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RARAF Quadrupole Triplet
The Radiological Research Accelerator Facility (RARAF), located on the Columbia University Nevis Laboratories campus in Irvington, New York is a National Institute of Biomedical Imaging and Bioengineering biotechnology resource center (P41) specializing in microbeam technology. The facility is currently built around a 5MV Singletron, a particle accelerator similar to a Van de Graaff. The RARAF microbeam can produce with high accuracy and precision: * 70-120 keV/μm alpha particles * 8-25 keV/μm protons * 0.6 μm diameter focused beam spot * 10,000 cells/hour throughput History RARAF was conceived by Victor P. Bond and Harald H. Rossi in the late 1960s . Their aim was to provide a source of monoenergetic neutrons designed and operated specifically for studies in radiation biology, dosimetry, and microdosimetry. The facility was built around the 4 MV Van de Graaff particle accelerator that originally served as the injector for the Cosmotron, a 2 GeV accelerator operated at Bro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiobiology
Radiobiology (also known as radiation biology, and uncommonly as actinobiology) is a field of clinical and basic medical sciences that involves the study of the action of ionizing radiation on living things, especially health effects of radiation. Ionizing radiation is generally harmful and potentially lethal to living things but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Its most common impact is the induction of cancer with a latent period of years or decades after exposure. High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled doses are used for medical imaging and radiotherapy. Health effects In general, ionizing radiation is harmful and potentially lethal to living beings but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Most adverse health effects of radiation exposure may be grouped in two general categori ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cosmotron
The Cosmotron was a particle accelerator, specifically a proton synchrotron, at Brookhaven National Laboratory. Its construction was approved by the U.S. Atomic Energy Commission in 1948, reaching its full energy in 1953, and continuing to run until 1966. It was dismantled in 1969. It was the first particle accelerator to impart kinetic energy in the range of GeV to a single particle, accelerating protons to 3.3 GeV. It was also the first accelerator to allow the extraction of the particle beam for experiments located physically outside the accelerator. It was used to observe a number of mesons previously seen only in cosmic rays, and to make the first discoveries of heavy, unstable particles (called V particles at the time) leading to the experimental confirmation of the theory of associated production of strange particles. It was the first accelerator that was able to produce all positive and negative mesons known to exist in cosmic rays. Its discoveries include the first ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thermal Neutrons
The neutron detection temperature, also called the neutron energy, indicates a free neutron's kinetic energy, usually given in electron volts. The term ''temperature'' is used, since hot, thermal and cold neutrons are moderated in a medium with a certain temperature. The neutron energy distribution is then adapted to the Maxwell distribution known for thermal motion. Qualitatively, the higher the temperature, the higher the kinetic energy of the free neutrons. The momentum and wavelength of the neutron are related through the de Broglie relation. The large wavelength of slow neutrons allows for the large cross section. Neutron energy distribution ranges But different ranges with different names are observed in other sources. The following is a detailed classification: Thermal A thermal neutron is a free neutron with a kinetic energy of about 0.025 eV (about 4.0×10−21 J or 2.4 MJ/kg, hence a speed of 2.19 km/s), which is the energy corresponding to the most pro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linear Energy Transfer
In dosimetry, linear energy transfer (LET) is the amount of energy that an ionizing particle transfers to the material traversed per unit distance. It describes the action of radiation into matter. It is identical to the retarding force acting on a charged ionizing particle travelling through the matter. By definition, LET is a positive quantity. LET depends on the nature of the radiation as well as on the material traversed. A high LET will attenuate the radiation more quickly, generally making shielding more effective and preventing deep penetration. On the other hand, the higher concentration of deposited energy can cause more severe damage to any microscopic structures near the particle track. If a microscopic defect can cause larger-scale failure, as is the case in biological cells and microelectronics, the LET helps explain why radiation damage is sometimes disproportionate to the absorbed dose. Dosimetry attempts to factor in this effect with radiation weighting factors. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Caenorhabditis Elegans
''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a blend of the Greek ''caeno-'' (recent), ''rhabditis'' (rod-like) and Latin ''elegans'' (elegant). In 1900, Maupas initially named it '' Rhabditides elegans.'' Osche placed it in the subgenus ''Caenorhabditis'' in 1952, and in 1955, Dougherty raised ''Caenorhabditis'' to the status of genus. ''C. elegans'' is an unsegmented pseudocoelomate and lacks respiratory or circulatory systems. Most of these nematodes are hermaphrodites and a few are males. Males have specialised tails for mating that include spicules. In 1963, Sydney Brenner proposed research into ''C. elegans,'' primarily in the area of neuronal development. In 1974, he began research into the molecular and developmental biology of ''C. elegans'', which has since been extensively used as a model organism. It was the first multicellu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Optoelectronic Tweezer
Optoelectronics (or optronics) is the study and application of electronic devices and systems that find, detect and control light, usually considered a sub-field of photonics. In this context, ''light'' often includes invisible forms of radiation such as gamma rays, X-rays, ultraviolet and infrared, in addition to visible light. Optoelectronic devices are electrical-to-optical or optical-to-electrical transducers, or instruments that use such devices in their operation. ''Electro-optics'' is often erroneously used as a synonym, but is a wider branch of physics that concerns all interactions between light and electric fields, whether or not they form part of an electronic device. Optoelectronics is based on the quantum mechanical effects of light on electronic materials, especially semiconductors, sometimes in the presence of electric fields. * Photoelectric or photovoltaic effect, used in: ** photodiodes (including solar cells) ** phototransistors ** photomultipliers ** optoiso ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microfluidic
Microfluidics refers to the behavior, precise control, and manipulation of fluids that are geometrically constrained to a small scale (typically sub-millimeter) at which surface forces dominate volumetric forces. It is a multidisciplinary field that involves engineering, physics, chemistry, biochemistry, nanotechnology, and biotechnology. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening. Microfluidics emerged in the beginning of the 1980s and is used in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. Typically, micro means one of the following features: * Small volumes (μL, nL, pL, fL) * Small size * Low energy consumption * Microdomain effects Typically microfluidic systems transport, mix, separate, or otherwise process fluids. Various applications rely on passive fluid control using capillary for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bystander Effect (radiobiology)
The radiation-induced bystander effect (bystander effect) is the phenomenon in which unirradiated cells exhibit irradiated effects as a result of signals received from nearby irradiated cells. In November 1992, Hatsumi Nagasawa and John B. Little first reported this radiobiological phenomenon. Effect There is evidence that targeted cytoplasmic irradiation results in mutation in the nucleus of the hit cells. Cells that are not directly hit by an alpha particle, but are in the vicinity of one that is hit, also contribute to the genotoxic response of the cell population. Similarly, when cells are irradiated, and the medium is transferred to unirradiated cells, these unirradiated cells show bystander responses when assayed for clonogenic survival and oncogenic transformation. This is also attributed to the bystander effect. Demonstration The demonstration of a bystander effect in 3D human tissues and, more recently, in whole organisms have clear implication of the potential relev ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Characteristic X-ray
Characteristic X-rays are emitted when outer-shell electrons fill a vacancy in the inner shell of an atom, releasing X-rays in a pattern that is "characteristic" to each element. Characteristic X-rays were discovered by Charles Glover Barkla in 1909, who later won the Nobel Prize in Physics for his discovery in 1917. Explanation Characteristic X-rays are produced when an element is bombarded with high-energy particles, which can be photons, electrons or ions (such as protons). When the incident particle strikes a bound electron (the target electron) in an atom, the target electron is ejected from the inner shell of the atom. After the electron has been ejected, the atom is left with a vacant energy level, also known as a core hole. Outer-shell electrons then fall into the inner shell, emitting quantized photons with an energy level equivalent to the energy difference between the higher and lower states. Each element has a unique set of energy levels, and thus the transition from hi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quadrupoles
A quadrupole or quadrapole is one of a sequence of configurations of things like electric charge or current, or gravitational mass that can exist in ideal form, but it is usually just part of a multipole expansion of a more complex structure reflecting various orders of complexity. Mathematical definition The quadrupole moment tensor ''Q'' is a rank-two tensor—3×3 matrix. There are several definitions, but it is normally stated in the traceless form (i.e. Q_ + Q_ + Q_ = 0). The quadrupole moment tensor has thus nine components, but because of transposition symmetry and zero-trace property, in this form only five of these are independent. For a discrete system of \ell point charges or masses in the case of a gravitational quadrupole, each with charge q_\ell, or mass m_\ell, and position \vec_\ell = \left(r_, r_, r_\right) relative to the coordinate system origin, the components of the ''Q'' matrix are defined by: : Q_ = \sum_\ell q_\ell\left(3r_ r_ - \left\, \vec_\ell \righ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RARAF Quadrupole Triplet
The Radiological Research Accelerator Facility (RARAF), located on the Columbia University Nevis Laboratories campus in Irvington, New York is a National Institute of Biomedical Imaging and Bioengineering biotechnology resource center (P41) specializing in microbeam technology. The facility is currently built around a 5MV Singletron, a particle accelerator similar to a Van de Graaff. The RARAF microbeam can produce with high accuracy and precision: * 70-120 keV/μm alpha particles * 8-25 keV/μm protons * 0.6 μm diameter focused beam spot * 10,000 cells/hour throughput History RARAF was conceived by Victor P. Bond and Harald H. Rossi in the late 1960s . Their aim was to provide a source of monoenergetic neutrons designed and operated specifically for studies in radiation biology, dosimetry, and microdosimetry. The facility was built around the 4 MV Van de Graaff particle accelerator that originally served as the injector for the Cosmotron, a 2 GeV accelerator operated at Bro ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Netherlands
) , anthem = ( en, "William of Nassau") , image_map = , map_caption = , subdivision_type = Sovereign state , subdivision_name = Kingdom of the Netherlands , established_title = Before independence , established_date = Spanish Netherlands , established_title2 = Act of Abjuration , established_date2 = 26 July 1581 , established_title3 = Peace of Münster , established_date3 = 30 January 1648 , established_title4 = Kingdom established , established_date4 = 16 March 1815 , established_title5 = Liberation Day (Netherlands), Liberation Day , established_date5 = 5 May 1945 , established_title6 = Charter for the Kingdom of the Netherlands, Kingdom Charter , established_date6 = 15 December 1954 , established_title7 = Dissolution of the Netherlands Antilles, Caribbean reorganisation , established_date7 = 10 October 2010 , official_languages = Dutch language, Dutch , languages_type = Regional languages , languages_sub = yes , languages = , languages2_type = Reco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
