wrongdoing


References

{{DEFAULTSORT:Darvasi, Ariel 1962 births Living people People from Santiago Chilean emigrants to Israel Hebrew University of Jerusalem alumni Hebrew University of Jerusalem faculty Israeli geneticists