AP-1 complex subunit gamma-1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''AP1G1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
Adaptin
Clathrin adaptor proteins, also known as adaptins, are vesicular transport adaptor proteins associated with clathrin. These proteins are synthesized in the ribosomes, processed in the endoplasmic reticulum and transported from the Golgi apparatu ...
s are important components of
clathrin
Clathrin is a protein that plays a major role in the formation of coated vesicles. Clathrin was first isolated and named by Barbara Pearse in 1976. It forms a triskelion shape composed of three clathrin heavy chains and three light chains. Whe ...
-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the
trans-Golgi network
The Golgi apparatus (), also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles ins ...
to
lysosome
A lysosome () is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane prot ...
s. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
AP1G1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
AP1B1
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the ''AP1B1'' gene.
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathr ...
,
*
AP1GBP1
Synergin gamma also known as AP1 subunit gamma-binding protein 1 (AP1GBP1) is a protein that in humans is encoded by the ''SYNRG'' gene.
Function
This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor comple ...
,
AP1M1
AP-1 complex subunit mu-1 is a protein that in humans is encoded by the ''AP1M1'' gene.
Function
The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of ...
,[
* ]AP1S1
AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the ''AP1S1'' gene.
Function
The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These ves ...
,[
* ]NECAP2
Adaptin ear-binding coat-associated protein 2 is a protein that in humans is encoded by the ''NECAP2'' gene.
Interactions
NECAP2 has been shown to interact with AP1G1
AP-1 complex subunit gamma-1 is a protein that in humans is encoded by th ...
,RABEP1
Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the ''RABEP1'' gene. It belongs to rabaptin protein family.
Interactions
RABEP1 has been shown to interact with:
* AP1G1,
* GGA1,
* GGA2,
* RAB4A, and
* RAB5A ...
,
References
Further reading
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External links
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{{PDB Gallery, geneid=164
Proteins