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RARAF
The Radiological Research Accelerator Facility (RARAF), located on the Columbia University Nevis Laboratories campus in Irvington, New York is a National Institute of Biomedical Imaging and Bioengineering biotechnology resource center (P41) specializing in microbeam technology. The facility is currently built around a 5MV Singletron, a particle accelerator similar to a Van de Graaff. The RARAF microbeam can produce with high accuracy and precision: * 70-120 keV/μm alpha particles * 8-25 keV/μm protons * 0.6 μm diameter focused beam spot * 10,000 cells/hour throughput History RARAF was conceived by Victor P. Bond and Harald H. Rossi in the late 1960s . Their aim was to provide a source of monoenergetic neutrons designed and operated specifically for studies in radiation biology, dosimetry, and microdosimetry. The facility was built around the 4 MV Van de Graaff particle accelerator that originally served as the injector for the Cosmotron, a 2 GeV accelerator operated at Bro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RARAF Quadrupole Triplet
The Radiological Research Accelerator Facility (RARAF), located on the Columbia University Nevis Laboratories campus in Irvington, New York is a National Institute of Biomedical Imaging and Bioengineering biotechnology resource center (P41) specializing in microbeam technology. The facility is currently built around a 5MV Singletron, a particle accelerator similar to a Van de Graaff. The RARAF microbeam can produce with high accuracy and precision: * 70-120 keV/μm alpha particles * 8-25 keV/μm protons * 0.6 μm diameter focused beam spot * 10,000 cells/hour throughput History RARAF was conceived by Victor P. Bond and Harald H. Rossi in the late 1960s . Their aim was to provide a source of monoenergetic neutrons designed and operated specifically for studies in radiation biology, dosimetry, and microdosimetry. The facility was built around the 4 MV Van de Graaff particle accelerator that originally served as the injector for the Cosmotron, a 2 GeV accelerator operated at Bro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microbeam
A microbeam is a narrow beam of radiation, of micrometer or sub-micrometer dimensions. Together with integrated imaging techniques, microbeams allow precisely defined quantities of damage to be introduced at precisely defined locations. Thus, the microbeam is a tool for investigators to study intra- and inter-cellular mechanisms of damage signal transduction. A schematic of microbeam operation is shown on the right. Essentially, an automated imaging system locates user-specified targets, and these targets are sequentially irradiated, one by one, with a highly-focused radiation beam. Targets can be single cells, sub-cellular locations, or precise locations in 3D tissues. Key features of a microbeam are throughput, precision, and accuracy. While irradiating targeted regions, the system must guarantee that adjacent locations receive no energy deposition. History The first microbeam facilities were developed in the mid-90s. These facilities were a response to challenges in studying ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microbeam
A microbeam is a narrow beam of radiation, of micrometer or sub-micrometer dimensions. Together with integrated imaging techniques, microbeams allow precisely defined quantities of damage to be introduced at precisely defined locations. Thus, the microbeam is a tool for investigators to study intra- and inter-cellular mechanisms of damage signal transduction. A schematic of microbeam operation is shown on the right. Essentially, an automated imaging system locates user-specified targets, and these targets are sequentially irradiated, one by one, with a highly-focused radiation beam. Targets can be single cells, sub-cellular locations, or precise locations in 3D tissues. Key features of a microbeam are throughput, precision, and accuracy. While irradiating targeted regions, the system must guarantee that adjacent locations receive no energy deposition. History The first microbeam facilities were developed in the mid-90s. These facilities were a response to challenges in studying ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |