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Paul Scherrer Institut
The Paul Scherrer Institute (PSI) is a multi-disciplinary research institute for natural and engineering sciences in Switzerland. It is located in the Canton of Aargau in the municipalities Villigen and Würenlingen on either side of the River Aare, and covers an area over 35 hectares in size. Like ETH Zurich and EPFL, PSI belongs to the Swiss Federal Institutes of Technology Domain of the Swiss Confederation. The PSI employs around 2,100 people. It conducts basic and applied research in the fields of matter and materials, human health, and energy and the environment. About 37% of PSI's research activities focus on material sciences, 24% on life sciences, 19% on general energy, 11% on nuclear energy and safety, and 9% on particle physics. PSI develops, builds and operates large and complex research facilities and makes them available to the national and international scientific communities. In 2017, for example, more than 2,500 researchers from 60 different countries came to PSI ...
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Paul Scherrer Institut
The Paul Scherrer Institute (PSI) is a multi-disciplinary research institute for natural and engineering sciences in Switzerland. It is located in the Canton of Aargau in the municipalities Villigen and Würenlingen on either side of the River Aare, and covers an area over 35 hectares in size. Like ETH Zurich and EPFL, PSI belongs to the Swiss Federal Institutes of Technology Domain of the Swiss Confederation. The PSI employs around 2,100 people. It conducts basic and applied research in the fields of matter and materials, human health, and energy and the environment. About 37% of PSI's research activities focus on material sciences, 24% on life sciences, 19% on general energy, 11% on nuclear energy and safety, and 9% on particle physics. PSI develops, builds and operates large and complex research facilities and makes them available to the national and international scientific communities. In 2017, for example, more than 2,500 researchers from 60 different countries came to PSI ...
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Proton Therapy
In medicine, proton therapy, or proton radiotherapy, is a type of particle therapy that uses a beam of protons to irradiate diseased tissue, most often to treat cancer. The chief advantage of proton therapy over other types of external beam radiotherapy is that the dose of protons is deposited over a narrow range of depth; hence in minimal entry, exit, or scattered radiation dose to healthy nearby tissues. When evaluating whether to treat a tumor with photon or proton therapy, physicians may choose proton therapy if it is important to deliver a higher radiation dose to targeted tissues while significantly decreasing radiation to nearby organs at risk. The American Society for Radiation Oncology Model Policy for Proton Beam therapy says proton therapy is considered reasonable if sparing the surrounding normal tissue "cannot be adequately achieved with photon-based radiotherapy" and can benefit the patient. Like photon radiation therapy, proton therapy is often used in conjuncti ...
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CERN
The European Organization for Nuclear Research, known as CERN (; ; ), is an intergovernmental organization that operates the largest particle physics laboratory in the world. Established in 1954, it is based in a northwestern suburb of Geneva, on the France–Switzerland border. It comprises 23 member states, and Israel (admitted in 2013) is currently the only non-European country holding full membership. CERN is an official United Nations General Assembly observer. The acronym CERN is also used to refer to the laboratory; in 2019, it had 2,660 scientific, technical, and administrative staff members, and hosted about 12,400 users from institutions in more than 70 countries. In 2016, CERN generated 49 petabytes of data. CERN's main function is to provide the particle accelerators and other infrastructure needed for high-energy physics research — consequently, numerous experiments have been constructed at CERN through international collaborations. CERN is the site of th ...
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Compact Muon Solenoid
The Compact Muon Solenoid (CMS) experiment is one of two large general-purpose particle physics detectors built on the Large Hadron Collider (LHC) at CERN in Switzerland and France. The goal of the CMS experiment is to investigate a wide range of physics, including the search for the Higgs boson, extra dimensions, and particles that could make up dark matter. CMS is 21 metres long, 15 m in diameter, and weighs about 14,000 tonnes. Over 4,000 people, representing 206 scientific institutes and 47 countries, form the CMS collaboration who built and now operate the detector. It is located in a cavern at Cessy in France, just across the border from Geneva. In July 2012, along with ATLAS, CMS tentatively discovered the Higgs boson. By March 2013 its existence was confirmed. Background Recent collider experiments such as the now-dismantled Large Electron-Positron Collider and the newly renovated Large Hadron Collider (LHC) at CERN, as well as the () recently closed ...
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Femtometer
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Muon
A muon ( ; from the Greek letter mu (μ) used to represent it) is an elementary particle similar to the electron, with an electric charge of −1 '' e'' and a spin of , but with a much greater mass. It is classified as a lepton. As with other leptons, the muon is not thought to be composed of any simpler particles; that is, it is a fundamental particle. The muon is an unstable subatomic particle with a mean lifetime of , much longer than many other subatomic particles. As with the decay of the non-elementary neutron (with a lifetime around 15 minutes), muon decay is slow (by subatomic standards) because the decay is mediated only by the weak interaction (rather than the more powerful strong interaction or electromagnetic interaction), and because the mass difference between the muon and the set of its decay products is small, providing few kinetic degrees of freedom for decay. Muon decay almost always produces at least three particles, which must include an electr ...
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Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid ...
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Ribosome
Ribosomes ( ) are macromolecular machines, found within all cells, that perform biological protein synthesis (mRNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA (mRNA) molecules to form polypeptide chains. Ribosomes consist of two major components: the small and large ribosomal subunits. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and many ribosomal proteins (RPs or r-proteins). The ribosomes and associated molecules are also known as the ''translational apparatus''. Overview The sequence of DNA that encodes the sequence of the amino acids in a protein is transcribed into a messenger RNA chain. Ribosomes bind to messenger RNAs and use their sequences for determining the correct sequence of amino acids to generate a given protein. Amino acids are selected and carried to the ribosome by transfer RNA (tRNA) molecules, which enter the ribosome and bind to the messenger RNA chain via an anti-co ...
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Venkatraman Ramakrishnan
Venkatraman Ramakrishnan (born 1952) is an Indian-born British and American structural biologist who shared the 2009 Nobel Prize in Chemistry with Thomas A. Steitz and Ada Yonath, "for studies of the structure and function of the ribosome". Since 1999, he has worked as a group leader at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) on the Cambridge Biomedical Campus, UK and is a Fellow of Trinity College, Cambridge. He served as President of the Royal Society from 2015 to 2020. Education and early life Ramakrishnan was born in a Tamil family of Chidambaram in Cuddalore district of Tamil Nadu, India to C. V. Ramakrishnan and Rajalakshmi Ramakrishnan on 1 April 1952. Both his parents were scientists, and his father was head of the Department of Biochemistry at the Maharaja Sayajirao University of Baroda. At the time of his birth, Ramakrishnan's father was away from India doing postdoctoral research with David E. Green at the University of Wisc ...
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Electrostatic Particle Accelerator
An electrostatic particle accelerator is a particle accelerator in which charged particles are accelerated to a high energy by a static high voltage potential. This contrasts with the other major category of particle accelerator, oscillating field particle accelerators, in which the particles are accelerated by oscillating electric fields. Owing to their simpler design, electrostatic types were the first particle accelerators. The two most common types are the Van de Graaf generator invented by Robert Van de Graaff in 1929, and the Cockcroft-Walton accelerator invented by John Cockcroft and Ernest Walton in 1932. The maximum particle energy produced by electrostatic accelerators is limited by the maximum voltage which can be achieved the machine. This is in turn limited by insulation breakdown to a few megavolts. Oscillating accelerators do not have this limitation, so they can achieve higher particle energies than electrostatic machines. The advantages of electro ...
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Ötzi
Ötzi, also called the Iceman, is the natural mummy of a man who lived some time between 3350 and 3105 BC, discovered in September 1991 in the Ötztal Alps (hence the nickname "Ötzi") on the border between Austria and Italy. Ötzi is believed to have been murdered, due to the discovery of an arrowhead embedded in his left shoulder and various other wounds. The nature of his life and the circumstances of his death are the subject of much investigation and speculation. He is Europe's oldest known natural human mummy, offering an unprecedented view of Chalcolithic (Copper Age) Europeans. His body and belongings are displayed in the South Tyrol Museum of Archaeology in Bolzano, South Tyrol, Italy. Discovery Ötzi was found on 19 September 1991 by two German tourists, at an elevation of on the east ridge of the Fineilspitze in the Ötztal Alps on the Austrian–Italian border, near Similaun mountain and the Tisenjoch pass. When the tourists, Helmut and Erika Simon, first saw the bo ...
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Radiocarbon Dating
Radiocarbon dating (also referred to as carbon dating or carbon-14 dating) is a method for determining the age of an object containing organic material by using the properties of radiocarbon, a radioactive isotope of carbon. The method was developed in the late 1940s at the University of Chicago by Willard Libby. It is based on the fact that radiocarbon () is constantly being created in the Earth's atmosphere by the interaction of cosmic rays with atmospheric nitrogen. The resulting combines with atmospheric oxygen to form radioactive carbon dioxide, which is incorporated into plants by photosynthesis; animals then acquire by eating the plants. When the animal or plant dies, it stops exchanging carbon with its environment, and thereafter the amount of it contains begins to decrease as the undergoes radioactive decay. Measuring the amount of in a sample from a dead plant or animal, such as a piece of wood or a fragment of bone, provides information that can be used to ca ...
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