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Quebrachitol
Quebrachitol is a naturally occurring optically active cyclitol, a cyclic polyol. It can be found in ''Allophylus edulis'' and in the serum left after the coagulation of the ''Hevea brasiliensis'' latex in the operation of rubber tapping. It is also found in ''Cannabis sativa'', in '' Paullinia pinnata'' and in seabuckthorn. It was first isolated by Tanret in 1887 from the bark of '' Aspidosperma quebracho''. The substance was tested as a sweetening agent for diabetics in 1933. It shows a sweetening property half of that of sucrose but induces colic or diarrhoea Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin w ... at concentration used to render the food palatable. Quebrachitol is a versatile building block in the construction of naturally occurring bioactive materials. For exampl ...
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Aspidosperma Quebracho
''Aspidosperma quebracho-blanco'', commonly known as Quebracho blanco, kebrako, or white quebracho, is a South American tree species, native to Brazil, northern Argentina, Bolivia, Paraguay, and Uruguay. It must not be confused with other species also known as '' quebracho'', but belonging to the genus ''Schinopsis''. Description ''Aspidosperma quebracho-blanco'' is an evergreen tree. It reaches 20 to 30 meters in height in the Humid Chaco, and 8 to 12 meters in the Dry Chaco. The foliage is sclerophyllous. Habitat and range ''Aspidosperma quebracho-blanco'' is generally found in dry deciduous forests, where it grows on clay soils. It is most common in the Gran Chaco, Humid Chaco, Argentine Espinal, and Bolivian montane dry forests ecoregions of Paraguay, Argentina, Bolivia, and Brazil. Its range extends to adjacent ecoregions, including the Uruguayan savanna, Paraná flooded savanna, Southern Cone Mesopotamian savanna, Southern Andean Yungas, Cerrado, Pantanal, Central Andean ...
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Cyclitol
In organic chemistry, a cyclitol is a cycloalkane containing at least three hydroxyl, each attached to a different ring carbon atom. The general formula for an unsubstituted cyclitol is or where 3 ≤ ''x'' ≤ ''n''. The name is also used for compounds that can be viewed as result of substituting various functional groups for the hydrogen atoms in such a molecule, as well as similar molecules with one or more double bonds in the ring. Cyclitols and their derivatives are some of the osmoprotectant, compatible solutes which are formed in a plant as a response to salt or water stress. Some cyclitols (e.g. quinic acid, quinic or shikimic acid) are parts of hydrolysable tannins. Isomerism and nomenclature Unsubstituted cyclitols with the same ring size and number of hydroxyls may exist in several structural isomers, depending on the position of the hydroxyls along the ring. For example, cyclohexanetriol exists in three distinct isomers (1,2,3-, 1,2,4-, and 1,3,5-). Furthermore, th ...
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Allophylus Edulis
''Allophylus edulis'' ( pt, chal-chal) is a plant species in the genus ''Allophylus'' endemic to the Guianas, Brazil, Bolivia, Paraguay, Argentina and Uruguay. Phytochemistry Quebrachitol, a cyclitol In organic chemistry, a cyclitol is a cycloalkane containing at least three hydroxyl, each attached to a different ring carbon atom. The general formula for an unsubstituted cyclitol is or where 3 ≤ ''x'' ≤ ''n''. The name is also used for c ..., and viridiflorol, a sesquiterpenoid, are found in ''A. edulis''. Vernacular names This plant has several different common names. In Paraguay it's called ''kokû'', with a nasal ending. In Argentina, the common name is ''chal-chal'' (hence Los Chalchaleros, a folkloric music group), as in Portuguese. Other names in Brazil are ''aperta-goela, baga-de-morcego, chala-chala, chale-chale, cocum, fruta-de-paraó, fruta-de-passarinho, fruta-de-pavão, fruta-de-pavó, fruta-de-pombo, murta-branca, murta-vermelha, olho-de-pombo, pé-de- ...
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Dimethyl Sulfoxide
Dimethyl sulfoxide (DMSO) is an organosulfur compound with the formula ( CH3)2. This colorless liquid is the sulfoxide most widely used commercially. It is an important polar aprotic solvent that dissolves both polar and nonpolar compounds and is miscible in a wide range of organic solvents as well as water. It has a relatively high boiling point. DMSO has the unusual property that many individuals perceive a garlic-like taste in the mouth after DMSO makes contact with their skin. In terms of chemical structure, the molecule has idealized Cs symmetry. It has a trigonal pyramidal molecular geometry consistent with other three-coordinate S(IV) compounds, with a nonbonded electron pair on the approximately tetrahedral sulfur atom. Synthesis and production Dimethyl sulfoxide was first synthesized in 1866 by the Russian scientist Alexander Zaytsev, who reported his findings in 1867. Dimethyl sulfoxide is produced industrially from dimethyl sulfide, a by-product of the K ...
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Dimethyl Formamide
Dimethylformamide is an organic compound with the formula ( CH3)2NC(O)H. Commonly abbreviated as DMF (although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate), this colourless liquid is miscible with water and the majority of organic liquids. DMF is a common solvent for chemical reactions. Dimethylformamide is odorless, but technical-grade or degraded samples often have a fishy smell due to impurity of dimethylamine. Dimethylamine degradation impurities can be removed by sparging samples with an inert gas such as argon or by sonicating the samples under reduced pressure. As its name indicates, it is structurally related to formamide, having two methyl groups in the place of the two hydrogens. DMF is a polar (hydrophilic) aprotic solvent with a high boiling point. It facilitates reactions that follow polar mechanisms, such as SN2 reactions. Structure and properties As for most amides, the spectroscopic evidence indicates partial double bond characte ...
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Hevea Brasiliensis
''Hevea brasiliensis'', the Pará rubber tree, ''sharinga'' tree, seringueira, or most commonly, rubber tree or rubber plant, is a flowering plant belonging to the spurge family Euphorbiaceae originally native to the Amazon basin, but is now pantropical in distribution due to introductions. It is the most economically important member of the genus ''Hevea'' because the milky latex extracted from the tree is the primary source of natural rubber. Description ''H. brasiliensis'' is a tall deciduous tree growing to a height of up to in the wild, but cultivated trees are usually much smaller because drawing off the latex restricts the growth of the tree. The trunk is cylindrical and may have a swollen, bottle-shaped base. The bark is some shade of brown, and the inner bark oozes latex when damaged. The leaves have three leaflets and are spirally arranged. The inflorescence include separate male and female flowers. The flowers are pungent, creamy-yellow and have no petals. The fru ...
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Rubber Tapping
Rubber tapping is the process by which latex is collected from a rubber tree. The latex is harvested by slicing a groove into the bark of the tree at a depth of with a hooked knife and peeling back the bark. Trees must be approximately six years old and in diameter in order to be tapped for latex. Rubber tapping is not damaging to the forest, as it does not require the tree to be cut down in order for the latex to be extracted. Jungle rubber is essentially old secondary forest, strongly resembling the primary forest. Its species' richness is about half that of the primary forest. Michon and de Foresta (1994) found that sample jungle rubber sites contained 92 tree species, 97 lianas, and 28 epiphytes compared with 171, 89, and 63, respectively, in the primary forest, and compared with 1, 1, and 2 in monoculture estates. Thiollay (1995) estimated that jungle rubber supports about 137 bird species, against 241 in the primary forest itself. Jungle rubber is expected to resemble prima ...
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Cannabis Sativa
''Cannabis sativa'' is an annual herbaceous flowering plant indigenous to Eastern Asia, but now of cosmopolitan distribution due to widespread cultivation. It has been cultivated throughout recorded history, used as a source of industrial fiber, seed oil, food, recreation, religious and spiritual moods and medicine. Each part of the plant is harvested differently, depending on the purpose of its use. The species was first classified by Carl Linnaeus in 1753. The word ''sativa'' means "things that are cultivated." Plant physiology The flowers of ''Cannabis sativa'' are unisexual and plants are most often either male or female. It is a short-day flowering plant, with staminate (male) plants usually taller and less robust than pistillate (female or male) plants. The flowers of the female plant are arranged in racemes and can produce hundreds of seeds. Male plants shed their pollen and die several weeks prior to seed ripening on the female plants. Under typical conditions with ...
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Paullinia Pinnata
''Paullinia pinnata'' is a flowering plant species in the genus of ''Paullinia'' found in South America and Africa. The long flexible stems of ''P. pinnata'' are used to poison fish in shallow pools, as described by the English naturalist Henry Walter Bates in his book ''The Naturalist on the River Amazons''. Chemistry The plant contains the ceramide paullinomide A, β-amyrin, steroids, the coumarinolignoid 2-(4-hydroxy-3,5-dimethoxyphenyl)-3-hydroxymethyl-2,3-dihydro-1,4,5-trioxaphenanthren-6-one, 5α-poriferastane-3ß,6α-diol and l-quebrachitol. It also contains the triterpenoids lupeyl steryl ether, 3-oxo-11α-hydroxyl-20(29)lupen and the lupeol-3-isovanniloyl ester paullinoyl (3-O-isovanilloyl-3R,5R,8R,9R,10R,13R,14S,17S,18R,19R-lup-20(29)-en), and the flavone glycosides diosmetin-7-O-(2‘ ‘-O-β-d-apiofuranosyl-6‘ ‘-acetyl-β-d-glucopyranoside) and tricetin-4‘-O-methyl-7-O-(2‘ ‘-O-β-d-apiofuranosyl-6‘ ‘-acetyl-β-d-glucopyranoside).Two New Flav ...
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Seabuckthorn
''Hippophae'' is the genus of sea buckthorns, deciduous shrubs in the family Elaeagnaceae. The name sea buckthorn may be hyphenated to avoid confusion with the unrelated true buckthorns (''Rhamnus'', family Rhamnaceae). It is also referred to as sandthorn, sallowthorn, or seaberry. It produces orange-yellow berries, which have been used over centuries as food, traditional medicine, and skin treatment in Mongolia, Ladakh, Russia, Ukraine, and northern Europe, which are its origin regions. It is an exceptionally hardy plant able to withstand winter temperatures as low as . Because ''Hippophae'' develops an aggressive and extensive root system, it is planted to inhibit soil erosion and is used in land reclamation for its nitrogen fixing properties, wildlife habitat, and soil enrichment. ''Hippophae'' berries and leaves are manufactured into various human and animal food and skincare products. Description The shrubs reach tall, rarely up to in central Asia. The leaf arrangement c ...
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Charles Joseph Tanret
Charles Joseph Tanret (9 August 1847 in Joinville, France – 10 July 1917 in Paris) was a French pharmacist and chemist. He notably studied the chemistry of sugars, reporting his observations of the mutarotation of glucose in 1895. He also identified quebrachitol in 1887 from the bark of ''Aspidosperma quebracho''. His son Georges was also a pharmacist, specialist of plant chemistry. Georges Tanret identified an alkaloid ( galegine) from ''Galega officinalis ''Galega officinalis'', commonly known as galega or goat's-rue, is an herbaceous plant in the subfamily Faboideae of the legume family Fabaceae. It is native to parts of northern Africa, western Asia and Europe, but is widely cultivated and natu ...'' that was evaluated in clinical trials in patients with diabetes in the 1920s and 1930s.Bailey CJ, Campbell IW, Chan JCN, Davidson JA, Howlett HCS, Ritz P (eds). 2007. Metformin: the Gold Standard. A Scientific handbook; Chichester: Wiley. Chapter 1: Galegine and antidiabetic ...
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Diarrhoea
Diarrhea, also spelled diarrhoea, is the condition of having at least three loose, liquid, or watery bowel movements each day. It often lasts for a few days and can result in dehydration due to fluid loss. Signs of dehydration often begin with loss of the normal stretchiness of the skin and irritable behaviour. This can progress to decreased urination, loss of skin color, a fast heart rate, and a decrease in responsiveness as it becomes more severe. Loose but non-watery stools in babies who are exclusively breastfed, however, are normal. The most common cause is an infection of the intestines due to either a virus, bacterium, or parasite—a condition also known as gastroenteritis. These infections are often acquired from food or water that has been contaminated by feces, or directly from another person who is infected. The three types of diarrhea are: short duration watery diarrhea, short duration bloody diarrhea, and persistent diarrhea (lasting more than two weeks, ...
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