Pierre-Jean Robiquet
Pierre Jean Robiquet (13 January 1780 – 29 April 1840) was a French chemist. He laid founding work in identifying amino acids, the fundamental building blocks of proteins. He did this through recognizing the first of them, asparagine, in 1806, in the industry's adoption of industrial dyes, with the identification of alizarin in 1826, and in the emergence of modern medications, through the identification of codeine in 1832, a opiate alkaloid substance of widespread use with analgesic and antidiarrheal properties. Robiquet was born in Rennes. He was at first a pharmacist in the French armies during the French Revolution years and became a professor at the École de pharmacie in Paris, where he died. Notable scientific achievements were among other things his isolation and characterization of properties of asparagine (the first amino acid to be identified, from asparagus, achieved. In 1806, with Louis Nicolas Vauquelin), cantharidin (1810), the sigma-1 receptor agonist noscapin ...
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Rennes
Rennes (; br, Roazhon ; Gallo: ''Resnn''; ) is a city in the east of Brittany in northwestern France at the confluence of the Ille and the Vilaine. Rennes is the prefecture of the region of Brittany, as well as the Ille-et-Vilaine department. In 2017, the urban area had a population of 357,327 inhabitants, and the larger metropolitan area had 739,974 inhabitants.Comparateur de territoire Unité urbaine 2020 de Rennes (35701), Aire d'attraction des villes 2020 de Rennes (013)
INSEE The inhabitants of Rennes are called Rennais/Rennaises in French. Rennes's history goes back more than 2,000 years, at a time when it ...
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Agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the agonist, while an inverse agonist causes an action opposite to that of the agonist. Etymology From the Greek αγωνιστής (agōnistēs), contestant; champion; rival < αγων (agōn), contest, combat; exertion, struggle < αγω (agō), I lead, lead towards, conduct; drive

Types of agonists

can be activated by either endogenous agonists (such as

École Polytechnique
École may refer to: * an elementary school in the French educational stages normally followed by secondary education establishments (collège and lycée) * École (river), a tributary of the Seine flowing in région Île-de-France * École, Savoie, a French commune * École-Valentin, a French commune in the Doubs département * Grandes écoles, higher education establishments in France * The École, a French-American bilingual school in New York City Ecole may refer to: * Ecole Software This is a list of Notability, notable video game companies that have made games for either computers (like PC or Mac), video game consoles, handheld or mobile devices, and includes companies that currently exist as well as now-defunct companies. ...

Amygdalin
Amygdalin (from Ancient Greek: ' "almond") is a naturally occurring chemical compound found in many plants, most notably in the seeds (kernels) of apricots, bitter almonds, apples, peaches, cherries, and plums. Amygdalin is classified as a cyanogenic glycoside because each amygdalin molecule includes a nitrile group, which can be released as the toxic cyanide anion by the action of a beta-glucosidase. Eating amygdalin will cause it to release cyanide in the human body, and may lead to cyanide poisoning. Since the early 1950s, both amygdalin and a chemical derivative named ''laetrile'' have been promoted as alternative cancer treatments, often under the misnomer vitamin B17 (neither amygdalin nor laetrile is a vitamin). Scientific study has found them to not only be clinically ineffective in treating cancer, but also potentially toxic or lethal when taken by mouth due to cyanide poisoning. The promotion of laetrile to treat cancer has been described in the medical literature a ...
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Orcin
Orcinol is an organic compound with the formula CH3C6H3(OH)2. It occurs in many species of lichens including ''Roccella tinctoria'' and ''Lecanora''. Orcinol has been detected in the "toxic glue" of the ant species ''Camponotus saundersi''. It is a colorless solid. It is related to resorcinol, 1,3-C6H4(OH)2. Synthesis and reactions Orcinol was first prepared by dehydroacetic acid, a conversion that involved ring-opening of the pyrone to a triketone. This early experiment helped establish the rich condensation chemistry of polyketides. It can be obtained by fusing extract of aloes with potash, followed by acidification. It undergoes O-methylation with dimethylsulfate. It is used in the production of the dye orcein and as a reagent in some chemical tests for pentoses, such as Bial's Test. It may be synthesized from toluene; more interesting is its production when acetone dicarboxylic ester is condensed with the aid of sodium. It crystallizes in colorless prisms with one molecule ...
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1,2,4-Trihydroxyanthraquinone
1,2,4-Trihydroxyanthraquinone, commonly called purpurin, is an anthraquinone. It is a naturally occurring red/yellow dye. It is formally derived from 9,10-anthraquinone by replacement of three hydrogen atoms by hydroxyl (OH) groups. Purpurin is also called verantin, smoke Brown G, hydroxylizaric acid, and C.I. 58205. It is a minor component of the classical lake pigment "madder lake" or Rose Madder. History Madder root has been used for dying cloth at least since 1500 BC.Madder Root'' catalog entry at Natural Pigments website. Accessed on 2010-01-22. Purpurin and alizarin were isolated from the root by Pierre Robiquet and Colin, two French chemists, in 1826. They were identified as anthracene derivatives by Gräbe and Liebermann in 1868. They also synthesized alizarin from bromoanthraquinone, which, together with the conversion of alizarin into purpurin published previously by M. F. De Lalande, provided the first synthetic route to purpurin. The positions of t ...
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William Henry Perkin
Sir William Henry Perkin (12 March 1838 – 14 July 1907) was a British chemist and entrepreneur best known for his serendipitous discovery of the first commercial synthetic organic dye, mauveine, made from aniline. Though he failed in trying to synthesise quinine for the treatment of malaria, he became successful in the field of dyes after his first discovery at the age of 18. Perkin set up a factory to produce the dye industrially. Lee Blaszczyk, professor of business history at the University of Leeds, states, "By laying the foundation for the synthetic organic chemicals industry, Perkin helped to revolutionize the world of fashion." Early years William Perkin was born in the East End of London, the youngest of the seven children of George Perkin, a successful carpenter. His mother, Sarah, was of Scottish descent and moved to East London as a child.UXL Encyclopedia of World Biography (2003). Accessed 18 March 2008. He was baptized in the Anglican parish church of St ...
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Carl Theodore Liebermann
Carl Theodore Liebermann (23 February 1842 – 28 December 1914) was a German chemist and student of Adolf von Baeyer. Life Liebermann first studied at the University of Heidelberg where Robert Wilhelm Bunsen was teaching. He then joined the group of Adolf von Baeyer at the University of Berlin where he received his PhD in 1865. Together with Carl Gräbe, Liebermann synthesised the orange-red dye alizarin in 1868. After his habilitation in 1870 he became professor at the University of Berlin after Adolf von Baeyer left for the University of Strasbourg. Shortly after Liebermann retired, in 1914, he died. Work In 1826, the French chemist Pierre Jean Robiquet had isolated from the root of a plant, madder, and defined the structure of, alizarin, a remarkable red dye. Liebermann's 1868 discovery that alizarin can be reduced to form anthracene, which is an abundant component in coal tar, opened the road for synthetic alizarin. The patent of Liebermann and Carl Gräbe for the s ...
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