Rotterdam Study
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Rotterdam Study
The Rotterdam Study or ERGO ( Dutch: ''Erasmus Rotterdam Gezondheid Onderzoek'') is a prospective, population-based cohort study. The aim of the Rotterdam Study is to investigate etiology, preclinical phase, prognosis and potential intervention targets of chronic diseases in mid- and late-life. The study focuses on several diseases, such as cardiovascular, neurological, ophthalmological, hepatic, endocrine, dermatological, otolaryngological, respiratory, locomotor and psychiatric diseases. History Researchers of the department of Epidemiology & Biostatistics at the Erasmus Medical Center led by Professor Albert Hofman, conceptualized the study in the mid-1980s as response to increase in the proportion of elderly persons in the population who are also living with chronic diseases. The study was established in 1990 in the Ommoord district of Rotterdam, The Netherlands. On March 26, 1991, Princess Juliana opened the ERGO research center at Briandplaats, Rotterdam. Cohort ...
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Prospective Cohort Study
A prospective cohort study is a longitudinal cohort study that follows over time a group of similar individuals (cohorts) who differ with respect to certain factors under study, to determine how these factors affect rates of a certain outcome. For example, one might follow a cohort of middle-aged truck drivers who vary in terms of smoking habits, to test the hypothesis that the 20-year incidence rate of lung cancer will be highest among heavy smokers, followed by moderate smokers, and then nonsmokers. The prospective study is important for research on the etiology of diseases and disorders. The distinguishing feature of a prospective cohort study is that at the time that the investigators begin enrolling subjects and collecting baseline exposure information, none of the subjects have developed any of the outcomes of interest. After baseline information is collected, subjects in a prospective cohort study are then followed "longitudinally," i.e. over a period of time, usually for ...
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Respiratory System
The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies greatly, depending on the size of the organism, the environment in which it lives and its evolutionary history. In land animals the respiratory surface is internalized as linings of the lungs. Gas exchange in the lungs occurs in millions of small air sacs; in mammals and reptiles these are called alveoli, and in birds they are known as atria. These microscopic air sacs have a very rich blood supply, thus bringing the air into close contact with the blood. These air sacs communicate with the external environment via a system of airways, or hollow tubes, of which the largest is the trachea, which branches in the middle of the chest into the two main bronchi. These enter the lungs where they branch into progressively narrower secondary and tert ...
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ICD-10
ICD-10 is the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD), a medical classification list by the World Health Organization (WHO). It contains codes for diseases, signs and symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or diseases. Work on ICD-10 began in 1983, became endorsed by the Forty-third World Health Assembly in 1990, and was first used by member states in 1994. It was replaced by ICD-11 on January 1, 2022. While WHO manages and publishes the base version of the ICD, several member states have modified it to better suit their needs. In the base classification, the code set allows for more than 14,000 different codes and permits the tracking of many new diagnoses compared to the preceding ICD-9. Through the use of optional sub-classifications, ICD-10 allows for specificity regarding the cause, manifestation, location, severity, and type of injury or disease. The ad ...
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Juliana Of The Netherlands
Juliana (; Juliana Louise Emma Marie Wilhelmina; 30 April 1909 – 20 March 2004) was Queen of the Netherlands from 1948 until her abdication in 1980. Juliana was the only child of Queen Wilhelmina and Prince Henry of Mecklenburg-Schwerin. She received a private education and studied international law at the University of Leiden. In 1937, she married Prince Bernhard of Lippe-Biesterfeld with whom she had four daughters: Beatrix, Irene, Margriet, and Christina. During the German invasion of the Netherlands in the Second World War, the royal family was evacuated to the United Kingdom. Juliana then relocated to Canada with her children, while Wilhelmina and Bernhard remained in Britain. The royal family returned to the Netherlands after its liberation in 1945. Due to Wilhelmina's failing health, Juliana took over royal duties briefly in 1947 and 1948. In September 1948 Wilhelmina abdicated and Juliana ascended to the Dutch throne. Her reign saw the decolonization and independe ...
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Netherlands
) , anthem = ( en, "William of Nassau") , image_map = , map_caption = , subdivision_type = Sovereign state , subdivision_name = Kingdom of the Netherlands , established_title = Before independence , established_date = Spanish Netherlands , established_title2 = Act of Abjuration , established_date2 = 26 July 1581 , established_title3 = Peace of Münster , established_date3 = 30 January 1648 , established_title4 = Kingdom established , established_date4 = 16 March 1815 , established_title5 = Liberation Day (Netherlands), Liberation Day , established_date5 = 5 May 1945 , established_title6 = Charter for the Kingdom of the Netherlands, Kingdom Charter , established_date6 = 15 December 1954 , established_title7 = Dissolution of the Netherlands Antilles, Caribbean reorganisation , established_date7 = 10 October 2010 , official_languages = Dutch language, Dutch , languages_type = Regional languages , languages_sub = yes , languages = , languages2_type = Reco ...
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Rotterdam
Rotterdam ( , , , lit. ''The Dam on the River Rotte'') is the second largest city and municipality in the Netherlands. It is in the province of South Holland, part of the North Sea mouth of the Rhine–Meuse–Scheldt delta, via the ''"New Meuse"'' inland shipping channel, dug to connect to the Meuse first, but now to the Rhine instead. Rotterdam's history goes back to 1270, when a dam was constructed in the Rotte. In 1340, Rotterdam was granted city rights by William IV, Count of Holland. The Rotterdam–The Hague metropolitan area, with a population of approximately 2.7 million, is the 10th-largest in the European Union and the most populous in the country. A major logistic and economic centre, Rotterdam is Europe's largest seaport. In 2020, it had a population of 651,446 and is home to over 180 nationalities. Rotterdam is known for its university, riverside setting, lively cultural life, maritime heritage and modern architecture. The near-complete destruction ...
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Ommoord
Ommoord is a neighbourhood in the borough Prins Alexander, part of the municipality of Rotterdam, South Holland, the Netherlands. Ommoord is surrounded by the neighbourhoods Zevenkamp, Het Lage Land and Terbregge. It has around 25.000 inhabitants across 12.500 households. The river Rotte flows through the north of Ommoord. Neighbourhoods Ommoord has 15 neighbourhoods: Bloemenbuurt (Flower-neighbourhood), Bremmenbuurt (Broom), Distelbuurt (Thistle), Doornenbuurt (Thorn), Grasbuurt (Grass), Heidebuurt (heather), Bessenbuurt (Berry), Klaverbuurt (Clover), Kruidenbuurt (Herbs), Middengebied-West (Middle area-West), Middengebied-Centrum (Middle area-Center, Middengebied-Oost (Middle area-East), Mossenbuurt (Moss), Rozenbuurt (Rose) and the Varenbuurt (Fern). Public transport Two buslines extend into ''Ommoord'': 34 en 35. The Calandlijn line of the Rotterdam subway extends into ''Ommoord'' and has 4 stations in it: *Graskruid (both ''Ommoord'' and ''Nesselande'' branches) *Rom ...
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Erasmus MC
Erasmus University Medical Center (Erasmus MC or EMC) based in Rotterdam, Netherlands, affiliated with Erasmus University and home to its faculty of medicine, is the largest and one of the most authoritative scientific University Medical Centers in Europe. The hospital is the largest of the eight university medical centers in the Netherlands, both in terms of turnover and number of beds. The Erasmus MC ranks #1 of the top European institution in clinical medicine and #20 in the world according to the Times Higher Education rankings. Structure The hospital has three locations: * Erasmus MC – the main location. * Erasmus MC Sophia Children's Hospital, the pediatric hospital, closely connected to the main location by a raised glass hallway. * Erasmus MC Cancer Institute, specialized in oncology. Special units include: * Neurosurgery * Cardiothoracic surgery * Neonatal and pediatric surgery and intensive care * Pediatric oncology * Level I trauma center (including trauma helicopter ...
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Biostatistics
Biostatistics (also known as biometry) are the development and application of statistical methods to a wide range of topics in biology. It encompasses the design of biological experiments, the collection and analysis of data from those experiments and the interpretation of the results. History Biostatistics and genetics Biostatistical modeling forms an important part of numerous modern biological theories. Genetics studies, since its beginning, used statistical concepts to understand observed experimental results. Some genetics scientists even contributed with statistical advances with the development of methods and tools. Gregor Mendel started the genetics studies investigating genetics segregation patterns in families of peas and used statistics to explain the collected data. In the early 1900s, after the rediscovery of Mendel's Mendelian inheritance work, there were gaps in understanding between genetics and evolutionary Darwinism. Francis Galton tried to expand Mendel's ...
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Epidemiology
Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidence-based practice by identifying risk factors for disease and targets for preventive healthcare. Epidemiologists help with study design, collection, and statistical analysis of data, amend interpretation and dissemination of results (including peer review and occasional systematic review). Epidemiology has helped develop methodology used in clinical research, public health studies, and, to a lesser extent, basic research in the biological sciences. Major areas of epidemiological study include disease causation, transmission, outbreak investigation, disease surveillance, environmental epidemiology, forensic epidemiology, occupational epidemiology, screening, biomonitoring, and comparisons of treatment effects such as in clinical trials. ...
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Psychiatry
Psychiatry is the medical specialty devoted to the diagnosis, prevention, and treatment of mental disorders. These include various maladaptations related to mood, behaviour, cognition, and perceptions. See glossary of psychiatry. Initial psychiatric assessment of a person typically begins with a case history and mental status examination. Physical examinations and psychological tests may be conducted. On occasion, neuroimaging or other neurophysiological techniques are used. Mental disorders are often diagnosed in accordance with clinical concepts listed in diagnostic manuals such as the ''International Classification of Diseases'' (ICD), edited and used by the World Health Organization (WHO) and the widely used '' Diagnostic and Statistical Manual of Mental Disorders'' (DSM), published by the American Psychiatric Association (APA). The fifth edition of the DSM (DSM-5) was published in May 2013 which re-organized the larger categories of various diseases and expanded upon the p ...
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