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Rabaptin-5
Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the ''RABEP1'' gene. It belongs to rabaptin protein family. Interactions RABEP1 has been shown to interact with: * AP1G1, * GGA1, * GGA2, * RAB4A, and * RAB5A Ras-related protein Rab-5A is a protein that in humans is encoded by the ''RAB5A'' gene. Function RAB5A localizes to early endosomes where it is involved in the recruitment of RAB7A and the maturation of these compartments to late endosomes. I .... References Further reading * * * * * * * * * * * * * * * {{Gene-17-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rabaptin
Rabaptin is a key protein involved in regeneration of injured axons. Regeneration of injured axons at neuromuscular junctions is regulated by extra-cellular protein factors that promote neurite outgrowth. A novel neurite outgrowth factor from chick denervated skeletal muscle has been cloned and characterised. The protein, termed neurocrescin (rabaptin), has been shown to be secreted in an activity-dependent fashion. Rabaptin is a 100kDa coiled-coil protein that interacts with the GTP form of the small GTPase Rab5 (see RAB5A, RAB5B, RAB5C) a potent regulator of endocytic transport. It is mainly cytosolic, but a fraction co-localises with Rab5 to early endosomes. Rab5 recruits rabaptin-5 to purified early endosomes in a GTP-dependent manner, demonstrating functional similarities with other members of the Ras family. Immunodepletion of rabaptin-5 from cytosol strongly inhibits Rab5-dependent early endosome membrane fusion. Thus, rabaptin-5 is a Rab effector required for membrane ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AP1G1
AP-1 complex subunit gamma-1 is a protein that in humans is encoded by the ''AP1G1'' gene. Function Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. Interactions AP1G1 has been shown to interact with: * AP1B1, * AP1GBP1, * AP1M1, * AP1S1, * NECAP2, * RABEP1 Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the ''RABEP ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GGA1
ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the ''GGA1'' gene. This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Interactions GGA1 has been shown to interact with Sortilin 1, BACE2, RABEP1 and ARF3 ADP-ribosylation factor 3 is a protein that in humans is encoded by the ''ARF3'' gene. Function ADP-ribosylation factor 3 (ARF3) is a member of the human ARF gene family. These genes encode smal ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RAB4A
Ras-related protein Rab-4A is a protein that in humans is encoded by the ''RAB4A'' gene. Interactions RAB4A has been shown to interact with: * CD2AP, * KIF3B, * RAB11FIP1, * RABEP1, and * STX4 Syntaxin-4 is a protein that in humans is encoded by the ''STX4'' gene. Interactions STX4 has been shown to interact with: * Gelsolin, * NAPA, * RAB4A, * SNAP-25, * SNAP23, * STXBP1, * STXBP5, * Syntaxin binding protein 3, * TXLNB, .... References Further reading * * * * * * * * * * * * * * * * * * * * {{Protein-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GGA2
ADP-ribosylation factor-binding protein GGA2 is a protein that in humans is encoded by the ''GGA2'' gene. Function This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. This family member may play a significant role in cargo molecules regulation and clathrin-coated vesicle assembly. Interactions GGA2 has been shown to interact with RABEP1, Sortilin 1, BACE2 and CLINT1 Clathrin interactor 1 (CLINT1), also known as EPSIN4, is a protein which in humans is encoded by the ''CLINT1'' gene. Function The CLINT1 protein binds to the terminal domain of the clath ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life. Metabolic pathways depend upon enzymes to catalyze individual steps. The study of enzymes is called ''enzymology'' and the field of pseudoenzyme analysis recognizes that during evolution, some enzymes have lost the ability to carry out biological catalysis, which is often reflected in their amino acid sequences and unusual 'pseudocatalytic' properties. Enzymes are known to catalyze more than 5,000 biochemical reaction types. Other biocatalysts are catalytic RNA molecules, called ribozymes. Enzymes' specificity comes from their unique three-dimensional structures. Like all catalysts, enzymes increase the reaction ra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and noncoding genes. During gene expression, the DNA is first copied into RNA. The RNA can be directly functional or be the intermediate template for a protein that performs a function. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. These genes make up different DNA sequences called genotypes. Genotypes along with environmental and developmental factors determine what the phenotypes will be. Most biological traits are under the influence of polygenes (many different genes) as well as gen ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
