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Robin Reed (biologist)
Robin Elizabeth Reed (August 1, 1956 – July 23, 2022) was an American professor of cell biology at the Harvard Medical School. Her research considered the molecular mechanisms that underpin neurodegenerative disease. Early life and education Reed was born on August 1, 1956, in Akron, Ohio, to Nancy Nobel Reed and Lawrence Andrew Reed. She was an equestrian, taking part in both dressage and show jumping. Reed was an undergraduate at Hiram College in Ohio, where she majored in biology. She joined Yale University as a technician, where she took advanced science courses to prepare herself for doctoral research there. For her PhD, she worked in the laboratory of Sidney Altman and was the first to clone and sequence the RNA gene. Altman acknowledged her contributions to science in his Nobel Prize lecture. Reed moved to Harvard University for postdoctoral research, where she started working on pre-RNA splicing with Tom Maniatis. Reed characterized the branchpoint sequence in mamm ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard University
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States and one of the most prestigious and highly ranked universities in the world. The university is composed of ten academic faculties plus Harvard Radcliffe Institute. The Faculty of Arts and Sciences offers study in a wide range of undergraduate and graduate academic disciplines, and other faculties offer only graduate degrees, including professional degrees. Harvard has three main campuses: the Cambridge campus centered on Harvard Yard; an adjoining campus immediately across Charles River in the Allston neighborhood of Boston; and the medical campus in Boston's Longwood Medical Area. Harvard's endowment is valued at $50.9 billion, making it the wealthiest academic institution in the world. Endowment inco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RNA-binding Protein FUS
RNA-binding protein FUS/TLS (FUused in Sarcoma/Translocated in LipoSarcoma), also known as heterogeneous nuclear ribonucleoprotein P2 is a protein that in humans is encoded by the ''FUS'' gene. Discovery FUS/TLS was initially identified as a fusion protein (FUS-CHOP) produced as a result of chromosomal translocations in human cancers, especially liposarcomas. In these instances, the promoter and N-terminal part of FUS/TLS is translocated to the C-terminal domain of various DNA-binding transcription factors (e.g. CHOP) conferring a strong transcriptional activation domain onto the fusion proteins. FUS/TLS was independently identified as the hnRNP P2 protein, a subunit of a complex involved in the maturation of pre-mRNA. Structure FUS/TLS is a member of the FET protein family that also includes the EWS protein, the TATA-binding protein TBP-associated factor TAFII68/TAF15, and the Drosophila cabeza/SARF protein. FUS/TLS, EWS and TAF15 have a similar structure, characteris ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Harvard Medical School Faculty
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher learning in the United States and one of the most prestigious and highly ranked universities in the world. The university is composed of ten academic faculties plus Harvard Radcliffe Institute. The Faculty of Arts and Sciences offers study in a wide range of undergraduate and graduate academic disciplines, and other faculties offer only graduate degrees, including professional degrees. Harvard has three main campuses: the Cambridge campus centered on Harvard Yard; an adjoining campus immediately across Charles River in the Allston neighborhood of Boston; and the medical campus in Boston's Longwood Medical Area. Harvard's endowment is valued at $50.9 billion, making it the wealthiest academic institution in the world. Endowment inco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hiram College Alumni
Hiram may refer to: People * Hiram (name) Places * Hiram, Georgia ** Hiram High School, Hiram, Georgia * Hiram, Maine * Hiram, Missouri * Hiram, Ohio ** Hiram College, a private liberal arts college located in Hiram, Ohio ***Hiram Terriers, the school's sports teams * Hiram, Texas * Hiram, West Virginia * Hiram Township, Cass County, Minnesota Other uses * ''Hiram'' (TV series), a TV drama series in the Philippines * Hiram's Highway, a road in Hong Kong * Hiram House, one of the first settlement houses in the United States * Hiram Masonic Lodge No. 7, a gothic revival building in Franklin, Tennessee; also the oldest masonic lodge in Tennessee * Operation Hiram Operation Hiram was a military operation conducted by the Israel Defense Forces (IDF) during the 1948 Arab-Israeli War. It was led by General Moshe Carmel, and aimed at capturing the Upper Galilee region from the Arab Liberation Army (ALA) forces ..., a three-day military operation in the Upper Galilee launched by the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Yale University Alumni
Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the world. It is a member of the Ivy League. Chartered by the Connecticut Colony, the Collegiate School was established in 1701 by clergy to educate Congregational ministers before moving to New Haven in 1716. Originally restricted to theology and sacred languages, the curriculum began to incorporate humanities and sciences by the time of the American Revolution. In the 19th century, the college expanded into graduate and professional instruction, awarding the first PhD in the United States in 1861 and organizing as a university in 1887. Yale's faculty and student populations grew after 1890 with rapid expansion of the physical campus and scientific research. Yale is organized into fourteen constituent schools: the original undergraduate colleg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
People From Akron, Ohio
A person ( : people) is a being that has certain capacities or attributes such as reason, morality, consciousness or self-consciousness, and being a part of a culturally established form of social relations such as kinship, ownership of property, or legal responsibility. The defining features of personhood and, consequently, what makes a person count as a person, differ widely among cultures and contexts. In addition to the question of personhood, of what makes a being count as a person to begin with, there are further questions about personal identity and self: both about what makes any particular person that particular person instead of another, and about what makes a person at one time the same person as they were or will be at another time despite any intervening changes. The plural form "people" is often used to refer to an entire nation or ethnic group (as in "a people"), and this was the original meaning of the word; it subsequently acquired its use as a plural form of per ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2022 Deaths
The following notable deaths occurred in 2022. Names are reported under the date of death, in alphabetical order. A typical entry reports information in the following sequence: * Name, age, country of citizenship at birth, subsequent nationality (if applicable), what subject was noted for, cause of death (if known), and reference. December 25 * Chalapathi Rao, 78, Indian actor and producer, heart attack. (death announced on this date) 24 *Vittorio Adorni, 85, Italian road racing cyclist. *Cotton Davidson, 91, American football player ( Baltimore Colts, Dallas Texans, Oakland Raiders). (death announced on this date) *Franco Frattini, 65, Italian politician and magistrate, twice minister of foreign affairs, twice of public administration, European commissioner for justice (2004–2008), cancer. *Madosini, 78, South African musician. *Barry Round, 72, Australian footballer (Sydney, Footscray, Williamstown), organ failure. *Royal Applause, 29, British Thoroughbred racehorse ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1956 Births
Events January * January 1 – The Anglo-Egyptian Sudan, Anglo-Egyptian Condominium ends in Sudan. * January 8 – Operation Auca: Five U.S. evangelical Christian Missionary, missionaries, Nate Saint, Roger Youderian, Ed McCully, Jim Elliot and Pete Fleming, are killed for trespassing by the Huaorani people of Ecuador, shortly after making contact with them. * January 16 – Egyptian leader Gamal Abdel Nasser vows to reconquer Palestine (region), Palestine. * January 25–January 26, 26 – Finnish troops reoccupy Porkkala, after Soviet Union, Soviet troops vacate its military base. Civilians can return February 4. * January 26 – The 1956 Winter Olympics open in Cortina d'Ampezzo, Italy. February * February 11 – British Espionage, spies Guy Burgess and Donald Maclean (spy), Donald Maclean resurface in the Soviet Union, after being missing for 5 years. * February 14–February 25, 25 – The 20th Congress of the Communist Party of the Soviet Union is held in Mosc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Branchpoint Binding Protein
Branchpoint Binding Protein (BBP) is an Orem RNA processing factor. The protein complex binds to the branchpoint sequence (BPS) in the pre-mRNA, aiding in splice site recognition. The role of the protein in yeast cells has been the subject of study, as for other eukaryotic Eukaryotes () are organisms whose cells have a nucleus. All animals, plants, fungi, and many unicellular organisms, are Eukaryotes. They belong to the group of organisms Eukaryota or Eukarya, which is one of the three domains of life. Bacte ... cells. The BPS that the protein binds to in yeast is UACUAAC.{{Cite journal, title = The Splicing Factor BBP Interacts Specifically with the Pre-mRNA Branchpoint Sequence UACUAAC, year=1997 , doi=10.1016/S0092-8674(00)80261-5 , last1=Berglund , first1=J.Andrew , last2=Chua , first2=Katrin , last3=Abovich , first3=Nadja , last4=Reed , first4=Robin , last5=Rosbash , first5=Michael , journal=Cell , volume=89 , issue=5 , pages=781–787 , pmid=918276 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
U2 Spliceosomal RNA
U2 spliceosomal snRNAs are a species of small nuclear RNA ( snRNA) molecules found in the major spliceosomal (Sm) machinery of virtually all eukaryotic organisms. ''In vivo'', U2 snRNA along with its associated polypeptides assemble to produce the U2 small nuclear ribonucleoprotein ( snRNP), an essential component of the major spliceosomal complex. The major spliceosomal-splicing pathway is occasionally referred to as U2 dependent, based on a class of Sm intron—found in mRNA primary transcripts—that are recognized exclusively by the U2 snRNP during early stages of spliceosomal assembly. In addition to U2 dependent intron recognition, U2 snRNA has been theorized to serve a catalytic role in the chemistry of pre-RNA splicing as well. Similar to ribosomal RNAs ( rRNAs), Sm snRNAs must mediate both RNA:RNA and RNA:protein contacts and hence have evolved specialized, highly conserved, primary and secondary structural elements to facilitate these types of interactions. Shortly after ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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